Class information for:
Level 1: MONOMERIC INSULIN//INSULIN MUTANT//FAST ACTING INSULIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10931 1023 33.9 58%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1552 2             INSULIN RECEPTOR//INSULIN DEGRADING ENZYME//INOSITOL PHOSPHOGLYCAN 7396
10931 1                   MONOMERIC INSULIN//INSULIN MUTANT//FAST ACTING INSULIN 1023

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MONOMERIC INSULIN authKW 198975 1% 67% 10
2 INSULIN MUTANT authKW 179084 1% 100% 6
3 FAST ACTING INSULIN authKW 119389 0% 100% 4
4 INSULIN DERIVATIVE authKW 95510 0% 80% 4
5 SINGLE CHAIN INSULIN authKW 95510 0% 80% 4
6 EXPT BIOTECHNOL PLANT address 89542 0% 100% 3
7 STRUCTURE AND FUNCTION OF INSULIN authKW 89542 0% 100% 3
8 DIABET PROT ENGN address 86332 1% 32% 9
9 INSULIN DIMER authKW 67155 0% 75% 3
10 NONSTANDARD MUTAGENESIS authKW 67155 0% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 6163 63% 0% 646
2 Biophysics 1312 14% 0% 141
3 Endocrinology & Metabolism 269 7% 0% 76
4 Biochemical Research Methods 208 6% 0% 58
5 Multidisciplinary Sciences 142 2% 0% 23
6 Biology 132 4% 0% 40
7 Chemistry, Multidisciplinary 118 10% 0% 102
8 Crystallography 55 3% 0% 27
9 Chemistry, Medicinal 49 3% 0% 29
10 Biotechnology & Applied Microbiology 43 4% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT BIOTECHNOL PLANT 89542 0% 100% 3
2 DIABET PROT ENGN 86332 1% 32% 9
3 S MED PHYS 67155 0% 75% 3
4 UP 461 59695 0% 100% 2
5 UP EA 3214 59695 0% 100% 2
6 GRPD 39795 0% 67% 2
7 PHARMACOL BIOL CHEM 38804 2% 7% 18
8 CELLULAR MOLEC BIOL HLTH CARE DISCOVERY 29847 0% 100% 1
9 CIENICIAS NAT 29847 0% 100% 1
10 CONICETDPTO QUIM BIOLOG 29847 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 31400 3% 4% 29
2 SCIENTIA SINICA SERIES B-CHEMICAL BIOLOGICAL AGRICULTURAL MEDICAL & EARTH SCIENCES 14272 2% 3% 19
3 BIOLOGICAL CHEMISTRY HOPPE-SEYLER 8607 2% 1% 21
4 BIOCHEMISTRY 7719 12% 0% 118
5 ACTA BIOCHIMICA ET BIOPHYSICA SINICA 5260 2% 1% 22
6 JOURNAL OF PROTEIN CHEMISTRY 4468 1% 1% 15
7 SCIENTIA SINICA 3684 0% 2% 5
8 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 3025 2% 1% 16
9 SCIENCE IN CHINA SERIES C-LIFE SCIENCES 2725 1% 1% 11
10 SCIENCE IN CHINA SERIES B-CHEMISTRY 2507 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MONOMERIC INSULIN 198975 1% 67% 10 Search MONOMERIC+INSULIN Search MONOMERIC+INSULIN
2 INSULIN MUTANT 179084 1% 100% 6 Search INSULIN+MUTANT Search INSULIN+MUTANT
3 FAST ACTING INSULIN 119389 0% 100% 4 Search FAST+ACTING+INSULIN Search FAST+ACTING+INSULIN
4 INSULIN DERIVATIVE 95510 0% 80% 4 Search INSULIN+DERIVATIVE Search INSULIN+DERIVATIVE
5 SINGLE CHAIN INSULIN 95510 0% 80% 4 Search SINGLE+CHAIN+INSULIN Search SINGLE+CHAIN+INSULIN
6 STRUCTURE AND FUNCTION OF INSULIN 89542 0% 100% 3 Search STRUCTURE+AND+FUNCTION+OF+INSULIN Search STRUCTURE+AND+FUNCTION+OF+INSULIN
7 INSULIN DIMER 67155 0% 75% 3 Search INSULIN+DIMER Search INSULIN+DIMER
8 NONSTANDARD MUTAGENESIS 67155 0% 75% 3 Search NONSTANDARD+MUTAGENESIS Search NONSTANDARD+MUTAGENESIS
9 DESPENTAPEPTIDE INSULIN 59695 0% 100% 2 Search DESPENTAPEPTIDE+INSULIN Search DESPENTAPEPTIDE+INSULIN
10 HUMAN INSULIN LIKE GROWTH FACTOR I 59695 0% 100% 2 Search HUMAN+INSULIN+LIKE+GROWTH+FACTOR+I Search HUMAN+INSULIN+LIKE+GROWTH+FACTOR+I

