Class information for:
Level 1: PYRAZINAMIDE//PNCA//PYRAZINAMIDASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
20105 476 27.9 56%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
141 3       TUBERCULOSIS//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE//MYCOBACTERIUM TUBERCULOSIS 64640
2486 2             PYRAZINAMIDE//ISONIAZID//RIFAMPICIN 3933
20105 1                   PYRAZINAMIDE//PNCA//PYRAZINAMIDASE 476

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PYRAZINAMIDE authKW 875165 14% 20% 67
2 PNCA authKW 866001 4% 75% 18
3 PYRAZINAMIDASE authKW 677568 3% 81% 13
4 PYRAZINAMIDE RESISTANCE authKW 384893 1% 100% 6
5 PYRAZINAMIDE DERIVATIVES authKW 267285 1% 83% 5
6 PYRAZINECARBOXAMIDES authKW 267285 1% 83% 5
7 PZA RESISTANCE authKW 256596 1% 100% 4
8 NICOTINAMIDASE authKW 241493 2% 47% 8
9 PYRAZINOIC ACID authKW 241493 2% 47% 8
10 PNCA GENE authKW 205275 1% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Microbiology 3293 35% 0% 167
2 Respiratory System 2834 20% 0% 97
3 Infectious Diseases 832 13% 0% 62
4 Pharmacology & Pharmacy 478 20% 0% 97
5 Medicine, General & Internal 218 11% 0% 54
6 Chemistry, Medicinal 170 6% 0% 30
7 Chemistry, Organic 83 8% 0% 36
8 Immunology 33 6% 0% 28
9 Chemistry, Multidisciplinary 21 8% 0% 36
10 Critical Care Medicine 6 1% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED CHEM DRUG ANAL 85531 0% 67% 2
2 ANTIBACTERIAL DRUG DISCOVERY MICROBIOL 64149 0% 100% 1
3 BACTERIOL TUBERCULOSE 64149 0% 100% 1
4 CARRERA 5 64149 0% 100% 1
5 CHALMERS HOSP 64149 0% 100% 1
6 CHINESE CONTEMPORARY CULTURAL STUDIES 64149 0% 100% 1
7 CHRON COMMUN DIS 64149 0% 100% 1
8 DIAGNOST BACTERIOL PARASITOL BPD 64149 0% 100% 1
9 DST EXCELLENCE BIOMED TB MRCNRF 64149 0% 100% 1
10 ER BACTERIOL HYG EA1541 5 64149 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TUBERCLE 17151 2% 2% 11
2 AMERICAN REVIEW OF RESPIRATORY DISEASE 6487 5% 0% 25
3 TUBERCULOSIS 6320 2% 1% 11
4 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 5713 10% 0% 46
5 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 4295 4% 0% 17
6 PRAXIS UND KLINIK DER PNEUMOLOGIE 2866 1% 1% 3
7 EMERGING MICROBES & INFECTIONS 2838 1% 1% 3
8 JOURNAL OF CLINICAL MICROBIOLOGY 2609 7% 0% 33
9 TUBERCLE AND LUNG DISEASE 2299 1% 1% 4
10 REVUE FRANCAISE DES MALADIES RESPIRATOIRES 1766 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRAZINAMIDE 875165 14% 20% 67 Search PYRAZINAMIDE Search PYRAZINAMIDE
2 PNCA 866001 4% 75% 18 Search PNCA Search PNCA
3 PYRAZINAMIDASE 677568 3% 81% 13 Search PYRAZINAMIDASE Search PYRAZINAMIDASE
4 PYRAZINAMIDE RESISTANCE 384893 1% 100% 6 Search PYRAZINAMIDE+RESISTANCE Search PYRAZINAMIDE+RESISTANCE
5 PYRAZINAMIDE DERIVATIVES 267285 1% 83% 5 Search PYRAZINAMIDE+DERIVATIVES Search PYRAZINAMIDE+DERIVATIVES
6 PYRAZINECARBOXAMIDES 267285 1% 83% 5 Search PYRAZINECARBOXAMIDES Search PYRAZINECARBOXAMIDES
7 PZA RESISTANCE 256596 1% 100% 4 Search PZA+RESISTANCE Search PZA+RESISTANCE
8 NICOTINAMIDASE 241493 2% 47% 8 Search NICOTINAMIDASE Search NICOTINAMIDASE
9 PYRAZINOIC ACID 241493 2% 47% 8 Search PYRAZINOIC+ACID Search PYRAZINOIC+ACID
10 PNCA GENE 205275 1% 80% 4 Search PNCA+GENE Search PNCA+GENE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 RAMIREZ-BUSBY, SM , VALAFAR, F , (2015) SYSTEMATIC REVIEW OF MUTATIONS IN PYRAZINAMIDASE ASSOCIATED WITH PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS CLINICAL ISOLATES.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 59. ISSUE 9. P. 5267 -5277 70 73% 6
2 WHITFIELD, MG , SOETERS, HM , WARREN, RM , YORK, T , SAMPSON, SL , STREICHER, EM , VAN HELDEN, PD , VAN RIE, A , (2015) A GLOBAL PERSPECTIVE ON PYRAZINAMIDE RESISTANCE: SYSTEMATIC REVIEW AND META-ANALYSIS.PLOS ONE. VOL. 10. ISSUE 7. P. - 71 65% 5
3 NJIRE, M , TAN, YJ , MUGWERU, J , WANG, CW , GUO, JT , YEW, WW , TAN, SY , ZHANG, TY , (2016) PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS: REVIEW AND UPDATE.ADVANCES IN MEDICAL SCIENCES. VOL. 61. ISSUE 1. P. 63 -71 52 71% 1
4 YEW, WW , CHANG, KC , ZHANG, Y , (2011) PYRAZINAMIDE SUSCEPTIBILITY TESTING IN MYCOBACTERIUM TUBERCULOSIS: A SYSTEMATIC REVIEW WITH META-ANALYSES.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 55. ISSUE 10. P. 4499 -4505 46 79% 46
5 STEHR, M , ELAMIN, AA , SINGH, M , (2015) PYRAZINAMIDE: THE IMPORTANCE OF UNCOVERING THE MECHANISMS OF ACTION IN MYCOBACTERIA.EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. VOL. 13. ISSUE 5. P. 593 -603 59 53% 2
6 ZHANG, Y , MITCHISON, D , (2003) THE CURIOUS CHARACTERISTICS OF PYRAZINAMIDE: A REVIEW.INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. VOL. 7. ISSUE 1. P. 6-21 46 70% 266
7 BHUJU, S , FONSECA, LD , MARSICO, AG , VIEIRA, GBD , SOBRAL, LF , STEHR, M , SINGH, M , SAAD, MHF , (2013) MYCOBACTERIUM TUBERCULOSIS ISOLATES FROM RIO DE JANEIRO REVEAL UNUSUALLY LOW CORRELATION BETWEEN PYRAZINAMIDE RESISTANCE AND MUTATIONS IN THE PNCA GENE.INFECTION GENETICS AND EVOLUTION. VOL. 19. ISSUE . P. 1-6 31 89% 8
8 ZIMIC, M , SHEEN, P , QUILIANO, M , GUTIERREZ, A , GILMAN, RH , (2010) PERUVIAN AND GLOBALLY REPORTED AMINO ACID SUBSTITUTIONS ON THE MYCOBACTERIUM TUBERCULOSIS PYRAZINAMIDASE SUGGEST A CONSERVED PATTERN OF MUTATIONS ASSOCIATED TO PYRAZINAMIDE RESISTANCE.INFECTION GENETICS AND EVOLUTION. VOL. 10. ISSUE 2. P. 346-349 32 89% 7
9 TAN, YJ , HU, ZQ , ZHANG, TY , CAI, XS , KUANG, HB , LIU, YW , CHEN, JY , YANG, F , ZHANG, K , TAN, SY , ET AL (2014) ROLE OF PNCA AND RPSA GENE SEQUENCING IN DETECTION OF PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATES FROM SOUTHERN CHINA.JOURNAL OF CLINICAL MICROBIOLOGY. VOL. 52. ISSUE 1. P. 291-297 26 84% 17
10 ZHANG, Y , CHANG, KC , LEUNG, CC , YEW, WW , GICQUEL, B , FALLOWS, D , KAPLAN, G , CHAISSON, RE , ZHANG, WH , (2012) 'Z(S)-MDR-TB' VERSUS 'Z(R)-MDR-TB': IMPROVING TREATMENT OF MDR-TB BY IDENTIFYING PYRAZINAMIDE SUSCEPTIBILITY.EMERGING MICROBES & INFECTIONS. VOL. 1. ISSUE . P. - 34 74% 9

