Class information for:
Level 2: TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1574 7292 44.6 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
636 3       TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 12838
1574 2             TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 7292
1125 1                   TIGHT JUNCTION//CLAUDIN//OCCLUDIN 2837
6187 1                   THROMBOSPONDIN 1//THROMBOSPONDIN//THROMBOSPONDIN 2 1516
9250 1                   SHP2//SHP 2//SHP 1 1174
9743 1                   NOONAN SYNDROME//COSTELLO SYNDROME//CARDIO FACIO CUTANEOUS SYNDROME 1124
19352 1                   CD47//BIOSIGNAL SCI//SHPS 1 509
32913 1                   TRANSEPITHELIAL MIGRATION//ALLERGY INFLAMMAT INFECT INFLAMMAT IMMUN//APICAL BASOLATERAL PLASMA MEMBRANES 132

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 TIGHT JUNCTION authKW 1516796 14% 35% 1040
2 NOONAN SYNDROME authKW 1310011 5% 81% 386
3 CLAUDIN authKW 1304714 6% 70% 446
4 THROMBOSPONDIN 1 authKW 577348 3% 56% 245
5 OCCLUDIN authKW 567934 4% 46% 295
6 COSTELLO SYNDROME authKW 547437 2% 93% 141
7 THROMBOSPONDIN authKW 452259 3% 48% 223
8 PTPN11 authKW 388483 2% 79% 118
9 CARDIO FACIO CUTANEOUS SYNDROME authKW 343408 1% 98% 84
10 CD47 authKW 327798 2% 64% 122

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 16644 25% 0% 1859
2 Biochemistry & Molecular Biology 5015 25% 0% 1822
3 Genetics & Heredity 2893 10% 0% 698
4 Oncology 2843 12% 0% 884
5 Physiology 1807 6% 0% 465
6 Pathology 1730 5% 0% 366
7 Hematology 1291 5% 0% 354
8 Gastroenterology & Hepatology 846 4% 0% 296
9 Medicine, Research & Experimental 806 5% 0% 372
10 Immunology 639 6% 0% 465

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOSIGNAL SCI 122409 1% 75% 39
2 BIOFUNCT MOL CHEM 71121 0% 50% 34
3 EPITHELIAL PATHOBIOL UNIT 45154 0% 30% 36
4 MOL CELL BIOLMINATO KU 39229 0% 63% 15
5 SECT HISTOL CELL BIOL 36875 0% 38% 23
6 PHYSIOL BIOPHYS NEUROSCI 34552 1% 18% 47
7 DIPARTIMENTO BIOL CELLULARE NEUROSCI 28116 0% 23% 29
8 GASTROENTEROL INFECT DIS RHEUMATOL 22867 0% 29% 19
9 TIGHT JUNCT STRUCT FUNCT 18832 0% 75% 6
10 MORPHOGENESIS CELL SIGNALING 17438 0% 83% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 15671 2% 3% 148
2 JOURNAL OF CELL BIOLOGY 4639 2% 1% 136
3 JOURNAL OF BIOLOGICAL CHEMISTRY 4537 6% 0% 432
4 MATRIX BIOLOGY 3132 0% 2% 32
5 JOURNAL OF CELL SCIENCE 2444 1% 1% 90
6 MOLECULAR BIOLOGY OF THE CELL 2272 1% 1% 69
7 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2003 1% 1% 56
8 EXPERIMENTAL CELL RESEARCH 1865 1% 1% 78
9 AMERICAN JOURNAL OF MEDICAL GENETICS 1844 1% 1% 64
10 JOURNAL OF MEMBRANE BIOLOGY 1742 1% 1% 45

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 TIGHT JUNCTION 1516796 14% 35% 1040 Search TIGHT+JUNCTION Search TIGHT+JUNCTION
2 NOONAN SYNDROME 1310011 5% 81% 386 Search NOONAN+SYNDROME Search NOONAN+SYNDROME
3 CLAUDIN 1304714 6% 70% 446 Search CLAUDIN Search CLAUDIN
4 THROMBOSPONDIN 1 577348 3% 56% 245 Search THROMBOSPONDIN+1 Search THROMBOSPONDIN+1
5 OCCLUDIN 567934 4% 46% 295 Search OCCLUDIN Search OCCLUDIN
6 COSTELLO SYNDROME 547437 2% 93% 141 Search COSTELLO+SYNDROME Search COSTELLO+SYNDROME
7 THROMBOSPONDIN 452259 3% 48% 223 Search THROMBOSPONDIN Search THROMBOSPONDIN
8 PTPN11 388483 2% 79% 118 Search PTPN11 Search PTPN11
9 CARDIO FACIO CUTANEOUS SYNDROME 343408 1% 98% 84 Search CARDIO+FACIO+CUTANEOUS+SYNDROME Search CARDIO+FACIO+CUTANEOUS+SYNDROME
10 CD47 327798 2% 64% 122 Search CD47 Search CD47

