Class information for:
Level 1: DOXORUBICIN//CARDIOTOXICITY//DEXRAZOXANE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1652 2553 39.3 66%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
2227 2             CARDIOTOXICITY//ANTHRACYCLINES//DOXORUBICIN 4791
1652 1                   DOXORUBICIN//CARDIOTOXICITY//DEXRAZOXANE 2553

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DOXORUBICIN authKW 837912 26% 11% 661
2 CARDIOTOXICITY authKW 726158 14% 18% 346
3 DEXRAZOXANE authKW 515376 3% 53% 82
4 ADRIAMYCIN authKW 424847 8% 17% 213
5 ICRF 187 authKW 213535 1% 71% 25
6 ANTHRACYCLINES authKW 209443 7% 10% 175
7 ROCKY MT CANC REHABIL address 128609 1% 51% 21
8 MONOHER authKW 123357 1% 74% 14
9 ADR 925 authKW 83711 0% 100% 7
10 ADR 529 authKW 73246 0% 88% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 7980 34% 0% 859
2 Toxicology 4187 13% 0% 324
3 Oncology 2769 19% 0% 475
4 Cardiac & Cardiovascular System 1500 11% 0% 272
5 Biochemistry & Molecular Biology 756 18% 0% 467
6 Biophysics 667 7% 0% 176
7 Medicine, Research & Experimental 395 6% 0% 148
8 Cell Biology 323 8% 0% 199
9 Pathology 285 4% 0% 94
10 Physiology 146 4% 0% 93

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ROCKY MT CANC REHABIL 128609 1% 51% 21
2 PNEUMOL ONCOL ALERGOL 47835 0% 100% 4
3 MED BIOL UNIT 31879 0% 33% 8
4 ISOTOPE NAT SCI 23918 0% 100% 2
5 ONCOL PNEUMOL ALERGOL 23918 0% 100% 2
6 OXIDAT ST S ANTIOXIDANT GRP 23918 0% 100% 2
7 PHARMACOL GERONTOL UNIT 23918 0% 100% 2
8 PULM DIS PEDIAT RHEUMATOL 23918 0% 100% 2
9 SECC BIOQUIM PARASITOS 23918 0% 100% 2
10 SPECIAL MED EDUC PROGRAM 23918 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARDIOVASCULAR TOXICOLOGY 25755 1% 7% 30
2 CANCER CHEMOTHERAPY AND PHARMACOLOGY 10324 3% 1% 80
3 BIOCHEMICAL PHARMACOLOGY 5835 4% 1% 96
4 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 4653 1% 1% 30
5 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 3997 2% 1% 47
6 TOXICOLOGY 2287 1% 1% 37
7 TOXICOLOGY AND APPLIED PHARMACOLOGY 2181 2% 0% 43
8 CANCER TREATMENT REPORTS 2135 1% 1% 20
9 PHARMACOLOGICAL RESEARCH 1658 1% 1% 24
10 DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH 1632 1% 1% 16

