Class information for:
Level 1: FATTY ACID SYNTHASE//FASN//C75

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10148 1087 40.5 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
2141 2             FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR 5046
10148 1                   FATTY ACID SYNTHASE//FASN//C75 1087

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FATTY ACID SYNTHASE authKW 2408385 23% 35% 245
2 FASN authKW 310800 3% 38% 29
3 C75 authKW 281515 2% 48% 21
4 CERULENIN authKW 262038 3% 30% 31
5 POLYKETIDE BIOSYNTHETIC ENZYME authKW 140449 0% 100% 5
6 FATTY ACID SYNTHASE FAS authKW 121705 1% 33% 13
7 6 HYDROXYMELLEIN SYNTHASE authKW 112359 0% 100% 4
8 FATTY ACID SYNTHASE FASN authKW 101119 1% 60% 6
9 BREAST CANC TRANSLAT PROGRAM address 84270 0% 100% 3
10 FATTY ACID SYNTHASE COMPLEX authKW 84270 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 3605 31% 0% 334
2 Biochemistry & Molecular Biology 2765 43% 0% 467
3 Biophysics 773 11% 0% 115
4 Cell Biology 428 12% 0% 130
5 Pathology 162 4% 0% 45
6 Endocrinology & Metabolism 90 5% 0% 52
7 Chemistry, Medicinal 74 3% 0% 35
8 Nutrition & Dietetics 64 3% 0% 29
9 Medicine, Research & Experimental 63 4% 0% 44
10 Pharmacology & Pharmacy 18 5% 0% 57

