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Cell Models

Our research focuses on the development of muscle and heart cell models on three dimensional, bio-compatible support structures.

Neuromuscular diseases urgently need suitable models to test the effect of therapies and develop true personalized therapies before entering clinical trials. Cell models in a petri dish can be created through reprogramming of skin cells or residual cells harvested from urine, through simple and harmless procedures. Our research focuses on the development of muscle and heart cell models on three dimensional, bio-compatible support structures. Using cutting-edge technologies to analyze the cellular RNA and proteins, we can monitor cell reprogramming, transformation and cell specialization. Such cell models may improve development of personalized gene therapies for each patient while replacing the use of animal models.

Publications

  1. Falzarano MS, et al. 2021 Urine-Derived Stem Cells Express 571 Neuromuscular Disorders Causing Genes, Making Them a Potential in vitro Model for Rare Genetic Diseases. Frontiers in Physiology 12, 716471.