Class information for:
Level 1: AICARDI GOUTIERES SYNDROME//TREX1//RIBONUCLEASE H

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15670 699 38.3 81%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
142 3       DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH 64602
160 2             WERNER SYNDROME//DNA POLYMERASE//DNA REPAIR 22798
15670 1                   AICARDI GOUTIERES SYNDROME//TREX1//RIBONUCLEASE H 699

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AICARDI GOUTIERES SYNDROME authKW 2375022 9% 86% 63
2 TREX1 authKW 621825 3% 65% 22
3 RIBONUCLEASE H authKW 381654 4% 29% 30
4 RNASE H2 authKW 352370 2% 73% 11
5 AICARDI GOUTIERES authKW 305781 1% 100% 7
6 NEUROGENET NEUROINFLAMMAT address 293638 2% 61% 11
7 FAMILIAL CHILBLAIN LUPUS authKW 262098 1% 100% 6
8 RNASE H authKW 234848 5% 15% 36
9 INTRACRANIAL CALCIFICATION authKW 217717 3% 28% 18
10 PSEUDO TORCH authKW 174732 1% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2280 48% 0% 335
2 Genetics & Heredity 890 16% 0% 111
3 Pediatrics 309 8% 0% 57
4 Clinical Neurology 236 9% 0% 66
5 Biophysics 200 7% 0% 50
6 Cell Biology 188 10% 0% 72
7 Biochemical Research Methods 104 5% 0% 35
8 Rheumatology 84 2% 0% 16
9 Immunology 55 6% 0% 43
10 Biotechnology & Applied Microbiology 36 5% 0% 32

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROGENET NEUROINFLAMMAT 293638 2% 61% 11
2 GEN NEUROL COMPLEX MOTOR DISORDERS SERV 139784 1% 80% 4
3 CENT MANCHESTER FDN TRUST UNIV HOSP 118906 1% 39% 7
4 CORE ANTISENSE 93054 1% 30% 7
5 BRADFORD CHILD DEV 87366 0% 100% 2
6 HUMAN DEVMANCHESTER GENOM MED 87366 0% 100% 2
7 PROTECCIO RADIOL 87366 0% 100% 2
8 SKAGGS CHEM BIOL MB4 87366 0% 100% 2
9 CHILD NEUROL PSYCHIAT UNIT 63873 2% 9% 16
10 MANCHESTER GENOM MED HUMAN DEV 63534 1% 36% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROPEDIATRICS 4822 2% 1% 15
2 DNA REPAIR 2581 2% 1% 11
3 FEBS JOURNAL 1807 2% 0% 15
4 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 1681 2% 0% 15
5 NUCLEIC ACIDS RESEARCH 1158 5% 0% 33
6 ARTHRITIS & RHEUMATOLOGY 1081 1% 0% 5
7 PROTEIN ENGINEERING 934 1% 0% 7
8 JOURNAL OF BIOLOGICAL CHEMISTRY 896 8% 0% 58
9 MOLECULAR CELL 784 1% 0% 10
10 NATURE GENETICS 700 1% 0% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 AICARDI GOUTIERES SYNDROME 2375022 9% 86% 63 Search AICARDI+GOUTIERES+SYNDROME Search AICARDI+GOUTIERES+SYNDROME
2 TREX1 621825 3% 65% 22 Search TREX1 Search TREX1
3 RIBONUCLEASE H 381654 4% 29% 30 Search RIBONUCLEASE+H Search RIBONUCLEASE+H
4 RNASE H2 352370 2% 73% 11 Search RNASE+H2 Search RNASE+H2
5 AICARDI GOUTIERES 305781 1% 100% 7 Search AICARDI+GOUTIERES Search AICARDI+GOUTIERES
6 FAMILIAL CHILBLAIN LUPUS 262098 1% 100% 6 Search FAMILIAL+CHILBLAIN+LUPUS Search FAMILIAL+CHILBLAIN+LUPUS
7 RNASE H 234848 5% 15% 36 Search RNASE+H Search RNASE+H
8 INTRACRANIAL CALCIFICATION 217717 3% 28% 18 Search INTRACRANIAL+CALCIFICATION Search INTRACRANIAL+CALCIFICATION
9 PSEUDO TORCH 174732 1% 100% 4 Search PSEUDO+TORCH Search PSEUDO+TORCH
10 RNASE HII 174732 1% 100% 4 Search RNASE+HII Search RNASE+HII

