Class information for:
Level 1: PROTEIN KNOCKDOWN//PROTACS//CHEMICAL INDUCERS OF DIMERIZATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22210 390 40.1 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
478 3       PHAGE DISPLAY//CELL FREE PROTEIN SYNTHESIS//ANTIBODY ENGINEERING 23687
1537 2             CELL FREE PROTEIN SYNTHESIS//INTEIN//PROTEIN SPLICING 7453
22210 1                   PROTEIN KNOCKDOWN//PROTACS//CHEMICAL INDUCERS OF DIMERIZATION 390

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN KNOCKDOWN authKW 576533 2% 82% 9
2 PROTACS authKW 391475 1% 100% 5
3 CHEMICAL INDUCERS OF DIMERIZATION authKW 326227 1% 83% 5
4 CHEMICALLY INDUCIBLE DIMERIZATION authKW 176162 1% 75% 3
5 ASKA authKW 156590 1% 100% 2
6 AUXIN INDUCIBLE DEGRADATION authKW 156590 1% 100% 2
7 DESTABILIZATION DOMAINS authKW 156590 1% 100% 2
8 GWYNN HAZEN CHERRY MEM S address 156590 1% 100% 2
9 PROTEIN DEGRADATION INDUCER authKW 156590 1% 100% 2
10 CHEMICALLY INDUCED DIMERIZATION authKW 156586 1% 50% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1368 49% 0% 193
2 Chemistry, Medicinal 697 13% 0% 51
3 Cell Biology 329 16% 0% 64
4 Chemistry, Multidisciplinary 210 17% 0% 68
5 Biochemical Research Methods 164 8% 0% 30
6 Chemistry, Organic 113 9% 0% 36
7 Biophysics 31 4% 0% 17
8 Biotechnology & Applied Microbiology 24 5% 0% 19
9 Mycology 18 1% 0% 4
10 Oncology 6 4% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GWYNN HAZEN CHERRY MEM S 156590 1% 100% 2
2 CELL BIOL GENET DEV 78295 0% 100% 1
3 CHROMOSONE BIOL 78295 0% 100% 1
4 CLARK W350A 78295 0% 100% 1
5 CPM UMR 6510 78295 0% 100% 1
6 GEN DEV PHYSIOL PLANTS 78295 0% 100% 1
7 GWYNN HAZEN CHERRY MEM S PEDIAT PATHOL 78295 0% 100% 1
8 GWYNNE HAZEN CHERRY SJONSSON COMPREHENS CANC 78295 0% 100% 1
9 MATTEL CHILDRENS HOSP PATHOL HEMATOL ONC 78295 0% 100% 1
10 MATTEL CHILDRENS HOSP PEDIAT 78295 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMISTRY & BIOLOGY 26441 8% 1% 30
2 ACS CHEMICAL BIOLOGY 7123 4% 1% 14
3 CHEMBIOCHEM 3944 4% 0% 15
4 NATURE CHEMICAL BIOLOGY 2788 2% 1% 7
5 FUNGAL BIOLOGY REVIEWS 1348 0% 2% 1
6 CURRENT OPINION IN CHEMICAL BIOLOGY 1033 1% 0% 5
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 875 4% 0% 17
8 NATURE METHODS 733 1% 0% 4
9 TRENDS IN CELL BIOLOGY 707 1% 0% 4
10 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 677 7% 0% 29

