Class information for:
Level 1: NNRTIS//REVERSE TRANSCRIPTASE//HIV 1 REVERSE TRANSCRIPTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1509 2619 38.4 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
29 3       HIV//VIROLOGY//HIV 1 108954
2356 2             NNRTIS//REVERSE TRANSCRIPTASE//HIV DRUG ISTANCE PROGRAM 4364
1509 1                   NNRTIS//REVERSE TRANSCRIPTASE//HIV 1 REVERSE TRANSCRIPTASE 2619

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NNRTIS authKW 1311492 8% 53% 214
2 REVERSE TRANSCRIPTASE authKW 822843 12% 22% 314
3 HIV 1 REVERSE TRANSCRIPTASE authKW 424814 3% 44% 83
4 HIV DRUG ISTANCE PROGRAM address 221037 4% 18% 105
5 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS authKW 213804 3% 27% 68
6 REGA MED address 198704 9% 7% 229
7 HEPT authKW 176177 1% 66% 23
8 HIV 1 RT authKW 169220 1% 52% 28
9 S DABOS authKW 163930 1% 94% 15
10 DIARYLPYRIMIDINES authKW 154285 1% 88% 15

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Chemistry, Medicinal 17233 24% 0% 637
2 Virology 11088 16% 0% 418
3 Biochemistry & Molecular Biology 5843 41% 0% 1063
4 Chemistry, Organic 1648 13% 0% 333
5 Pharmacology & Pharmacy 1632 17% 0% 437
6 Biophysics 348 5% 0% 138
7 Infectious Diseases 195 3% 0% 88
8 Biochemical Research Methods 146 3% 0% 91
9 Computer Science, Interdisciplinary Applications 146 3% 0% 70
10 Microbiology 142 5% 0% 120

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HIV DRUG ISTANCE PROGRAM 221037 4% 18% 105
2 REGA MED 198704 9% 7% 229
3 RT BIOCHEM SECT 90430 1% 52% 15
4 ISTANCE MECH 82965 0% 65% 11
5 VIROL DRUG DISCOVERY 69944 0% 100% 6
6 HIV DRUG ISTANCE PROGRAMNIH 58287 0% 100% 5
7 SEZ MICROBIOL VIROL GEN BIOTECNOL MICROB 58277 0% 50% 10
8 MOL INTERACT GRP 57384 0% 62% 8
9 REVERSE TRANSCRIPTASE BIOCHEM SECT 51923 0% 64% 7
10 DIPARTIMENTO STUDI FARMACEUT 50879 1% 15% 30

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 43466 2% 9% 43
2 JOURNAL OF MEDICINAL CHEMISTRY 16852 7% 1% 177
3 ANTIVIRAL RESEARCH 6154 2% 1% 43
4 BIOORGANIC & MEDICINAL CHEMISTRY 5347 3% 1% 78
5 JOURNAL OF VIROLOGY 5097 5% 0% 134
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 4956 4% 0% 105
7 CHEMICAL BIOLOGY & DRUG DESIGN 4025 1% 1% 24
8 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 3601 3% 0% 87
9 BIOCHEMISTRY 3404 5% 0% 128
10 JOURNAL OF BIOLOGICAL CHEMISTRY 2936 8% 0% 204

