Class information for:
Level 1: VESNARINONE//TSC 22//POSITIVE INOTROPIC ACTIVITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23565 342 28.9 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
62 3       CARDIAC & CARDIOVASCULAR SYSTEM//HEART FAILURE//PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 86105
2676 2             LEVOSIMENDAN//CALCIUM SENSITIZER//MILRINONE 3400
23565 1                   VESNARINONE//TSC 22//POSITIVE INOTROPIC ACTIVITY 342

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VESNARINONE authKW 3013314 13% 75% 45
2 TSC 22 authKW 2244412 8% 93% 27
3 POSITIVE INOTROPIC ACTIVITY authKW 1032113 5% 68% 17
4 OPC 18790 authKW 657452 3% 82% 9
5 BUNCHED authKW 285707 1% 80% 4
6 1 2 4TRIAZOLO3 4 APHTHALAZINE authKW 267852 1% 100% 3
7 OPC 8212 authKW 267852 1% 100% 3
8 1 2 4TRIAZOLO4 3 AQUINOLINES authKW 238088 1% 67% 4
9 TOBORINONE authKW 238088 1% 67% 4
10 QUINOLINONE DERIVATIVE authKW 200888 1% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 1099 17% 0% 59
2 Pharmacology & Pharmacy 784 29% 0% 100
3 Cardiac & Cardiovascular System 293 13% 0% 43
4 Oncology 146 13% 0% 43
5 Developmental Biology 118 4% 0% 14
6 Chemistry, Multidisciplinary 94 13% 0% 46
7 Chemistry, Organic 80 8% 0% 29
8 Cell Biology 32 7% 0% 24
9 Biochemistry & Molecular Biology 28 12% 0% 42
10 Peripheral Vascular Diseases 18 3% 0% 10

