Class information for:
Level 2: CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3420 1575 26.3 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
499 3       MEDICAL ETHICS//INFORMED CONSENT//ETHICS 22534
3420 2             CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL 1575
13262 1                   CONTINUAL REASSESSMENT METHOD//DOSE FINDING//PHASE I TRIAL 850
28722 1                   MANAGEMENT HEALTHCARE//ACADEMIC ASSOCIATE PROGRAM//CLINICAL RESEARCH MANAGEMENT 201
29589 1                   HRDG//ACADEMIC CLINICAL COLLABORATION//ACADEMIC CLINICAL RELATIONSHIPS 183
31688 1                   CLINICAL COOPERATIVE GROUPS//COMMUNITY CLINICAL ONCOLOGY PROGRAM//CCOP 149
33716 1                   TARGET BASED DRUG//FULL TIME RESEARCHERS//ACADEMY OF MEDICINE 121
36921 1                   WICHITA CLIN TRIALS UNIT//AIRWAY SPLINT//BIOMACROMOLECULE PROTEIN 71

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CONTINUAL REASSESSMENT METHOD authKW 1539441 6% 88% 90
2 DOSE FINDING authKW 1159702 8% 48% 124
3 PHASE I TRIAL authKW 515712 7% 24% 111
4 DOSE FINDING STUDIES authKW 447351 2% 77% 30
5 MAXIMUM TOLERATED DOSE authKW 378583 4% 30% 66
6 BAYESIAN ADAPTIVE DESIGN authKW 216573 1% 62% 18
7 UP AND DOWN DESIGN authKW 192712 1% 76% 13
8 ESCALATION WITH OVERDOSE CONTROL authKW 174472 1% 100% 9
9 ADAPTIVE DESIGN authKW 158617 4% 13% 65
10 TRANSLAT PL STAT address 151973 1% 56% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Statistics & Probability 11711 21% 0% 335
2 Medical Informatics 8700 9% 0% 146
3 Mathematical & Computational Biology 7453 13% 0% 202
4 Oncology 4223 28% 0% 439
5 Health Care Sciences & Services 3392 10% 0% 162
6 Medicine, Research & Experimental 3078 17% 0% 272
7 Education, Scientific Disciplines 1997 6% 0% 89
8 Health Policy & Services 822 4% 0% 63
9 Public, Environmental & Occupational Health 810 10% 0% 165
10 Pharmacology & Pharmacy 587 14% 0% 214

