Class information for:
Level 1: M2 CHANNEL//M2 PROTON CHANNEL//M2 ION CHANNEL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19931 483 44.4 81%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
237 3       INFLUENZA//RESPIRATORY SYNCYTIAL VIRUS//AVIAN INFLUENZA 47995
76 2             INFLUENZA//AVIAN INFLUENZA//INFLUENZA VIRUS 27762
19931 1                   M2 CHANNEL//M2 PROTON CHANNEL//M2 ION CHANNEL 483

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 M2 CHANNEL authKW 712266 3% 87% 13
2 M2 PROTON CHANNEL authKW 599398 3% 59% 16
3 M2 ION CHANNEL authKW 387216 1% 88% 7
4 M2 PROTEIN authKW 304481 4% 28% 17
5 ANTI INFLUENZA A VIRUS AGENT authKW 189658 1% 100% 3
6 NB PROTEIN authKW 189658 1% 100% 3
7 S31N authKW 189658 1% 100% 3
8 RIMANTADINE authKW 175584 3% 19% 15
9 AMANTADINE authKW 130672 7% 6% 34
10 BASE INDUCED CYCLIZATION authKW 126438 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Virology 1879 15% 0% 74
2 Biophysics 1001 17% 0% 83
3 Chemistry, Medicinal 801 13% 0% 61
4 Biochemistry & Molecular Biology 719 34% 0% 165
5 Chemistry, Organic 120 9% 0% 42
6 Chemistry, Multidisciplinary 111 13% 0% 61
7 Cell Biology 45 7% 0% 34
8 Physics, Atomic, Molecular & Chemical 17 4% 0% 18
9 Multidisciplinary Sciences 10 1% 0% 5
10 Computer Science, Interdisciplinary Applications 9 2% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROBIOL PHYSIOL 100671 8% 4% 40
2 BIOMOL CELLULAR MODELLING PROGRAM 63219 0% 100% 1
3 BIOPHYS IBF MILAN 63219 0% 100% 1
4 BIOTECHNOL INT UNIV 63219 0% 100% 1
5 DKFZ DEUT KREBSFOR UNGSZENTRUM 63219 0% 100% 1
6 DRUG DISCOVERY UNIT BIOL CHEM DRUG DISCOVE 63219 0% 100% 1
7 HIGH MAGNET FEILD 63219 0% 100% 1
8 KLINIKUM CHARITE MED VIROL 63219 0% 100% 1
9 LEV GROMASHEVSKI EPIDEMIOL INFECT DIS 63219 0% 100% 1
10 METODOS BIOFIS 63219 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPHYSICAL JOURNAL 2889 6% 0% 30
2 BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1442 2% 0% 12
3 EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 1406 1% 0% 7
4 VIROLOGY 1203 4% 0% 19
5 PROTEIN SCIENCE 1202 2% 0% 11
6 JOURNAL OF GENERAL VIROLOGY 780 3% 0% 13
7 ACTA VIROLOGICA 763 1% 0% 5
8 ACS MEDICINAL CHEMISTRY LETTERS 729 1% 0% 4
9 ORGANIC SYNTHESES 710 0% 1% 2
10 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 498 6% 0% 28

