Class information for:
Level 1: LEVOSIMENDAN//CALCIUM SENSITIZER//PIMOBENDAN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10864 1030 35.8 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
62 3       CARDIAC & CARDIOVASCULAR SYSTEM//HEART FAILURE//PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 86105
2676 2             LEVOSIMENDAN//CALCIUM SENSITIZER//MILRINONE 3400
10864 1                   LEVOSIMENDAN//CALCIUM SENSITIZER//PIMOBENDAN 1030

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEVOSIMENDAN authKW 9520269 37% 84% 381
2 CALCIUM SENSITIZER authKW 2141785 8% 85% 85
3 PIMOBENDAN authKW 975695 5% 69% 48
4 CA2 SENSITIZER authKW 768624 3% 79% 33
5 MCI 154 authKW 446408 2% 94% 16
6 EMD 57033 authKW 389412 2% 77% 17
7 INOTROPIC AGENTS authKW 338307 5% 21% 55
8 CARDIOTONIC AGENTS authKW 337684 3% 38% 30
9 EMD 53998 authKW 275918 1% 85% 11
10 OR 1896 authKW 237155 1% 100% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cardiac & Cardiovascular System 12040 43% 0% 438
2 Pharmacology & Pharmacy 3759 36% 0% 372
3 Anesthesiology 1957 9% 0% 88
4 Critical Care Medicine 974 6% 0% 65
5 Peripheral Vascular Diseases 726 8% 0% 87
6 Respiratory System 218 4% 0% 45
7 Physiology 66 4% 0% 39
8 Emergency Medicine 56 1% 0% 12
9 Chemistry, Medicinal 39 3% 0% 27
10 Veterinary Sciences 26 3% 0% 30

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CRIT CARE PROPRIETARY PROD 177867 1% 100% 6
2 CARDIOVASC PROJECTS 148222 0% 100% 5
3 CARDIOTHORAC ANAESTHESIA INTENS CARE UNIT 66698 0% 75% 3
4 ANAESTHESIA INTENS CAREUMR 942 59289 0% 100% 2
5 ANESTHESIOL SCI CRIT MED PAIN THER Y 59289 0% 100% 2
6 BLOOMSBURY INTENS CARE 59289 0% 100% 2
7 HEART FAILURE CLIN ECHO 59289 0% 100% 2
8 HEART TRANSPLANT CLIN 59289 0% 100% 2
9 SO HLTH EMERGENCY MED TOXICOL GRP 59289 0% 100% 2
10 DRUG DISCOVERY PHARMACOL 47426 0% 40% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 17209 8% 1% 80
2 CARDIOVASCULAR DRUGS AND THERAPY 11121 3% 1% 27
3 CARDIOVASCULAR DRUG REVIEWS 5700 1% 2% 9
4 EUROPEAN JOURNAL OF HEART FAILURE 5000 2% 1% 20
5 JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA 4434 2% 1% 24
6 SCANDINAVIAN CARDIOVASCULAR JOURNAL 1595 1% 1% 8
7 EUROPEAN JOURNAL OF PHARMACOLOGY 1391 4% 0% 37
8 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 1306 3% 0% 31
9 JOURNAL OF VETERINARY CARDIOLOGY 1191 0% 1% 3
10 EXPERIMENTAL & CLINICAL CARDIOLOGY 1049 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LEVOSIMENDAN 9520269 37% 84% 381 Search LEVOSIMENDAN Search LEVOSIMENDAN
2 CALCIUM SENSITIZER 2141785 8% 85% 85 Search CALCIUM+SENSITIZER Search CALCIUM+SENSITIZER
3 PIMOBENDAN 975695 5% 69% 48 Search PIMOBENDAN Search PIMOBENDAN
4 CA2 SENSITIZER 768624 3% 79% 33 Search CA2+SENSITIZER Search CA2+SENSITIZER
5 MCI 154 446408 2% 94% 16 Search MCI+154 Search MCI+154
6 EMD 57033 389412 2% 77% 17 Search EMD+57033 Search EMD+57033
7 INOTROPIC AGENTS 338307 5% 21% 55 Search INOTROPIC+AGENTS Search INOTROPIC+AGENTS
8 CARDIOTONIC AGENTS 337684 3% 38% 30 Search CARDIOTONIC+AGENTS Search CARDIOTONIC+AGENTS
9 EMD 53998 275918 1% 85% 11 Search EMD+53998 Search EMD+53998
10 OR 1896 237155 1% 100% 8 Search OR+1896 Search OR+1896

