Class information for:
Level 1: FLUX BALANCE ANALYSIS//METABOLIC NETWORK//CONSTRAINT BASED MODELING

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2029 2381 46.8 80%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
90 3       MATHEMATICAL & COMPUTATIONAL BIOLOGY//BIOINFORMATICS//BMC BIOINFORMATICS 77178
548 2             BMC SYSTEMS BIOLOGY//MATHEMATICAL & COMPUTATIONAL BIOLOGY//BOOLEAN NETWORKS 14655
2029 1                   FLUX BALANCE ANALYSIS//METABOLIC NETWORK//CONSTRAINT BASED MODELING 2381

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FLUX BALANCE ANALYSIS authKW 1439746 7% 63% 177
2 METABOLIC NETWORK authKW 1006912 8% 42% 188
3 CONSTRAINT BASED MODELING authKW 634622 3% 71% 70
4 ELEMENTARY FLUX MODES authKW 381825 2% 66% 45
5 GENOME SCALE METABOLIC MODEL authKW 364241 2% 57% 50
6 ELEMENTARY MODES authKW 288498 1% 75% 30
7 METABOLIC MODELING authKW 230813 2% 33% 55
8 BMC SYSTEMS BIOLOGY journal 225611 7% 10% 168
9 GENOME SCALE MODEL authKW 188407 1% 64% 23
10 METABOLIC NETWORK RECONSTRUCTION authKW 131888 1% 86% 12

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Mathematical & Computational Biology 88354 35% 1% 841
2 Biotechnology & Applied Microbiology 18671 38% 0% 898
3 Biochemical Research Methods 13254 25% 0% 601
4 Biochemistry & Molecular Biology 1291 23% 0% 543
5 Biology 1148 7% 0% 163
6 Genetics & Heredity 402 7% 0% 162
7 Microbiology 311 6% 0% 148
8 Computer Science, Interdisciplinary Applications 297 4% 0% 87
9 Multidisciplinary Sciences 97 1% 0% 32
10 Biophysics 78 3% 0% 77

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COMPUTAT SYST BIOTECHNOL 112268 1% 49% 18
2 ARTIFICIAL INTELLIGENCE BIOINFORMAT GRP 60179 1% 36% 13
3 SYST BIOL MATH MODELING GRP 58552 1% 35% 13
4 CELL SYST MODELLING GRP 51291 0% 100% 4
5 IND ENGN MECH ENGN COMP SCI 48849 1% 21% 18
6 METAB BIOMOL ENGN 42164 1% 14% 24
7 BIOCOMP STRUCT PROGRAM 38468 0% 100% 3
8 INT MAX PLANCK COMPUTAT BIOL SCI COMP I 38468 0% 100% 3
9 MOL BIOMOL INFORMAT NCMLS 38468 0% 100% 3
10 GORTNER 240 37082 0% 32% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BMC SYSTEMS BIOLOGY 225611 7% 10% 168
2 METABOLIC ENGINEERING 46253 3% 6% 62
3 MOLECULAR SYSTEMS BIOLOGY 45767 2% 7% 52
4 BIOINFORMATICS 35883 7% 2% 173
5 PLOS COMPUTATIONAL BIOLOGY 31040 4% 2% 106
6 IEE PROCEEDINGS SYSTEMS BIOLOGY 18674 0% 13% 11
7 BMC BIOINFORMATICS 13411 4% 1% 89
8 CURRENT OPINION IN BIOTECHNOLOGY 11143 2% 2% 45
9 BIOTECHNOLOGY JOURNAL 10162 1% 3% 28
10 MOLECULAR BIOSYSTEMS 7152 2% 1% 39

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FLUX BALANCE ANALYSIS 1439746 7% 63% 177 Search FLUX+BALANCE+ANALYSIS Search FLUX+BALANCE+ANALYSIS
2 METABOLIC NETWORK 1006912 8% 42% 188 Search METABOLIC+NETWORK Search METABOLIC+NETWORK
3 CONSTRAINT BASED MODELING 634622 3% 71% 70 Search CONSTRAINT+BASED+MODELING Search CONSTRAINT+BASED+MODELING
4 ELEMENTARY FLUX MODES 381825 2% 66% 45 Search ELEMENTARY+FLUX+MODES Search ELEMENTARY+FLUX+MODES
5 GENOME SCALE METABOLIC MODEL 364241 2% 57% 50 Search GENOME+SCALE+METABOLIC+MODEL Search GENOME+SCALE+METABOLIC+MODEL
6 ELEMENTARY MODES 288498 1% 75% 30 Search ELEMENTARY+MODES Search ELEMENTARY+MODES
7 METABOLIC MODELING 230813 2% 33% 55 Search METABOLIC+MODELING Search METABOLIC+MODELING
8 GENOME SCALE MODEL 188407 1% 64% 23 Search GENOME+SCALE+MODEL Search GENOME+SCALE+MODEL
9 METABOLIC NETWORK RECONSTRUCTION 131888 1% 86% 12 Search METABOLIC+NETWORK+RECONSTRUCTION Search METABOLIC+NETWORK+RECONSTRUCTION
10 GENOME SCALE METABOLIC NETWORK 120385 1% 72% 13 Search GENOME+SCALE+METABOLIC+NETWORK Search GENOME+SCALE+METABOLIC+NETWORK

