Class information for:
Level 1: ISONIAZID//ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY//DRUG REASSESSMENT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16470 651 34.0 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
141 3       TUBERCULOSIS//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE//MYCOBACTERIUM TUBERCULOSIS 64640
2486 2             PYRAZINAMIDE//ISONIAZID//RIFAMPICIN 3933
16470 1                   ISONIAZID//ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY//DRUG REASSESSMENT 651

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ISONIAZID authKW 493368 18% 9% 114
2 ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY authKW 375232 1% 100% 8
3 DRUG REASSESSMENT address 328328 1% 100% 7
4 DRUG INDUCED HEPATOTOXICITY authKW 307836 3% 35% 19
5 ATDH authKW 281424 1% 100% 6
6 ANTITUBERCULOSIS DRUGS authKW 263786 5% 19% 30
7 HEPATOTOXICITY authKW 226508 21% 4% 134
8 ANTI TUBERCULOSIS DRUG INDUCED LIVER INJURY authKW 187612 1% 67% 6
9 ACETYLHYDRAZINE authKW 146571 1% 63% 5
10 ANTI TB DRUGS authKW 136438 1% 36% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Respiratory System 3041 18% 0% 118
2 Toxicology 1850 16% 0% 107
3 Pharmacology & Pharmacy 1503 29% 0% 191
4 Infectious Diseases 776 11% 0% 71
5 Gastroenterology & Hepatology 618 10% 0% 65
6 Medicine, General & Internal 210 10% 0% 64
7 Chemistry, Medicinal 85 4% 0% 27
8 Tropical Medicine 78 2% 0% 12
9 Public, Environmental & Occupational Health 77 6% 0% 38
10 Critical Care Medicine 55 2% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG REASSESSMENT 328328 1% 100% 7
2 TB MYCOBACTERIA CLIN 93808 0% 100% 2
3 TB TREATMENT 68219 1% 36% 4
4 TB CONTROL PREVENT 53900 2% 9% 13
5 ANTI POISON PHARMACOVIGILANCE 46904 0% 100% 1
6 B ALAL VAIDYA BOTAN 46904 0% 100% 1
7 BJIANGSU PHARMACODYNAM EVALUAT 46904 0% 100% 1
8 COMPLEXO HOSP SANTIAGO DE COMPOSTELA 46904 0% 100% 1
9 DESENVOLVIMENTO CIENT TECNOL FUNDACAO 46904 0% 100% 1
10 DOENCAS TORAXHOSP UNIV CLEMENTINO FRAGA FIL 46904 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 14121 6% 1% 36
2 TUBERCLE 8388 1% 2% 9
3 TUBERCULOSIS 4615 2% 1% 11
4 DRUG AND CHEMICAL TOXICOLOGY 1701 1% 1% 7
5 TUBERCLE AND LUNG DISEASE 1679 1% 1% 4
6 JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 1386 1% 0% 8
7 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 1182 2% 0% 13
8 ARCHIVES OF TOXICOLOGY 1062 2% 0% 10
9 TOXICOLOGY RESEARCH 1004 0% 1% 3
10 ANNALS OF HEPATOLOGY 1001 1% 1% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ISONIAZID 493368 18% 9% 114 Search ISONIAZID Search ISONIAZID
2 ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY 375232 1% 100% 8 Search ANTITUBERCULOSIS+DRUG+INDUCED+HEPATOTOXICITY Search ANTITUBERCULOSIS+DRUG+INDUCED+HEPATOTOXICITY
3 DRUG INDUCED HEPATOTOXICITY 307836 3% 35% 19 Search DRUG+INDUCED+HEPATOTOXICITY Search DRUG+INDUCED+HEPATOTOXICITY
4 ATDH 281424 1% 100% 6 Search ATDH Search ATDH
5 ANTITUBERCULOSIS DRUGS 263786 5% 19% 30 Search ANTITUBERCULOSIS+DRUGS Search ANTITUBERCULOSIS+DRUGS
6 HEPATOTOXICITY 226508 21% 4% 134 Search HEPATOTOXICITY Search HEPATOTOXICITY
7 ANTI TUBERCULOSIS DRUG INDUCED LIVER INJURY 187612 1% 67% 6 Search ANTI+TUBERCULOSIS+DRUG+INDUCED+LIVER+INJURY Search ANTI+TUBERCULOSIS+DRUG+INDUCED+LIVER+INJURY
8 ACETYLHYDRAZINE 146571 1% 63% 5 Search ACETYLHYDRAZINE Search ACETYLHYDRAZINE
9 ANTI TB DRUGS 136438 1% 36% 8 Search ANTI+TB+DRUGS Search ANTI+TB+DRUGS
