Class information for:
Level 2: COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2644 3490 35.1 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
2644 2             COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS 3490
5476 1                   COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS 1619
14569 1                   THIOCOLCHICOSIDE//COLCHICINOIDS//THIOCOLCHICINE 762
20741 1                   COLCHICINE//COLCHICINE POISONING//COLCHICUM AUTUMNALE 447
22006 1                   DMXAA//FLAVONE ACETIC ACID//5 6 DIMETHYLXANTHENONE 4 ACETIC ACID 397
31212 1                   INDUCTIVE LABILITY//LABILE STATE//PERIPHERAL IMMUNE RESPONSES 156
34573 1                   CI 980//1 ACETYLINDOLINE//ALPHA AMINOALKYL ARYL KETONE 109

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COMBRETASTATIN authKW 1076470 4% 89% 139
2 COMBRETASTATIN A 4 authKW 762646 3% 75% 117
3 VASCULAR DISRUPTING AGENTS authKW 641612 3% 65% 112
4 COLCHICINE authKW 583498 9% 20% 331
5 DMXAA authKW 400891 1% 88% 52
6 FLAVONE ACETIC ACID authKW 233502 1% 86% 31
7 SCREENING TECHNOL BRANCH address 197423 2% 31% 73
8 CANC TREATMENT DIAGFREDERICK CANC address 194388 1% 67% 33
9 TUBULIN authKW 191892 6% 10% 218
10 PHENSTATIN authKW 183698 1% 100% 21

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 25035 25% 0% 885
2 Oncology 4882 21% 0% 726
3 Chemistry, Organic 3513 16% 0% 544
4 Pharmacology & Pharmacy 3079 19% 0% 673
5 Biochemistry & Molecular Biology 617 15% 0% 537
6 Chemistry, Multidisciplinary 223 8% 0% 291
7 Toxicology 151 3% 0% 97
8 Rheumatology 59 1% 0% 37
9 Chemistry, Analytical 39 3% 0% 107
10 Biochemical Research Methods 30 2% 0% 70

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SCREENING TECHNOL BRANCH 197423 2% 31% 73
2 CANC TREATMENT DIAGFREDERICK CANC 194388 1% 67% 33
3 CANC TREATMENT DIAGNIH 119495 1% 33% 41
4 DEV THER EUT PROGRAMNIH 96421 1% 53% 21
5 AUCKLAND CANC SOC 89675 2% 13% 81
6 UNITE BIOTECHNOL BIOINGN 62187 0% 44% 16
7 ONCOEMATOL 48593 0% 33% 17
8 DEV THER EUT PROGRAM 37801 2% 6% 69
9 LP4 36446 0% 83% 5
10 UNITA ONCOL SPERIMENTALE IMMUNOL 34990 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 13586 5% 1% 184
2 BIOORGANIC & MEDICINAL CHEMISTRY 12282 4% 1% 136
3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 7311 3% 1% 89
4 ANTI-CANCER DRUG DESIGN 5000 1% 3% 19
5 INVESTIGATIONAL NEW DRUGS 4885 1% 1% 38
6 CANCER CHEMOTHERAPY AND PHARMACOLOGY 4337 2% 1% 61
7 MEDCHEMCOMM 4007 1% 2% 25
8 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3961 3% 0% 109
9 CHEMMEDCHEM 3854 1% 1% 32
10 BRITISH JOURNAL OF CANCER 2149 2% 0% 68

