Class information for:
Level 1: CARBOXYPEPTIDASE A//GENERAL ACID GENERAL BASE//5 BROMOACETYLSALICYLIC ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
21098 433 32.2 46%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
427 3       JOURNAL OF THE INSTITUTE OF BREWING//KERATINASE//CYSTATIN 27946
1547 2             KERATINASE//ALKALINE PROTEASE//ASPARTIC PROTEINASE 7420
21098 1                   CARBOXYPEPTIDASE A//GENERAL ACID GENERAL BASE//5 BROMOACETYLSALICYLIC ACID 433

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARBOXYPEPTIDASE A authKW 247276 4% 22% 16
2 GENERAL ACID GENERAL BASE authKW 211559 1% 100% 3
3 5 BROMOACETYLSALICYLIC ACID authKW 141039 0% 100% 2
4 MNDO H authKW 141039 0% 100% 2
5 TRANSITION STATE ANALOG INHIBITOR authKW 141039 0% 100% 2
6 O O DIHYDROXYAZOBENZENE authKW 94025 0% 67% 2
7 BIOFUNCT MOL address 74262 4% 7% 16
8 2 BENZYL 3 NITROPROPIONIC AMIDE authKW 70520 0% 100% 1
9 2 BENZYL 5 BROMO 4 OXOPENTANOIC ACID authKW 70520 0% 100% 1
10 2 BENZYL 5 HYDROXY 4 OXOPENTANOIC ACID authKW 70520 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1467 49% 0% 211
2 Chemistry, Organic 998 23% 0% 98
3 Chemistry, Medicinal 567 11% 0% 49
4 Chemistry, Multidisciplinary 496 24% 0% 103
5 Chemistry, Inorganic & Nuclear 211 9% 0% 38
6 Biophysics 88 6% 0% 27
7 Biochemical Research Methods 34 4% 0% 17
8 Biology 28 3% 0% 13
9 Crystallography 5 2% 0% 7
10 Polymer Science 2 2% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOFUNCT MOL 74262 4% 7% 16
2 BIOCAT BCPS 70520 0% 100% 1
3 BIOL OURCES FUNCT MOL CHANGBAI MT 70520 0% 100% 1
4 CHANGBAI MT MINIST EDUC 70520 0% 100% 1
5 ORGANISM FUNCT TORS CHANGBAI MOUNTAINS 70520 0% 100% 1
6 UNIV CITY SCI BIOSTRUCT 70520 0% 100% 1
7 BIOFUNCTIONAL MOL 35259 0% 50% 1
8 ORGAN FUNCT TORS 35259 0% 50% 1
9 MOE GREEN CHEM TECHNOL 23503 0% 17% 2
10 INTEGRATED MOL SYST 21868 2% 3% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC CHEMISTRY 46010 7% 2% 31
2 MAGNETIC RESONANCE IN BIOLOGY 14102 0% 20% 1
3 BIOCHEMISTRY 3409 12% 0% 51
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1721 6% 0% 25
5 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 1568 4% 0% 17
6 JOURNAL OF INORGANIC BIOCHEMISTRY 1502 3% 0% 11
7 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 1241 9% 0% 41
8 BIOORGANIC & MEDICINAL CHEMISTRY 1044 3% 0% 14
9 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 708 2% 0% 9
10 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 536 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CARBOXYPEPTIDASE A 247276 4% 22% 16 Search CARBOXYPEPTIDASE+A Search CARBOXYPEPTIDASE+A
2 GENERAL ACID GENERAL BASE 211559 1% 100% 3 Search GENERAL+ACID+GENERAL+BASE Search GENERAL+ACID+GENERAL+BASE
3 5 BROMOACETYLSALICYLIC ACID 141039 0% 100% 2 Search 5+BROMOACETYLSALICYLIC+ACID Search 5+BROMOACETYLSALICYLIC+ACID
4 MNDO H 141039 0% 100% 2 Search MNDO+H Search MNDO+H
5 TRANSITION STATE ANALOG INHIBITOR 141039 0% 100% 2 Search TRANSITION+STATE+ANALOG+INHIBITOR Search TRANSITION+STATE+ANALOG+INHIBITOR
6 O O DIHYDROXYAZOBENZENE 94025 0% 67% 2 Search O+O+DIHYDROXYAZOBENZENE Search O+O+DIHYDROXYAZOBENZENE
7 2 BENZYL 3 NITROPROPIONIC AMIDE 70520 0% 100% 1 Search 2+BENZYL+3+NITROPROPIONIC+AMIDE Search 2+BENZYL+3+NITROPROPIONIC+AMIDE
8 2 BENZYL 5 BROMO 4 OXOPENTANOIC ACID 70520 0% 100% 1 Search 2+BENZYL+5+BROMO+4+OXOPENTANOIC+ACID Search 2+BENZYL+5+BROMO+4+OXOPENTANOIC+ACID
9 2 BENZYL 5 HYDROXY 4 OXOPENTANOIC ACID 70520 0% 100% 1 Search 2+BENZYL+5+HYDROXY+4+OXOPENTANOIC+ACID Search 2+BENZYL+5+HYDROXY+4+OXOPENTANOIC+ACID
10 2 CARBOXYPYRAZINYL 70520 0% 100% 1 Search 2+CARBOXYPYRAZINYL Search 2+CARBOXYPYRAZINYL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 WU, SS , ZHANG, CC , XU, DG , GUO, H , (2010) CATALYSIS OF CARBOXYPEPTIDASE A: PROMOTED-WATER VERSUS NUCLEOPHILIC PATHWAYS.JOURNAL OF PHYSICAL CHEMISTRY B. VOL. 114. ISSUE 28. P. 9259 -9267 41 58% 8
2 XU, DG , GUO, H , (2009) QUANTUM MECHANICAL/MOLECULAR MECHANICAL AND DENSITY FUNCTIONAL THEORY STUDIES OF A PROTOTYPICAL ZINC PEPTIDASE (CARBOXYPEPTIDASE A) SUGGEST A GENERAL ACID-GENERAL BASE MECHANISM.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 131. ISSUE 28. P. 9780 -9788 39 51% 41
3 WU, SS , ZHANG, CC , CAO, RY , XU, DG , GUO, H , (2011) PH-DEPENDENT REACTIVITY FOR GLYCYL-L-TYROSINE IN CARBOXYPEPTIDASE-A-CATALYZED HYDROLYSIS.JOURNAL OF PHYSICAL CHEMISTRY B. VOL. 115. ISSUE 34. P. 10360 -10367 31 61% 3
4 KIM, DH , (2004) CHEMISTRY-BASED DESIGN OF INHIBITORS FOR CARBOXYPEPTIDASE A.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 4. ISSUE 12. P. 1217-1226 26 87% 8
5 CHRISTIANSON, DW , LIPSCOMB, WN , (1989) CARBOXYPEPTIDASE-A.ACCOUNTS OF CHEMICAL RESEARCH. VOL. 22. ISSUE 2. P. 62-69 30 71% 559
6 VARDI-KILSHTAIN, A , SHOHAM, G , GOLDBLUM, A , (2003) ANHYDRIDE FORMATION IS NOT A VALID MECHANISM FOR PEPTIDE CLEAVAGE BY CARBOXYPEPTIDASE-A: A SEMIEMPIRICAL REACTION PATHWAY STUDY.MOLECULAR PHYSICS. VOL. 101. ISSUE 17. P. 2715-2724 26 70% 7
7 BUKRINSKY, ET , BJERRUM, MJ , KADZIOLA, A , (1998) NATIVE CARBOXYPEPTIDASE A IN A NEW CRYSTAL ENVIRONMENT REVEALS A DIFFERENT CONFORMATION OF THE IMPORTANT TYROSINE 248.BIOCHEMISTRY. VOL. 37. ISSUE 47. P. 16555 -16564 27 77% 21
8 SUH, JH , PARK, TH , HWANG, BK , (1992) COMPARABLE RATES FOR CLEAVAGE OF AMIDE AND ESTER BONDS THROUGH NUCLEOPHILIC-ATTACK BY CARBOXYLATE ANION AND GENERAL ACID CATALYSIS BY METAL-BOUND WATER IN A CARBOXYPEPTIDASE-A MODEL.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 114. ISSUE 13. P. 5141-5146 29 83% 39
9 CHAI, JJ , HE, CH , LI, M , TANG, L , LUO, M , (1998) CRYSTAL STRUCTURE OF CARBOXYPEPTIDASE A COMPLEXED WITH AN INACTIVATOR IN TWO CRYSTAL FORMS.PROTEIN ENGINEERING. VOL. 11. ISSUE 10. P. 841 -845 19 100% 3
10 KILSHTAIN-VARDI, A , SHOHAM, G , GOLDBLUM, A , (2003) THEORETICAL STUDIES OF CATALYSIS BY CARBOXYPEPTIDASE A: COULD GAS-PHASE CALCULATIONS SUPPORT A MECHANISM?.COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS. VOL. 68. ISSUE 11. P. 2055-2079 26 60% 1

