Class information for:
Level 1: XCT//SYSTEM XC//CYSTINE GLUTAMATE ANTIPORTER

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18669 541 45.2 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
285 3       ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE 42405
870 2             PEROXIREDOXIN//THIOREDOXIN//GLUTATHIONE 11539
18669 1                   XCT//SYSTEM XC//CYSTINE GLUTAMATE ANTIPORTER 541

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 XCT authKW 1416761 9% 53% 47
2 SYSTEM XC authKW 1362625 7% 62% 39
3 CYSTINE GLUTAMATE ANTIPORTER authKW 397429 2% 54% 13
4 FOOD PL LIFE SCI address 285726 2% 56% 9
5 SLC7A11 authKW 251415 1% 64% 7
6 OXIDATIVE GLUTAMATE TOXICITY authKW 230463 1% 58% 7
7 CYSTINE GLUTAMATE EXCHANGE authKW 203184 1% 60% 6
8 GLUTAMATE CYSTINE TRANSPORTER authKW 169324 1% 100% 3
9 XC CYSTINE TRANSPORTER authKW 169324 1% 100% 3
10 XCT SLC7A11 authKW 169324 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 1525 32% 0% 173
2 Biochemistry & Molecular Biology 525 29% 0% 155
3 Cell Biology 412 16% 0% 85
4 Oncology 363 15% 0% 82
5 Pharmacology & Pharmacy 129 11% 0% 62
6 Physiology 80 5% 0% 28
7 Clinical Neurology 40 5% 0% 29
8 Biophysics 27 4% 0% 20
9 CYTOLOGY & HISTOLOGY 26 0% 0% 2
10 Chemistry, Medicinal 20 3% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FOOD PL LIFE SCI 285726 2% 56% 9
2 PHARMACEUT BIOTECHNOL MOL BIOL 76812 1% 19% 7
3 GLIAL BIOL MED 75937 2% 11% 12
4 CELLULAR BIOL ANAT OPHTHALMOL 75254 0% 67% 2
5 ARRHYTHMIASMINIST EDUC CHIHA 56441 0% 100% 1
6 BIOL BIOASSAYS SIGNAL TRANSDUCT 56441 0% 100% 1
7 CCM2 56441 0% 100% 1
8 CEAUMR E01SERV NEUROVIROLSNVCRSSAIFR13 56441 0% 100% 1
9 CIRC 425 56441 0% 100% 1
10 CNRSIFRMP 23 HOSP UNIV RECH BIOMED 56441 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENDOTHELIUM-NEW YORK 4340 0% 8% 1
2 ASN NEURO 2262 1% 1% 3
3 NEUROCHEMISTRY INTERNATIONAL 1773 2% 0% 13
4 GLIA 969 1% 0% 8
5 JOURNAL OF NEUROCHEMISTRY 951 4% 0% 19
6 ANTIOXIDANTS & REDOX SIGNALING 886 1% 0% 7
7 JOURNAL OF NEURO-ONCOLOGY 833 2% 0% 9
8 NEUROSCIENCE 556 3% 0% 15
9 PHARMACOGNOSY MAGAZINE 541 1% 0% 3
10 JOURNAL OF NEUROSCIENCE 514 3% 0% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 XCT 1416761 9% 53% 47 Search XCT Search XCT
2 SYSTEM XC 1362625 7% 62% 39 Search SYSTEM+XC Search SYSTEM+XC
3 CYSTINE GLUTAMATE ANTIPORTER 397429 2% 54% 13 Search CYSTINE+GLUTAMATE+ANTIPORTER Search CYSTINE+GLUTAMATE+ANTIPORTER
4 SLC7A11 251415 1% 64% 7 Search SLC7A11 Search SLC7A11
5 OXIDATIVE GLUTAMATE TOXICITY 230463 1% 58% 7 Search OXIDATIVE+GLUTAMATE+TOXICITY Search OXIDATIVE+GLUTAMATE+TOXICITY
6 CYSTINE GLUTAMATE EXCHANGE 203184 1% 60% 6 Search CYSTINE+GLUTAMATE+EXCHANGE Search CYSTINE+GLUTAMATE+EXCHANGE
7 GLUTAMATE CYSTINE TRANSPORTER 169324 1% 100% 3 Search GLUTAMATE+CYSTINE+TRANSPORTER Search GLUTAMATE+CYSTINE+TRANSPORTER
8 XC CYSTINE TRANSPORTER 169324 1% 100% 3 Search XC+CYSTINE+TRANSPORTER Search XC+CYSTINE+TRANSPORTER
9 XCT SLC7A11 169324 1% 100% 3 Search XCT+SLC7A11 Search XCT+SLC7A11
10 CYSTINE GLUTAMATE EXCHANGER 156293 1% 46% 6 Search CYSTINE+GLUTAMATE+EXCHANGER Search CYSTINE+GLUTAMATE+EXCHANGER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LEWERENZ, J , HEWETT, SJ , HUANG, Y , LAMBROS, M , GOUT, PW , KALIVAS, PW , MASSIE, A , SMOLDERS, I , METHNER, A , PERGANDE, M , ET AL (2013) THE CYSTINE/GLUTAMATE ANTIPORTER SYSTEM X(C)(-) IN HEALTH AND DISEASE: FROM MOLECULAR MECHANISMS TO NOVEL THERAPEUTIC OPPORTUNITIES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 18. ISSUE 5. P. 522 -555 107 37% 71
2 CONRAD, M , SATO, H , (2012) THE OXIDATIVE STRESS-INDUCIBLE CYSTINE/GLUTAMATE ANTIPORTER, SYSTEM X(C)(-): CYSTINE SUPPLIER AND BEYOND.AMINO ACIDS. VOL. 42. ISSUE 1. P. 231-246 63 57% 76
3 LO, M , WANG, YZ , GOUT, PW , (2008) THE X(C)(-) CYSTINE/GLUTAMATE ANTIPORTER: A POTENTIAL TARGET FOR THERAPY OF CANCER AND OTHER DISEASES.JOURNAL OF CELLULAR PHYSIOLOGY. VOL. 215. ISSUE 3. P. 593 -602 71 52% 135
4 JACKMAN, NA , ULIASZ, TF , HEWETT, JA , HEWETT, SJ , (2010) REGULATION OF SYSTEM X(C)(-) ACTIVITY AND EXPRESSION IN ASTROCYTES BY INTERLEUKIN-1 BETA: IMPLICATIONS FOR HYPOXIC NEURONAL INJURY.GLIA. VOL. 58. ISSUE 15. P. 1806-1815 46 64% 28
5 MASSIE, A , BOILLEE, S , HEWETT, S , KNACKSTEDT, L , LEWERENZ, J , (2015) MAIN PATH AND BYWAYS: NON-VESICULAR GLUTAMATE RELEASE BY SYSTEM X(C)(-) AS AN IMPORTANT MODIFIER OF GLUTAMATERGIC NEUROTRANSMISSION.JOURNAL OF NEUROCHEMISTRY. VOL. 135. ISSUE 6. P. 1062 -1079 59 40% 7
6 SHI, JX , HE, Y , HEWETT, SJ , HEWETT, JA , (2016) INTERLEUKIN 1 BETA REGULATION OF THE SYSTEM X(C)(-), SUBSTRATE-SPECIFIC SUBUNIT, XCT, IN PRIMARY MOUSE ASTROCYTES INVOLVES THE RNA-BINDING PROTEIN HUR.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 291. ISSUE 4. P. 1643 -1651 40 61% 0
7 BRIDGES, RJ , NATALE, NR , PATEL, SA , (2012) SYSTEM XC- CYSTINE/GLUTAMATE ANTIPORTER: AN UPDATE ON MOLECULAR PHARMACOLOGY AND ROLES WITHIN THE CNS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 165. ISSUE 1. P. 20 -34 51 40% 56
8 THOMAS, AG , SATTLER, R , TENDYKE, K , LOIACONO, KA , HANSEN, H , SAHNI, V , HASHIZUME, Y , ROJAS, C , SLUSHER, BS , (2015) HIGH-THROUGHPUT ASSAY DEVELOPMENT FOR CYSTINE-GLUTAMATE ANTIPORTER (X(C)(-)) HIGHLIGHTS FASTER CYSTINE UPTAKE THAN GLUTAMATE RELEASE IN GLIOMA CELLS.PLOS ONE. VOL. 10. ISSUE 8. P. - 32 68% 1
9 LEWERENZ, J , MAHER, P , METHNER, A , (2012) REGULATION OF XCT EXPRESSION AND SYSTEM X(C)(-) FUNCTION IN NEURONAL CELLS.AMINO ACIDS. VOL. 42. ISSUE 1. P. 171-179 38 52% 28
10 SORIA, FN , ZABALA, A , PAMPLIEGA, O , PALOMINO, A , MIGUELEZ, C , UGEDO, L , SATO, H , MATUTE, C , DOMERCQ, M , (2016) CYSTINE/GLUTAMATE ANTIPORTER BLOCKAGE INDUCES MYELIN DEGENERATION.GLIA. VOL. 64. ISSUE 8. P. 1381 -1395 34 59% 0