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BREAST CANC TRANSLAT PROGRAM 84270 0% 100% 3
2 HLTH SERV CATALONIA 84264 1% 50% 6
3 MOL ONCOL NEOMA 56180 0% 100% 2
4 AUTOMATED LEAD OPTIMIZAT 37452 0% 67% 2
5 MUNICIPAL BEIJING REGULAT LIVER PROTECT 37452 0% 67% 2
6 EXPT MED ENDOCRINOL 30144 2% 6% 19
7 ACIDES AMINES PEPTIDES PROTCNRS UMR5247 CC 28090 0% 100% 1
8 ARKANSAS CHILDRENS NUT 28090 0% 100% 1
9 BEIJING BIOMED MAT NEUROSURG 28090 0% 100% 1
10 BIOL PATHOL PIERRE MARIE DEGAND CBP 28090 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 1145 1% 0% 13
2 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 910 1% 0% 8
3 ONCOTARGET 883 2% 0% 20
4 JOURNAL OF BIOLOGICAL CHEMISTRY 861 7% 0% 72
5 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 832 1% 0% 9
6 CELL CHEMICAL BIOLOGY 799 0% 1% 2
7 CANCER RESEARCH 780 3% 0% 34
8 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 764 2% 0% 22
9 JOURNAL OF ENZYME INHIBITION 704 0% 1% 3
10 INTERNATIONAL JOURNAL OF ONCOLOGY 476 1% 0% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FATTY ACID SYNTHASE 2408385 23% 35% 245 Search FATTY+ACID+SYNTHASE Search FATTY+ACID+SYNTHASE
2 FASN 310800 3% 38% 29 Search FASN Search FASN
3 C75 281515 2% 48% 21 Search C75 Search C75
4 CERULENIN 262038 3% 30% 31 Search CERULENIN Search CERULENIN
5 POLYKETIDE BIOSYNTHETIC ENZYME 140449 0% 100% 5 Search POLYKETIDE+BIOSYNTHETIC+ENZYME Search POLYKETIDE+BIOSYNTHETIC+ENZYME
6 FATTY ACID SYNTHASE FAS 121705 1% 33% 13 Search FATTY+ACID+SYNTHASE+FAS Search FATTY+ACID+SYNTHASE+FAS
7 6 HYDROXYMELLEIN SYNTHASE 112359 0% 100% 4 Search 6+HYDROXYMELLEIN+SYNTHASE Search 6+HYDROXYMELLEIN+SYNTHASE
8 FATTY ACID SYNTHASE FASN 101119 1% 60% 6 Search FATTY+ACID+SYNTHASE+FASN Search FATTY+ACID+SYNTHASE+FASN
9 FATTY ACID SYNTHASE COMPLEX 84270 0% 100% 3 Search FATTY+ACID+SYNTHASE+COMPLEX Search FATTY+ACID+SYNTHASE+COMPLEX
10 ACLY 70220 0% 50% 5 Search ACLY Search ACLY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MENENDEZ, JA , LUPU, R , (2007) FATTY ACID SYNTHASE AND THE LIPOGENIC PHENOTYPE IN CANCER PATHOGENESIS.NATURE REVIEWS CANCER. VOL. 7. ISSUE 10. P. 763-777 87 59% 832
2 FLAVIN, R , PELUSO, S , NGUYEN, PL , LODA, M , (2010) FATTY ACID SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET IN CANCER.FUTURE ONCOLOGY. VOL. 6. ISSUE 4. P. 551 -562 87 84% 146
3 KRIDEL, SJ , LOWTHER, WT , PEMBLE, CW , (2007) FATTY ACID SYNTHASE INHIBITORS: NEW DIRECTIONS FOR ONCOLOGY.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 16. ISSUE 11. P. 1817-1829 72 77% 48
4 LUPU, R , MENENDEZ, JA , (2006) PHARMACOLOGICAL INHIBITORS OF FATTY ACID SYNTHASE (FASN)-CATALYZED ENDOGENOUS FATTY ACID BIOGENESIS: A NEW FAMILY OF ANTI-CANCER AGENTS?.CURRENT PHARMACEUTICAL BIOTECHNOLOGY. VOL. 7. ISSUE 6. P. 483 -494 58 87% 80
5 MULLEN, GE , YET, L , (2015) PROGRESS IN THE DEVELOPMENT OF FATTY ACID SYNTHASE INHIBITORS AS ANTICANCER TARGETS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 25. ISSUE 20. P. 4363 -4369 55 68% 12
6 KUHAJDA, FP , (2006) FATTY ACID SYNTHASE AND CANCER: NEW APPLICATION OF AN OLD PATHWAY.CANCER RESEARCH. VOL. 66. ISSUE 12. P. 5977-5980 36 95% 343
7 SMITH, S , WITKOWSKI, A , JOSHI, AK , (2003) STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE ANIMAL FATTY ACID SYNTHASE.PROGRESS IN LIPID RESEARCH. VOL. 42. ISSUE 4. P. 289-317 53 78% 265
8 ABRAMSON, HN , (2011) THE LIPOGENESIS PATHWAY AS A CANCER TARGET.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 16. P. 5615-5638 80 46% 46
9 SILVA, SD , PEREZ, DE , NISHIMOTO, IN , ALVES, FA , PINTO, CAL , KOWALSKI, LP , GRANER, E , (2008) FATTY ACID SYNTHASE EXPRESSION IN SQUAMOUS CELL CARCINOMA OF THE TONGUE: CLINICOPATHOLOGICAL FINDINGS.ORAL DISEASES. VOL. 14. ISSUE 4. P. 376 -382 48 92% 13
10 ANGELES, TS , HUDKINS, RL , (2016) RECENT ADVANCES IN TARGETING THE FATTY ACID BIOSYNTHETIC PATHWAY USING FATTY ACID SYNTHASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 11. ISSUE 12. P. 1187 -1199 58 65% 0

Classes with closest relation at Level 1


Rank Class id link
1 17998 ACETYL COA CARBOXYLASE//SORAPHEN A//SORAPHEN
2 7161 ENOYL ACP REDUCTASE//ACYL CARRIER PROTEIN//FABH
3 12692 CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN
4 4289 3 BROMOPYRUVATE//WARBURG EFFECT//CANCER METABOLISM
5 27804 ACYL COA THIOESTERASE//ACETYL COA HYDROLASE//ACYL COA HYDROLASE
6 37064 MALONIC ACIDURIA//MALONYL COA DECARBOXYLASE DEFICIENCY//MALONYL COA DECARBOXYLASE
7 8938 SREBP//SCAP//STEROL REGULATORY ELEMENT BINDING PROTEIN
8 8130 STEAROYL COA DESATURASE//SCD1//STEAROYL COA DESATURASE 1
9 1288 POLYKETIDE SYNTHASE//POLYKETIDES//NONRIBOSOMAL PEPTIDE SYNTHETASE
10 20454 ACYL COA BINDING PROTEIN//DIAZEPAM BINDING INHIBITOR//ENDOZEPINES

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