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LEWIS, NE , NAGARAJAN, H , PALSSON, BO , (2012) CONSTRAINING THE METABOLIC GENOTYPE-PHENOTYPE RELATIONSHIP USING A PHYLOGENY OF IN SILICO METHODS.NATURE REVIEWS MICROBIOLOGY. VOL. 10. ISSUE 4. P. 291 -305 124 89% 205
2 O'BRIEN, EJ , MONK, JM , PALSSON, BO , (2015) USING GENOME-SCALE MODELS TO PREDICT BIOLOGICAL CAPABILITIES.CELL. VOL. 161. ISSUE 5. P. 971 -987 79 90% 33
3 BOURGUIGNON, PY , SCHACHTER, V , DUROT, M , (2009) GENOME-SCALE MODELS OF BACTERIAL METABOLISM: RECONSTRUCTION AND APPLICATIONS.FEMS MICROBIOLOGY REVIEWS. VOL. 33. ISSUE 1. P. 164 -190 130 65% 119
4 BORDBAR, A , MONK, JM , KING, ZA , PALSSON, BO , (2014) CONSTRAINT-BASED MODELS PREDICT METABOLIC AND ASSOCIATED CELLULAR FUNCTIONS.NATURE REVIEWS GENETICS. VOL. 15. ISSUE 2. P. 107-120 74 73% 111
5 MAIA, P , ROCHA, M , ROCHA, I , (2016) IN SILICO CONSTRAINT-BASED STRAIN OPTIMIZATION METHODS: THE QUEST FOR OPTIMAL CELL FACTORIES.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 80. ISSUE 1. P. 45 -67 110 71% 2
6 MCCLOSKEY, D , PALSSON, BO , FEIST, AM , (2013) BASIC AND APPLIED USES OF GENOME-SCALE METABOLIC NETWORK RECONSTRUCTIONS OF ESCHERICHIA COLI.MOLECULAR SYSTEMS BIOLOGY. VOL. 9. ISSUE . P. - 92 70% 90
7 OBERHARDT, MA , PALSSON, BO , PAPIN, JA , (2009) APPLICATIONS OF GENOME-SCALE METABOLIC RECONSTRUCTIONS.MOLECULAR SYSTEMS BIOLOGY. VOL. 5. ISSUE . P. - 94 62% 299
8 SCHELLENBERGER, J , QUE, R , FLEMING, RMT , THIELE, I , ORTH, JD , FEIST, AM , ZIELINSKI, DC , BORDBAR, A , LEWIS, NE , RAHMANIAN, S , ET AL (2011) QUANTITATIVE PREDICTION OF CELLULAR METABOLISM WITH CONSTRAINT-BASED MODELS: THE COBRA TOOLBOX V2.0.NATURE PROTOCOLS. VOL. 6. ISSUE 9. P. 1290-1307 55 83% 343
9 PRICE, ND , REED, JL , PALSSON, BO , (2004) GENOME-SCALE MODELS OF MICROBIAL CELLS: EVALUATING THE CONSEQUENCES OF CONSTRAINTS.NATURE REVIEWS MICROBIOLOGY. VOL. 2. ISSUE 11. P. 886-897 74 77% 567
10 FEIST, AM , PALSSON, BO , (2008) THE GROWING SCOPE OF APPLICATIONS OF GENOME-SCALE METABOLIC RECONSTRUCTIONS USING ESCHERICHIA COLI.NATURE BIOTECHNOLOGY. VOL. 26. ISSUE 6. P. 659 -667 73 74% 259

Classes with closest relation at Level 1


Rank Class id link
1 10338 METABOLIC FLUX ANALYSIS//METAB ENGN SYST BIOL//RAPID SAMPLING
2 15220 CELLML//SBML//AUCKLAND BIOENGN
3 8123 METABOLIC CONTROL ANALYSIS//BIOCHEMICAL SYSTEMS THEORY//S SYSTEM
4 25773 CYBERNETIC MODEL//SUBSTITUTABLE SUBSTRATES//DYNAMIC METABOLIC MODEL
5 6253 METABOLIC ENGINEERING//SYNTHETIC BIOLOGY//BIORENEWABLE CHEMICALS
6 19843 ESSENTIAL GENES//TN SEQ//SUBTRACTIVE GENOMICS
7 14502 SUCCINIC ACID//ACTINOBACILLUS SUCCINOGENES//FUMARIC ACID
8 21530 NETWORK MOTIFS//SUBGRAPH SAMPLING//PROGRAMA GENOM COMPUTAC
9 681 PROTEIN INTERACTION NETWORK//PROTEIN PROTEIN INTERACTION NETWORK//ESSENTIAL PROTEINS
10 24624 APPARENT EQUILIBRIUM CONSTANTS//TRANSFORMED THERMODYNAMIC PROPERTIES//TRANSFORMED GIBBS ENERGY

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