PC-based real-time simulation of cardiovascular physiology

The goal of this project is to develop a real-time simulation model of hemodynamics and oxygen transport in the entire human cardiovascular system. The aim is to increase understanding of the complex interactions between cardiac, valvular and vascular function in health and disease. Our vision is to develop basic and advanced education and ultimately to aid decision making in clinical diagnostics and therapeutics.

Strategy, Methods

The model is programmed and validated as a stand-alone compilated software based on earlier publications, clinical experience and physical properties of the cardiovascular system. Pressures, volumes, oxygen saturation and flows are updated with 4000 Hz. Output parameters are presented in an attractive graphical user interface, where parameters can be modified and effects studied and quantified.

Preliminary Results

Our working model is currently based on the four cardiac chambers, 27 vascular segments and valves opening and closing depending on pressure gradients and flows. Autoregulatory reflexes can be activated. Treatment with intra-aortic balloon pump and heart-lung machine as well as effects of changes in intrathoracic pressure can be studied.