Class information for:
Level 1: PPAR DELTA//PPAR BETA DELTA//PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3123 2060 47.1 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
1300 2             THIAZOLIDINEDIONES//PPAR GAMMA//ROSIGLITAZONE 8578
3123 1                   PPAR DELTA//PPAR BETA DELTA//PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 2060

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PPAR DELTA authKW 721780 4% 55% 88
2 PPAR BETA DELTA authKW 434964 2% 68% 43
3 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR authKW 395799 8% 16% 172
4 PPAR authKW 373689 8% 15% 163
5 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA authKW 364799 2% 62% 40
6 GW501516 authKW 184684 1% 69% 18
7 GW0742 authKW 164172 1% 92% 12
8 MOL TOXICOL CARCINOGENESIS address 162591 3% 19% 57
9 PPAR AGONIST authKW 161814 2% 35% 31
10 ATHEROSCLEROSE address 158951 3% 21% 52

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 10996 22% 0% 453
2 Endocrinology & Metabolism 1871 13% 0% 260
3 Biochemistry & Molecular Biology 1755 27% 0% 560
4 Pharmacology & Pharmacy 1223 16% 0% 337
5 Chemistry, Organic 952 11% 0% 230
6 Cell Biology 616 11% 0% 221
7 Medicine, Research & Experimental 546 7% 0% 148
8 Peripheral Vascular Diseases 368 5% 0% 96
9 Biophysics 232 5% 0% 102
10 Dermatology 122 2% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL TOXICOL CARCINOGENESIS 162591 3% 19% 57
2 ATHEROSCLEROSE 158951 3% 21% 52
3 FRONTIERS GENET 121363 1% 30% 27
4 U545 74912 2% 16% 31
5 INTEGRAT GENOM 52403 3% 6% 60
6 NUCL RECEPTOR DISCOVERY 50943 1% 25% 14
7 TAKARA BIO ENDOWED 49915 0% 42% 8
8 MOL BIOL TUMOR IMT 46365 1% 24% 13
9 METAB DIS EXCELLENCE DRUG DISCOVERY 46313 0% 63% 5
10 METAB DIS CHEM 46162 0% 35% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PPAR RESEARCH 144480 3% 14% 69
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13817 7% 1% 154
3 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 3142 1% 1% 24
4 JOURNAL OF MEDICINAL CHEMISTRY 2821 3% 0% 65
5 CHEMMEDCHEM 2302 1% 1% 19
6 MOLECULAR ENDOCRINOLOGY 2169 1% 1% 29
7 BIOORGANIC & MEDICINAL CHEMISTRY 1945 2% 0% 42
8 CURRENT OPINION IN INVESTIGATIONAL DRUGS 1223 0% 1% 7
9 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1200 1% 0% 28
10 CURRENT OPINION IN LIPIDOLOGY 1100 0% 1% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PPAR DELTA 721780 4% 55% 88 Search PPAR+DELTA Search PPAR+DELTA
2 PPAR BETA DELTA 434964 2% 68% 43 Search PPAR+BETA+DELTA Search PPAR+BETA+DELTA
3 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 395799 8% 16% 172 Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR
4 PPAR 373689 8% 15% 163 Search PPAR Search PPAR
5 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA 364799 2% 62% 40 Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+DELTA Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+DELTA
6 GW501516 184684 1% 69% 18 Search GW501516 Search GW501516
7 GW0742 164172 1% 92% 12 Search GW0742 Search GW0742
8 PPAR AGONIST 161814 2% 35% 31 Search PPAR+AGONIST Search PPAR+AGONIST
9 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BETA DELTA 151758 1% 64% 16 Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+BETA+DELTA Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+BETA+DELTA
