Class information for:
Level 1: GLUCAGON RECEPTOR//GLUCAGON RECEPTOR ANTAGONIST//GLUCAGON ANTAGONIST

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17101 617 35.5 58%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1167 2             GLUCAGON LIKE PEPTIDE 1//GLP 1//INCRETIN 9383
17101 1                   GLUCAGON RECEPTOR//GLUCAGON RECEPTOR ANTAGONIST//GLUCAGON ANTAGONIST 617

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GLUCAGON RECEPTOR authKW 1123437 6% 58% 39
2 GLUCAGON RECEPTOR ANTAGONIST authKW 839398 3% 81% 21
3 GLUCAGON ANTAGONIST authKW 570572 2% 82% 14
4 GLUCAGON RECEPTOR GENE authKW 380678 2% 77% 10
5 GLUCAGON authKW 216986 15% 5% 93
6 METAB DISORDERS MOL ENDOCRINOL address 111348 0% 75% 3
7 GLUCAGON ANALOGS authKW 98978 0% 100% 2
8 MESSENGER RNA POLYMORPHISM authKW 98978 0% 100% 2
9 METAB DISORDER MOL ENDOCRINOL address 98978 0% 100% 2
10 UNITE CHIM BIOL NUTR address 98978 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 4457 33% 0% 204
2 Biochemistry & Molecular Biology 706 31% 0% 189
3 Chemistry, Medicinal 322 7% 0% 46
4 Biophysics 226 8% 0% 49
5 Medicine, Research & Experimental 208 8% 0% 49
6 Cell Biology 102 9% 0% 53
7 Pharmacology & Pharmacy 80 9% 0% 57
8 Physiology 65 5% 0% 28
9 Gastroenterology & Hepatology 29 3% 0% 18
10 Chemistry, Organic 13 4% 0% 24

