Class information for:
Level 1: MEMANTINE//AMANTADINE//UNCOMPETITIVE ANTAGONIST

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19745 491 38.5 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
100 3       NEUROSCIENCES//METABOTROPIC GLUTAMATE RECEPTOR//HIPPOCAMPUS 73970
488 2             SIGMA RECEPTOR//NMDA RECEPTOR//PHENCYCLIDINE 15502
19745 1                   MEMANTINE//AMANTADINE//UNCOMPETITIVE ANTAGONIST 491

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MEMANTINE authKW 2202330 39% 19% 191
2 AMANTADINE authKW 576598 15% 13% 72
3 UNCOMPETITIVE ANTAGONIST authKW 259120 1% 83% 5
4 AMINOADAMANTANES authKW 248752 1% 67% 6
5 RIMANTADINE authKW 172723 3% 19% 15
6 UNCOMPETITIVE N METHYL D ASPARTATE RECEPTOR ANTAGONIST authKW 139924 1% 75% 3
7 1 3 2 METHOXYPHENOXY 2 HYDROXYPROPYL 4 2 6 DIMETHYLPHENYLAMINOCARBONYLMETHYLPIPERAZINE DIHYDROCHLORIDE SALT authKW 124378 0% 100% 2
8 CAS 41100 52 1 authKW 124378 0% 100% 2
9 NR1A 2A authKW 124378 0% 100% 2
10 MEMANTINE HYDROCHLORIDE authKW 124374 1% 50% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 2082 39% 0% 190
2 Neurosciences 1627 34% 0% 169
3 Chemistry, Analytical 487 15% 0% 72
4 Psychiatry 352 11% 0% 52
5 Clinical Neurology 219 11% 0% 52
6 Biochemical Research Methods 110 6% 0% 29
7 Behavioral Sciences 88 3% 0% 17
8 Geriatrics & Gerontology 53 2% 0% 10
9 Chemistry, Medicinal 47 4% 0% 18
10 Toxicology 11 2% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ABT PRAKLIN FOR ENTWICKLING 62189 0% 100% 1
2 BEING INSPECT QUARANTINE TESTING 62189 0% 100% 1
3 CLIN EXPT NEUROSCIENCE NICE 62189 0% 100% 1
4 CLIN RECH ISAR 62189 0% 100% 1
5 CNS NEUROSURG SERV 62189 0% 100% 1
6 EXPT NUEROL 62189 0% 100% 1
7 FREIDRICH IEDEL NEUROSCI 62189 0% 100% 1
8 FUNCT GENOM BIOINOFRMAT 62189 0% 100% 1
9 HLP 62189 0% 100% 1
10 IMAM HOSSEIN MED EDUC 62189 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROPHARMACOLOGY 4818 5% 0% 27
2 PROGRESS IN MEDICINAL CHEMISTRY 3453 0% 6% 1
3 JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 2818 1% 1% 6
4 JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION 2493 1% 1% 3
5 BEHAVIOURAL PHARMACOLOGY 2039 2% 0% 8
6 ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH 1696 2% 0% 11
7 BIBLIOTHECA PSYCHIATRICA 1350 0% 2% 1
8 JOURNAL OF NEURAL TRANSMISSION 1222 2% 0% 9
9 PHARMACOPSYCHIATRY 1107 1% 0% 6
10 EUROPEAN JOURNAL OF PHARMACOLOGY 948 4% 0% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MEMANTINE 2202330 39% 19% 191 Search MEMANTINE Search MEMANTINE
2 AMANTADINE 576598 15% 13% 72 Search AMANTADINE Search AMANTADINE
3 UNCOMPETITIVE ANTAGONIST 259120 1% 83% 5 Search UNCOMPETITIVE+ANTAGONIST Search UNCOMPETITIVE+ANTAGONIST
4 AMINOADAMANTANES 248752 1% 67% 6 Search AMINOADAMANTANES Search AMINOADAMANTANES
5 RIMANTADINE 172723 3% 19% 15 Search RIMANTADINE Search RIMANTADINE
6 UNCOMPETITIVE N METHYL D ASPARTATE RECEPTOR ANTAGONIST 139924 1% 75% 3 Search UNCOMPETITIVE+N+METHYL+D+ASPARTATE+RECEPTOR+ANTAGONIST Search UNCOMPETITIVE+N+METHYL+D+ASPARTATE+RECEPTOR+ANTAGONIST
7 1 3 2 METHOXYPHENOXY 2 HYDROXYPROPYL 4 2 6 DIMETHYLPHENYLAMINOCARBONYLMETHYLPIPERAZINE DIHYDROCHLORIDE SALT 124378 0% 100% 2 Search 1+3+2+METHOXYPHENOXY+2+HYDROXYPROPYL+4+2+6+DIMETHYLPHENYLAMINOCARBONYLMETHYLPIPERAZINE+DIHYDROCHLORIDE+SALT Search 1+3+2+METHOXYPHENOXY+2+HYDROXYPROPYL+4+2+6+DIMETHYLPHENYLAMINOCARBONYLMETHYLPIPERAZINE+DIHYDROCHLORIDE+SALT
8 CAS 41100 52 1 124378 0% 100% 2 Search CAS+41100+52+1 Search CAS+41100+52+1
9 NR1A 2A 124378 0% 100% 2 Search NR1A+2A Search NR1A+2A
10 MEMANTINE HYDROCHLORIDE 124374 1% 50% 4 Search MEMANTINE+HYDROCHLORIDE Search MEMANTINE+HYDROCHLORIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PARSONS, CG , DANYSZ, W , QUACK, G , (1999) MEMANTINE IS A CLINICALLY WELL TOLERATED N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST - A REVIEW OF PRECLINICAL DATA.NEUROPHARMACOLOGY. VOL. 38. ISSUE 6. P. 735 -767 85 32% 538
2 DANYSZ, W , PARSONS, CG , KORNHUBER, J , SCHMIDT, WJ , QUACK, G , (1997) AMINOADAMANTANES AS NMDA RECEPTOR ANTAGONISTS AND ANTIPARKINSONIAN AGENTS - PRECLINICAL STUDIES.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. VOL. 21. ISSUE 4. P. 455-468 53 51% 220
3 PARSONS, CG , STOFFLER, A , DANYSZ, W , (2007) MEMANTINE: A NMDA RECEPTOR ANTAGONIST THAT IMPROVES MEMORY BY RESTORATION OF HOMEOSTASIS IN THE GLUTARNATERGIC SYSTEM - TOO LITTLE ACTIVATION IS BAD, TOO MUCH IS EVEN WORSE.NEUROPHARMACOLOGY. VOL. 53. ISSUE 6. P. 699 -723 55 27% 285
4 JARVIS, B , FIGGITT, DP , (2003) MEMANTINE.DRUGS & AGING. VOL. 20. ISSUE 6. P. 465-476 30 67% 34
5 WENK, GL , PARSONS, CG , DANYSZ, W , (2006) POTENTIAL ROLE OF N-METHYL-D-ASPARTATE RECEPTORS AS EXECUTORS OF NEURODEGENERATION RESULTING FROM DIVERSE INSULTS: FOCUS ON MEMANTINE.BEHAVIOURAL PHARMACOLOGY. VOL. 17. ISSUE 5-6. P. 411-424 52 33% 59
6 YEH, HH , YANG, YH , CHEN, SH , (2010) SIMULTANEOUS DETERMINATION OF MEMANTINE AND AMANTADINE IN HUMAN PLASMA AS FLUORESCEIN DERIVATIVES BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY WITH LASER-INDUCED FLUORESCENCE DETECTION AND ITS CLINICAL APPLICATION.ELECTROPHORESIS. VOL. 31. ISSUE 11. P. 1903-1911 21 72% 21
7 ROGAWSKI, MA , WENK, GL , (2003) THE NEUROPHARMACOLOGICAL BASIS FOR THE USE OF MEMANTINE IN THE TREATMENT OF ALZHEIMER'S DISEASE.CNS DRUG REVIEWS. VOL. 9. ISSUE 3. P. 275-308 44 31% 189
8 LEIS, HJ , WINDISCHHOFER, W , (2012) DETERMINATION OF MEMANTINE IN HUMAN PLASMA BY GC USING NEGATIVE ION CHEMICAL IONIZATION MS DETECTION AFTER DERIVATIZATION WITH A NEW REAGENT.MICROCHIMICA ACTA. VOL. 178. ISSUE 3-4. P. 309-314 19 68% 5
9 RAMMES, G , DANYSZ, W , PARSONS, CG , (2008) PHARMACODYNAMICS OF MEMANTINE: AN UPDATE.CURRENT NEUROPHARMACOLOGY. VOL. 6. ISSUE 1. P. 55-78 58 21% 62
10 DOUSA, M , PIVONKOVA, V , SYKORA, D , (2016) OPTIMIZATION OF O-PHTALDIALDEHYDE/2-MERCAPTOETHANOL POSTCOLUMN REACTION FOR THE HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY DETERMINATION OF MEMANTINE UTILIZING A SILICA HYDRIDE STATIONARY PHASE.JOURNAL OF SEPARATION SCIENCE. VOL. 39. ISSUE 16. P. 3145 -3155 18 60% 1