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DOXORUBICIN 837912 26% 11% 661 Search DOXORUBICIN Search DOXORUBICIN
2 CARDIOTOXICITY 726158 14% 18% 346 Search CARDIOTOXICITY Search CARDIOTOXICITY
3 DEXRAZOXANE 515376 3% 53% 82 Search DEXRAZOXANE Search DEXRAZOXANE
4 ADRIAMYCIN 424847 8% 17% 213 Search ADRIAMYCIN Search ADRIAMYCIN
5 ICRF 187 213535 1% 71% 25 Search ICRF+187 Search ICRF+187
6 ANTHRACYCLINES 209443 7% 10% 175 Search ANTHRACYCLINES Search ANTHRACYCLINES
7 MONOHER 123357 1% 74% 14 Search MONOHER Search MONOHER
8 ADR 925 83711 0% 100% 7 Search ADR+925 Search ADR+925
9 ADR 529 73246 0% 88% 7 Search ADR+529 Search ADR+529
10 MONOHYDROXYETHYLRUTOSIDE 71753 0% 100% 6 Search MONOHYDROXYETHYLRUTOSIDE Search MONOHYDROXYETHYLRUTOSIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 STERBA, M , POPELOVA, O , VAVROVA, A , JIRKOVSKY, E , KOVARIKOVA, P , GERSL, V , SIMUNEK, T , (2013) OXIDATIVE STRESS, REDOX SIGNALING, AND METAL CHELATION IN ANTHRACYCLINE CARDIOTOXICITY AND PHARMACOLOGICAL CARDIOPROTECTION.ANTIOXIDANTS & REDOX SIGNALING. VOL. 18. ISSUE 8. P. 899 -929 176 64% 67
2 CARVALHO, FS , BURGEIRO, A , GARCIA, R , MORENO, AJ , CARVALHO, RA , OLIVEIRA, PJ , (2014) DOXORUBICIN-INDUCED CARDIOTOXICITY: FROM BIOENERGETIC FAILURE AND CELL DEATH TO CARDIOMYOPATHY.MEDICINAL RESEARCH REVIEWS. VOL. 34. ISSUE 1. P. 106 -135 119 61% 76
3 SIMUNEK, T , STERBA, M , POPELOVA, O , ADAMCOVA, M , HRDINA, R , GERSL, V , (2009) ANTHRACYCLINE-INDUCED CARDIOTOXICITY: OVERVIEW OF STUDIES EXAMINING THE ROLES OF OXIDATIVE STRESS AND FREE CELLULAR IRON.PHARMACOLOGICAL REPORTS. VOL. 61. ISSUE 1. P. 154 -171 95 69% 262
4 WALLACE, KB , (2003) DOXORUBICIN-INDUCED CARDIAC MITOCHONDRIONOPATHY.PHARMACOLOGY & TOXICOLOGY. VOL. 93. ISSUE 3. P. 105-115 88 85% 170
5 CRIJNS, HJ , MOENS, AL , OCTAVIA, Y , TOCCHETTI, CG , GABRIELSON, KL , JANSSENS, S , (2012) DOXORUBICIN-INDUCED CARDIOMYOPATHY: FROM MOLECULAR MECHANISMS TO THERAPEUTIC STRATEGIES.JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. VOL. 52. ISSUE 6. P. 1213 -1225 74 50% 225
6 HASINOFF, BB , HELLMANN, K , HERMAN, EH , FERRANS, VJ , (1998) CHEMICAL, BIOLOGICAL AND CLINICAL ASPECTS OF DEXRAZOXANE AND OTHER BISDIOXOPIPERAZINES.CURRENT MEDICINAL CHEMISTRY. VOL. 5. ISSUE 1. P. 1 -28 108 76% 86
7 TOKARSKA-SCHLATTNER, M , ZAUGG, M , ZUPPINGER, C , WALLIMANN, T , SCHLATTNER, U , (2006) NEW INSIGHTS INTO DOXORUBICIN-INDUCED CARDIOTOXICITY: THE CRITICAL ROLE OF CELLULAR ENERGETICS.JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. VOL. 41. ISSUE 3. P. 389 -405 92 54% 122
8 TOKARSKA-SCHLATTNER, M , WALLIMANN, T , SCHLATTNER, U , (2006) ALTERATIONS IN MYOCARDIAL ENERGY METABOLISM INDUCED BY THE ANTI-CANCER DRUG DOXORUBICIN.COMPTES RENDUS BIOLOGIES. VOL. 329. ISSUE 9. P. 657-668 70 73% 42
9 MINOTTI, G , MENNA, P , SALVATORELLI, E , CAIRO, G , GIANNI, L , (2004) ANTHRACYCLINES: MOLECULAR ADVANCES AND PHARMACOLOGIC DEVELOPMENTS IN ANTITUMOR ACTIVITY AND CARDIOTOXICITY.PHARMACOLOGICAL REVIEWS. VOL. 56. ISSUE 2. P. 185-229 86 26% 1532
10 TAKEMURA, G , FUJIWARA, H , (2007) DOXORUBICIN-INDUCCD CARDIOMYOPATHY FROM THE CARDIOTOXIC MECHANISMS TO MANAGEMENT.PROGRESS IN CARDIOVASCULAR DISEASES. VOL. 49. ISSUE 5. P. 330-352 70 45% 299

Classes with closest relation at Level 1


Rank Class id link
1 4400 CARDIOTOXICITY//ANTHRACYCLINES//CARDIO ONCOLOGY
2 33216 BIMOLANE//PROBIMANE//MST 16
3 8111 IDARUBICIN//IDARUBICINOL//MODIFIED ANTIBIOT
4 22766 ANTHRAQUINONE DISULPHONATES//NAA UNIT//SOLVENT POLARITY EFFECT
5 32890 INTRANASAL PHOTOTHERAPY//RHINOPHOTOTHERAPY//RHINOLIGHT R
6 10232 MITOXANTRONE//PIXANTRONE//PIROXANTRONE
7 36891 GLUTATHIONE DOXORUBICIN CONJUGATE//RAT HEPATOMA CELL//EXPT CYTOL
8 9157 SABARUBICIN//BARMINOMYCIN//ACTINOMYCIN
9 15583 METHOXYMORPHOLINO DOXORUBICIN//AD 198//MORPHOLINYLANTHRACYCLINES
10 34581 MENOGARIL//DNA UNWINDING ACTIVITY//N O O TRIANGULAR PHARMACOPHORE

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