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METAB DISORDERS MOL ENDOCRINOL 111348 0% 75% 3
2 METAB DISORDER MOL ENDOCRINOL 98978 0% 100% 2
3 UNITE CHIM BIOL NUTR 98978 0% 100% 2
4 ST S AD TAT RECOGNIT 55671 0% 38% 3
5 149 RUE DE SEV 49489 0% 100% 1
6 ANIM OURCESD 49489 0% 100% 1
7 CARDIOMETAB MOL MED 49489 0% 100% 1
8 CATTEDRA MALATTIE RICAMBIO VIA GIUSTINIANI 2 49489 0% 100% 1
9 CELL BASED HTS 49489 0% 100% 1
10 CHU SAR TILMAN 49489 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETOLOGIA 3408 4% 0% 24
2 DIABETES 3202 5% 0% 28
3 DIABETES OBESITY & METABOLISM 2232 2% 0% 10
4 BIOMEDICAL RESEARCH-TOKYO 2146 2% 0% 11
5 HORMONE AND METABOLIC RESEARCH 1515 2% 0% 14
6 MOLECULAR METABOLISM 1332 0% 1% 3
7 ENDOCRINOLOGIA JAPONICA 1256 1% 0% 6
8 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 904 2% 0% 11
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 835 3% 0% 21
10 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 701 1% 0% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GLUCAGON RECEPTOR 1123437 6% 58% 39 Search GLUCAGON+RECEPTOR Search GLUCAGON+RECEPTOR
2 GLUCAGON RECEPTOR ANTAGONIST 839398 3% 81% 21 Search GLUCAGON+RECEPTOR+ANTAGONIST Search GLUCAGON+RECEPTOR+ANTAGONIST
3 GLUCAGON ANTAGONIST 570572 2% 82% 14 Search GLUCAGON+ANTAGONIST Search GLUCAGON+ANTAGONIST
4 GLUCAGON RECEPTOR GENE 380678 2% 77% 10 Search GLUCAGON+RECEPTOR+GENE Search GLUCAGON+RECEPTOR+GENE
5 GLUCAGON 216986 15% 5% 93 Search GLUCAGON Search GLUCAGON
6 GLUCAGON ANALOGS 98978 0% 100% 2 Search GLUCAGON+ANALOGS Search GLUCAGON+ANALOGS
7 MESSENGER RNA POLYMORPHISM 98978 0% 100% 2 Search MESSENGER+RNA+POLYMORPHISM Search MESSENGER+RNA+POLYMORPHISM
8 GCGR 65984 0% 67% 2 Search GCGR Search GCGR
9 GLUCAGON RECEPTOR GCGR 65984 0% 67% 2 Search GLUCAGON+RECEPTOR+GCGR Search GLUCAGON+RECEPTOR+GCGR
10 ACYLATED PEPTIDE ANALOGUES 49489 0% 100% 1 Search ACYLATED+PEPTIDE+ANALOGUES Search ACYLATED+PEPTIDE+ANALOGUES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 AUTHIER, F , DESBUQUOIS, B , (2008) GLUCAGON RECEPTORS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 65. ISSUE 12. P. 1880 -1899 71 49% 32
2 XIONG, YS , GUO, J , CANDELORE, MR , LIANG, R , MILLER, C , DALLAS-YANG, Q , JIANG, GQ , MCCANN, PE , QURESHI, SA , TONG, XC , ET AL (2012) DISCOVERY OF A NOVEL GLUCAGON RECEPTOR ANTAGONIST N-[(4-{(1S)-1-[3-(3, 5-DICHLOROPHENYL)-5-(6-METHOXYNAPHTHALEN-2-YL)-1H-PYRAZOL-1-YL]ETHYL}PHENYL)CARBONYL]-BETA-ALANINE (MK-0893) FOR THE TREATMENT OF TYPE II DIABETES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 13. P. 6137 -6148 36 72% 31
3 FILIPSKI, KJ , (2015) SMALL MOLECULE GLUCAGON RECEPTOR ANTAGONISTS: A PATENT REVIEW (2011-2014).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 25. ISSUE 7. P. 819 -830 28 85% 3
4 MU, J , QURESHI, SA , BRADY, EJ , MUISE, ES , CANDELORE, MR , JIANG, GQ , LI, ZH , WU, MS , YANG, XD , DALLAS-YANG, Q , ET AL (2012) ANTI-DIABETIC EFFICACY AND IMPACT ON AMINO ACID METABOLISM OF GRA1, A NOVEL SMALL-MOLECULE GLUCAGON RECEPTOR ANTAGONIST.PLOS ONE. VOL. 7. ISSUE 11. P. - 30 81% 21
5 KAZDA, CM , DING, Y , KELLY, RP , GARHYAN, P , SHI, CX , LIM, CN , FU, HD , WATSON, DE , LEWIN, AJ , LANDSCHULZ, WH , ET AL (2016) EVALUATION OF EFFICACY AND SAFETY OF THE GLUCAGON RECEPTOR ANTAGONIST LY2409021 IN PATIENTS WITH TYPE 2 DIABETES: 12-AND 24-WEEK PHASE 2 STUDIES.DIABETES CARE. VOL. 39. ISSUE 7. P. 1241 -1249 19 76% 8
6 LI, XC , ZHUO, JL , (2013) CURRENT INSIGHTS AND NEW PERSPECTIVES ON THE ROLES OF HYPERGLUCAGONEMIA IN NON-INSULIN-DEPENDENT TYPE 2 DIABETES.CURRENT HYPERTENSION REPORTS. VOL. 15. ISSUE 5. P. 522-530 32 70% 3
7 SHEN, DM , LIN, SNA , PARMEE, ER , (2011) A SURVEY OF SMALL MOLECULE GLUCAGON RECEPTOR ANTAGONISTS FROM RECENT PATENTS (2006-2010).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 21. ISSUE 8. P. 1211 -1240 27 77% 10
8 OKAMOTO, H , KIM, J , AGLIONE, J , LEE, J , CAVINO, K , NA, E , RAFIQUE, A , KIM, JH , HARP, J , VALENZUELA, DM , ET AL (2015) GLUCAGON RECEPTOR BLOCKADE WITH A HUMAN ANTIBODY NORMALIZES BLOOD GLUCOSE IN DIABETIC MICE AND MONKEYS.ENDOCRINOLOGY. VOL. 156. ISSUE 8. P. 2781 -2794 30 60% 4
9 FRANKLIN, ZJ , O'HARTE, FPM , IRWIN, N , (2014) EFFECTS OF SHORT-TERM CHEMICAL ABLATION OF GLUCAGON SIGNALLING BY PEPTIDE-BASED GLUCAGON RECEPTOR ANTAGONISTS ON INSULIN SECRETION AND GLUCOSE HOMEOSTASIS IN MICE.BIOLOGICAL CHEMISTRY. VOL. 395. ISSUE 4. P. 433-442 24 77% 3
10 SAMMONS, MF , LEE, ECY , (2015) RECENT PROGRESS IN THE DEVELOPMENT OF SMALL-MOLECULE GLUCAGON RECEPTOR ANTAGONISTS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 25. ISSUE 19. P. 4057 -4064 19 83% 9

Classes with closest relation at Level 1


Rank Class id link
1 376 GLUCAGON LIKE PEPTIDE 1//GLP 1//INCRETIN
2 20289 SECRETIN RECEPTOR//SECRETIN//SECRETIN ANALOGUES
3 9990 INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE
4 7510 GLUCONEOGENESIS//GLYCOGENOLYSIS//ENDOGENOUS GLUCOSE PRODUCTION
5 4911 PULSATILE INSULIN SECRETION//PANCREATIC BETA CELL//UNITE ENDOCRINOL METAB
6 21136 NECROLYTIC MIGRATORY ERYTHEMA//GLUCAGONOMA//GRANULAR PARAKERATOSIS
7 11808 ADRENERGIC RECEPTOR BINDING//OTTAWA CARLETON BIOL BIOL//ADENOSINE 3 5 MONOPHOSPHATE CAMP
8 35237 2 NBDG//2 NBDLG//FLUORESCENT GLUCOSE
9 31748 CARDIOVASC PHARMACOL HYPERTENS SECT//HUMAN BIOPATHOL ANAT PATHOL//INSERMU743
10 19466 E2A GENE//RAT INSULIN II GENE//UNITE DIABETOL CLIN

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