Class information for:
Level 1: ALISKIREN//PRORENIN RECEPTOR//DIRECT RENIN INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9376 1161 41.0 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
57 3       ANGIOTENSIN II//HYPERTENSION//PERIPHERAL VASCULAR DISEASES 89232
85 2             ANGIOTENSIN II//RENIN ANGIOTENSIN SYSTEM//ANGIOTENSIN 27105
9376 1                   ALISKIREN//PRORENIN RECEPTOR//DIRECT RENIN INHIBITOR 1161

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALISKIREN authKW 3764541 20% 62% 232
2 PRORENIN RECEPTOR authKW 2790627 11% 84% 127
3 DIRECT RENIN INHIBITOR authKW 1659097 7% 78% 81
4 PRORENIN authKW 1353974 10% 46% 113
5 RENIN authKW 428741 17% 8% 193
6 RENIN INHIBITOR authKW 378619 5% 24% 60
7 INTRACRINE authKW 349228 3% 40% 33
8 DIRECT RENIN INHIBITION authKW 268961 1% 68% 15
9 HANDLE REGION PEPTIDE authKW 265183 1% 92% 11
10 RENIN INHIBITION authKW 261151 2% 41% 24

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Peripheral Vascular Diseases 18127 37% 0% 426
2 Urology & Nephrology 1854 12% 0% 142
3 Cardiac & Cardiovascular System 1224 14% 0% 160
4 Physiology 772 10% 0% 113
5 Pharmacology & Pharmacy 638 16% 0% 184
6 Endocrinology & Metabolism 320 8% 0% 88
7 Medicine, Research & Experimental 229 6% 0% 74
8 Medicine, General & Internal 133 7% 0% 77
9 Cell Biology 52 6% 0% 65
10 Hematology 11 2% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOL VASC MED 202278 2% 38% 20
2 ENDOCRINOL PL MED SCI 177156 1% 42% 16
3 UNIT 833 157796 1% 100% 6
4 SYNTHET WELF 127276 1% 44% 11
5 MED ENDOCRINOL HYPERTENS 2 99122 1% 54% 7
6 VASC PHARMACOL METAB 94673 1% 60% 6
7 ANTIAGING MED ENDOCRINOL 78898 0% 100% 3
8 ENDOCRINOL ANTIAGING MED INTERNAL MED 78898 0% 100% 3
9 BEHAV SLEEP MED 52599 0% 100% 2
10 ENDOCRINOL ANTIAGING MED 47336 0% 60% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 93830 5% 6% 56
2 HYPERTENSION 14977 7% 1% 81
3 AMERICAN JOURNAL OF HYPERTENSION 11094 4% 1% 50
4 JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION 10673 1% 3% 16
5 JOURNAL OF CLINICAL HYPERTENSION 9533 2% 2% 20
6 HYPERTENSION RESEARCH 7141 2% 1% 26
7 JOURNAL OF HYPERTENSION 7024 4% 1% 51
8 CURRENT HYPERTENSION REPORTS 6424 1% 2% 16
9 CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 3224 1% 1% 14
10 CLINICAL AND EXPERIMENTAL NEPHROLOGY 2514 1% 1% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ALISKIREN 3764541 20% 62% 232 Search ALISKIREN Search ALISKIREN
2 PRORENIN RECEPTOR 2790627 11% 84% 127 Search PRORENIN+RECEPTOR Search PRORENIN+RECEPTOR
3 DIRECT RENIN INHIBITOR 1659097 7% 78% 81 Search DIRECT+RENIN+INHIBITOR Search DIRECT+RENIN+INHIBITOR
4 PRORENIN 1353974 10% 46% 113 Search PRORENIN Search PRORENIN
5 RENIN 428741 17% 8% 193 Search RENIN Search RENIN
6 RENIN INHIBITOR 378619 5% 24% 60 Search RENIN+INHIBITOR Search RENIN+INHIBITOR
7 INTRACRINE 349228 3% 40% 33 Search INTRACRINE Search INTRACRINE
8 DIRECT RENIN INHIBITION 268961 1% 68% 15 Search DIRECT+RENIN+INHIBITION Search DIRECT+RENIN+INHIBITION
9 HANDLE REGION PEPTIDE 265183 1% 92% 11 Search HANDLE+REGION+PEPTIDE Search HANDLE+REGION+PEPTIDE
10 RENIN INHIBITION 261151 2% 41% 24 Search RENIN+INHIBITION Search RENIN+INHIBITION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DANSER, AHJ , (2015) THE ROLE OF THE (PRO)RENIN RECEPTOR IN HYPERTENSIVE DISEASE.AMERICAN JOURNAL OF HYPERTENSION. VOL. 28. ISSUE 10. P. 1187 -1196 82 82% 4
2 BATENBURG, WW , DANSER, AHJ , (2012) (PRO)RENIN AND ITS RECEPTORS: PATHOPHYSIOLOGICAL IMPLICATIONS.CLINICAL SCIENCE. VOL. 123. ISSUE 3-4. P. 121-133 88 69% 17
3 KROP, M , LU, XF , DANSER, AHJ , MEIMA, ME , (2013) THE (PRO)RENIN RECEPTOR. A DECADE OF RESEARCH: WHAT HAVE WE LEARNED?.PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. VOL. 465. ISSUE 1. P. 87 -97 75 77% 14
4 NGUYEN, G , (2011) RENIN, (PRO)RENIN AND RECEPTOR: AN UPDATE.CLINICAL SCIENCE. VOL. 120. ISSUE 5-6. P. 169 -178 59 80% 56
5 JAGADEESH, G , BALAKUMAR, P , STOCKBRIDGE, N , (2012) HOW WELL DO ALISKIREN'S PURPORTED MECHANISMS TRACK ITS EFFECTS ON CARDIOVASCULAR AND RENAL DISORDERS?.CELLULAR SIGNALLING. VOL. 24. ISSUE 8. P. 1583-1591 73 72% 3
6 RASHIKH, A , AHMAD, SJ , PILLAI, KK , NAJMI, AK , (2012) ALISKIREN AS A NOVEL THERAPEUTIC AGENT FOR HYPERTENSION AND CARDIO-RENAL DISEASES.JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL. 64. ISSUE 4. P. 470-481 70 74% 2
7 DANSER, AHJ , (2010) THE INCREASE IN RENIN DURING RENIN INHIBITION: DOES IT RESULT IN HARMFUL EFFECTS BY THE (PRO)RENIN RECEPTOR?.HYPERTENSION RESEARCH. VOL. 33. ISSUE 1. P. 4-10 52 95% 18
8 BALAKUMAR, P , JAGADEESH, G , (2010) CARDIOVASCULAR AND RENAL PATHOLOGIC IMPLICATIONS OF PRORENIN, RENIN, AND THE (PRO)RENIN RECEPTOR: PROMISING YOUNG PLAYERS FROM THE OLD RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. VOL. 56. ISSUE 5. P. 570 -579 68 68% 19
9 BRUNETTI, ND , DE GENNARO, L , PELLEGRINO, PL , CUCULO, A , ZICCARDI, L , GAGLIONE, A , DI BIASE, M , (2011) DIRECT RENIN INHIBITION: UPDATE ON CLINICAL INVESTIGATIONS WITH ALISKIREN.EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION. VOL. 18. ISSUE 3. P. 424 -437 58 75% 0
10 AHMED, BAM , SEDA, O , LAVOIE, JL , (2011) (PRO)RENIN RECEPTOR AS A NEW DRUG TARGET.CURRENT PHARMACEUTICAL DESIGN. VOL. 17. ISSUE 33. P. 3611-3621 55 76% 2