Classes with closest relation at Level 1


Rank Class id link
1 5434 BEDAQUILINE//INFECT DIS PHARMACOKINET//DELAMANID
2 21746 IN VITRO ANTIMYCOBACTERIAL ACTIVITY//SPINACH CHLOROPLASTS//INORGAN ORGAN CHEM
3 567 MULTIDRUG RESISTANT TUBERCULOSIS//MDR TB//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
4 16318 ISONIAZID//RIFAMPICIN//PYRAZINAMIDE
5 29195 ACUTE TOXIC MYOPATHY//ANTI TUBERCULOSIS CHEMOPROPHYLAXIS//ANTIBIOTIC RELATED TOXICITY
6 16470 ISONIAZID//ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY//DRUG REASSESSMENT
7 5819 MYCOBACTERIUM AVIUM//RIFABUTIN//MYCOBACTERIUM AVIUM COMPLEX
8 9997 CHILDHOOD TUBERCULOSIS//DESMOND TUTU TB//TUBERCULOSIS
9 31726 ETHAMBUTOL//TOXIC OPTIC NEUROPATHY//ETHAMBUTOL OPTIC NEUROPATHY
10 25576 DIPARTIMENTO CHIM PIAZZA LEONARDO DA VINCI 32//NUCLEOPHILIC SUBSTITUTION OF PYRAZINE//PTERIDINE SYNTHESIS

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