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSLAT PL STAT 151973 1% 56% 14
2 MANAGEMENT HEALTHCARE 63439 0% 55% 6
3 UNIT MOL THER Y CANC 58157 0% 100% 3
4 UNIT EA2694 43617 0% 75% 3
5 CNRS UMR8203 38772 0% 100% 2
6 DATA HLTH CARE GEN INTERNAL MED 38772 0% 100% 2
7 DEV REGULATORY SERV 38772 0% 100% 2
8 EQUIPE 22UNIV PARIS 5U1138 38772 0% 100% 2
9 HRDG 38772 0% 100% 2
10 INVESTIGATOR SUPPORT INTEGRAT SERV 38772 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STATISTICS IN MEDICINE 40847 8% 2% 123
2 CLINICAL TRIALS 35697 2% 5% 37
3 CTS-CLINICAL AND TRANSLATIONAL SCIENCE 27681 2% 5% 28
4 PHARMACEUTICAL STATISTICS 23031 2% 5% 25
5 JOURNAL OF BIOPHARMACEUTICAL STATISTICS 20323 2% 3% 31
6 ACADEMIC MEDICINE 15720 4% 1% 70
7 CONTEMPORARY CLINICAL TRIALS 10794 2% 2% 28
8 BIOMETRICS 10256 3% 1% 49
9 CLINICAL CANCER RESEARCH 4471 4% 0% 59
10 STATISTICS IN BIOPHARMACEUTICAL RESEARCH 3101 0% 2% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CONTINUAL REASSESSMENT METHOD 1539441 6% 88% 90 Search CONTINUAL+REASSESSMENT+METHOD Search CONTINUAL+REASSESSMENT+METHOD
2 DOSE FINDING 1159702 8% 48% 124 Search DOSE+FINDING Search DOSE+FINDING
3 PHASE I TRIAL 515712 7% 24% 111 Search PHASE+I+TRIAL Search PHASE+I+TRIAL
4 DOSE FINDING STUDIES 447351 2% 77% 30 Search DOSE+FINDING+STUDIES Search DOSE+FINDING+STUDIES
5 MAXIMUM TOLERATED DOSE 378583 4% 30% 66 Search MAXIMUM+TOLERATED+DOSE Search MAXIMUM+TOLERATED+DOSE
6 BAYESIAN ADAPTIVE DESIGN 216573 1% 62% 18 Search BAYESIAN+ADAPTIVE+DESIGN Search BAYESIAN+ADAPTIVE+DESIGN
7 UP AND DOWN DESIGN 192712 1% 76% 13 Search UP+AND+DOWN+DESIGN Search UP+AND+DOWN+DESIGN
8 ESCALATION WITH OVERDOSE CONTROL 174472 1% 100% 9 Search ESCALATION+WITH+OVERDOSE+CONTROL Search ESCALATION+WITH+OVERDOSE+CONTROL
9 ADAPTIVE DESIGN 158617 4% 13% 65 Search ADAPTIVE+DESIGN Search ADAPTIVE+DESIGN
10 RESEARCH BIOPSY 142747 1% 82% 9 Search RESEARCH+BIOPSY Search RESEARCH+BIOPSY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HARRINGTON, JA , WHEELER, GM , SWEETING, MJ , MANDER, AP , JODRELL, DI , (2013) ADAPTIVE DESIGNS FOR DUAL-AGENT PHASE I DOSE-ESCALATION STUDIES.NATURE REVIEWS CLINICAL ONCOLOGY. VOL. 10. ISSUE 5. P. 277 -288 61 85% 16
2 DOUSSAU, A , GEOERGER, B , JIMENEZ, I , PAOLETTI, X , (2016) INNOVATIONS FOR PHASE I DOSE-FINDING DESIGNS IN PEDIATRIC ONCOLOGY CLINICAL TRIALS.CONTEMPORARY CLINICAL TRIALS. VOL. 47. ISSUE . P. 217 -227 40 83% 2
3 POTTER, DM , (2006) PHASE I STUDIES OF CHEMOTHERAPEUTIC AGENTS IN CANCER PATIENTS: A REVIEW OF THE DESIGNS.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 16. ISSUE 5. P. 579-604 55 85% 17
4 PETRONI, GR , WAGES, NA , PAUX, G , DUBOIS, F , (2017) IMPLEMENTATION OF ADAPTIVE METHODS IN EARLY-PHASE CLINICAL TRIALS.STATISTICS IN MEDICINE. VOL. 36. ISSUE 2. P. 215 -224 25 89% 1
5 WAGES, NA , IVANOVA, A , MARCHENKO, O , (2016) PRACTICAL DESIGNS FOR PHASE I COMBINATION STUDIES IN ONCOLOGY.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 26. ISSUE 1. P. 150 -166 35 92% 0
6 HORTON, BJ , WAGES, NA , CONAWAY, MR , (2017) PERFORMANCE OF TOXICITY PROBABILITY INTERVAL BASED DESIGNS IN CONTRAST TO THE CONTINUAL REASSESSMENT METHOD.STATISTICS IN MEDICINE. VOL. 36. ISSUE 2. P. 291 -300 19 100% 1
7 ORON, AP , HOFF, PD , (2013) SMALL-SAMPLE BEHAVIOR OF NOVEL PHASE I CANCER TRIAL DESIGNS.CLINICAL TRIALS. VOL. 10. ISSUE 1. P. 63 -80 36 88% 6
8 ZHOU, YH , (2010) ADAPTIVE DESIGNS FOR PHASE I DOSE-FINDING STUDIES.FUNDAMENTAL & CLINICAL PHARMACOLOGY. VOL. 24. ISSUE 2. P. 129 -138 36 97% 2
9 O'QUIGLEY, J , CONAWAY, M , (2010) CONTINUAL REASSESSMENT AND RELATED DOSE-FINDING DESIGNS.STATISTICAL SCIENCE. VOL. 25. ISSUE 2. P. 202 -216 36 92% 9
10 NEUENSCHWANDER, B , BRANSON, M , GSPONER, T , (2008) CRITICAL ASPECTS OF THE BAYESIAN APPROACH TO PHASE I CANCER TRIALS.STATISTICS IN MEDICINE. VOL. 27. ISSUE 13. P. 2420-2439 31 100% 63

Classes with closest relation at Level 2


Rank Class id link
1 1075 ADAPTIVE DESIGN//STATISTICS IN MEDICINE//STATISTICS & PROBABILITY
2 795 INFORMED CONSENT//RESEARCH ETHICS//MEDICAL ETHICS
3 1487 ACADEMIC MEDICINE//CAREER CHOICE//UK MED CAREERS GRP
4 1716 D OPTIMALITY//STATISTICS & PROBABILITY//JOURNAL OF STATISTICAL PLANNING AND INFERENCE
5 1464 FOOD AND DRUG LAW JOURNAL//CONFLICT OF INTEREST//ORPHAN DRUGS
6 1717 GEFITINIB//EGFR MUTATION//MIDKINE
7 1521 AMERICAN JOURNAL OF EVALUATION//JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE//EVALUATION AND PROGRAM PLANNING
8 3220 AMERICAN STATISTICIAN//STATISTICAL EDUCATION//STATISTICS EDUCATION
9 162 ACADEMIC MEDICINE//EDUCATION, SCIENTIFIC DISCIPLINES//MEDICAL EDUCATION
10 4109 BURGOS//ECCLESIASTICAL BENEFICES//ECCLESIASTICAL JUSTICE

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