Class information for:
Level 1: SHP2//SHP 2//SHP 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9250 1174 47.8 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
636 3       TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 12838
1574 2             TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 7292
9250 1                   SHP2//SHP 2//SHP 1 1174

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SHP2 authKW 1111796 7% 50% 86
2 SHP 2 authKW 682758 6% 37% 71
3 SHP 1 authKW 645005 6% 34% 72
4 GAB1 authKW 618068 3% 61% 39
5 GAB2 authKW 318567 2% 44% 28
6 PTPN11 authKW 177498 3% 21% 32
7 SHP1 authKW 141582 1% 39% 14
8 SHP2 INHIBITORS authKW 133754 1% 86% 6
9 MOTHEATEN authKW 92883 0% 71% 5
10 PROTEIN TYROSINE PHOSPHATASE authKW 90415 5% 6% 61

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 3938 30% 0% 357
2 Biochemistry & Molecular Biology 3287 45% 0% 526
3 Oncology 909 16% 0% 189
4 Immunology 757 14% 0% 161
5 Hematology 638 8% 0% 92
6 Genetics & Heredity 247 7% 0% 87
7 Medicine, Research & Experimental 203 6% 0% 71
8 Biophysics 83 4% 0% 49
9 Pathology 64 3% 0% 33
10 Developmental Biology 38 2% 0% 18

