Class information for:
Level 1: COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16660 642 42.7 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
16660 1                   COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3 642

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COFFIN LOWRY SYNDROME authKW 1888464 7% 88% 45
2 RSK2 authKW 847441 4% 64% 28
3 PHOSPHOHISTONE H3 authKW 554310 4% 45% 26
4 SL0101 authKW 479578 2% 92% 11
5 RSK authKW 392469 4% 29% 28
6 PHH3 authKW 310721 2% 47% 14
7 RSK4 authKW 258943 1% 78% 7
8 MSK1 authKW 209809 2% 29% 15
9 HISTONE PHOSPHORYLATION authKW 208237 3% 26% 17
10 COFFIN LOWRY authKW 198172 1% 83% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 2319 31% 0% 202
2 Biochemistry & Molecular Biology 1608 43% 0% 274
3 Genetics & Heredity 929 17% 0% 108
4 Oncology 563 17% 0% 109
5 Pathology 224 6% 0% 38
6 Biophysics 68 5% 0% 31
7 Medical Ethics 59 1% 0% 4
8 Developmental Biology 52 2% 0% 14
9 Chemistry, Medicinal 45 3% 0% 21
10 Pediatrics 19 3% 0% 19

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HORMEL 82228 6% 5% 36
2 EQUIPE MECANISMES ASSEMBLAGE MAT GENET 63414 0% 67% 2
3 MED DIAGNOST GUANGDONG PROV 63414 0% 67% 2
4 PARTNERS DRUG DISCOVERY 61147 0% 43% 3
5 ACVRI 47562 0% 100% 1
6 AGING ASSOC VASCULAR DIS 47562 0% 100% 1
7 ARRHUS SYGEHUS 47562 0% 100% 1
8 BIOMED SCI BMSI 47562 0% 100% 1
9 BRAZIL SCI TECHNOL ONCOGEN INCITO 47562 0% 100% 1
10 CANC BIOL NUCL ARCHITECTURE CHROMATIN STRU 47562 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 950 9% 0% 57
2 MOLECULAR AND CELLULAR BIOLOGY 825 3% 0% 20
3 GENETIC COUNSELING 801 1% 0% 4
4 CYTOGENETIC AND GENOME RESEARCH 779 1% 0% 6
5 MOLECULAR CELL 691 1% 0% 9
6 EUROPEAN JOURNAL OF MEDICAL GENETICS 662 1% 0% 4
7 ONCOGENE 569 2% 0% 15
8 POSTEPY BIOLOGII KOMORKI 543 0% 1% 2
9 APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 505 1% 0% 4
10 ESSAYS IN BIOCHEMISTRY 470 0% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 COFFIN LOWRY SYNDROME 1888464 7% 88% 45 Search COFFIN+LOWRY+SYNDROME Search COFFIN+LOWRY+SYNDROME
2 RSK2 847441 4% 64% 28 Search RSK2 Search RSK2
3 PHOSPHOHISTONE H3 554310 4% 45% 26 Search PHOSPHOHISTONE+H3 Search PHOSPHOHISTONE+H3
4 SL0101 479578 2% 92% 11 Search SL0101 Search SL0101
5 RSK 392469 4% 29% 28 Search RSK Search RSK
6 PHH3 310721 2% 47% 14 Search PHH3 Search PHH3
7 RSK4 258943 1% 78% 7 Search RSK4 Search RSK4
8 MSK1 209809 2% 29% 15 Search MSK1 Search MSK1
9 HISTONE PHOSPHORYLATION 208237 3% 26% 17 Search HISTONE+PHOSPHORYLATION Search HISTONE+PHOSPHORYLATION
10 COFFIN LOWRY 198172 1% 83% 5 Search COFFIN+LOWRY Search COFFIN+LOWRY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CARGNELLO, M , ROUX, PP , (2011) ACTIVATION AND FUNCTION OF THE MAPKS AND THEIR SUBSTRATES, THE MAPK-ACTIVATED PROTEIN KINASES.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 75. ISSUE 1. P. 50 -83 85 20% 501
2 LUDWIK, KA , LANNIGAN, DA , (2016) RIBOSOMAL S6 KINASE (RSK) MODULATORS: A PATENT REVIEW.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 26. ISSUE 9. P. 1061 -1078 68 49% 0
3 ROMEO, Y , ZHANG, XC , ROUX, PP , (2012) REGULATION AND FUNCTION OF THE RSK FAMILY OF PROTEIN KINASES.BIOCHEMICAL JOURNAL. VOL. 441. ISSUE . P. 553-569 67 37% 117
4 ANJUM, R , BLENIS, J , (2008) THE RSK FAMILY OF KINASES: EMERGING ROLES IN CELLULAR SIGNALLING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 9. ISSUE 10. P. 747 -758 52 44% 335
5 PEREIRA, PM , SCHNEIDER, A , PANNETIER, S , HERON, D , HANAUER, A , (2010) COFFIN-LOWRY SYNDROME.EUROPEAN JOURNAL OF HUMAN GENETICS. VOL. 18. ISSUE 6. P. 627 -633 29 91% 35
6 COFFIN, GS , (2003) POSTMORTEM FINDINGS IN THE COFFIN-LOWRY SYNDROME.GENETICS IN MEDICINE. VOL. 5. ISSUE 3. P. 187-193 39 89% 4
7 HANAUER, A , YOUNG, ID , (2002) COFFIN-LOWRY SYNDROME: CLINICAL AND MOLECULAR FEATURES.JOURNAL OF MEDICAL GENETICS. VOL. 39. ISSUE 10. P. 705-713 39 72% 85
8 HEALY, S , KHAN, P , HE, SH , DAVIE, JR , (2012) HISTONE H3 PHOSPHORYLATION, IMMEDIATE-EARLY GENE EXPRESSION, AND THE NUCLEOSOMAL RESPONSE: A HISTORICAL PERSPECTIVE.BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE. VOL. 90. ISSUE 1. P. 39 -54 53 41% 15
9 CARRIERE, A , RAY, H , BLENIS, J , ROUX, PP , (2008) THE RSK FACTORS OF ACTIVATING THE RAS/MAPK SIGNALING CASCADE.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 13. ISSUE . P. 4258-4275 53 40% 85
10 NISHIMOTO, HK , HA, K , JONES, JR , DWIVEDI, A , CHO, HM , LAYMAN, LC , KIM, HG , (2014) THE HISTORICAL COFFIN-LOWRY SYNDROME FAMILY REVISITED: IDENTIFICATION OF TWO NOVEL MUTATIONS OF RPS6KA3 IN THREE MALE PATIENTS.AMERICAN JOURNAL OF MEDICAL GENETICS PART A. VOL. 164. ISSUE 9. P. 2172 -2179 21 95% 2

Classes with closest relation at Level 1


Rank Class id link
1 12023 SET8//HISTONE//PR SET7
2 36490 VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM
3 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
4 31962 PEA 15//IST ENDOCRINOL ONCOL SPERIMENTALE GAETANO SALVA//BIKDD
5 6479 AURORA KINASE//AURORA A//AURORA KINASE INHIBITOR
6 8733 CREM//CREB//ICER
7 5307 MK2//P38 INHIBITORS//P38 ALPHA
8 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
9 8667 X LINKED MENTAL RETARDATION//XLMR//PQBP1
10 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR

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