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEIN KNOCKDOWN 576533 2% 82% 9 Search PROTEIN+KNOCKDOWN Search PROTEIN+KNOCKDOWN
2 PROTACS 391475 1% 100% 5 Search PROTACS Search PROTACS
3 CHEMICAL INDUCERS OF DIMERIZATION 326227 1% 83% 5 Search CHEMICAL+INDUCERS+OF+DIMERIZATION Search CHEMICAL+INDUCERS+OF+DIMERIZATION
4 CHEMICALLY INDUCIBLE DIMERIZATION 176162 1% 75% 3 Search CHEMICALLY+INDUCIBLE+DIMERIZATION Search CHEMICALLY+INDUCIBLE+DIMERIZATION
5 ASKA 156590 1% 100% 2 Search ASKA Search ASKA
6 AUXIN INDUCIBLE DEGRADATION 156590 1% 100% 2 Search AUXIN+INDUCIBLE+DEGRADATION Search AUXIN+INDUCIBLE+DEGRADATION
7 DESTABILIZATION DOMAINS 156590 1% 100% 2 Search DESTABILIZATION+DOMAINS Search DESTABILIZATION+DOMAINS
8 PROTEIN DEGRADATION INDUCER 156590 1% 100% 2 Search PROTEIN+DEGRADATION+INDUCER Search PROTEIN+DEGRADATION+INDUCER
9 CHEMICALLY INDUCED DIMERIZATION 156586 1% 50% 4 Search CHEMICALLY+INDUCED+DIMERIZATION Search CHEMICALLY+INDUCED+DIMERIZATION
10 1S CAMPHANIC ACID CHLORIDE 78295 0% 100% 1 Search 1S+CAMPHANIC+ACID+CHLORIDE Search 1S+CAMPHANIC+ACID+CHLORIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TOURE, M , CREWS, CM , (2016) SMALL-MOLECULE PROTACS: NEW APPROACHES TO PROTEIN DEGRADATION.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 55. ISSUE 6. P. 1966 -1973 36 59% 14
2 BUCKLEY, DL , RAINA, K , DARRICARRERE, N , HINES, J , GUSTAFSON, JL , SMITH, IE , MIAH, AH , HARLING, JD , CREWS, CM , (2015) HALOPROTACS: USE OF SMALL MOLECULE PROTACS TO INDUCE DEGRADATION OF HALO TAG FUSION PROTEINS.ACS CHEMICAL BIOLOGY. VOL. 10. ISSUE 8. P. 1831 -1837 26 70% 9
3 RAKHIT, R , NAVARRO, R , WANDLESS, TJ , (2014) CHEMICAL BIOLOGY STRATEGIES FOR POSTTRANSLATIONAL CONTROL OF PROTEIN FUNCTION.CHEMISTRY & BIOLOGY. VOL. 21. ISSUE 9. P. 1238 -1252 43 41% 23
4 TOMOSHIGE, S , HASHIMOTO, Y , ISHIKAWA, M , (2016) EFFICIENT PROTEIN KNOCKDOWN OF HALOTAG-FUSED PROTEINS USING HYBRID MOLECULES CONSISTING OF IAP ANTAGONIST AND HALOTAG LIGAND.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 24. ISSUE 14. P. 3144 -3148 23 82% 0
5 TOMOSHIGE, S , NAITO, M , HASHIMOTO, Y , ISHIKAWA, M , (2015) DEGRADATION OF HALOTAG-FUSED NUCLEAR PROTEINS USING BESTATIN-HALOTAG LIGAND HYBRID MOLECULES.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 13. ISSUE 38. P. 9746 -9750 23 61% 1
6 PUTYRSKI, M , SCHULTZ, C , (2012) PROTEIN TRANSLOCATION AS A TOOL: THE CURRENT RAPAMYCIN STORY.FEBS LETTERS. VOL. 586. ISSUE 15. P. 2097-2105 34 37% 40
7 FEGAN, A , WHITE, B , CARLSON, JCT , WAGNER, CR , (2010) CHEMICALLY CONTROLLED PROTEIN ASSEMBLY: TECHNIQUES AND APPLICATIONS.CHEMICAL REVIEWS. VOL. 110. ISSUE 6. P. 3315-3336 42 28% 88
8 RUTKOWSKA, A , SCHULTZ, C , (2012) PROTEIN TANGO: THE TOOLBOX TO CAPTURE INTERACTING PARTNERS.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 51. ISSUE 33. P. 8166 -8176 36 35% 11
9 GUO, ZF , ZHANG, RS , LIANG, FS , (2014) FACILE FUNCTIONALIZATION OF FK506 FOR BIOLOGICAL STUDIES BY THE THIOL-ENE 'CLICK' REACTION.RSC ADVANCES. VOL. 4. ISSUE 22. P. 11400 -11403 19 61% 0
10 GESTWICKI, JE , MARINEC, PS , (2007) CHEMICAL CONTROL OVER PROTEIN-PROTEIN INTERACTIONS: BEYOND INHIBITORS.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. VOL. 10. ISSUE 8. P. 667-675 37 35% 25

Classes with closest relation at Level 1


Rank Class id link
1 19599 MOL BIOSENSOR IMAGING//FLUOROGEN ACTIVATING PROTEIN//FLUOROGEN
2 14228 BIMOLECULAR FLUORESCENCE COMPLEMENTATION//SPLIT UBIQUITIN//PROTEIN FRAGMENT COMPLEMENTATION ASSAY
3 37475 ANTIBODY VARIABLE REGION//TRANSGENE SELECTION//COMMUNICATION DISTANCE
4 16265 DIVERSITY ORIENTED SYNTHESIS//SMALL MOLECULE MICROARRAYS//ICCB
5 8740 CRE RECOMBINASE//TET SYSTEM//RTTA
6 27924 HIGH INTENS XRAY DIFFRACT//ARTIFICIAL SELENOENZYME//BIOELECTRONIS
7 22758 ARGINYLATION//JOHANSON BLIZZARD SYNDROME//N END RULE
8 7757 PHOTOTROPIN//CHLOROPLAST MOVEMENT//LOV DOMAIN
9 31500 TRANSDOMINANT GENETICS//TRANSDOMINANT//PEPTIDE APTAMERS
10 2873 CYCLOPHILIN//PEPTIDYL PROLYL CIS TRANS ISOMERASE//IMMUNOPHILIN

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