Class information for:
Level 1: HIV 1 PROTEASE//HIV PROTEASE//HIV 1 PROTEASE INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2183 2330 38.2 81%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
29 3       HIV//VIROLOGY//HIV 1 108954
773 2             EFAVIRENZ//NEVIRAPINE//RALTEGRAVIR 12242
2183 1                   HIV 1 PROTEASE//HIV PROTEASE//HIV 1 PROTEASE INHIBITORS 2330

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HIV 1 PROTEASE authKW 1643156 9% 59% 211
2 HIV PROTEASE authKW 633052 4% 52% 93
3 HIV 1 PROTEASE INHIBITORS authKW 455917 3% 52% 67
4 EXPT RETROVIROL SECT address 223571 2% 36% 48
5 RETROVIRAL PROTEASE authKW 147808 1% 59% 19
6 HIV 1 PROTEINASE authKW 145145 1% 92% 12
7 KNI 272 authKW 144139 0% 100% 11
8 HIV PROTEINASE authKW 138401 1% 81% 13
9 MOL BASIS DIS PROGRAM address 123754 1% 41% 23
10 OLIGOPEPTIDE SUBSTRATES authKW 119121 0% 91% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 15292 24% 0% 566
2 Biochemistry & Molecular Biology 5421 41% 0% 963
3 Virology 5058 12% 0% 270
4 Chemistry, Organic 2387 16% 0% 366
5 Biophysics 2349 12% 0% 288
6 Biochemical Research Methods 508 6% 0% 136
7 Pharmacology & Pharmacy 463 11% 0% 250
8 Computer Science, Interdisciplinary Applications 400 4% 0% 97
9 Chemistry, Multidisciplinary 203 9% 0% 213
10 Infectious Diseases 70 2% 0% 57

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT RETROVIROL SECT 223571 2% 36% 48
2 MOL BASIS DIS PROGRAM 123754 1% 41% 23
3 HIV AIDS MALIGNANCY BRANCH 111334 2% 16% 52
4 STRUCT BIOCHEM PROGRAM 109987 1% 44% 19
5 GENE MANIPULAT 53500 0% 58% 7
6 MOLEC VIROL CARCINOGENESIS 53500 0% 58% 7
7 MOL VIROL CARCINOGENESIS 52406 0% 50% 8
8 BIOCALORIMETRY 47156 1% 30% 12
9 BIOL MOL BASIS DIS 41930 0% 80% 4
10 RETROVIRAL DIS SECT 39311 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 17087 7% 1% 168
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14178 7% 1% 166
3 ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 6746 1% 3% 16
4 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 4271 2% 1% 46
5 JOURNAL OF MOLECULAR GRAPHICS & MODELLING 3359 1% 1% 22
6 BIOORGANIC & MEDICINAL CHEMISTRY 3077 2% 0% 56
7 JOURNAL OF VIROLOGY 2967 4% 0% 97
8 CHEMICAL BIOLOGY & DRUG DESIGN 2831 1% 1% 19
9 PROTEIN SCIENCE 2500 2% 1% 35
10 JOURNAL OF CHEMICAL INFORMATION AND MODELING 2387 1% 1% 24

