Class information for:
Level 1: POLYKETIDE SYNTHASE//POLYKETIDES//NONRIBOSOMAL PEPTIDE SYNTHETASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1288 2741 45.0 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
3 4 PLANT SCIENCES//AGRONOMY//FOOD SCIENCE & TECHNOLOGY 1882812
243 3       INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY//MICROBIOLOGY//STREPTOMYCES 47319
1180 2             STREPTOMYCES//POLYKETIDES//POLYKETIDE SYNTHASE 9307
1288 1                   POLYKETIDE SYNTHASE//POLYKETIDES//NONRIBOSOMAL PEPTIDE SYNTHETASE 2741

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 POLYKETIDE SYNTHASE authKW 625079 6% 37% 153
2 POLYKETIDES authKW 609831 9% 23% 242
3 NONRIBOSOMAL PEPTIDE SYNTHETASE authKW 538888 4% 47% 102
4 HBEREICH CHEM BIOCHEM address 344852 2% 61% 51
5 ADENYLATION DOMAIN authKW 289287 1% 84% 31
6 NONRIBOSOMAL PEPTIDES authKW 201284 1% 44% 41
7 PEPTIDE SYNTHETASE authKW 191433 1% 45% 38
8 GENOME MINING authKW 160128 2% 28% 52
9 POLYKETIDE SYNTHASES authKW 151056 1% 47% 29
10 CHEMISTRY & BIOLOGY journal 144575 7% 7% 186

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 9211 49% 0% 1331
2 Microbiology 4026 17% 0% 467
3 Chemistry, Medicinal 4023 12% 0% 327
4 Biotechnology & Applied Microbiology 3254 16% 0% 430
5 Chemistry, Multidisciplinary 966 15% 0% 405
6 Chemistry, Organic 652 9% 0% 234
7 Biophysics 293 5% 0% 133
8 Biochemical Research Methods 270 4% 0% 117
9 Pharmacology & Pharmacy 146 7% 0% 192
10 Genetics & Heredity 46 3% 0% 89

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HBEREICH CHEM BIOCHEM 344852 2% 61% 51
2 BIOL CHEM MOL PHARMACOL 69671 5% 4% 145
3 COOPERAT DRUG DISCOVERY GRP 57257 1% 29% 18
4 MICROBIAL NAT PROD 55662 1% 25% 20
5 GENETICALLY ENCODED SMALL MOL 54560 1% 35% 14
6 CHAIR NAT PROD CHEM 51961 1% 33% 14
7 BIOCHEM HBEREICH CHEM 50912 0% 57% 8
8 PHARMAZEUT BIOTECHNOL 46388 1% 28% 15
9 HELMHOLTZ PHARMACEUT SAARLAND 45448 1% 19% 21
10 GENET ENCODED SMALL MOL 45101 0% 45% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMISTRY & BIOLOGY 144575 7% 7% 186
2 CHEMBIOCHEM 47583 5% 3% 138
3 NATURAL PRODUCT REPORTS 39744 3% 5% 71
4 JOURNAL OF ANTIBIOTICS 12556 3% 1% 87
5 ACS CHEMICAL BIOLOGY 10893 2% 2% 46
6 JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 10159 2% 2% 51
7 NATURE CHEMICAL BIOLOGY 9339 1% 2% 34
8 BIOCHEMISTRY 6702 7% 0% 182
9 CURRENT OPINION IN CHEMICAL BIOLOGY 5282 1% 2% 30
10 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 3802 7% 0% 183

