Class information for:
Level 1: ACETYL COA CARBOXYLASE//SORAPHEN A//SORAPHEN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17998 571 34.5 59%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
2141 2             FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR 5046
17998 1                   ACETYL COA CARBOXYLASE//SORAPHEN A//SORAPHEN 571

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACETYL COA CARBOXYLASE authKW 559324 12% 15% 68
2 SORAPHEN A authKW 311128 1% 73% 8
3 SORAPHEN authKW 240638 1% 75% 6
4 ACC ALPHA authKW 213903 1% 100% 4
5 4 PIPERIDINYL PIPERAZINE authKW 160427 1% 100% 3
6 ACC INHIBITORS authKW 106952 0% 100% 2
7 FATTY ACID OXIDATION IN MUSCLE authKW 106952 0% 100% 2
8 LIVER ACETYL COA CARBOXYLASE authKW 106952 0% 100% 2
9 SORAPHEN A1 ALPHA authKW 106952 0% 100% 2
10 UNITS MOL BIOL address 106952 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3023 60% 0% 340
2 Biophysics 981 16% 0% 90
3 Chemistry, Medicinal 289 7% 0% 42
4 Endocrinology & Metabolism 202 8% 0% 48
5 Nutrition & Dietetics 106 4% 0% 24
6 Agriculture, Dairy & Animal Science 76 3% 0% 18
7 Cell Biology 70 8% 0% 44
8 Chemistry, Organic 60 6% 0% 36
9 Genetics & Heredity 21 4% 0% 23
10 Biology 7 2% 0% 10