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NNRTIS 1311492 8% 53% 214 Search NNRTIS Search NNRTIS
2 REVERSE TRANSCRIPTASE 822843 12% 22% 314 Search REVERSE+TRANSCRIPTASE Search REVERSE+TRANSCRIPTASE
3 HIV 1 REVERSE TRANSCRIPTASE 424814 3% 44% 83 Search HIV+1+REVERSE+TRANSCRIPTASE Search HIV+1+REVERSE+TRANSCRIPTASE
4 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 213804 3% 27% 68 Search NON+NUCLEOSIDE+REVERSE+TRANSCRIPTASE+INHIBITORS Search NON+NUCLEOSIDE+REVERSE+TRANSCRIPTASE+INHIBITORS
5 HEPT 176177 1% 66% 23 Search HEPT Search HEPT
6 HIV 1 RT 169220 1% 52% 28 Search HIV+1+RT Search HIV+1+RT
7 S DABOS 163930 1% 94% 15 Search S+DABOS Search S+DABOS
8 DIARYLPYRIMIDINES 154285 1% 88% 15 Search DIARYLPYRIMIDINES Search DIARYLPYRIMIDINES
9 TIBO 146468 1% 74% 17 Search TIBO Search TIBO
10 NON NUCLEOSIDE INHIBITORS 134934 1% 37% 31 Search NON+NUCLEOSIDE+INHIBITORS Search NON+NUCLEOSIDE+INHIBITORS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ZHAN, P , CHEN, XW , LI, DY , FANG, ZJ , DE CLERCQ, E , LIU, XY , (2013) HIV-1 NNRTIS: STRUCTURAL DIVERSITY, PHARMACOPHORE SIMILARITY, AND IMPLIATIONS FOR DRUG DESIGN.MEDICINAL RESEARCH REVIEWS. VOL. 33. ISSUE . P. E1-E72 216 67% 32
2 SONG, YN , FANG, ZJ , ZHAN, P , LIU, XY , (2014) RECENT ADVANCES IN THE DISCOVERY AND DEVELOPMENT OF NOVEL HIV-1 NNRTI PLATFORMS (PART II): 2009-2013 UPDATE.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 3. P. 329-355 122 79% 7
3 BALZARINI, J , (2004) CURRENT STATUS OF THE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 4. ISSUE 9. P. 921 -944 143 75% 101
4 SCHULTZ, SJ , CHAMPOUX, JJ , (2008) RNASE H ACTIVITY: STRUCTURE, SPECIFICITY, AND FUNCTION IN REVERSE TRANSCRIPTION.VIRUS RESEARCH. VOL. 134. ISSUE 1-2. P. 86-103 122 80% 53
5 CAMPIANI, G , RAMUNNO, A , MAGA, G , NACCI, V , FATTORUSSO, C , CATALANOTTI, B , MORELLI, E , NOVELLINO, E , (2002) NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE (RT) INHIBITORS: PAST, PRESENT, AND FUTURE PERSPECTIVES.CURRENT PHARMACEUTICAL DESIGN. VOL. 8. ISSUE 8. P. 615-657 139 78% 107
6 DE CLERCQ, E , (2004) NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIS): PAST, PRESENT, AND FUTURE.CHEMISTRY & BIODIVERSITY. VOL. 1. ISSUE 1. P. 44-64 109 81% 156
7 CHEN, WM , ZHAN, P , WU, JD , LI, ZY , LIU, XY , (2012) THE DEVELOPMENT OF HEPT-TYPE HIV NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND ITS IMPLICATIONS FOR DABO FAMILY.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 27. P. 4165 -4186 100 81% 6
8 DECLERCQ, E , (1996) NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIS) FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTIONS: STRATEGIES TO OVERCOME DRUG RESISTANCE DEVELOPMENT.MEDICINAL RESEARCH REVIEWS. VOL. 16. ISSUE 2. P. 125-157 130 83% 117
9 CHAMPOUX, JJ , SCHULTZ, SJ , (2009) RIBONUCLEASE H: PROPERTIES, SUBSTRATE SPECIFICITY AND ROLES IN RETROVIRAL REVERSE TRANSCRIPTION.FEBS JOURNAL. VOL. 276. ISSUE 6. P. 1506-1516 85 90% 27
10 ZHAN, P , LIU, XY , LI, ZY , PANNECOUQUE, C , DE CLERCQ, E , (2009) DESIGN STRATEGIES OF NOVEL NNRTIS TO OVERCOME DRUG RESISTANCE.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 29. P. 3903-3917 87 88% 24

Classes with closest relation at Level 1


Rank Class id link
1 31862 RT ASSAY//POLY DNP RNA//REVERSE TRANSCRIPTASE INHIBITING ANTIBODY
2 5490 NCP7//RNA DIMERIZATION//NUCLEOCAPSID PROTEIN
3 545 HIV DRUG RESISTANCE//HIV 1 DRUG RESISTANCE//TRANSMITTED DRUG RESISTANCE
4 33146 3 METHYL 1 6 METHYL 2 METHYLSULFANYLPYRIMIDIN 4 YL 4 PHENYLIMINOMETHYL 1H PYRAZOL 5 OL//5 ALKYL OR ARYLTHIO 6 VINYL URACILS//5 BENZYLPYRIMIDIN 2 4 6 TRIONES
5 15670 AICARDI GOUTIERES SYNDROME//TREX1//RIBONUCLEASE H
6 5405 ZIDOVUDINE//DIDANOSINE//ZALCITABINE
7 5439 DNA POLYMERASE BETA//DNA POLYMERASE//DNA POLYMERASE LAMBDA
8 2499 INTEGRASE//HIV 1 INTEGRASE//LEDGF P75
9 36331 MULTIDISTANCE//ESTADD//ESTOUT
10 30780 1 AZABICYCLO330OCTANE//PILSICAINIDE HYDROCHLORIDE//SUN 1165

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