Classes with closest relation at Level 1


Rank Class id link
1 29713 OCULAR RENIN ANGIOTENSIN SYSTEM//REN 2 RAT//S PHARMACOL MOL BIOL
2 15903 RENIN INHIBITOR//KETOPIPERAZINE//REMIKIREN
3 15547 HYPERTENS RENAL EXCELLENCE//URINARY ANGIOTENSINOGEN//RENAL EXCELLENCE
4 3425 PRORENIN//RENIN//JUXTAGLOMERULAR CELLS
5 4584 PROTEINURIA//ANGIOTENSIN RECEPTOR BLOCKER//DUAL BLOCKADE
6 10106 ANGIOTENSINOGEN//ADRENAL RENIN//HIGH MOLECULAR WEIGHT ANGIOTENSINOGEN
7 36439 CIHR GRP IMMUNOCARDIOVASC INTERACT//R TYPE CA2 CHANNEL//ENDOCARDIAL ENDOTHELIAL CELLS
8 29435 TGRMREN227//ENOS KNOCK OUT MICE//TRANSGENIC RATS TGR
9 6313 ANGIOTENSIN 1 7//ANGIOTENSIN CONVERTING ENZYME 2//MAS RECEPTOR
10 11979 TELMISARTAN//AZILSARTAN//AZILSARTAN MEDOXOMIL

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