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNITS MOL BIOL 106952 0% 100% 2
2 BRAIN KOREA 21 PROJECT MED SCI GENET SCI 53476 0% 100% 1
3 ECOLE SUPER TECNOL BIOMOL BORDEAUX 53476 0% 100% 1
4 ENDOCRINE A 53476 0% 100% 1
5 ESPERION THER EUT 53476 0% 100% 1
6 ESPERION THERPEUT 53476 0% 100% 1
7 ESTAC SER 53476 0% 100% 1
8 EXCELLENCE METAB PATHWAYS DRUG DISCOVERY 53476 0% 100% 1
9 FEDERATIF RECH BIOSCI GERLAND LYON SUD 128 53476 0% 100% 1
10 GREEN SCI TECHNOLSURUGA KU 53476 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UKRAINSKII BIOKHIMICHESKII ZHURNAL 3739 2% 1% 9
2 BIOCHEMICAL JOURNAL 2749 7% 0% 39
3 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1935 4% 0% 25
4 JOURNAL OF BIOLOGICAL CHEMISTRY 1379 11% 0% 64
5 EUROPEAN JOURNAL OF BIOCHEMISTRY 950 3% 0% 19
6 REVUE CANADIENNE DE BIOLOGIE EXPERIMENTALE 889 0% 2% 1
7 ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 834 0% 2% 1
8 ENDOKRINOLOGIE 825 0% 1% 2
9 RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY 819 0% 1% 2
10 BIOCHEMICAL SOCIETY TRANSACTIONS 709 2% 0% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ACETYL COA CARBOXYLASE 559324 12% 15% 68 Search ACETYL+COA+CARBOXYLASE Search ACETYL+COA+CARBOXYLASE
2 SORAPHEN A 311128 1% 73% 8 Search SORAPHEN+A Search SORAPHEN+A
3 SORAPHEN 240638 1% 75% 6 Search SORAPHEN Search SORAPHEN
4 ACC ALPHA 213903 1% 100% 4 Search ACC+ALPHA Search ACC+ALPHA
5 4 PIPERIDINYL PIPERAZINE 160427 1% 100% 3 Search 4+PIPERIDINYL+PIPERAZINE Search 4+PIPERIDINYL+PIPERAZINE
6 ACC INHIBITORS 106952 0% 100% 2 Search ACC+INHIBITORS Search ACC+INHIBITORS
7 FATTY ACID OXIDATION IN MUSCLE 106952 0% 100% 2 Search FATTY+ACID+OXIDATION+IN+MUSCLE Search FATTY+ACID+OXIDATION+IN+MUSCLE
8 LIVER ACETYL COA CARBOXYLASE 106952 0% 100% 2 Search LIVER+ACETYL+COA+CARBOXYLASE Search LIVER+ACETYL+COA+CARBOXYLASE
9 SORAPHEN A1 ALPHA 106952 0% 100% 2 Search SORAPHEN+A1+ALPHA Search SORAPHEN+A1+ALPHA
10 ACC2 85556 1% 40% 4 Search ACC2 Search ACC2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 BOURBEAU, MP , BARTBERGER, MD , (2015) RECENT ADVANCES IN THE DEVELOPMENT OF ACETYL-COA CARBOXYLASE (ACC) INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 2. P. 525 -536 41 80% 10
2 BARBER, MC , PRICE, NT , TRAVERS, MT , (2005) STRUCTURE AND REGULATION OF ACETYL-COA CARBOXYLASE GENES OF METAZOA.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1733. ISSUE 1. P. 1 -28 84 39% 63
3 KIM, KH , (1997) REGULATION OF MAMMALIAN ACETYL-COENZYME A CARBOXYLASE.ANNUAL REVIEW OF NUTRITION. VOL. 17. ISSUE . P. 77 -99 54 59% 204
4 ALLRED, JB , REILLY, KE , (1996) SHORT-TERM REGULATION OF ACETYL COA CARBOXYLASE IN TISSUES OF HIGHER ANIMALS.PROGRESS IN LIPID RESEARCH. VOL. 35. ISSUE 4. P. 371-385 50 54% 11
5 KIM, KW , YAMANE, H , ZONDLO, J , BUSBY, J , WANG, MH , (2007) EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF HUMAN ACETYL-COA CARBOXYLASE 2.PROTEIN EXPRESSION AND PURIFICATION. VOL. 53. ISSUE 1. P. 16 -23 19 95% 9
6 HARRIMAN, G , GREENWOOD, J , BHAT, S , HUANG, XY , WANG, RY , PAUL, D , TONG, L , SAHA, AK , WESTLIN, WF , KAPELLER, R , ET AL (2016) ACETYL-COA CARBOXYLASE INHIBITION BY ND-630 REDUCES HEPATIC STEATOSIS, IMPROVES INSULIN SENSITIVITY, AND MODULATES DYSLIPIDEMIA IN RATS.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 113. ISSUE 13. P. E1796 -E1805 23 43% 4
7 MAO, JQ , CHIRALA, SS , WAKIL, SJ , (2003) HUMAN ACETYL-COA CARBOXYLASE 1 GENE: PRESENCE OF THREE PROMOTERS AND HETEROGENEITY AT THE 5 '-UNTRANSLATED MRNA REGION.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 100. ISSUE 13. P. 7515-7520 21 72% 30
8 BOURBEAU, MP , ALLEN, JG , GU, W , (2010) RECENT ADVANCES IN ACETYL-COA CARBOXYLASE INHIBITORS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45. VOL. 45. ISSUE . P. 95-108 19 66% 4
9 QUAYLE, KA , DENTON, RM , BROWNSEY, RW , (1993) EVIDENCE FOR A PROTEIN REGULATOR FROM RAT-LIVER WHICH ACTIVATES ACETYL-COA CARBOXYLASE.BIOCHEMICAL JOURNAL. VOL. 292. ISSUE . P. 75-84 21 95% 8
10 LEE, WM , ELLIOTT, JE , BROWNSEY, RW , (2005) INHIBITION OF ACETYL-COA CARBOXYLASE ISOFORMS BY PYRIDOXAL PHOSPHATE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 280. ISSUE 51. P. 41835 -41843 22 59% 7

Classes with closest relation at Level 1


Rank Class id link
1 12692 CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN
2 14819 BIOTIN PROTEIN LIGASE//PYRUVATE CARBOXYLASE//BIRA
3 10148 FATTY ACID SYNTHASE//FASN//C75
4 37064 MALONIC ACIDURIA//MALONYL COA DECARBOXYLASE DEFICIENCY//MALONYL COA DECARBOXYLASE
5 16922 LACTOSE SYNTHESIS//DAM RAT//URIDINE NUCLEOTIDE CYCLE
6 33435 SUCCINYL COA SYNTHETASE//PHOSPHORYLATED HISTIDINE//OFF VP
7 1917 AMPK//AMP ACTIVATED PROTEIN KINASE//AICAR
8 8921 CARNITINE PALMITOYLTRANSFERASE//CARNITINE PALMITOYLTRANSFERASE I//CARNITINE PALMITOYLTRANSFERASE DEFICIENCY
9 28781 GARCINIA CAMBOGIA//HYDROXYCITRIC ACID//HYDROXYCITRATE
10 23687 ACETOACETYL COA SYNTHETASE//ACETOACETYL COA SYNTHETASE AACS//KETONE BODY UTILIZATION

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