10 RIFAMPICIN 111094 8% 4% 54 Search RIFAMPICIN Search RIFAMPICIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HASSAN, HM , GUO, HL , YOUSEF, BA , ZHANG, LY , JIANG, ZZ , (2015) HEPATOTOXICITY MECHANISMS OF ISONIAZID: A MINI-REVIEW.JOURNAL OF APPLIED TOXICOLOGY. VOL. 35. ISSUE 12. P. 1427 -1432 59 77% 3
2 SHI, J , XIE, M , WANG, JM , XU, YJ , LIU, XS , (2015) SUSCEPTIBILITY OF N-ACETYLTRANSFERASE 2 SLOW ACETYLATORS TO ANTITUBERCULOSIS DRUG-INDUCED LIVER INJURY: A META-ANALYSIS.PHARMACOGENOMICS. VOL. 16. ISSUE 18. P. 2083 -2097 38 88% 1
3 CHEN, R , WANG, J , ZHANG, Y , TANG, SW , ZHAN, SY , (2015) KEY FACTORS OF SUSCEPTIBILITY TO ANTI-TUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY.ARCHIVES OF TOXICOLOGY. VOL. 89. ISSUE 6. P. 883 -897 55 53% 6
4 SENOUSY, BE , BELAL, SI , DRAGANOV, PV , (2010) HEPATOTOXIC EFFECTS OF THERAPIES FOR TUBERCULOSIS.NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. VOL. 7. ISSUE 10. P. 543 -556 64 53% 19
5 TOSTMANN, A , BOEREE, MJ , AARNOUTSE, RE , DE LANGE, WCM , VAN DER VEN, AJAM , DEKHUIJZEN, R , (2008) ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY: CONCISE UP-TO-DATE REVIEW.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. VOL. 23. ISSUE 2. P. 192 -202 47 55% 190
6 XIANG, Y , MA, L , WU, WD , LIU, W , LI, YG , ZHU, X , WANG, Q , MA, JF , CAO, MQ , WANG, Q , ET AL (2014) THE INCIDENCE OF LIVER INJURY IN UYGHUR PATIENTS TREATED FOR TB IN XINJIANG UYGHUR AUTONOMOUS REGION, CHINA, AND ITS ASSOCIATION WITH HEPATIC ENZYME POLYMORPHISMS NAT2, CYP2E1, GSTM1 AND GSTT1.PLOS ONE. VOL. 9. ISSUE 1. P. - 32 73% 8
7 CAI, Y , YI, JY , ZHOU, CH , SHEN, XZ , (2012) PHARMACOGENETIC STUDY OF DRUG-METABOLISING ENZYME POLYMORPHISMS ON THE RISK OF ANTI-TUBERCULOSIS DRUG-INDUCED LIVER INJURY: A META-ANALYSIS.PLOS ONE. VOL. 7. ISSUE 10. P. - 28 78% 34
8 WANG, FJ , WANG, Y , NIU, T , LU, WX , SANDFORD, AJ , HE, JQ , (2016) UPDATE META-ANALYSIS OF THE CYP2E1 RSAI/PSTI AND DRAI POLYMORPHISMS AND RISK OF ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY: EVIDENCE FROM 26 STUDIES.JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. VOL. 41. ISSUE 3. P. 334 -340 27 82% 0
9 SINGANAYAGAM, A , SRIDHAR, S , DHARIWAL, J , ABDEL-AZIZ, D , MUNRO, K , CONNELL, DW , GEORGE, PM , MOLYNEAUX, PL , COOKE, GS , BURROUGHS, AK , ET AL (2012) A COMPARISON BETWEEN TWO STRATEGIES FOR MONITORING HEPATIC FUNCTION DURING ANTITUBERCULOUS THERAPY.AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. VOL. 185. ISSUE 6. P. 653-659 24 96% 10
10 BOELSTERLI, UA , LEE, KK , (2014) MECHANISMS OF ISONIAZID-INDUCED IDIOSYNCRATIC LIVER INJURY: EMERGING ROLE OF MITOCHONDRIAL STRESS.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. VOL. 29. ISSUE 4. P. 678-687 35 53% 20

Classes with closest relation at Level 1


Rank Class id link
1 29195 ACUTE TOXIC MYOPATHY//ANTI TUBERCULOSIS CHEMOPROPHYLAXIS//ANTIBIOTIC RELATED TOXICITY
2 5104 DRUG INDUCED LIVER INJURY//HEPATOTOXICITY//HERB INDUCED LIVER INJURY
3 33978 AGROCHEMICAL INTERACTIONS//ATENOLOL METABOLIC ACTIONS//METOPROLOL METABOLIC ACTIONS
4 16318 ISONIAZID//RIFAMPICIN//PYRAZINAMIDE
5 6238 ARYLAMINE N ACETYLTRANSFERASE//NAT2//N ACETYLTRANSFERASE
6 4255 TUBERCULOSIS//TB ELIMINAT//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
7 31726 ETHAMBUTOL//TOXIC OPTIC NEUROPATHY//ETHAMBUTOL OPTIC NEUROPATHY
8 5434 BEDAQUILINE//INFECT DIS PHARMACOKINET//DELAMANID
9 14602 TUBERCULOSIS//TUBERCULOUS PERITONITIS//RENAL ALLOGRAFT RECIPIENT
10 20105 PYRAZINAMIDE//PNCA//PYRAZINAMIDASE

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