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FARMAKIS, D , ALVAREZ, J , BEN GAL, T , BRITO, D , FEDELE, F , FONSECA, C , GORDON, AC , GOTSMAN, I , GROSSINI, E , GUARRACINO, F , ET AL (2016) LEVOSIMENDAN BEYOND INOTROPY AND ACUTE HEART FAILURE: EVIDENCE OF PLEIOTROPIC EFFECTS ON THE HEART AND OTHER ORGANS: AN EXPERT PANEL POSITION PAPER.INTERNATIONAL JOURNAL OF CARDIOLOGY. VOL. 222. ISSUE . P. 303 -312 108 89% 3
2 PAPP, Z , EDES, I , FRUHWALD, S , DE HERT, SG , SALMENPERA, M , LEPPIKANGAS, H , MEBAZAA, A , LANDONI, G , GROSSINI, E , CAIMMI, P , ET AL (2012) LEVOSIMENDAN: MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS CONSENSUS OF EXPERTS ON THE MECHANISMS OF ACTION OF LEVOSIMENDAN.INTERNATIONAL JOURNAL OF CARDIOLOGY. VOL. 159. ISSUE 2. P. 82 -87 79 86% 46
3 LANDONI, G , BIONDI-ZOCCAI, G , GRECO, M , GRECO, T , BIGNAMI, E , MORELLI, A , GUARRACINO, F , ZANGRILLO, A , (2012) EFFECTS OF LEVOSIMENDAN ON MORTALITY AND HOSPITALIZATION. A META-ANALYSIS OF RANDOMIZED CONTROLLED STUDIES.CRITICAL CARE MEDICINE. VOL. 40. ISSUE 2. P. 634 -646 76 84% 63
4 NIEMINEN, MS , POLLESELLO, P , VAJDA, G , PAPP, Z , (2009) EFFECTS OF LEVOSIMENDAN ON THE ENERGY BALANCE: PRECLINICAL AND CLINICAL EVIDENCE.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. VOL. 53. ISSUE 4. P. 302 -310 82 85% 11
5 TOLLER, WG , STRANZ, C , (2006) LEVOSIMENDAN, A NEW INOTROPIC AND VASODILATOR AGENT.ANESTHESIOLOGY. VOL. 104. ISSUE 3. P. 556-569 88 75% 77
6 PAPP, Z , CSAPO, K , POLLESELLO, P , HAIKALA, H , EDES, I , (2005) PHARMACOLOGICAL MECHANISMS CONTRIBUTING TO THE CLINICAL EFFICACY OF LEVOSIMENDAN.CARDIOVASCULAR DRUG REVIEWS. VOL. 23. ISSUE 1. P. 71-98 90 80% 44
7 MORENO, N , TAVARES-SILVA, M , LOURENCO, AP , OLIVEIRA-PINTO, J , HENRIQUES-COELHO, T , LEITE-MOREIRA, AF , (2014) LEVOSIMENDAN: THE CURRENT SITUATION AND NEW PROSPECTS.REVISTA PORTUGUESA DE CARDIOLOGIA. VOL. 33. ISSUE 12. P. 797 -802 60 94% 1
8 TOLLER, W , HERINGLAKE, M , GUARRACINO, F , ALGOTSSON, L , ALVAREZ, J , ARGYRIADOU, H , BEN-GAL, T , CERNY, V , CHOLLEY, B , EREMENKO, A , ET AL (2015) PREOPERATIVE AND PERIOPERATIVE USE OF LEVOSIMENDAN IN CARDIAC SURGERY: EUROPEAN EXPERT OPINION.INTERNATIONAL JOURNAL OF CARDIOLOGY. VOL. 184. ISSUE . P. 323 -336 52 81% 15
9 ANTONIADES, C , ANTONOPOULOS, AS , TOUSOULIS, D , BAKOGIANNIS, C , STEFANADI, E , STEFANADIS, C , (2009) RELATIONSHIP BETWEEN THE PHARMACOKINETICS OF LEVOSIMENDAN AND ITS EFFECTS ON CARDIOVASCULAR SYSTEM.CURRENT DRUG METABOLISM. VOL. 10. ISSUE 2. P. 95-103 59 95% 6
10 ANTILA, S , SUNDBERG, S , LEHTONEN, LA , (2007) CLINICAL PHARMACOLOGY OF LEVOSIMENDAN.CLINICAL PHARMACOKINETICS. VOL. 46. ISSUE 7. P. 535-552 57 97% 41

Classes with closest relation at Level 1


Rank Class id link
1 3744 ENOXIMONE//MILRINONE//AMRINONE
2 34620 BDF 9148//DPI 201 106//NA CHANNEL ACTIVATOR
3 1716 ACUTE HEART FAILURE//CARDIORENAL SYNDROME//NESIRITIDE
4 23565 VESNARINONE//TSC 22//POSITIVE INOTROPIC ACTIVITY
5 1190 TROPONIN C//TROPOMYOSIN//TROPONIN
6 6863 CONDUCTANCE CATHETER//PRESSURE VOLUME AREA//END SYSTOLIC PRESSURE VOLUME RELATIONSHIP
7 23358 2 3 BUTANEDIONE MONOXIME//ACTIVATION HEAT//ENTHALPY OUTPUT
8 3797 JOURNAL OF VETERINARY CARDIOLOGY//UNITE CARDIOL ALFORT//MYXOMATOUS MITRAL VALVE DISEASE
9 3746 PHOSPHOLAMBAN//SARCOPLASMIC RETICULUM//PHARMACOL CELL BIOPHYS
10 10507 SEPTIC CARDIOMYOPATHY//MYOCARDIAL DEPRESSION//SEPSIS

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