Classes with closest relation at Level 1


Rank Class id link
1 21813 THERMOLYSIN//NEUTRAL PROTEASE//HALOPHILICITY
2 16979 PEPTIDE CLEAVING CATALYST//ARTIFICIAL PROTEASE//ARTIFICIAL PEPTIDASE
3 13030 TAFI//THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR//CARBOXYPEPTIDASE U
4 17545 AMINOPEPTIDASE//LEUCINE AMINOPEPTIDASE//PROLYL AMINOPEPTIDASE
5 11541 CARBONIC ANHYDRASE//HUMAN CARBONIC ANHYDRASE II//IMIDAZOLIDINE RING HYDROLYSIS
6 18692 METALLO BETA LACTAMASE//INGN PROT//ZINC BETA LACTAMASE
7 3037 METALLOMICELLE//ARTIFICIAL RIBONUCLEASES//MIMIC HYDROLASE
8 6635 TACE INHIBITORS//MMP INHIBITORS//MATRIX METALLOPROTEINASE INHIBITOR
9 30425 INORGAN CHEM ELE OCHEM//OUTER SPHERE CHARGE TRANSFER//ACTIVATION CONTROLLED REACTION RATE CONSTANTS
10 22614 AMINOACYLASE//L AMINOACYLASE//D AMINOACYLASE

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