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IMMUNOL INNOVAT BASE POST EDUC GUIZHOU PROV 78024 0% 100% 3
2 PROGRAM STEM CELLS REGENERAT 72240 0% 56% 5
3 MARRY BABB RANDOLPH CANC 69352 0% 67% 4
4 BIOTECHNOL MOLEC BIOL SECT 52016 0% 100% 2
5 MOL ONCOL GRP H5 10 52016 0% 100% 2
6 HIGH THROUGHPUT SCREENING CHEM CORE IL 46812 0% 60% 3
7 CHEM GENOM CORE IL 42550 1% 27% 6
8 MOL ONCOL C7 42550 1% 27% 6
9 AFFILIATED HOSP 2 HEMATOL 26008 0% 100% 1
10 ANAT MOL BIOL GENET 26008 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 4945 15% 0% 172
2 MOLECULAR AND CELLULAR BIOLOGY 3727 5% 0% 57
3 ONCOGENE 2856 4% 0% 45
4 JOURNAL OF IMMUNOLOGY 2096 6% 0% 67
5 CELLULAR SIGNALLING 1147 1% 0% 14
6 CELL COMMUNICATION AND SIGNALING 1099 0% 1% 4
7 EXPERIMENTAL HEMATOLOGY 748 1% 0% 13
8 BLOOD 724 3% 0% 32
9 JOURNAL OF EXPERIMENTAL MEDICINE 516 1% 0% 16
10 SEMINARS IN IMMUNOLOGY 464 0% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SHP2 1111796 7% 50% 86 Search SHP2 Search SHP2
2 SHP 2 682758 6% 37% 71 Search SHP+2 Search SHP+2
3 SHP 1 645005 6% 34% 72 Search SHP+1 Search SHP+1
4 GAB1 618068 3% 61% 39 Search GAB1 Search GAB1
5 GAB2 318567 2% 44% 28 Search GAB2 Search GAB2
6 PTPN11 177498 3% 21% 32 Search PTPN11 Search PTPN11
7 SHP1 141582 1% 39% 14 Search SHP1 Search SHP1
8 SHP2 INHIBITORS 133754 1% 86% 6 Search SHP2+INHIBITORS Search SHP2+INHIBITORS
9 MOTHEATEN 92883 0% 71% 5 Search MOTHEATEN Search MOTHEATEN
10 PROTEIN TYROSINE PHOSPHATASE 90415 5% 6% 61 Search PROTEIN+TYROSINE+PHOSPHATASE Search PROTEIN+TYROSINE+PHOSPHATASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HUANG, WQ , LIN, Q , ZHUANG, X , CAI, LL , RUAN, RS , LU, ZX , TZENG, CM , (2014) STRUCTURE, FUNCTION, AND PATHOGENESIS OF SHP2 IN DEVELOPMENTAL DISORDERS AND TUMORIGENESIS.CURRENT CANCER DRUG TARGETS. VOL. 14. ISSUE 6. P. 567 -588 137 68% 7
2 TAJAN, M , SERRA, AD , VALET, P , EDOUARD, T , YART, A , (2015) SHP2 SAILS FROM PHYSIOLOGY TO PATHOLOGY.EUROPEAN JOURNAL OF MEDICAL GENETICS. VOL. 58. ISSUE 10. P. 509 -525 134 61% 4
3 ZHANG, J , ZHANG, F , NIU, RF , (2015) FUNCTIONS OF SHP2 IN CANCER.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. VOL. 19. ISSUE 9. P. 2075 -2083 62 70% 7
4 WOHRLE, FU , DALY, RJ , BRUMMER, T , (2009) FUNCTION, REGULATION AND PATHOLOGICAL ROLES OF THE GAB/DOS DOCKING PROTEINS.CELL COMMUNICATION AND SIGNALING. VOL. 7. ISSUE . P. - 105 45% 74
5 POOLE, AW , JONES, ML , (2005) A SHPING TALE: PERSPECTIVES ON THE REGULATION OF SHP-1 AND SHP-2 TYROSINE PHOSPHATASES BY THE C-TERMINAL TAIL.CELLULAR SIGNALLING. VOL. 17. ISSUE 11. P. 1323-1332 60 87% 97
6 GROSSMANN, KS , ROSARIO, M , BIRCHMEIER, C , BIRCHMEIER, W , (2010) THE TYROSINE PHOSPHATASE SHP2 IN DEVELOPMENT AND CANCER.ADVANCES IN CANCER RESEARCH, VOL 106. VOL. 106. ISSUE . P. 53-89 85 48% 65
7 DING, CB , YU, WN , FENG, JH , LUO, JM , (2015) STRUCTURE AND FUNCTION OF GAB2 AND ITS ROLE IN CANCER (REVIEW).MOLECULAR MEDICINE REPORTS. VOL. 12. ISSUE 3. P. 4007 -4014 55 69% 8
8 LI, SM , (2016) THE BIOLOGICAL FUNCTION OF SHP2 IN HUMAN DISEASE.MOLECULAR BIOLOGY. VOL. 50. ISSUE 1. P. 22 -27 53 78% 0
9 MATOZAKI, T , MURATA, Y , SAITO, Y , OKAZAWA, H , OHNISHI, H , (2009) PROTEIN TYROSINE PHOSPHATASE SHP-2: A PROTO-ONCOGENE PRODUCT THAT PROMOTES RAS ACTIVATION.CANCER SCIENCE. VOL. 100. ISSUE 10. P. 1786 -1793 58 67% 59
10 BUTTERWORTH, S , OVERDUIN, M , BARR, AJ , (2014) TARGETING PROTEIN TYROSINE PHOSPHATASE SHP2 FOR THERAPEUTIC INTERVENTION.FUTURE MEDICINAL CHEMISTRY. VOL. 6. ISSUE 12. P. 1423 -1437 60 55% 5

Classes with closest relation at Level 1


Rank Class id link
1 9743 NOONAN SYNDROME//COSTELLO SYNDROME//CARDIO FACIO CUTANEOUS SYNDROME
2 19352 CD47//BIOSIGNAL SCI//SHPS 1
3 1580 PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B
4 12290 SH3 DOMAIN//SH2 DOMAIN//GRB2
5 14683 SHIP2//SHIP1//DOK
6 17423 JUVENILE MYELOMONOCYTIC LEUKEMIA//JMML//JUVENILE MYELOMONOCYTIC LEUKAEMIA
7 16383 LAIR 1//CD300A//ITIM
8 9406 INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1
9 12766 SIGLEC//CD22//SIALOADHESIN
10 13788 SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING

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