10 PPARS 140587 2% 22% 44 Search PPARS Search PPARS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PIRAT, C , FARCE, A , LEBEGUE, N , RENAULT, N , FURMAN, C , MILLET, R , YOUS, S , SPECA, S , BERTHELOT, P , DESREUMAUX, P , ET AL (2012) TARGETING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS): DEVELOPMENT OF MODULATORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 9. P. 4027 -4061 134 79% 55
2 NEELS, JG , GRIMALDI, PA , (2014) PHYSIOLOGICAL FUNCTIONS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA.PHYSIOLOGICAL REVIEWS. VOL. 94. ISSUE 3. P. 795 -858 221 34% 33
3 GREWAL, AS , BENIWAL, M , PANDITA, D , SEKHON, BS , LATHER, V , (2016) RECENT UPDATES ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS FOR THE TREATMENT OF METABOLIC SYNDROME.MEDICINAL CHEMISTRY. VOL. 12. ISSUE 1. P. 3 -21 101 86% 0
4 LOIODICE, F , POCHETTI, G , (2011) STRUCTURAL INSIGHT INTO THE CRUCIAL ROLE OF LIGAND CHIRALITY IN THE ACTIVATION OF PPARS BY CRYSTALLOGRAPHIC METHODS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 7. P. 819-839 99 87% 5
5 EHRENBORG, E , SKOGSBERG, J , (2013) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA AND CARDIOVASCULAR DISEASE.ATHEROSCLEROSIS. VOL. 231. ISSUE 1. P. 95-106 83 85% 15
6 MICHALIK, L , AUWERX, J , BERGER, JP , CHATTERJEE, VK , GLASS, CK , GONZALEZ, FJ , GRIMALDI, PA , KADOWAKI, T , LAZAR, MA , O'RAHILLY, S , ET AL (2006) INTERNATIONAL UNION OF PHARMACOLOGY. LXI. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 58. ISSUE 4. P. 726-741 124 44% 418
7 PETERS, JM , FOREMAN, JE , GONZALEZ, FJ , (2011) DISSECTING THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA (PPAR BETA/DELTA) IN COLON, BREAST, AND LUNG CARCINOGENESIS.CANCER AND METASTASIS REVIEWS. VOL. 30. ISSUE 3-4. P. 619 -640 104 71% 16
8 ZHANG, J , LIU, X , XIE, XB , CHENG, XC , WANG, RL , (2016) MULTITARGETED BIOACTIVE LIGANDS FOR PPARS DISCOVERED IN THE LAST DECADE.CHEMICAL BIOLOGY & DRUG DESIGN. VOL. 88. ISSUE 5. P. 635 -663 86 77% 0
9 WAGNER, KD , WAGNER, N , (2010) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA (PPAR BETA/DELTA) ACTS AS REGULATOR OF METABOLISM LINKED TO MULTIPLE CELLULAR FUNCTIONS.PHARMACOLOGY & THERAPEUTICS. VOL. 125. ISSUE 3. P. 423-435 115 56% 59
10 BORSOTTO, M , VEYSSIERE, J , MAATI, HMO , DEVADER, C , MAZELLA, J , HEURTEAUX, C , (2015) TARGETING TWO-PORE DOMAIN K+ CHANNELS TREK-1 AND TASK-3 FOR THE TREATMENT OF DEPRESSION: A NEW THERAPEUTIC CONCEPT.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 172. ISSUE 3. P. 771 -784 75 72% 11

Classes with closest relation at Level 1


Rank Class id link
1 15078 TROGLITAZONE//JTT 501//CS 045
2 29356 REPROD METAB//ADIPQ//AIB3
3 9168 PPAR GAMMA//PPAR RESEARCH//TROGLITAZONE
4 13971 PRO12ALA POLYMORPHISM//PRO12ALA//PPAR GAMMA 2
5 5985 15D PGJ2//15 DEOXY DELTA12 14 PROSTAGLANDIN J2//CYCLOPENTENONE PROSTAGLANDINS
6 3093 PIOGLITAZONE//THIAZOLIDINEDIONES//ROSIGLITAZONE
7 3761 PEROXISOME PROLIFERATOR//PEROXISOME PROLIFERATION//3 THIA FATTY ACIDS
8 10374 FENOFIBRATE//FENOFIBRIC ACID//FIBRATES
9 6406 ADIPOGENESIS//ADIPOCYTE DIFFERENTIATION//MITOTIC CLONAL EXPANSION
10 10090 LIVER X RECEPTOR//LXR//T0901317

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