Class information for:
Level 1: ORPHAN DRUGS//RARE DISEASES//ORPHAN DRUG ACT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16184 668 27.9 50%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
320 3       AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION//MEDICATION ERRORS//AMERICAN JOURNAL OF HOSPITAL PHARMACY 39312
1464 2             FOOD AND DRUG LAW JOURNAL//CONFLICT OF INTEREST//ORPHAN DRUGS 7747
16184 1                   ORPHAN DRUGS//RARE DISEASES//ORPHAN DRUG ACT 668

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ORPHAN DRUGS authKW 2942854 17% 56% 116
2 RARE DISEASES authKW 1758582 25% 23% 164
3 ORPHAN DRUG ACT authKW 454408 2% 76% 13
4 OFF ORPHAN PROD DEV address 386243 2% 65% 13
5 ORPHAN MEDICINAL PRODUCTS authKW 279974 1% 88% 7
6 ORPHAN DESIGNATION authKW 182841 1% 100% 4
7 ADAPTIVE LICENSING authKW 163248 1% 71% 5
8 CONDITIONAL APPROVAL authKW 163248 1% 71% 5
9 EUROPEAN REFERENCE NETWORKS authKW 163248 1% 71% 5
10 ORPHANET JOURNAL OF RARE DISEASES journal 138421 9% 5% 58

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Health Care Sciences & Services 2699 14% 0% 93
2 Health Policy & Services 2240 10% 0% 65
3 Pharmacology & Pharmacy 2134 34% 0% 227
4 Medicine, Research & Experimental 740 13% 0% 89
5 Genetics & Heredity 462 12% 0% 81
6 Medical Informatics 359 3% 0% 20
7 Medical Ethics 306 1% 0% 9
8 Medicine, General & Internal 299 11% 0% 75
9 Law 289 4% 0% 28
10 Public, Environmental & Occupational Health 210 9% 0% 57