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 NAKAGAWA, SH , ZHAO, M , HUA, QX , HU, SQ , WAN, ZL , JIA, WH , WEISS, MA , (2005) CHIRAL MUTAGENESIS OF INSULIN. FOLDABILITY AND FUNCTION ARE INVERSELY REGULATED BY A STEREOSPECIFIC SWITCH IN THE B CHAIN.BIOCHEMISTRY. VOL. 44. ISSUE 13. P. 4984-4999 63 86% 32
2 HUA, QX , XU, B , HUANG, K , HU, SQ , NAKAGAWA, S , JIA, WH , WANG, S , WHITTAKER, J , KATSOYANNIS, PG , WEISS, MA , (2009) ENHANCING THE ACTIVITY OF A PROTEIN BY STEREOSPECIFIC UNFOLDING CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 284. ISSUE 21. P. 14586-14596 59 82% 12
3 HUA, QX , (2010) INSULIN: A SMALL PROTEIN WITH A LONG JOURNEY.PROTEIN & CELL. VOL. 1. ISSUE 6. P. 537 -551 67 66% 17
4 NAKAGAWA, SH , HUA, QX , HU, SQ , JIA, WH , WANG, SH , KATSOYANNIS, PG , WEISS, MA , (2006) CHIRAL MUTAGENESIS OF INSULIN - CONTRIBUTION OF THE B20-B23 BETA-TURN TO ACTIVITY AND STABILITY.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 281. ISSUE 31. P. 22386-22396 49 89% 17
5 WAN, ZL , HUANG, K , XU, B , HU, SQ , WANG, SH , CHU, YC , KATSOYANNIS, PG , WEISS, MA , (2005) DIABETES-ASSOCIATED MUTATIONS IN HUMAN INSULIN: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING STUDIES OF A-CHAIN VARIANT INSULIN WAKAYAMA.BIOCHEMISTRY. VOL. 44. ISSUE 13. P. 5000-5016 67 65% 31
6 HUA, QX , NAKAGAWA, SH , JIA, W , HUANG, K , PHILLIPS, NB , HU, SQ , WEISS, MA , (2008) DESIGN OF AN ACTIVE ULTRASTABLE SINGLE-CHAIN INSULIN ANALOG - SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 283. ISSUE 21. P. 14703-14716 59 67% 17
7 HUA, QX , LIU, M , HU, SQ , JIA, WH , ARVAN, P , WEISS, MA , (2006) A CONSERVED HISTIDINE IN INSULIN IS REQUIRED FOR THE FOLDABILITY OF HUMAN PROINSULIN - STRUCTURE AND FUNCTION OF AN ALA(B5) ANALOG.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 281. ISSUE 34. P. 24889-24899 51 81% 11
8 GUO, ZY , QIAO, ZS , FENG, YM , (2008) THE IN VITRO OXIDATIVE FOLDING OF THE INSULIN SUPERFAMILY.ANTIOXIDANTS & REDOX SIGNALING. VOL. 10. ISSUE 1. P. 127 -139 50 76% 11
9 WEISS, MA , (2013) DIABETES MELLITUS DUE TO THE TOXIC MISFOLDING OF PROINSULIN VARIANTS.FEBS LETTERS. VOL. 587. ISSUE 13. P. 1942-1950 62 52% 10
10 HUA, QX , (2004) INSIGHT INTO FOLDING, BINDING AND STABILITY OF INSULIN BY NMR.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. VOL. 31. ISSUE 1. P. 1 -26 66 65% 4

Classes with closest relation at Level 1


Rank Class id link
1 5349 INSULIN ANALOGUES//INSULIN ASPART//INSULIN GLARGINE
2 1594 INSULIN RECEPTOR//LEPRECHAUNISM//DONOHUE SYNDROME
3 16095 BPTI//BAKER CHEM CHEM BIOL//BOVINE PANCREATIC TRYPSIN INHIBITOR
4 20705 PROINSULIN//INTACT PROINSULIN//TRUE INSULIN
5 16491 NEONATAL DIABETES//NEONATAL DIABETES MELLITUS//WOLCOTT RALLISON SYNDROME
6 24507 C PEPTIDE//PROINSULIN C PEPTIDE//SECT CLIN PHYSIOL
7 9990 INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE
8 2153 AMYLOID FIBRILS//AMYLOID//DIALYSIS RELATED AMYLOIDOSIS
9 13259 INSULIN AUTOIMMUNE SYNDROME//INSULIN ALLERGY//INSULIN ANTIBODIES
10 26980 CANC CAMPAIGN MED ONCOL UNIT//HTGF ALPHA//2ND SITE MUTATION

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