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 POLYKETIDE SYNTHASE 625079 6% 37% 153 Search POLYKETIDE+SYNTHASE Search POLYKETIDE+SYNTHASE
2 POLYKETIDES 609831 9% 23% 242 Search POLYKETIDES Search POLYKETIDES
3 NONRIBOSOMAL PEPTIDE SYNTHETASE 538888 4% 47% 102 Search NONRIBOSOMAL+PEPTIDE+SYNTHETASE Search NONRIBOSOMAL+PEPTIDE+SYNTHETASE
4 ADENYLATION DOMAIN 289287 1% 84% 31 Search ADENYLATION+DOMAIN Search ADENYLATION+DOMAIN
5 NONRIBOSOMAL PEPTIDES 201284 1% 44% 41 Search NONRIBOSOMAL+PEPTIDES Search NONRIBOSOMAL+PEPTIDES
6 PEPTIDE SYNTHETASE 191433 1% 45% 38 Search PEPTIDE+SYNTHETASE Search PEPTIDE+SYNTHETASE
7 GENOME MINING 160128 2% 28% 52 Search GENOME+MINING Search GENOME+MINING
8 POLYKETIDE SYNTHASES 151056 1% 47% 29 Search POLYKETIDE+SYNTHASES Search POLYKETIDE+SYNTHASES
9 BIOSYNTHESIS 137885 9% 5% 246 Search BIOSYNTHESIS Search BIOSYNTHESIS
10 STREPTOMYCES TSUKUBAENSIS 133661 0% 100% 12 Search STREPTOMYCES+TSUKUBAENSIS Search STREPTOMYCES+TSUKUBAENSIS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WEISSMAN, KJ , (2016) GENETIC ENGINEERING OF MODULAR PKSS: FROM COMBINATORIAL BIOSYNTHESIS TO SYNTHETIC BIOLOGY.NATURAL PRODUCT REPORTS. VOL. 33. ISSUE 2. P. 203 -230 145 78% 4
2 HERTWECK, C , (2009) THE BIOSYNTHETIC LOGIC OF POLYKETIDE DIVERSITY.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 48. ISSUE 26. P. 4688-4716 151 61% 359
3 STAUNTON, J , WEISSMAN, KJ , (2001) POLYKETIDE BIOSYNTHESIS: A MILLENNIUM REVIEW.NATURAL PRODUCT REPORTS. VOL. 18. ISSUE 4. P. 380 -416 131 68% 831
4 WEISSMAN, KJ , (2015) THE STRUCTURAL BIOLOGY OF BIOSYNTHETIC MEGAENZYMES.NATURE CHEMICAL BIOLOGY. VOL. 11. ISSUE 9. P. 660 -670 91 95% 20
5 KOGLIN, A , WALSH, CT , (2009) STRUCTURAL INSIGHTS INTO NONRIBOSOMAL PEPTIDE ENZYMATIC ASSEMBLY LINES.NATURAL PRODUCT REPORTS. VOL. 26. ISSUE 8. P. 987 -1000 145 73% 83
6 FISCHBACH, MA , WALSH, CT , (2006) ASSEMBLY-LINE ENZYMOLOGY FOR POLYKETIDE AND NONRIBOSOMAL PEPTIDE ANTIBIOTICS: LOGIC, MACHINERY, AND MECHANISMS.CHEMICAL REVIEWS. VOL. 106. ISSUE 8. P. 3468-3496 116 65% 569
7 HUR, GH , VICKERY, CR , BURKART, MD , (2012) EXPLORATIONS OF CATALYTIC DOMAINS IN NON-RIBOSOMAL PEPTIDE SYNTHETASE ENZYMOLOGY.NATURAL PRODUCT REPORTS. VOL. 29. ISSUE 10. P. 1074 -1098 124 71% 81
8 CROSBY, J , CRUMP, MP , (2012) THE STRUCTURAL ROLE OF THE CARRIER PROTEIN - ACTIVE CONTROLLER OR PASSIVE CARRIER.NATURAL PRODUCT REPORTS. VOL. 29. ISSUE 10. P. 1111 -1137 179 52% 47
9 WEISSMAN, KJ , MULLER, R , (2008) PROTEIN-PROTEIN INTERACTIONS IN MULTIENZYME MEGASYNTHETASES.CHEMBIOCHEM. VOL. 9. ISSUE 6. P. 826-848 120 81% 57
10 LADNER, CC , WILLIAMS, GJ , (2016) HARNESSING NATURAL PRODUCT ASSEMBLY LINES: STRUCTURE, PROMISCUITY, AND ENGINEERING.JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY. VOL. 43. ISSUE 2-3. P. 371 -387 113 74% 1

Classes with closest relation at Level 1


Rank Class id link
1 11799 GLMU//BIOSYNTHET CHEM//DEOXYSUGARS
2 33161 DITHIOLOPYRROLONE//SACCHAROTHRIX ALGERIENSIS//ANTILEUKOPENIA
3 2604 STREPTOMYCES//STREPTOMYCES COELICOLOR//ANTIBIOTIC PRODUCTION
4 11327 LAEA//VEA//ASPERGILLUS NIDULANS
5 29403 CUEVAENE A//FLUVIRUCIN//CREMIMYCIN
6 33814 TOLYPOCLADIUM INFLATUM//CYCLOSPORIN SYNTHETASE//WHEAT BRAN FLOUR
7 21777 ANSAMITOCINS//ACTINOSYNNEMA PRETIOSUM//TRIENE ANSAMYCIN
8 19902 TYPE III POLYKETIDE SYNTHASE//CHALCONE SYNTHASE//BENZALACETONE SYNTHASE
9 7161 ENOYL ACP REDUCTASE//ACYL CARRIER PROTEIN//FABH
10 25667 FLUORINASE//HALOGENASE//4 FLUOROTHREONINE

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