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OFF ORPHAN PROD DEV 386243 2% 65% 13
2 COORDINATING PIEDMONT AOSTA VALLEY NETWORK 91421 0% 100% 2
3 EUROPEAN GAUCHER ALLIANCE 91421 0% 100% 2
4 SHIRE HUMAN GENET THER IES 91421 0% 100% 2
5 SPAINRDR 91421 0% 100% 2
6 PEDIAT NEUROL METAB MED 66483 1% 36% 4
7 ORDR 60946 0% 67% 2
8 OFF RARE DIS 60930 1% 13% 10
9 ADV MANAGEMENT TRAINING PROGRAMME PHARMACOECON PH 45710 0% 100% 1
10 ALTALANOS ORVOSTUDOMANYI KAR GENOMIKAI MED RITK 45710 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ORPHANET JOURNAL OF RARE DISEASES 138421 9% 5% 58
2 EXPERT OPINION ON ORPHAN DRUGS 17572 2% 3% 13
3 FOOD AND DRUG LAW JOURNAL 16597 3% 2% 19
4 THERAPEUTIC INNOVATION & REGULATORY SCIENCE 15215 2% 3% 11
5 EJHP PRACTICE 11242 1% 4% 7
6 DRUG INFORMATION JOURNAL 9346 2% 1% 15
7 CLINICAL PHARMACOLOGY & THERAPEUTICS 9043 5% 1% 34
8 PUBLIC HEALTH GENOMICS 8770 1% 2% 8
9 DRUG DISCOVERY TODAY 4168 2% 1% 15
10 EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH 3227 1% 1% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ORPHAN DRUGS 2942854 17% 56% 116 Search ORPHAN+DRUGS Search ORPHAN+DRUGS
2 RARE DISEASES 1758582 25% 23% 164 Search RARE+DISEASES Search RARE+DISEASES
3 ORPHAN DRUG ACT 454408 2% 76% 13 Search ORPHAN+DRUG+ACT Search ORPHAN+DRUG+ACT
4 ORPHAN MEDICINAL PRODUCTS 279974 1% 88% 7 Search ORPHAN+MEDICINAL+PRODUCTS Search ORPHAN+MEDICINAL+PRODUCTS
5 ORPHAN DESIGNATION 182841 1% 100% 4 Search ORPHAN+DESIGNATION Search ORPHAN+DESIGNATION
6 ADAPTIVE LICENSING 163248 1% 71% 5 Search ADAPTIVE+LICENSING Search ADAPTIVE+LICENSING
7 CONDITIONAL APPROVAL 163248 1% 71% 5 Search CONDITIONAL+APPROVAL Search CONDITIONAL+APPROVAL
8 EUROPEAN REFERENCE NETWORKS 163248 1% 71% 5 Search EUROPEAN+REFERENCE+NETWORKS Search EUROPEAN+REFERENCE+NETWORKS
9 ORPHAN DISEASES 130587 1% 29% 10 Search ORPHAN+DISEASES Search ORPHAN+DISEASES
10 NEW DRUG LAUNCHES 102847 0% 75% 3 Search NEW+DRUG+LAUNCHES Search NEW+DRUG+LAUNCHES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ZELEI, T , MOLNAR, MJ , SZEGEDI, M , KALO, Z , (2016) SYSTEMATIC REVIEW ON THE EVALUATION CRITERIA OF ORPHAN MEDICINES IN CENTRAL AND EASTERN EUROPEAN COUNTRIES.ORPHANET JOURNAL OF RARE DISEASES. VOL. 11. ISSUE . P. - 45 85% 0
2 GAMMIE, T , LU, CY , BABAR, ZUD , (2015) ACCESS TO ORPHAN DRUGS: A COMPREHENSIVE REVIEW OF LEGISLATIONS, REGULATIONS AND POLICIES IN 35 COUNTRIES.PLOS ONE. VOL. 10. ISSUE 10. P. - 28 97% 6
3 GUTIERREZ, L , PATRIS, J , HUTCHINGS, A , COWELL, W , (2015) PRINCIPLES FOR CONSISTENT VALUE ASSESSMENT AND SUSTAINABLE FUNDING OF ORPHAN DRUGS IN EUROPE.ORPHANET JOURNAL OF RARE DISEASES. VOL. 10. ISSUE . P. - 24 89% 2
4 HERDER, M , (2013) WHEN EVERYONE IS AN ORPHAN: AGAINST ADOPTING A US-STYLED ORPHAN DRUG POLICY IN CANADA.ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE. VOL. 20. ISSUE 4. P. 227 -269 30 56% 6
5 HOEKMAN, J , BOON, WPC , BOUVY, JC , EBBERS, HC , DE JONG, JP , DE BRUIN, ML , (2015) USE OF THE CONDITIONAL MARKETING AUTHORIZATION PATHWAY FOR ONCOLOGY MEDICINES IN EUROPE.CLINICAL PHARMACOLOGY & THERAPEUTICS. VOL. 98. ISSUE 5. P. 534 -541 17 89% 4
6 MARTINALBO, J , BOWEN, D , CAMARERO, J , CHAPELIN, M , DEMOLIS, P , FOGGI, P , JONSSON, B , LLINARES, J , MOREAU, A , O'CONNOR, D , ET AL (2016) EARLY MARKET ACCESS OF CANCER DRUGS IN THE EU.ANNALS OF ONCOLOGY. VOL. 27. ISSUE 1. P. 96 -105 18 62% 6
7 PAULDEN, M , STAFINSKI, T , MENON, D , MCCABE, C , (2015) VALUE-BASED REIMBURSEMENT DECISIONS FOR ORPHAN DRUGS: A SCOPING REVIEW AND DECISION FRAMEWORK.PHARMACOECONOMICS. VOL. 33. ISSUE 3. P. 255 -269 22 69% 3
8 RODRIGUEZ-MONGUIO, R , SPARGO, T , SEOANE-VAZQUEZ, E , (2017) ETHICAL IMPERATIVES OF TIMELY ACCESS TO ORPHAN DRUGS: IS POSSIBLE TO RECONCILE ECONOMIC INCENTIVES AND PATIENTS' HEALTH NEEDS?.ORPHANET JOURNAL OF RARE DISEASES. VOL. 12. ISSUE . P. - 21 72% 0
9 PINTO, D , MARTIN, D , CHENHALL, R , (2016) THE INVOLVEMENT OF PATIENT ORGANISATIONS IN RARE DISEASE RESEARCH: A MIXED METHODS STUDY IN AUSTRALIA.ORPHANET JOURNAL OF RARE DISEASES. VOL. 11. ISSUE . P. - 22 52% 4
10 LOGVISS, K , KRIEVINS, D , PURVINA, S , (2016) IMPACT OF ORPHAN DRUGS ON LATVIAN BUDGET.ORPHANET JOURNAL OF RARE DISEASES. VOL. 11. ISSUE . P. - 14 93% 0

Classes with closest relation at Level 1


Rank Class id link
1 26445 DRUG LAG//JAPANESE CLINICAL TRIALS//GLOBAL DRUG DEVELOPMENT
2 16867 CLINICAL TRIAL RISK//DRUG DISCOVERY TODAY//TUFTS STUDY DRUG DEV
3 25741 ANTIBACTERIAL DRUG DEVELOPMENT//INFECT GLOBAL MED DEV//ANTIBIOTIC INNOVATION
4 7853 HEALTH TECHNOLOGY ASSESSMENT//INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE//HTA
5 30020 BENEFIT RISK//BENEFIT RISK ASSESSMENT//BENEFIT RISK COMMUNICATION
6 21788 CRHAM//SOCIOL SUBJECT GRP//CORPORATE BIAS
7 16303 FOOD AND DRUG LAW JOURNAL//MEDICAL DEVICE INNOVATION//DEVICE APPROVAL
8 34368 BRITISH PAEDIAT SURVEILLANCE UNIT//COPPER SULFATE POISONING//BLUISH VOMITING
9 28567 CODISPENSING//RISK EVALUATION AND MITIGATION STRATEGIES//BOXED WARNINGS
10 18139 SURROGATE ENDPOINT//SURROGATE OUTCOME//PRENTICE CRITERION

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