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 COMBRETASTATIN 1076470 4% 89% 139 Search COMBRETASTATIN Search COMBRETASTATIN
2 COMBRETASTATIN A 4 762646 3% 75% 117 Search COMBRETASTATIN+A+4 Search COMBRETASTATIN+A+4
3 VASCULAR DISRUPTING AGENTS 641612 3% 65% 112 Search VASCULAR+DISRUPTING+AGENTS Search VASCULAR+DISRUPTING+AGENTS
4 COLCHICINE 583498 9% 20% 331 Search COLCHICINE Search COLCHICINE
5 DMXAA 400891 1% 88% 52 Search DMXAA Search DMXAA
6 FLAVONE ACETIC ACID 233502 1% 86% 31 Search FLAVONE+ACETIC+ACID Search FLAVONE+ACETIC+ACID
7 TUBULIN 191892 6% 10% 218 Search TUBULIN Search TUBULIN
8 PHENSTATIN 183698 1% 100% 21 Search PHENSTATIN Search PHENSTATIN
9 ZD6126 177124 1% 75% 27 Search ZD6126 Search ZD6126
10 TUBULIN POLYMERIZATION 171336 1% 38% 52 Search TUBULIN+POLYMERIZATION Search TUBULIN+POLYMERIZATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GREENE, LM , MEEGAN, MJ , ZISTERER, DM , (2015) COMBRETASTATINS: MORE THAN JUST VASCULAR TARGETING AGENTS?.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 355. ISSUE 2. P. 212 -227 160 83% 8
2 PEREZ-PEREZ, MJ , PRIEGO, EM , BUENO, O , MARTINS, MS , CANELA, MD , LIEKENS, S , (2016) BLOCKING BLOOD FLOW TO SOLID TUMORS BY DESTABILIZING TUBULIN: AN APPROACH TO TARGETING TUMOR GROWTH.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 19. P. 8685 -8711 141 71% 3
3 KRETZSCHMANN, VK , FURST, R , (2014) PLANT-DERIVED VASCULAR DISRUPTING AGENTS: COMPOUNDS, ACTIONS, AND CLINICAL TRIALS.PHYTOCHEMISTRY REVIEWS. VOL. 13. ISSUE 1. P. 191-206 107 86% 14
4 RAJAK, H , DEWANGAN, PK , PATEL, V , JAIN, DK , SINGH, A , VEERASAMY, R , SHARMA, PC , DIXIT, A , (2013) DESIGN OF COMBRETASTATIN A-4 ANALOGS AS TUBULIN TARGETED VASCULAR DISRUPTING AGENT WITH SPECIAL EMPHASIS ON THEIR CIS-RESTRICTED ISOMERS.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 10. P. 1923-1955 112 78% 18
5 LU, Y , CHEN, JJ , XIAO, M , LI, W , MILLER, DD , (2012) AN OVERVIEW OF TUBULIN INHIBITORS THAT INTERACT WITH THE COLCHICINE BINDING SITE.PHARMACEUTICAL RESEARCH. VOL. 29. ISSUE 11. P. 2943 -2971 100 66% 122
6 TRON, GC , PIRALI, T , SORBA, G , PAGLIAI, F , BUSACCA, S , GENAZZANI, AA , (2006) MEDICINAL CHEMISTRY OF COMBRETASTATIN A4: PRESENT AND FUTURE DIRECTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 11. P. 3033-3044 82 85% 344
7 TOZER, GM , KANTHOU, C , BAGULEY, BC , (2005) DISRUPTING TUMOUR BLOOD VESSELS.NATURE REVIEWS CANCER. VOL. 5. ISSUE 6. P. 423-435 96 66% 553
8 CHAUDHARY, A , PANDEYA, SN , KUMAR, P , SHARMA, P , GUPTA, S , SONI, N , VERMA, KK , BHARDWAJ, G , (2007) COMBRETASTATIN A-4 ANALOGS AS ANTICANCER AGENTS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 7. ISSUE 12. P. 1186-1205 98 89% 80
9 PATIL, PO , PATIL, AG , RANE, RA , PATIL, PC , DESHMUKH, PK , BARI, SB , PATIL, DA , NAPHADE, SS , (2015) RECENT ADVANCEMENT IN DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCT COMBRETASTATIN-INSPIRED ANTICANCER AGENTS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 8. P. 955 -969 81 94% 5
10 ALVAREZ, R , ARAMBURU, L , PUEBLA, P , CABALLERO, E , GONZALEZ, M , VICENTE, A , MEDARDE, M , PELAEZ, R , (2016) PYRIDINE BASED ANTITUMOUR COMPOUNDS ACTING AT THE COLCHICINE SITE.CURRENT MEDICINAL CHEMISTRY. VOL. 23. ISSUE 11. P. 1100 -1130 136 59% 0

Classes with closest relation at Level 2


Rank Class id link
1 1567 KINESIN//MICROTUBULES//STATHMIN
2 2936 CHALCONES//CLAISEN SCHMIDT CONDENSATION//BMIC
3 1102 PACLITAXEL//TAXANES//EPOTHILONES
4 1803 LANTIBIOTIC//OXAZOLE//DOLASTATIN 10
5 1950 PODOPHYLLOTOXIN//LIGNANS//SCHISANDRA CHINENSIS
6 2133 TETRANDRINE//SINOMENINE//MENISPERMACEAE
7 2221 DCE MRI//DIFFUSION WEIGHTED IMAGING//INTRAVOXEL INCOHERENT MOTION
8 3596 HINOKITIOL//BETA THUJAPLICIN//TROPOLONE
9 2102 FAMILIAL MEDITERRANEAN FEVER//INFLAMMASOME//NLRP3
10 3060 SULTAMS//BETA SULTAMS//SULTONES

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