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GUNZEL, D , YU, ASL , (2013) CLAUDINS AND THE MODULATION OF TIGHT JUNCTION PERMEABILITY.PHYSIOLOGICAL REVIEWS. VOL. 93. ISSUE 2. P. 525 -569 232 63% 152
2 GUNZEL, D , FROMM, M , (2012) CLAUDINS AND OTHER TIGHT JUNCTION PROTEINS.COMPREHENSIVE PHYSIOLOGY. VOL. 2. ISSUE 3. P. 1819-1852 211 78% 55
3 TAJAN, M , SERRA, AD , VALET, P , EDOUARD, T , YART, A , (2015) SHP2 SAILS FROM PHYSIOLOGY TO PATHOLOGY.EUROPEAN JOURNAL OF MEDICAL GENETICS. VOL. 58. ISSUE 10. P. 509 -525 174 80% 4
4 SZASZI, K , AMOOZADEH, Y , (2014) NEW INSIGHTS INTO FUNCTIONS, REGULATION, AND PATHOLOGICAL ROLES OF TIGHT JUNCTIONS IN KIDNEY TUBULAR EPITHELIUM.INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 308. VOL. 308. ISSUE . P. 205 -271 202 67% 8
5 ADAMS, JC , LAWLER, J , (2011) THE THROMBOSPONDINS.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 3. ISSUE 10. P. - 192 63% 66
6 HUANG, WQ , LIN, Q , ZHUANG, X , CAI, LL , RUAN, RS , LU, ZX , TZENG, CM , (2014) STRUCTURE, FUNCTION, AND PATHOGENESIS OF SHP2 IN DEVELOPMENTAL DISORDERS AND TUMORIGENESIS.CURRENT CANCER DRUG TARGETS. VOL. 14. ISSUE 6. P. 567 -588 154 76% 7
7 VALLE, BL , MORIN, PJ , (2010) CLAUDINS IN CANCER BIOLOGY.CLAUDINS. VOL. 65. ISSUE . P. 293-333 171 76% 5
8 ROMANO, AA , ALLANSON, JE , DAHLGREN, J , GELB, BD , HALL, B , PIERPONT, ME , ROBERTS, AE , ROBINSON, W , TAKEMOTO, CM , NOONAN, JA , (2010) NOONAN SYNDROME: CLINICAL FEATURES, DIAGNOSIS, AND MANAGEMENT GUIDELINES.PEDIATRICS. VOL. 126. ISSUE 4. P. 746 -759 104 95% 124
9 BARCLAY, AN , VAN DEN BERG, TK , (2014) THE INTERACTION BETWEEN SIGNAL REGULATORY PROTEIN ALPHA (SIRP ALPHA) AND CD47: STRUCTURE, FUNCTION, AND THERAPEUTIC TARGET.ANNUAL REVIEW OF IMMUNOLOGY, VOL 32. VOL. 32. ISSUE . P. 25 -50 109 74% 51
10 KRUG, SM , SCHULZKE, JD , FROMM, M , (2014) TIGHT JUNCTION, SELECTIVE PERMEABILITY, AND RELATED DISEASES.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 36. ISSUE . P. 166 -176 107 85% 27

Classes with closest relation at Level 2


Rank Class id link
1 2172 PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B
2 2409 BLOOD BRAIN BARRIER//CEREBROLYSIN//TYR MIF 1
3 3178 FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME//INTESTINAL PERMEABILITY//ALLERGIC PROCTOCOLITIS
4 2034 E CADHERIN//CADHERIN//CATENIN
5 3692 SPARC//OSTEONECTIN//JWA
6 2906 SIGLEC//TREM2//TREM 1
7 4018 PEDF//PIGMENT EPITHELIUM DERIVED FACTOR//PIGMENT EPITHELIUM DERIVED FACTOR PEDF
8 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN
9 4096 HISTIDINE RICH GLYCOPROTEIN//HRG//SODIUM TETRAHYDROBORATE
10 2452 HEPATOCYTE GROWTH FACTOR//C MET//HGF

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