Classes with closest relation at Level 1


Rank Class id link
1 24411 ADP DEPENDENT GLUCOKINASE ADPGK//ANTI METHYLDITHIO FACTOR//ASSAY FOR METHYLTHIO DISULFIDES
2 20933 GRM1//PREFERENTIAL LOCALIZATION//H 3GLUTAMATE ACCUMULATION
3 17747 BIOMOL INTERACT BREMEN//BIOL CHEM 2//GLUTATHIONE
4 3711 GLUTAMATE TRANSPORTER//GLT 1//EAAT2
5 35725 GLUTAMATE PYRUVATE TRANSAMINASE GPT//BLOOD GLUTAMATE SCAVENGING//GLUTAMATE OXALOACETATE TRANSAMINASE GOT
6 33806 MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY
7 14974 MITOCHONDRIAL APOPTOSIS SIGNALING//APOPTOSIS IN UNDIFFERENTIATED CELLS//GSH COMPARTMENTATION
8 5386 CYSTINURIA//LAT1//LYSINURIC PROTEIN INTOLERANCE
9 16464 GLUTAMATE CYSTEINE LIGASE//GAMMA GLUTAMYLCYSTEINE SYNTHETASE//GLUTATHIONE SYNTHETASE
10 12192 SYSTEM A//SYSTEM N//ASC SYSTEM

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