Class information for:
Level 1: METHIONINE DEPENDENCE//METHIONINASE//METHIONINE GAMMA LYASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22761 369 32.2 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
3291 2             PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE 1872
22761 1                   METHIONINE DEPENDENCE//METHIONINASE//METHIONINE GAMMA LYASE 369

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METHIONINE DEPENDENCE authKW 1406766 5% 100% 17
2 METHIONINASE authKW 1276723 5% 86% 18
3 METHIONINE GAMMA LYASE authKW 665938 4% 62% 13
4 L METHIONINE GAMMA LYASE authKW 609344 2% 82% 9
5 L METHIONINASE authKW 413755 1% 100% 5
6 METHIONINE DEPLETION authKW 413755 1% 100% 5
7 METHIONINE FREE DIET authKW 331004 1% 100% 4
8 POLYHEMOGLOBIN TYROSINASE authKW 248253 1% 100% 3
9 AFMETASE authKW 165502 1% 100% 2
10 BIOSTAT PUBL HLTH UNIT address 165502 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1840 37% 0% 137
2 Nutrition & Dietetics 223 7% 0% 26
3 Biochemistry & Molecular Biology 212 23% 0% 86
4 Biochemical Research Methods 176 8% 0% 30
5 Biotechnology & Applied Microbiology 136 9% 0% 35
6 Medicine, Research & Experimental 69 6% 0% 23
7 Biophysics 67 6% 0% 22
8 Cell Biology 48 8% 0% 29
9 Agronomy 29 3% 0% 11
10 Pharmacology & Pharmacy 17 7% 0% 25