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 RICE, GI , RODERO, MP , CROW, YJ , (2015) HUMAN DISEASE PHENOTYPES ASSOCIATED WITH MUTATIONS IN TREX1.JOURNAL OF CLINICAL IMMUNOLOGY. VOL. 35. ISSUE 3. P. 235 -243 44 81% 14
2 ORCESI, S , LA PIANA, R , FAZZI, E , (2009) AICARDI-GOUTIERES SYNDROME.BRITISH MEDICAL BULLETIN. VOL. 89. ISSUE 1. P. 183 -201 49 96% 23
3 CROW, YJ , CHASE, DS , SCHMIDT, JL , SZYNKIEWICZ, M , FORTE, GMA , GORNALL, HL , OOJAGEER, A , ANDERSON, B , PIZZINO, A , HELMAN, G , ET AL (2015) CHARACTERIZATION OF HUMAN DISEASE PHENOTYPES ASSOCIATED WITH MUTATIONS IN TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, AND IFIH1.AMERICAN JOURNAL OF MEDICAL GENETICS PART A. VOL. 167. ISSUE 2. P. 296 -312 32 84% 41
4 REIJNS, MAM , JACKSON, AP , (2014) RIBONUCLEASE H2 IN HEALTH AND DISEASE.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 42. ISSUE . P. 717 -725 49 78% 12
5 CROW, YJ , MANEL, N , (2015) AICARDI-GOUTIERES SYNDROME AND THE TYPE I INTERFERONOPATHIES.NATURE REVIEWS IMMUNOLOGY. VOL. 15. ISSUE 7. P. 429 -440 43 45% 72
6 TANNOUS, E , KANAYA, E , KANAYA, S , (2015) ROLE OF RNASE H1 IN DNA REPAIR: REMOVAL OF SINGLE RIBONUCLEOTIDE MISINCORPORATED INTO DNA IN COLLABORATION WITH RNASE H2.SCIENTIFIC REPORTS. VOL. 5. ISSUE . P. - 41 85% 2
7 JONGRUJA, N , YOU, DJ , ANGKAWIDJAJA, C , KANAYA, E , KOGA, Y , KANAYA, S , (2012) STRUCTURE AND CHARACTERIZATION OF RNASE H3 FROM AQUIFEX AEOLICUS.FEBS JOURNAL. VOL. 279. ISSUE 15. P. 2737 -2753 44 85% 2
8 CERRITELLI, SM , CROUCH, RJ , (2009) RIBONUCLEASE H: THE ENZYMES IN EUKARYOTES.FEBS JOURNAL. VOL. 276. ISSUE 6. P. 1494-1505 34 81% 181
9 ROSSLER, L , LUDWIG-SEIBOLD, C , THIELS, C , SCHAPER, J , (2012) AICARDI-GOUTISRES SYNDROME WITH EMPHASIS ON SONOGRAPHIC FEATURES IN INFANCY.PEDIATRIC RADIOLOGY. VOL. 42. ISSUE 8. P. 932-940 40 87% 0
10 FENG, SL , CAO, ZH , (2016) IS THE ROLE OF HUMAN RNASE H2 RESTRICTED TO ITS ENZYME ACTIVITY?.PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. VOL. 121. ISSUE 1. P. 66 -73 45 61% 2

Classes with closest relation at Level 1


Rank Class id link
1 21108 FEN1//BRAUN S//CREAT INITIAT CELL CYCLE CONTROL
2 12511 VPR//SAMHD1//VPX
3 17964 FAHRS DISEASE//FAHRS SYNDROME//SLC20A2
4 19522 REPLICATION FORK BARRIER//FORK ARREST//REPLICATION TERMINATOR PROTEIN
5 10461 IRF5//GENOM INVEST ONCOL GENYO//INTERFERON REGULATORY FACTOR 5
6 36765 PROGRAM BIOCHEM CHEM//2 SELENOURIDINE TRIPHOSPHATE//3 5 O DIACETYL 5 AMINOMETHYL 2 DEOXYURIDINE
7 1509 NNRTIS//REVERSE TRANSCRIPTASE//HIV 1 REVERSE TRANSCRIPTASE
8 2033 RIG I//MAVS//MDA5
9 28255 CHILBLAINS//ERYTHEMA AB IGNE//PERNIOSIS
10 26991 DRUG DESIGN BIOTECHNOL//METAL BINDING RESIDUES//METAL CATIONS M2

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