Class information for:
Level 1: GEMCITABINE//DEOXYCYTIDINE KINASE//HENT1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8385 1259 36.9 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
216 3       NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG 51214
1422 2             XRCC1//GEMCITABINE//ERCC1 7962
8385 1                   GEMCITABINE//DEOXYCYTIDINE KINASE//HENT1 1259

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GEMCITABINE authKW 1804283 43% 14% 541
2 DEOXYCYTIDINE KINASE authKW 753601 6% 41% 75
3 HENT1 authKW 352077 2% 52% 28
4 CYTIDINE DEAMINASE authKW 247838 4% 22% 46
5 CP 4126 authKW 169764 1% 100% 7
6 FIXED DOSE RATE authKW 151786 1% 48% 13
7 HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 authKW 142651 1% 59% 10
8 DFDU authKW 132036 1% 78% 7
9 ELACYTARABINE authKW 129339 1% 67% 8
10 CP 4055 authKW 124723 0% 86% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 11776 50% 0% 629
2 Pharmacology & Pharmacy 2382 27% 0% 338
3 Hematology 364 6% 0% 75
4 Materials Science, Biomaterials 72 2% 0% 19
5 Radiology, Nuclear Medicine & Medical Imaging 67 4% 0% 52
6 Chemistry, Medicinal 48 3% 0% 33
7 Medicine, Research & Experimental 46 3% 0% 44
8 Gastroenterology & Hepatology 44 3% 0% 33
9 Biochemical Research Methods 39 3% 0% 36
10 Biophysics 22 3% 0% 34

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN PHARMACOL ANALYT SERV 77605 0% 80% 4
2 TRANSFER ONCOL 77605 0% 80% 4
3 UMR 8612IFR 141 75784 0% 63% 5
4 LA TIMONE UNIV HOSP MARSEILLE 72756 0% 100% 3
5 UMR BIOCIS 8076 53079 1% 24% 9
6 BIO ORGAN CHEM ELED CPDS 48504 0% 100% 2
7 EP9932 48504 0% 100% 2
8 ETUD METAB TUMORAL 48504 0% 100% 2
9 NORD UNIV HOSP MARSEILLE 48504 0% 100% 2
10 UOC FARM OSPED 48504 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 10305 4% 1% 56
2 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 4637 2% 1% 30
3 ANTI-CANCER DRUGS 4607 2% 1% 25
4 PHARMACOGENOMICS 3928 1% 1% 17
5 INVESTIGATIONAL NEW DRUGS 3769 2% 1% 20
6 SEMINARS IN ONCOLOGY 3110 2% 1% 26
7 PHARMACOGENETICS AND GENOMICS 2121 1% 1% 10
8 CLINICAL CANCER RESEARCH 1839 3% 0% 34
9 ANNALS OF ONCOLOGY 1147 2% 0% 20
10 EUROPEAN JOURNAL OF CANCER 1142 2% 0% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GEMCITABINE 1804283 43% 14% 541 Search GEMCITABINE Search GEMCITABINE
2 DEOXYCYTIDINE KINASE 753601 6% 41% 75 Search DEOXYCYTIDINE+KINASE Search DEOXYCYTIDINE+KINASE
3 HENT1 352077 2% 52% 28 Search HENT1 Search HENT1
4 CYTIDINE DEAMINASE 247838 4% 22% 46 Search CYTIDINE+DEAMINASE Search CYTIDINE+DEAMINASE
5 CP 4126 169764 1% 100% 7 Search CP+4126 Search CP+4126
6 FIXED DOSE RATE 151786 1% 48% 13 Search FIXED+DOSE+RATE Search FIXED+DOSE+RATE
7 HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 142651 1% 59% 10 Search HUMAN+EQUILIBRATIVE+NUCLEOSIDE+TRANSPORTER+1 Search HUMAN+EQUILIBRATIVE+NUCLEOSIDE+TRANSPORTER+1
8 DFDU 132036 1% 78% 7 Search DFDU Search DFDU
9 ELACYTARABINE 129339 1% 67% 8 Search ELACYTARABINE Search ELACYTARABINE
10 CP 4055 124723 0% 86% 6 Search CP+4055 Search CP+4055

