Class information for:
Level 1: SREBP//SCAP//STEROL REGULATORY ELEMENT BINDING PROTEIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8938 1203 41.1 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
2141 2             FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR 5046
8938 1                   SREBP//SCAP//STEROL REGULATORY ELEMENT BINDING PROTEIN 1203

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SREBP authKW 1022025 9% 38% 106
2 SCAP authKW 521484 3% 62% 33
3 STEROL REGULATORY ELEMENT BINDING PROTEIN authKW 304641 4% 26% 47
4 INSIG authKW 282493 1% 70% 16
5 SREBP CLEAVAGE ACTIVATING PROTEIN authKW 279192 1% 100% 11
6 SREBP 1 authKW 196977 2% 28% 28
7 INSIG 1 authKW 195234 1% 77% 10
8 STEROL REGULATORY ELEMENT BINDING PROTEIN SREBP authKW 154326 1% 41% 15
9 SREBP 2 authKW 138376 1% 32% 17
10 STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN authKW 126905 0% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5958 58% 0% 695
2 Cell Biology 1869 21% 0% 258
3 Endocrinology & Metabolism 837 11% 0% 135
4 Nutrition & Dietetics 587 6% 0% 77
5 Biophysics 353 7% 0% 87
6 Peripheral Vascular Diseases 162 4% 0% 50
7 Genetics & Heredity 144 6% 0% 72
8 Medicine, Research & Experimental 98 5% 0% 55
9 Agriculture, Dairy & Animal Science 75 2% 0% 28
10 Integrative & Complementary Medicine 30 1% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM PROGRAMMES 76143 0% 100% 3
2 DIABET GEN INTERNAL MED 57106 0% 75% 3
3 U465 48173 1% 15% 13
4 METAB LIPID GLUCOSE 45117 0% 44% 4
5 JOHN MOORHEAD 37318 0% 29% 5
6 CHILDRENS FDN LE BONHEUR CHILDRENS HOSP 33840 0% 67% 2
7 UNIT 465 33840 0% 67% 2
8 BABS 33389 0% 26% 5
9 ABT ALLGEMEINE INNERE MED ENDOKRINOL DIABET SOF 25381 0% 100% 1
10 ADIPOCYTE SIGNALLING 25381 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF LIPID RESEARCH 12152 5% 1% 64
2 CELL METABOLISM 9195 2% 2% 23
3 JOURNAL OF BIOLOGICAL CHEMISTRY 6375 16% 0% 197
4 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 3385 2% 1% 19
5 CURRENT OPINION IN LIPIDOLOGY 2737 1% 1% 12
6 GENES AND NUTRITION 838 0% 1% 4
7 LIPIDS IN HEALTH AND DISEASE 811 1% 0% 7
8 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 730 5% 0% 55
9 DIABETES 655 1% 0% 18
10 MOLECULAR AND CELLULAR BIOLOGY 617 2% 0% 24

