Class information for:
Level 1: CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13262 850 27.3 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
499 3       MEDICAL ETHICS//INFORMED CONSENT//ETHICS 22534
3420 2             CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL 1575
13262 1                   CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL 850

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CONTINUAL REASSESSMENT METHOD authKW 2852648 11% 88% 90
2 DOSE FINDING authKW 2149072 15% 48% 124
3 PHASE I TRIAL authKW 955773 13% 24% 111
4 DOSE FINDING STUDIES authKW 828967 4% 77% 30
5 MAXIMUM TOLERATED DOSE authKW 701604 8% 30% 66
6 BAYESIAN ADAPTIVE DESIGN authKW 401327 2% 62% 18
7 UP AND DOWN DESIGN authKW 357106 2% 76% 13
8 ESCALATION WITH OVERDOSE CONTROL authKW 323303 1% 100% 9
9 ADAPTIVE DESIGN authKW 294019 8% 13% 65
10 TRANSLAT PL STAT address 281620 2% 56% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Statistics & Probability 21326 39% 0% 328
2 Medical Informatics 14182 16% 0% 136
3 Mathematical & Computational Biology 13725 23% 0% 199
4 Oncology 4662 39% 0% 330
5 Medicine, Research & Experimental 2604 21% 0% 181
6 Public, Environmental & Occupational Health 916 14% 0% 123
7 Pharmacology & Pharmacy 910 21% 0% 178
8 Biology 361 6% 0% 55
9 Health Care Sciences & Services 45 2% 0% 17
10 Computer Science, Interdisciplinary Applications 17 2% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSLAT PL STAT 281620 2% 56% 14
2 UNIT MOL THER Y CANC 107768 0% 100% 3
3 UNIT EA2694 80824 0% 75% 3
4 CNRS UMR8203 71845 0% 100% 2
5 EQUIPE 22UNIV PARIS 5U1138 71845 0% 100% 2
6 DRUG DEV UNIT 63847 2% 9% 19
7 MED PHARMACEUT STAT UNIT 55415 2% 11% 14
8 EQUIPE ACCUEIL ST PUBL EPIDEMIOL MODELISAT MALA 53881 0% 50% 3
9 U717 51865 2% 11% 13
10 CLIN PHARMACODYNAM PROGRAM 47895 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STATISTICS IN MEDICINE 73444 14% 2% 121
2 PHARMACEUTICAL STATISTICS 42717 3% 5% 25
3 JOURNAL OF BIOPHARMACEUTICAL STATISTICS 37710 4% 3% 31
4 CLINICAL TRIALS 32677 3% 4% 26
5 BIOMETRICS 19087 6% 1% 49
6 CONTEMPORARY CLINICAL TRIALS 13519 3% 2% 23
7 CLINICAL CANCER RESEARCH 6500 6% 0% 52
8 STATISTICS IN BIOPHARMACEUTICAL RESEARCH 5757 1% 2% 7
9 DRUG INFORMATION JOURNAL 3941 1% 1% 11
10 JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS 3585 1% 1% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CONTINUAL REASSESSMENT METHOD 2852648 11% 88% 90 Search CONTINUAL+REASSESSMENT+METHOD Search CONTINUAL+REASSESSMENT+METHOD
2 DOSE FINDING 2149072 15% 48% 124 Search DOSE+FINDING Search DOSE+FINDING
3 PHASE I TRIAL 955773 13% 24% 111 Search PHASE+I+TRIAL Search PHASE+I+TRIAL
4 DOSE FINDING STUDIES 828967 4% 77% 30 Search DOSE+FINDING+STUDIES Search DOSE+FINDING+STUDIES
5 MAXIMUM TOLERATED DOSE 701604 8% 30% 66 Search MAXIMUM+TOLERATED+DOSE Search MAXIMUM+TOLERATED+DOSE
6 BAYESIAN ADAPTIVE DESIGN 401327 2% 62% 18 Search BAYESIAN+ADAPTIVE+DESIGN Search BAYESIAN+ADAPTIVE+DESIGN
7 UP AND DOWN DESIGN 357106 2% 76% 13 Search UP+AND+DOWN+DESIGN Search UP+AND+DOWN+DESIGN
8 ESCALATION WITH OVERDOSE CONTROL 323303 1% 100% 9 Search ESCALATION+WITH+OVERDOSE+CONTROL Search ESCALATION+WITH+OVERDOSE+CONTROL
9 ADAPTIVE DESIGN 294019 8% 13% 65 Search ADAPTIVE+DESIGN Search ADAPTIVE+DESIGN
10 RESEARCH BIOPSY 264517 1% 82% 9 Search RESEARCH+BIOPSY Search RESEARCH+BIOPSY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HARRINGTON, JA , WHEELER, GM , SWEETING, MJ , MANDER, AP , JODRELL, DI , (2013) ADAPTIVE DESIGNS FOR DUAL-AGENT PHASE I DOSE-ESCALATION STUDIES.NATURE REVIEWS CLINICAL ONCOLOGY. VOL. 10. ISSUE 5. P. 277 -288 61 85% 16
2 DOUSSAU, A , GEOERGER, B , JIMENEZ, I , PAOLETTI, X , (2016) INNOVATIONS FOR PHASE I DOSE-FINDING DESIGNS IN PEDIATRIC ONCOLOGY CLINICAL TRIALS.CONTEMPORARY CLINICAL TRIALS. VOL. 47. ISSUE . P. 217 -227 40 83% 2
3 POTTER, DM , (2006) PHASE I STUDIES OF CHEMOTHERAPEUTIC AGENTS IN CANCER PATIENTS: A REVIEW OF THE DESIGNS.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 16. ISSUE 5. P. 579-604 55 85% 17
4 PETRONI, GR , WAGES, NA , PAUX, G , DUBOIS, F , (2017) IMPLEMENTATION OF ADAPTIVE METHODS IN EARLY-PHASE CLINICAL TRIALS.STATISTICS IN MEDICINE. VOL. 36. ISSUE 2. P. 215 -224 25 89% 1
5 WAGES, NA , IVANOVA, A , MARCHENKO, O , (2016) PRACTICAL DESIGNS FOR PHASE I COMBINATION STUDIES IN ONCOLOGY.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 26. ISSUE 1. P. 150 -166 35 92% 0
6 HORTON, BJ , WAGES, NA , CONAWAY, MR , (2017) PERFORMANCE OF TOXICITY PROBABILITY INTERVAL BASED DESIGNS IN CONTRAST TO THE CONTINUAL REASSESSMENT METHOD.STATISTICS IN MEDICINE. VOL. 36. ISSUE 2. P. 291 -300 19 100% 1
7 ORON, AP , HOFF, PD , (2013) SMALL-SAMPLE BEHAVIOR OF NOVEL PHASE I CANCER TRIAL DESIGNS.CLINICAL TRIALS. VOL. 10. ISSUE 1. P. 63 -80 36 88% 6
8 ZHOU, YH , (2010) ADAPTIVE DESIGNS FOR PHASE I DOSE-FINDING STUDIES.FUNDAMENTAL & CLINICAL PHARMACOLOGY. VOL. 24. ISSUE 2. P. 129 -138 36 97% 2
9 O'QUIGLEY, J , CONAWAY, M , (2010) CONTINUAL REASSESSMENT AND RELATED DOSE-FINDING DESIGNS.STATISTICAL SCIENCE. VOL. 25. ISSUE 2. P. 202 -216 36 92% 9
10 NEUENSCHWANDER, B , BRANSON, M , GSPONER, T , (2008) CRITICAL ASPECTS OF THE BAYESIAN APPROACH TO PHASE I CANCER TRIALS.STATISTICS IN MEDICINE. VOL. 27. ISSUE 13. P. 2420-2439 31 100% 63