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 M2 CHANNEL 712266 3% 87% 13 Search M2+CHANNEL Search M2+CHANNEL
2 M2 PROTON CHANNEL 599398 3% 59% 16 Search M2+PROTON+CHANNEL Search M2+PROTON+CHANNEL
3 M2 ION CHANNEL 387216 1% 88% 7 Search M2+ION+CHANNEL Search M2+ION+CHANNEL
4 M2 PROTEIN 304481 4% 28% 17 Search M2+PROTEIN Search M2+PROTEIN
5 ANTI INFLUENZA A VIRUS AGENT 189658 1% 100% 3 Search ANTI+INFLUENZA+A+VIRUS+AGENT Search ANTI+INFLUENZA+A+VIRUS+AGENT
6 NB PROTEIN 189658 1% 100% 3 Search NB+PROTEIN Search NB+PROTEIN
7 S31N 189658 1% 100% 3 Search S31N Search S31N
8 RIMANTADINE 175584 3% 19% 15 Search RIMANTADINE Search RIMANTADINE
9 AMANTADINE 130672 7% 6% 34 Search AMANTADINE Search AMANTADINE
10 BASE INDUCED CYCLIZATION 126438 0% 100% 2 Search BASE+INDUCED+CYCLIZATION Search BASE+INDUCED+CYCLIZATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GU, RX , LIU, LA , WEI, DQ , (2013) STRUCTURAL AND ENERGETIC ANALYSIS OF DRUG INHIBITION OF THE INFLUENZA A M2 PROTON CHANNEL.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 34. ISSUE 10. P. 571-580 59 86% 11
2 GU, RX , LIU, LA , WEI, DQ , (2015) DRUG INHIBITION AND PROTON CONDUCTION MECHANISMS OF THE INFLUENZA A M2 PROTON CHANNEL.ADVANCE IN STRUCTURAL BIOINFORMATICS. VOL. 827. ISSUE . P. 205 -226 54 90% 3
3 HONG, M , DEGRADO, WF , (2012) STRUCTURAL BASIS FOR PROTON CONDUCTION AND INHIBITION BY THE INFLUENZA M2 PROTEIN.PROTEIN SCIENCE. VOL. 21. ISSUE 11. P. 1620 -1633 69 66% 36
4 WANG, J , QIU, JXY , SOTO, C , DEGRADO, WF , (2011) STRUCTURAL AND DYNAMIC MECHANISMS FOR THE FUNCTION AND INHIBITION OF THE M2 PROTON CHANNEL FROM INFLUENZA A VIRUS.CURRENT OPINION IN STRUCTURAL BIOLOGY. VOL. 21. ISSUE 1. P. 68 -80 73 61% 55
5 WANG, J , LI, F , MA, CL , (2015) RECENT PROGRESS IN DESIGNING INHIBITORS THAT TARGET THE DRUG-RESISTANT M2 PROTON CHANNELS FROM THE INFLUENZA A VIRUSES.BIOPOLYMERS. VOL. 104. ISSUE 4. P. 291 -309 70 60% 8
6 CADY, SD , LUO, WB , HU, FH , HONG, M , (2009) STRUCTURE AND FUNCTION OF THE INFLUENZA A M2 PROTON CHANNEL.BIOCHEMISTRY. VOL. 48. ISSUE 31. P. 7356-7364 58 82% 38
7 ZHOU, HX , CROSS, TA , (2013) MODELING THE MEMBRANE ENVIRONMENT HAS IMPLICATIONS FOR MEMBRANE PROTEIN STRUCTURE AND FUNCTION: INFLUENZA A M2 PROTEIN.PROTEIN SCIENCE. VOL. 22. ISSUE 4. P. 381-394 57 74% 19
8 LLABRES, S , JUAREZ-JIMENEZ, J , MASETTI, M , LEIVA, R , VAZQUEZ, S , GAZZARRINI, S , MORONI, A , CAVALLI, A , LUQUE, FJ , (2016) MECHANISM OF THE PSEUDOIRREVERSIBLE BINDING OF AMANTADINE TO THE M2 PROTON CHANNEL.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 138. ISSUE 47. P. 15345 -15358 58 67% 0
9 MARKIEWICZ, BN , LEMMIN, T , ZHANG, W , AHMED, IA , JO, H , FIORIN, G , TROXLER, T , DEGRADO, WF , GAI, F , (2016) INFRARED AND FLUORESCENCE ASSESSMENT OF THE HYDRATION STATUS OF THE TRYPTOPHAN GATE IN THE INFLUENZA A M2 PROTON CHANNEL.PHYSICAL CHEMISTRY CHEMICAL PHYSICS. VOL. 18. ISSUE 41. P. 28939 -28950 50 68% 1
10 WEI, CY , POHORILLE, A , (2013) ACTIVATION AND PROTON TRANSPORT MECHANISM IN INFLUENZA A M2 CHANNEL.BIOPHYSICAL JOURNAL. VOL. 105. ISSUE 9. P. 2036-2045 49 73% 13

Classes with closest relation at Level 1


Rank Class id link
1 17542 VPU//TETHERIN//BST 2
2 3071 INFLUENZA VIRUS//VIROLOGY//PA SUBUNIT
3 1978 NEURAMINIDASE INHIBITORS//OSELTAMIVIR//ZANAMIVIR
4 32316 N ADAMANTAN 2 YLIDENEBENZOHYDRAZIDE//1 ADAMANTYL DERIVATIVES//TRIPLE HYDROGEN BOND
5 24425 PROTON CHANNEL//VOLTAGE GATED PROTON CHANNEL//HV1
6 4131 TRANSMEMBRANE HELIX//TRANSMEMBRANE HELICES//MEMBRANE PROTEIN
7 19745 MEMANTINE//AMANTADINE//UNCOMPETITIVE ANTAGONIST
8 17166 INFLUENZA C VIRUS//ACHATININ H//9 O ACETYLATED SIALOGLYCOCONJUGATES
9 442 MAGIC ANGLE SPINNING//SOLID STATE NMR//JOURNAL OF MAGNETIC RESONANCE
10 4519 FUSION PEPTIDE//MEMBRANE FUSION//TILTED PEPTIDE

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