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SREBP 1022025 9% 38% 106 Search SREBP Search SREBP
2 SCAP 521484 3% 62% 33 Search SCAP Search SCAP
3 STEROL REGULATORY ELEMENT BINDING PROTEIN 304641 4% 26% 47 Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN
4 INSIG 282493 1% 70% 16 Search INSIG Search INSIG
5 SREBP CLEAVAGE ACTIVATING PROTEIN 279192 1% 100% 11 Search SREBP+CLEAVAGE+ACTIVATING+PROTEIN Search SREBP+CLEAVAGE+ACTIVATING+PROTEIN
6 SREBP 1 196977 2% 28% 28 Search SREBP+1 Search SREBP+1
7 INSIG 1 195234 1% 77% 10 Search INSIG+1 Search INSIG+1
8 STEROL REGULATORY ELEMENT BINDING PROTEIN SREBP 154326 1% 41% 15 Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN+SREBP Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN+SREBP
9 SREBP 2 138376 1% 32% 17 Search SREBP+2 Search SREBP+2
10 STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN 126905 0% 100% 5 Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN+CLEAVAGE+ACTIVATING+PROTEIN Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN+CLEAVAGE+ACTIVATING+PROTEIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GOLDSTEIN, JL , BROWN, MS , (2009) CHOLESTEROL FEEDBACK: FROM SCHOENHEIMER'S BOTTLE TO SCAP'S MELADL.JOURNAL OF LIPID RESEARCH. VOL. 50. ISSUE . P. S15-S27 63 71% 195
2 SHIMANO, H , (2001) STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBPS): TRANSCRIPTIONAL REGULATORS OF LIPID SYNTHETIC GENES.PROGRESS IN LIPID RESEARCH. VOL. 40. ISSUE 6. P. 439-452 73 75% 339
3 HORTON, JD , GOLDSTEIN, JL , BROWN, MS , (2002) SREBPS: ACTIVATORS OF THE COMPLETE PROGRAM OF CHOLESTEROL AND FATTY ACID SYNTHESIS IN THE LIVER.JOURNAL OF CLINICAL INVESTIGATION. VOL. 109. ISSUE 9. P. 1125-1131 35 78% 2078
4 EBERLE, D , HEGARTY, B , BOSSARD, P , FERRE, P , FOUFELLE, F , (2004) SREBP TRANSCRIPTION FACTORS: MASTER REGULATORS OF LIPID HOMEOSTASIS.BIOCHIMIE. VOL. 86. ISSUE 11. P. 839-848 66 66% 449
5 DONG, XY , TANG, SQ , CHEN, JD , (2012) DUAL FUNCTIONS OF INSIG PROTEINS IN CHOLESTEROL HOMEOSTASIS.LIPIDS IN HEALTH AND DISEASE. VOL. 11. ISSUE . P. - 65 80% 7
6 YE, J , DEBOSE-BOYD, RA , (2011) REGULATION OF CHOLESTEROL AND FATTY ACID SYNTHESIS.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 3. ISSUE 7. P. - 53 91% 36
7 SHIMANO, H , (2002) STEROL REGULATORY ELEMENT-BINDING PROTEIN FAMILY AS GLOBAL REGULATORS OF LIPID SYNTHETIC GENES IN ENERGY METABOLISM.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 65. VOL. 65. ISSUE . P. 167-194 90 70% 70
8 RAGHOW, R , YELLATURU, C , DENG, X , PARK, EA , ELAM, MB , (2008) SREBPS: THE CROSSROADS OF PHYSIOLOGICAL AND PATHOLOGICAL LIPID HOMEOSTASIS.TRENDS IN ENDOCRINOLOGY AND METABOLISM. VOL. 19. ISSUE 2. P. 65-73 56 68% 148
9 MCPHERSON, R , GAUTHIER, A , (2004) MOLECULAR REGULATION OF SREBP FUNCTION: THE INSIG-SCAP CONNECTION AND ISOFORM-SPECIFIC MODULATION OF LIPID SYNTHESIS.BIOCHEMISTRY AND CELL BIOLOGY. VOL. 82. ISSUE 1. P. 201-211 69 75% 60
10 OSBORNE, TF , ESPENSHADE, PJ , (2009) EVOLUTIONARY CONSERVATION AND ADAPTATION IN THE MECHANISM THAT REGULATES SREBP ACTION: WHAT A LONG, STRANGE TRIP IT'S BEEN.GENES & DEVELOPMENT. VOL. 23. ISSUE 22. P. 2578-2591 73 55% 82

Classes with closest relation at Level 1


Rank Class id link
1 12692 CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN
2 10090 LIVER X RECEPTOR//LXR//T0901317
3 13816 HMG COA REDUCTASE//APOMINE//FOOD FUS COMPLEX
4 8130 STEAROYL COA DESATURASE//SCD1//STEAROYL COA DESATURASE 1
5 20665 SUCROSE RICH DIET//ADIPOSE TISSUE BIOL//LONG CHAIN MONOUNSATURATED FATTY ACIDS
6 10148 FATTY ACID SYNTHASE//FASN//C75
7 31559 DAIRY COW MAMMARY EPITHELIAL CELLS//CROSS KINGDOM REGULATION//IMMUNE RELATED MIRNAS
8 14729 MIR 33//MARC RUTI BELL VASC BIOL DIS PROGRAM//INTEGRAT CELL SIGNALING NEUROBIOL METAB PROGRAM
9 20907 OXYSTEROL BINDING PROTEIN//MEMBRANE CONTACT SITES//OSBP
10 9366 PCSK9//PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9//ALIROCUMAB

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