Class information for:
Level 1: SIRT1//SIRTUINS//SIRT3

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
913 2965 54.9 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
2649 2             SIRT1//SIRTUINS//SIRT3 3472
913 1                   SIRT1//SIRTUINS//SIRT3 2965

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SIRT1 authKW 2985582 21% 47% 622
2 SIRTUINS authKW 2884356 17% 57% 490
3 SIRT3 authKW 1079600 5% 77% 137
4 SIRT2 authKW 636224 3% 78% 79
5 SIRT6 authKW 498359 2% 77% 63
6 SIRTUIN 1 authKW 274520 3% 34% 79
7 SIRT5 authKW 260403 1% 90% 28
8 SIR2 authKW 243709 2% 37% 64
9 DEACETYLASE authKW 214378 2% 37% 57
10 SIRT4 authKW 209494 1% 88% 23

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 10612 31% 0% 929
2 Biochemistry & Molecular Biology 5060 36% 0% 1073
3 Geriatrics & Gerontology 1105 4% 0% 105
4 Endocrinology & Metabolism 950 8% 0% 239
5 Oncology 875 11% 0% 322
6 Biophysics 716 7% 0% 198
7 Chemistry, Medicinal 661 5% 0% 153
8 Medicine, Research & Experimental 381 5% 0% 160
9 Genetics & Heredity 158 5% 0% 134
10 Pharmacology & Pharmacy 126 7% 0% 195

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PAUL F GLENN 129372 1% 74% 17
2 PAUL F GLENN S BIOL MECH AGING 122088 1% 46% 26
3 GLENN S BIOL MECH AGING 54911 0% 67% 8
4 SIRTRIS 52953 0% 86% 6
5 INTEGRAT SYST PHYSIOL 51444 1% 20% 25
6 GLENN SCI AGING 50686 0% 62% 8
7 COMM CELLULAR MOL PHYSIOL 43925 0% 53% 8
8 PAUL F GLENN SCI AGING 41187 0% 100% 4
9 CELL SENESCENCE 36234 0% 27% 13
10 GLADSTONE VIROL IMMUNOL 35976 1% 10% 35

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AGING-US 24014 2% 5% 46
2 CELL METABOLISM 9630 1% 3% 37
3 AGING CELL 5636 1% 2% 26
4 MOLECULAR CELL 2661 1% 1% 38
5 CELL REPORTS 1488 1% 1% 22
6 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1475 1% 1% 27
7 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1120 3% 0% 91
8 ONCOTARGET 1025 1% 0% 36
9 PLOS ONE 1002 5% 0% 143
10 CLINICAL EPIGENETICS 901 0% 1% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SIRT1 2985582 21% 47% 622 Search SIRT1 Search SIRT1
2 SIRTUINS 2884356 17% 57% 490 Search SIRTUINS Search SIRTUINS
3 SIRT3 1079600 5% 77% 137 Search SIRT3 Search SIRT3
4 SIRT2 636224 3% 78% 79 Search SIRT2 Search SIRT2
5 SIRT6 498359 2% 77% 63 Search SIRT6 Search SIRT6
6 SIRTUIN 1 274520 3% 34% 79 Search SIRTUIN+1 Search SIRTUIN+1
7 SIRT5 260403 1% 90% 28 Search SIRT5 Search SIRT5
8 SIR2 243709 2% 37% 64 Search SIR2 Search SIR2
9 DEACETYLASE 214378 2% 37% 57 Search DEACETYLASE Search DEACETYLASE
10 SIRT4 209494 1% 88% 23 Search SIRT4 Search SIRT4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MORRIS, BJ , (2013) SEVEN SIRTUINS FOR SEVEN DEADLY DISEASES OF AGING.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 56. ISSUE . P. 133 -171 353 62% 84
2 YUAN, HF , SU, LL , CHEN, WY , (2013) THE EMERGING AND DIVERSE ROLES OF SIRTUINS IN CANCER: A CLINICAL PERSPECTIVE.ONCOTARGETS AND THERAPY. VOL. 6. ISSUE . P. 1399-1416 215 87% 66
3 HAIGIS, MC , SINCLAIR, DA , (2010) MAMMALIAN SIRTUINS: BIOLOGICAL INSIGHTS AND DISEASE RELEVANCE.ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE. VOL. 5. ISSUE . P. 253 -295 164 59% 704
4 POULOSE, N , RAJU, R , (2015) SIRTUIN REGULATION IN AGING AND INJURY.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. VOL. 1852. ISSUE 11. P. 2442 -2455 210 71% 23
5 NOGUEIRAS, R , HABEGGER, KM , CHAUDHARY, N , FINAN, B , BANKS, AS , DIETRICH, MO , HORVATH, TL , SINCLAIR, DA , PFLUGER, PT , TSCHOP, MH , (2012) SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM.PHYSIOLOGICAL REVIEWS. VOL. 92. ISSUE 3. P. 1479 -1514 225 63% 120
6 GERTZ, M , STEEGBORN, C , (2016) USING MITOCHONDRIAL SIRTUINS AS DRUG TARGETS: DISEASE IMPLICATIONS AND AVAILABLE COMPOUNDS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 73. ISSUE 15. P. 2871 -2896 202 87% 1
7 AUWERX, J , HOUTKOOPER, RH , PIRINEN, E , (2012) SIRTUINS AS REGULATORS OF METABOLISM AND HEALTHSPAN.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 4. P. 225 -238 105 70% 421
8 WU, XY , CAO, N , FENECH, M , WANG, X , (2016) ROLE OF SIRTUINS IN MAINTENANCE OF GENOMIC STABILITY: RELEVANCE TO CANCER AND HEALTHY AGING.DNA AND CELL BIOLOGY. VOL. 35. ISSUE 10. P. 542 -575 231 65% 0
9 JING, H , LIN, HN , (2015) SIRTUINS IN EPIGENETIC REGULATION.CHEMICAL REVIEWS. VOL. 115. ISSUE 6. P. 2350 -2375 215 59% 11
10 STUNKEL, W , CAMPBELL, RM , (2011) SIRTUIN 1 (SIRT1): THE MISUNDERSTOOD HDAC.JOURNAL OF BIOMOLECULAR SCREENING. VOL. 16. ISSUE 10. P. 1153-1169 166 82% 59

Classes with closest relation at Level 1


Rank Class id link
1 19394 N TERMINAL ACETYLTRANSFERASE//ARD1//N TERMINAL ACETYLATION
2 11974 VISFATIN//NAMPT//NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
3 12501 SIR COMPLEX//SIR PROTEINS//SIR3
4 15453 WLDS//NAD BIOSYNTHESIS//WALLERIAN DEGENERATION
5 8936 FOXO1//FOXO//FOXO3A
6 250 RESVERATROL//TRANS RESVERATROL//PICEID
7 8664 PGC 1 ALPHA//MITOCHONDRIAL BIOGENESIS//PGC 1
8 9347 CHRONOLOGICAL LIFESPAN//REPLICATIVE LIFESPAN//YEAST APOPTOSIS
9 3766 CALORIC RESTRICTION//DIETARY RESTRICTION//CALORIE RESTRICTION
10 20328 REYNOLDS OKLAHOMA AGING//VASCULAR AGING//DONALD W REYNOLDS GERIATR MED

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