Class information for:
Level 1: ARGININE DEIMINASE//ARGININE DEPRIVATION//ARGININOSUCCINATE SYNTHETASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23814 334 38.6 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
630 3       HEPATIC ENCEPHALOPATHY//ASYMMETRIC DIMETHYLARGININE//HYPERAMMONEMIA 13067
2078 2             ASYMMETRIC DIMETHYLARGININE//ARGINASE//ADMA 5239
23814 1                   ARGININE DEIMINASE//ARGININE DEPRIVATION//ARGININOSUCCINATE SYNTHETASE 334

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARGININE DEIMINASE authKW 3433020 20% 57% 66
2 ARGININE DEPRIVATION authKW 1210002 4% 88% 15
3 ARGININOSUCCINATE SYNTHETASE authKW 686443 9% 26% 29
4 ADI PEG20 authKW 548536 2% 100% 6
5 RECOMBINANT HUMAN ARGINASE authKW 457113 1% 100% 5
6 AZURIN authKW 307082 8% 12% 27
7 ARGININE DEIMINASE ADI authKW 274268 1% 100% 3
8 H8 EPITOPE authKW 274268 1% 100% 3
9 PHOENIX PHARMACOL INC address 274268 1% 100% 3
10 RECOMBINANT ARGININE DEIMINASE authKW 274268 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1842 39% 0% 130
2 Cell Biology 249 16% 0% 52
3 Biochemistry & Molecular Biology 193 23% 0% 78
4 Biotechnology & Applied Microbiology 146 10% 0% 34
5 Biophysics 139 8% 0% 28
6 Medicine, Research & Experimental 31 5% 0% 16
7 Pharmacology & Pharmacy 29 8% 0% 27
8 Hematology 27 4% 0% 12
9 Biochemical Research Methods 16 3% 0% 11
10 Microbiology 14 4% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHOENIX PHARMACOL INC 274268 1% 100% 3
2 SYLVERSTER COMPREHENS CANC 182845 1% 100% 2
3 ADV SCI TECHNOL COMMERICALIZAT 91423 0% 100% 1
4 AMBULATORY SERV ADM 91423 0% 100% 1
5 BIOMEDES 91423 0% 100% 1
6 BIOTECHNOL BIO ENGN 91423 0% 100% 1
7 CANC DRUG RD 91423 0% 100% 1
8 GENET ONCOL ONCOL TRANSLAZ 91423 0% 100% 1
9 GUT MICROBIOL IMMUNOL GRP CENT EXCELLENCE ADV S 91423 0% 100% 1
10 HISTOPATHOL ISH 91423 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MOLECULAR RECOGNITION 3664 2% 1% 7
2 BIOENGINEERED 3019 1% 1% 3
3 RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY 1403 1% 1% 2
4 CANCER BIOCHEMISTRY BIOPHYSICS 992 1% 1% 2
5 CELL DEATH & DISEASE 961 1% 0% 5
6 TRANSLATIONAL ONCOLOGY 663 1% 0% 2
7 BRITISH JOURNAL OF CANCER 602 3% 0% 11
8 CANCER LETTERS 599 3% 0% 9
9 INVESTIGATIONAL NEW DRUGS 566 1% 0% 4
10 MOLECULAR CANCER THERAPEUTICS 554 1% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ARGININE DEIMINASE 3433020 20% 57% 66 Search ARGININE+DEIMINASE Search ARGININE+DEIMINASE
2 ARGININE DEPRIVATION 1210002 4% 88% 15 Search ARGININE+DEPRIVATION Search ARGININE+DEPRIVATION
3 ARGININOSUCCINATE SYNTHETASE 686443 9% 26% 29 Search ARGININOSUCCINATE+SYNTHETASE Search ARGININOSUCCINATE+SYNTHETASE
4 ADI PEG20 548536 2% 100% 6 Search ADI+PEG20 Search ADI+PEG20
5 RECOMBINANT HUMAN ARGINASE 457113 1% 100% 5 Search RECOMBINANT+HUMAN+ARGINASE Search RECOMBINANT+HUMAN+ARGINASE
6 AZURIN 307082 8% 12% 27 Search AZURIN Search AZURIN
7 ARGININE DEIMINASE ADI 274268 1% 100% 3 Search ARGININE+DEIMINASE+ADI Search ARGININE+DEIMINASE+ADI
8 H8 EPITOPE 274268 1% 100% 3 Search H8+EPITOPE Search H8+EPITOPE
9 RECOMBINANT ARGININE DEIMINASE 274268 1% 100% 3 Search RECOMBINANT+ARGININE+DEIMINASE Search RECOMBINANT+ARGININE+DEIMINASE