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NAT OURCES FUNCT MOL CHANGBAI MT 196407 3% 20% 11
2 AFFILIATED MINIST EDUC 136438 3% 17% 9
3 AVD CLIN 89284 0% 100% 1
4 DKFZ ZMBH ALLIANCENETWORK AGING GERMAN CANC 89284 0% 100% 1
5 HEMATOPOIESIS PHYSIOL 89284 0% 100% 1
6 JOINT MOL METAB CONTROL MOL BIOL HEIDELBE 89284 0% 100% 1
7 JR GRP CELLULAR SENESCENCE 89284 0% 100% 1
8 MARYLAND OFF CLIN 89284 0% 100% 1
9 PASTEURSECT NEUROSCI 89284 0% 100% 1
10 STADT KRANKENHAUS FRIEDRICHSHAFEN 89284 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH 2911 4% 0% 12
2 CARDIOVASCULAR DRUG REVIEWS 1907 1% 1% 3
3 CHEMICAL & PHARMACEUTICAL BULLETIN 1146 4% 0% 15
4 HELVETICA CHIMICA ACTA 819 3% 0% 9
5 JAPANESE JOURNAL OF PHARMACOLOGY 724 2% 0% 6
6 JAPANESE HEART JOURNAL 668 1% 0% 4
7 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 507 2% 0% 8
8 CHEMICAL BIOLOGY & DRUG DESIGN 481 1% 0% 3
9 CHINESE JOURNAL OF ORGANIC CHEMISTRY 449 1% 0% 5
10 CARDIOVASCULAR DRUGS AND THERAPY 410 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 VESNARINONE 3013314 13% 75% 45 Search VESNARINONE Search VESNARINONE
2 TSC 22 2244412 8% 93% 27 Search TSC+22 Search TSC+22
3 POSITIVE INOTROPIC ACTIVITY 1032113 5% 68% 17 Search POSITIVE+INOTROPIC+ACTIVITY Search POSITIVE+INOTROPIC+ACTIVITY
4 OPC 18790 657452 3% 82% 9 Search OPC+18790 Search OPC+18790
5 BUNCHED 285707 1% 80% 4 Search BUNCHED Search BUNCHED
6 1 2 4TRIAZOLO3 4 APHTHALAZINE 267852 1% 100% 3 Search 1+2+4TRIAZOLO3+4+APHTHALAZINE Search 1+2+4TRIAZOLO3+4+APHTHALAZINE
7 OPC 8212 267852 1% 100% 3 Search OPC+8212 Search OPC+8212
8 1 2 4TRIAZOLO4 3 AQUINOLINES 238088 1% 67% 4 Search 1+2+4TRIAZOLO4+3+AQUINOLINES Search 1+2+4TRIAZOLO4+3+AQUINOLINES
9 TOBORINONE 238088 1% 67% 4 Search TOBORINONE Search TOBORINONE
10 QUINOLINONE DERIVATIVE 200888 1% 75% 3 Search QUINOLINONE+DERIVATIVE Search QUINOLINONE+DERIVATIVE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KAWAMATA, H , ORNOTEHARA, F , NAKASHIRO, K , UCHIDA, D , HINO, S , FUJIMORI, T , (2003) VESNARINONE: A DIFFERENTIATION-INDUCING ANTI-CANCER DRUG.ANTI-CANCER DRUGS. VOL. 14. ISSUE 6. P. 391-395 44 88% 3
2 UCHIDA, D , KAWAMATA, H , OMOTEHARA, F , MIWA, Y , HORIUCHI, H , FURIHATA, T , TACHIBANA, M , FUJIMORI, T , (2016) OVEREXPRESSION OF TSC-22 (TRANSFORMING GROWTH FACTOR-BETA-STIMULATED CLONE-22) CAUSES MARKED OBESITY, SPLENIC ABNORMALITY AND B CELL LYMPHOMA IN TRANSGENIC MICE.ONCOTARGET. VOL. 7. ISSUE 12. P. 14310 -14323 32 84% 0
3 KAWAMATA, H , TACHIBANA, M , FUJIMORI, T , IMAI, Y , (2006) DIFFERENTIATION-INDUCING THERAPY FOR SOLID TUMORS.CURRENT PHARMACEUTICAL DESIGN. VOL. 12. ISSUE 3. P. 379-385 44 57% 37
4 CHEN, LC , CHEN, IL , HUANG, CC , LIAO, CH , CHEN, JY , WANG, TC , (2010) SYNTHESIS, ANTIPROLIFERATIVE, AND ANTIPLATELET ACTIVITIES OF OXIME-CONTAINING 3,4-DIHYDROQUINOLIN-2(1H)-ONE DERIVATIVES.JOURNAL OF THE CHINESE CHEMICAL SOCIETY. VOL. 57. ISSUE 6B. P. 1331-1340 20 80% 2
5 WU, Y , PIAO, HR , (2013) THE PROGRESS TOWARDS THE DEVELOPMENT OF DHQO DERIVATIVES AND RELATED ANALOGUES WITH INOTROPIC EFFECTS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 12. P. 1801 -1811 26 54% 1
6 CHEN, IL , CHANG, KM , MIAW, CL , LIAO, CH , CHEN, JJ , WANG, TC , (2007) SYNTHESIS, ANTIPROLIFERATIVE, AND ANTIPLATELET ACTIVITIES OF OXIME- AND AMIDE-CONTAINING QUINOLIN-2(1H)-ONE DERIVATIVES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 15. ISSUE 20. P. 6527-6534 19 83% 12
7 HINO, S , KAWAMATA, H , OMOTEHARA, F , UCHIDA, D , MIWA, Y , BEGUM, NM , YOSHIDA, H , SATO, M , FUJIMORI, T , (2002) CYTOPLASMIC TSC-22 (TRANSFORMING GROWTH FACTOR-BETA-STIMULATED CLONE-22) MARKEDLY ENHANCES THE RADIATION SENSITIVITY OF SALIVARY GLAND CANCER CELLS.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. VOL. 292. ISSUE 4. P. 957-963 18 90% 16
8 KAWAMATA, H , FUJIMORI, T , IMAI, Y , (2004) TSC-22 (TGF-BETA STIMULATED CLONE-22): A NOVEL MOLECULAR TARGET FOR DIFFERENTIATION-INDUCING THERAPY IN SALIVARY GLAND CANCER.CURRENT CANCER DRUG TARGETS. VOL. 4. ISSUE 6. P. 521-529 23 64% 15
9 WANG, TC , ZHAO, YL , KUO, DH , (2001) SYNTHESIS AND VASORELAXING EVALUATION OF ALPHA-METHYLIDENE-GAMMA-BUTYROLACTONE BEARING QUINOLIN-2(1H)-ONE AND 3,4-DIHYDROQUINOLIN-2(1H)-ONE DERIVATIVES.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 36. ISSUE 11-12. P. 909-914 20 80% 7
10 HINO, S , KAWAMATA, H , OMOTEHARA, F , UCHIDA, D , BEGUM, NM , YOSHIDA, H , SATO, M , FUJIMORI, T , (2002) LEUCINE ZIPPER STRUCTURE OF TSC-22 (TGF-BETA STIMULATED CLONE-22) MARKEDLY INHIBITS THE ANCHORAGE-INDEPENDENT GROWTH OF SALIVARY GLAND CANCER CELLS.ONCOLOGY REPORTS. VOL. 9. ISSUE 2. P. 371-374 17 89% 7

Classes with closest relation at Level 1


Rank Class id link
1 3744 ENOXIMONE//MILRINONE//AMRINONE
2 10864 LEVOSIMENDAN//CALCIUM SENSITIZER//PIMOBENDAN
3 27608 INTRAMOLECULAR KNOEVENAGEL CONDENSATION//YAEQUINOLONE//2 QUINOLONES
4 17435 CILOSTAZOL//CLIN PHARMACOKINET PHARMACODYNAM METAB//TRIPLE ANTIPLATELET THERAPY
5 8297 WINTERS HEART FAILURE//CARDIAC CACHEXIA//HEART FAILURE
6 34620 BDF 9148//DPI 201 106//NA CHANNEL ACTIVATOR
7 26291 IN VIVO ANTITUMOUR ACTIVITY//MOUSE LYMPHOID NEOPLASMA P 388//MOUSE MAMMARY CARCINOMA FM 3A
8 21161 PARACONIC ACIDS//GARCINIA ACID//ISOAVENACIOLIDE
9 25512 IBOPAMINE//EPININE//DOPAMINE PRODRUG
10 2021 BETA BLOCKERS//HEART FAILURE//CARVEDILOL

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