Classes with closest relation at Level 1


Rank Class id link
1 1949 ADAPTIVE DESIGN//INTERIM ANALYSIS//GROUP SEQUENTIAL TEST
2 9031 D OPTIMALITY//APPROXIMATE DESIGN//C OPTIMALITY
3 3516 INFORMED CONSENT//TRIAL PARTICIPATION//THERAPEUTIC MISCONCEPTION
4 15440 RESPONSE ADAPTIVE DESIGN//URN MODEL//BIASED COIN DESIGN
5 28722 MANAGEMENT HEALTHCARE//ACADEMIC ASSOCIATE PROGRAM//CLINICAL RESEARCH MANAGEMENT
6 36772 PENCLOMEDINE//BOETIUS THERMOMICROSCOPY//THERMOTROP LIQUID CRYSTAL
7 33716 TARGET BASED DRUG//FULL TIME RESEARCHERS//ACADEMY OF MEDICINE
8 26445 DRUG LAG//JAPANESE CLINICAL TRIALS//GLOBAL DRUG DEVELOPMENT
9 31893 CORONARY ANGIOGRAPHY AND INTERVENTION//DOSE ADVERSE EVENT RELATIONSHIP//DOSE LIMITING ADVERSE EFFECTS
10 16116 SUBGROUP ANALYSIS//MULTIREGIONAL CLINICAL TRIAL//MULTIREGIONAL TRIAL

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