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HIV 1 PROTEASE 1643156 9% 59% 211 Search HIV+1+PROTEASE Search HIV+1+PROTEASE
2 HIV PROTEASE 633052 4% 52% 93 Search HIV+PROTEASE Search HIV+PROTEASE
3 HIV 1 PROTEASE INHIBITORS 455917 3% 52% 67 Search HIV+1+PROTEASE+INHIBITORS Search HIV+1+PROTEASE+INHIBITORS
4 RETROVIRAL PROTEASE 147808 1% 59% 19 Search RETROVIRAL+PROTEASE Search RETROVIRAL+PROTEASE
5 HIV 1 PROTEINASE 145145 1% 92% 12 Search HIV+1+PROTEINASE Search HIV+1+PROTEINASE
6 KNI 272 144139 0% 100% 11 Search KNI+272 Search KNI+272
7 HIV PROTEINASE 138401 1% 81% 13 Search HIV+PROTEINASE Search HIV+PROTEINASE
8 OLIGOPEPTIDE SUBSTRATES 119121 0% 91% 10 Search OLIGOPEPTIDE+SUBSTRATES Search OLIGOPEPTIDE+SUBSTRATES
9 DIMERIZATION INHIBITORS 116730 1% 64% 14 Search DIMERIZATION+INHIBITORS Search DIMERIZATION+INHIBITORS
10 ASPARTIC PROTEASE 89535 2% 15% 47 Search ASPARTIC+PROTEASE Search ASPARTIC+PROTEASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GHOSH, AK , OSSWALD, HL , PRATO, G , (2016) RECENT PROGRESS IN THE DEVELOPMENT OF HIV-1 PROTEASE INHIBITORS FOR THE TREATMENT OF HIV/AIDS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 11. P. 5172 -5208 129 71% 6
2 KEMPF, DJ , SHAM, HL , (1996) HIV PROTEASE INHIBITORS.CURRENT PHARMACEUTICAL DESIGN. VOL. 2. ISSUE 2. P. 225 -246 158 86% 93
3 WLODAWER, A , VONDRASEK, J , (1998) INHIBITORS OF HIV-1 PROTEASE: A MAJOR SUCCESS OF STRUCTURE-ASSISTED DRUG DESIGN.ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE. VOL. 27. ISSUE . P. 249 -284 92 76% 428
4 GULNIK, S , ERICKSON, JW , XIE, D , (2000) HIV PROTEASE: ENZYME FUNCTION AND DRUG RESISTANCE.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 58. VOL. 58. ISSUE . P. 213 -256 122 79% 23
5 WLODAWER, A , GUSTCHINA, A , (2000) STRUCTURAL AND BIOCHEMICAL STUDIES OF RETROVIRAL PROTEASES.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. VOL. 1477. ISSUE 1-2. P. 16 -34 87 94% 127
6 LEBON, F , LEDECQ, M , (2000) APPROACHES TO THE DESIGN OF EFFECTIVE HIV-1 PROTEASE INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 7. ISSUE 4. P. 455 -477 114 73% 55
7 GHOSH, AK , ANDERSON, DD , WEBER, IT , MITSUYA, H , (2012) ENHANCING PROTEIN BACKBONE BINDINGUA FRUITFUL CONCEPT FOR COMBATING DRUG-RESISTANT HIV.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 51. ISSUE 8. P. 1778 -1802 69 67% 25
8 DEBOUCK, C , (1992) THE HIV-1 PROTEASE AS A THERAPEUTIC TARGET FOR AIDS.AIDS RESEARCH AND HUMAN RETROVIRUSES. VOL. 8. ISSUE 2. P. 153 -164 83 75% 314
9 WLODAWER, A , ERICKSON, JW , (1993) STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 62. ISSUE . P. 543 -585 57 84% 640
10 HUANG, LQ , CHEN, CP , (2013) UNDERSTANDING HIV-1 PROTEASE AUTOPROCESSING FOR NOVEL THERAPEUTIC DEVELOPMENT.FUTURE MEDICINAL CHEMISTRY. VOL. 5. ISSUE 11. P. 1215 -1229 67 64% 3

Classes with closest relation at Level 1


Rank Class id link
1 12014 HAPALOSIN//HYDROXYETHYLENE DIPEPTIDE ISOSTERE//ALPHA AMINO ALDEHYDES
2 545 HIV DRUG RESISTANCE//HIV 1 DRUG RESISTANCE//TRANSMITTED DRUG RESISTANCE
3 6181 ATAZANAVIR//RITONAVIR//LOPINAVIR
4 3841 VIRUS CELL INTERACT SECT//GAG//HIV DRUG ISTANCE PROGRAM
5 15903 RENIN INHIBITOR//KETOPIPERAZINE//REMIKIREN
6 5422 ASPARTIC PROTEINASE//CATHEPSIN E//MILK CLOTTING ENZYME
7 5802 THERMODYNAMIC INTEGRATION//FREE ENERGY CALCULATIONS//FREE ENERGY PERTURBATION
8 35517 COMPLEX AUTOMATA//DISTRIBUTED MULTISCALE COMPUTING//HPC INFRASTRUCTURE
9 1509 NNRTIS//REVERSE TRANSCRIPTASE//HIV 1 REVERSE TRANSCRIPTASE
10 23925 WATERMAP//CAMBRIDGE MOL THER EUT PROGRAMME//PROTEIN HYDRATION

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