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOSTAT PUBL HLTH UNIT 165502 1% 100% 2
2 PHARMACEUT SCIPHARMACOL TOXICOL PROG 165502 1% 100% 2
3 MED SERV 111H 165498 1% 50% 4
4 KIDSCAN CHILDRENS CANC 110333 1% 67% 2
5 AFFILIATED RAILWAY HOSP 82751 0% 100% 1
6 CANC GENET ABIL UNIT 82751 0% 100% 1
7 ENGELHARDT MOL BIO 82751 0% 100% 1
8 EQUIPE ACCUEIL 4233 82751 0% 100% 1
9 FEDERAT SERV MALAD SANGUINES TUMORALES 82751 0% 100% 1
10 FRSQ GRPEQUIPE BLOOD SUBSTITUTES TRANSFUS ME 82751 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTICANCER RESEARCH 2687 7% 0% 25
2 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 2473 2% 0% 9
3 CANCER RESEARCH 1635 8% 0% 28
4 NUTRITION AND METABOLISM 1450 0% 2% 1
5 AGRICULTURAL AND BIOLOGICAL CHEMISTRY 1420 3% 0% 11
6 CLINICAL & EXPERIMENTAL METASTASIS 1029 1% 0% 5
7 ACTA NATURAE 939 1% 1% 2
8 JOURNAL OF MARINE BIOTECHNOLOGY 851 0% 1% 1
9 ZEITSCHRIFT FUR CHEMIE 797 1% 0% 5
10 IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION 552 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 METHIONINE DEPENDENCE 1406766 5% 100% 17 Search METHIONINE+DEPENDENCE Search METHIONINE+DEPENDENCE
2 METHIONINASE 1276723 5% 86% 18 Search METHIONINASE Search METHIONINASE
3 METHIONINE GAMMA LYASE 665938 4% 62% 13 Search METHIONINE+GAMMA+LYASE Search METHIONINE+GAMMA+LYASE
4 L METHIONINE GAMMA LYASE 609344 2% 82% 9 Search L+METHIONINE+GAMMA+LYASE Search L+METHIONINE+GAMMA+LYASE
5 L METHIONINASE 413755 1% 100% 5 Search L+METHIONINASE Search L+METHIONINASE
6 METHIONINE DEPLETION 413755 1% 100% 5 Search METHIONINE+DEPLETION Search METHIONINE+DEPLETION
7 METHIONINE FREE DIET 331004 1% 100% 4 Search METHIONINE+FREE+DIET Search METHIONINE+FREE+DIET
8 POLYHEMOGLOBIN TYROSINASE 248253 1% 100% 3 Search POLYHEMOGLOBIN+TYROSINASE Search POLYHEMOGLOBIN+TYROSINASE
9 AFMETASE 165502 1% 100% 2 Search AFMETASE Search AFMETASE
10 CITROBACTER FREUNDII METHIONINE GAMMA LYASE 165502 1% 100% 2 Search CITROBACTER+FREUNDII+METHIONINE+GAMMA+LYASE Search CITROBACTER+FREUNDII+METHIONINE+GAMMA+LYASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HOFFMAN, RM , (2015) DEVELOPMENT OF RECOMBINANT METHIONINASE TO TARGET THE GENERAL CANCER-SPECIFIC METABOLIC DEFECT OF METHIONINE DEPENDENCE: A 40-YEAR ODYSSEY.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 15. ISSUE 1. P. 21 -31 39 91% 5
2 TAN, YY , XU, MX , HOFFMAN, RM , (2010) BROAD SELECTIVE EFFICACY OF RECOMBINANT METHIONINASE AND POLYETHYLENE GLYCOL-MODIFIED RECOMBINANT METHIONINASE ON CANCER CELLS IN VITRO.ANTICANCER RESEARCH. VOL. 30. ISSUE 4. P. 1041-1046 41 87% 12
3 DURANDO, X , THIVAT, E , GIMBERGUES, P , CELLARIER, E , ABRIAL, C , DIB, M , TACCA, O , CHOLLET, P , (2008) METHIONINE DEPENDENCY OF CANCER CELLS: A NEW THERAPEUTIC APPROACH?.BULLETIN DU CANCER. VOL. 95. ISSUE 1. P. 69-76 47 81% 6
4 CELLARIER, E , DURANDO, X , VASSON, MP , FARGES, MC , DEMIDEN, A , MAURIZIS, JC , MADELMONT, JC , CHOLLET, P , (2003) METHIONINE DEPENDENCY AND CANCER TREATMENT.CANCER TREATMENT REVIEWS. VOL. 29. ISSUE 6. P. 489-499 58 66% 74
5 SHARMA, B , SINGH, S , KANWAR, SS , (2014) L-METHIONASE: A THERAPEUTIC ENZYME TO TREAT MALIGNANCIES.BIOMED RESEARCH INTERNATIONAL. VOL. . ISSUE . P. - 62 48% 0
6 EPNER, DE , (2001) CAN DIETARY METHIONINE RESTRICTION INCREASE THE EFFECTIVENESS OF CHEMOTHERAPY IN TREATMENT OF ADVANCED CANCER?.JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION. VOL. 20. ISSUE 5. P. 443S-449S 48 69% 13
7 TAN, YY , XU, MX , HOFFMAN, RM , (2010) BROAD SELECTIVE EFFICACY OF RMETASE AND PEG-RMETASE ON CANCER CELLS IN VITRO.ANTICANCER RESEARCH. VOL. 30. ISSUE 3. P. 793 -798 29 88% 2
8 EL-SAYED, AS , (2010) MICROBIAL L-METHIONINASE: PRODUCTION, MOLECULAR CHARACTERIZATION, AND THERAPEUTIC APPLICATIONS.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. VOL. 86. ISSUE 2. P. 445 -467 49 48% 19
9 EL-SAYED, AS , SHOUMAN, SA , NASSRAT, HM , (2012) PHARMACOKINETICS, IMMUNOGENICITY AND ANTICANCER EFFICIENCY OF ASPERGILLUS FLAVIPES L-METHIONINASE.ENZYME AND MICROBIAL TECHNOLOGY. VOL. 51. ISSUE 4. P. 200 -210 30 71% 6
10 FOO, TC , TERENTIS, AC , VENKATACHALAM, KV , (2016) A CONTINUOUS SPECTROPHOTOMETRIC ASSAY AND NONLINEAR KINETIC ANALYSIS OF METHIONINE GAMMA-LYASE CATALYSIS.ANALYTICAL BIOCHEMISTRY. VOL. 507. ISSUE . P. 21 -26 24 83% 0

Classes with closest relation at Level 1


Rank Class id link
1 22214 MTAP//METHYLTHIOADENOSINE PHOSPHORYLASE//METHIONINE SALVAGE PATHWAY
2 23814 ARGININE DEIMINASE//ARGININE DEPRIVATION//ARGININOSUCCINATE SYNTHETASE
3 19331 METHIONINE BIOSYNTHESIS//COBALAMIN INDEPENDENT//METHIONINE REPRESSOR
4 12247 ASPARTATE AMINOTRANSFERASE//PYRIDOXAL 5 PHOSPHATE//AMINOTRANSFERASE
5 17778 HALITOSIS//ORAL MALODOUR//ORAL MALODOR
6 35213 L GLUTAMINASE//MICROCOCCUS LUTEUS K 3//GLUTAMINASE
7 35899 4 METHYL 1 THIOXO 1 2 4 5 TETRAHYDRO1 2 4TRIAZOLO4 3 AQUINAZOLIN 5 ONE//CYCLIC THIOAMIDES//DCC AND AZIDE COUPLING
8 33232 PESTICIDE WASTES//AMINOINDEX CANCER SCREENING//ARNINO INDEX
9 25710 CYSTEAMINYLPHENOL//5 S GAD//ANTIMELANOMA
10 15558 TYROSINE PHENOL LYASE//TRYPTOPHAN SYNTHASE//TRYPTOPHANASE

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