Classes with closest relation at Level 1


Rank Class id link
1 34927 REMACEMIDE//LOSIGAMONE//DESGLYCINYL REMACEMIDE
2 36616 BUDIPINE//1 TERT BUTYL 4 4 DIPHENYLPIPERIDINE//ADENOSINE A2 ANTAGONISTS
3 2910 DONEPEZIL//RIVASTIGMINE//GALANTAMINE
4 13747 MK 801//CGP 43487//JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
5 16847 MK 801//NMDA ANTAGONIST//POSTERIOR CINGULATE AND RETROSPLENIAL CORTICES
6 22367 CELLULAR NEUROSCI NEURODEGENERAT REPAIR PROGRAM//AMYLOID BETA PEPTIDE 25 35//AMYLOID BETA PROTEIN OLIGOMERS
7 2042 NMDA RECEPTOR//NR2B//NR2A
8 35963 CUTANEOUS ANALGESIA//INFILTRATIVE CUTANEOUS ANALGESIA//SPINAL BLOCKADE
9 30937 INNER BLOOD RETINAL BARRIER//PROTON COUPLED ORGANIC CATION ANTIPORTER//RETINAL CAPILLARY ENDOTHELIAL CELLS
10 19931 M2 CHANNEL//M2 PROTON CHANNEL//M2 ION CHANNEL

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