10 ARGININE STARVATION 243791 1% 67% 4 Search ARGININE+STARVATION Search ARGININE+STARVATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 QIU, FM , HUANG, J , SUI, MH , (2015) TARGETING ARGININE METABOLISM PATHWAY TO TREAT ARGININE-DEPENDENT CANCERS.CANCER LETTERS. VOL. 364. ISSUE 1. P. 1 -7 57 81% 13
2 PATIL, MD , BHAUMIK, J , BABYKUTTY, S , BANERJEE, UC , FUKUMURA, D , (2016) ARGININE DEPENDENCE OF TUMOR CELLS: TARGETING A CHINK IN CANCER'S ARMOR.ONCOGENE. VOL. 35. ISSUE 38. P. 4957 -4972 81 43% 2
3 PHILLIPS, MM , SHEAFF, MT , SZLOSAREK, PW , (2013) TARGETING ARGININE-DEPENDENT CANCERS WITH ARGININE-DEGRADING ENZYMES: OPPORTUNITIES AND CHALLENGES.CANCER RESEARCH AND TREATMENT. VOL. 45. ISSUE 4. P. 251 -262 53 58% 40
4 HAN, RZ , XU, GC , DONG, JJ , NI, Y , (2016) ARGININE DEIMINASE: RECENT ADVANCES IN DISCOVERY, CRYSTAL STRUCTURE, AND PROTEIN ENGINEERING FOR IMPROVED PROPERTIES AS AN ANTI-TUMOR DRUG.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. VOL. 100. ISSUE 11. P. 4747 -4760 41 72% 1
5 KELLY, MP , JUNGBLUTH, AA , WU, BW , BOMALASKI, J , OLD, LJ , RITTER, G , (2012) ARGININE DEIMINASE PEG20 INHIBITS GROWTH OF SMALL CELL LUNG CANCERS LACKING EXPRESSION OF ARGININOSUCCINATE SYNTHETASE.BRITISH JOURNAL OF CANCER. VOL. 106. ISSUE 2. P. 324 -332 28 74% 28
6 FEUN, LG , KUO, MT , SAVARAJ, N , (2015) ARGININE DEPRIVATION IN CANCER THERAPY.CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. VOL. 18. ISSUE 1. P. 78 -82 18 90% 14
7 FEUN, L , YOU, M , WU, CJ , KUO, MT , WANGPAICHITR, M , SPECTOR, S , SAVARAJ, N , (2008) ARGININE DEPRIVATION AS A TARGETED THERAPY FOR CANCER.CURRENT PHARMACEUTICAL DESIGN. VOL. 14. ISSUE 11. P. 1049-1057 34 54% 79
8 MCALPINE, JA , LU, HT , WU, KC , KNOWLES, SK , THOMSON, JA , (2014) DOWN-REGULATION OF ARGININOSUCCINATE SYNTHETASE IS ASSOCIATED WITH CISPLATIN RESISTANCE IN HEPATOCELLULAR CARCINOMA CELL LINES: IMPLICATIONS FOR PEGYLATED ARGININE DEIMINASE COMBINATION THERAPY.BMC CANCER. VOL. 14. ISSUE . P. - 27 63% 8
9 FEUN, LG , MARINI, A , WALKER, G , ELGART, G , MOFFAT, F , RODGERS, SE , WU, CJ , YOU, M , WANGPAICHITR, M , KUO, MT , ET AL (2012) NEGATIVE ARGININOSUCCINATE SYNTHETASE EXPRESSION IN MELANOMA TUMOURS MAY PREDICT CLINICAL BENEFIT FROM ARGININE-DEPLETING THERAPY WITH PEGYLATED ARGININE DEIMINASE.BRITISH JOURNAL OF CANCER. VOL. 106. ISSUE 9. P. 1481-1485 19 86% 31
10 STASYK, OV , BORETSKY, YR , GONCHAR, MV , SIBIRNY, AA , (2015) RECOMBINANT ARGININE-DEGRADING ENZYMES IN METABOLIC ANTICANCER THERAPY AND BIOANALYTICS.CELL BIOLOGY INTERNATIONAL. VOL. 39. ISSUE 3. P. 246 -252 21 78% 3

Classes with closest relation at Level 1


Rank Class id link
1 7846 ARGINASE//ARGINASE II//ARGINASE INHIBITORS
2 24992 L CANAVANINE//CANAVANINE//BIOCHEM ECOL
3 22761 METHIONINE DEPENDENCE//METHIONINASE//METHIONINE GAMMA LYASE
4 22069 ARGININE REPRESSOR//ARGININE REPRESSOR PROTEIN//ARGR
5 35322 LAPTM4B//LAPTM4B 35//LYSOSOMAL PROTEIN TRANSMEMBRANE 4 BETA
6 10658 CITRULLINE//HUBEI ANIM NUTR FEED SCI//SUBTROP AGR
7 33232 PESTICIDE WASTES//AMINOINDEX CANCER SCREENING//ARNINO INDEX
8 8348 L ASPARAGINASE//ASPARAGINASE//PEG ASPARAGINASE
9 5534 PLASTOCYANIN//BLUE COPPER PROTEIN//AZURIN
10 7258 PEGYLATION//MONOMETHOXYPOLYETHYLENE GLYCOL//PEGYLATED PROTEINS

Go to start page