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ELNAGGAR, M , GIOVANNETTI, E , PETERS, GJ , (2012) MOLECULAR TARGETS OF GEMCITABINE ACTION: RATIONALE FOR DEVELOPMENT OF NOVEL DRUGS AND DRUG COMBINATIONS.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 19. P. 2811-2829 136 62% 13
2 CICCOLINI, J , SERDJEBI, C , PETERS, GJ , GIOVANNETTI, E , (2016) PHARMACOKINETICS AND PHARMACOGENETICS OF GEMCITABINE AS A MAINSTAY IN ADULT AND PEDIATRIC ONCOLOGY: AN EORTC-PAMM PERSPECTIVE.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 78. ISSUE 1. P. 1 -12 76 75% 2
3 MINI, E , NOBILI, S , CACIAGLI, B , LANDINI, I , MAZZEI, T , (2006) CELLULAR PHARMACOLOGY OF GEMCITABINE.ANNALS OF ONCOLOGY. VOL. 17. ISSUE . P. V7-V12 44 76% 201
4 ALVARELLOS, ML , LAMBA, J , SANGKUHL, K , THORN, CF , WANG, LW , KLEIN, DJ , ALTMAN, RB , KLEIN, TE , (2014) PHARMGKB SUMMARY: GEMCITABINE PATHWAY.PHARMACOGENETICS AND GENOMICS. VOL. 24. ISSUE 11. P. 564 -574 47 76% 3
5 SERDJEBI, C , MILANO, G , CICCOLINI, J , (2015) ROLE OF CYTIDINE DEAMINASE IN TOXICITY AND EFFICACY OF NUCLEOSIDIC ANALOGS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 11. ISSUE 5. P. 665 -672 36 77% 8
6 MOYSAN, E , BASTIAT, G , BENOIT, JP , (2013) GEMCITABINE VERSUS MODIFIED GEMCITABINE: A REVIEW OF SEVERAL PROMISING CHEMICAL MODIFICATIONS.MOLECULAR PHARMACEUTICS. VOL. 10. ISSUE 2. P. 430 -444 54 49% 33
7 WONG, A , SOO, RA , YONG, WP , INNOCENTI, F , (2009) CLINICAL PHARMACOLOGY AND PHARMACOGENETICS OF GEMCITABINE.DRUG METABOLISM REVIEWS. VOL. 41. ISSUE 2. P. 77 -88 44 67% 64
8 DUBEY, RD , SANEJA, A , GUPTA, PK , GUPTA, PN , (2016) RECENT ADVANCES IN DRUG DELIVERY STRATEGIES FOR IMPROVED THERAPEUTIC EFFICACY OF GEMCITABINE.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 93. ISSUE . P. 147 -162 63 39% 0
9 PAUWELS, B , KORST, AEC , LARDON, F , VERMORKEN, JB , (2005) COMBINED MODALITY THERAPY OF GEMCITABINE AND RADIATION.ONCOLOGIST. VOL. 10. ISSUE 1. P. 34-51 57 51% 74
10 BERGMAN, AM , PINEDO, HM , PETERS, GJ , (2002) DETERMINANTS OF RESISTANCE TO 2 ',2 '-DIFLUORODEOXYCYTIDINE (GEMCITABINE).DRUG RESISTANCE UPDATES. VOL. 5. ISSUE 1. P. 19-33 61 46% 189

Classes with closest relation at Level 1


Rank Class id link
1 13135 CLOFARABINE//CLADRIBINE//2 CHLORODEOXYADENOSINE
2 6138 PANCREATIC CANCER//GEMCITABINE//ADVANCED PANCREATIC CANCER
3 26087 CYTIDINE DEAMINASE//ANTIBIOTIC FUNGICIDE//BLASTICIDIN S
4 26418 TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE
5 13007 ERCC1//RRM1//MED OVARIAN CANC SECT
6 8598 POLG//MNGIE//DEOXYRIBONUCLEOSIDE KINASE
7 6949 NUCLEOSIDE TRANSPORT//NUCLEOSIDE TRANSPORTER//NITROBENZYLTHIOINOSINE
8 24391 HALOGENATED PYRIMIDINES//EXPT ONCOL RADIOBIOL LEXOR EXPT MOL MED//IPDR
9 3806 CYTOSINE ARABINOSIDE//ARA CTP//CYTARABINE
10 22701 PEMETREXED//MULTITARGETED ANTIFOLATE//AFFILIATED JIANGSU CANC HOSP

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