Class information for:
Level 1: BROMODOMAIN//BRD4//NUT MIDLINE CARCINOMA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13694 819 45.9 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
71 3       GENETICS & HEREDITY//CHROMATIN//CELL BIOLOGY 83302
343 2             EZH2//CHROMATIN//POLYCOMB 17754
13694 1                   BROMODOMAIN//BRD4//NUT MIDLINE CARCINOMA 819

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BROMODOMAIN authKW 2533593 14% 59% 116
2 BRD4 authKW 1475780 7% 65% 61
3 NUT MIDLINE CARCINOMA authKW 1201857 4% 92% 35
4 JQ1 authKW 1037958 4% 80% 35
5 BET INHIBITORS authKW 489746 2% 77% 17
6 ATAD2 authKW 441494 2% 79% 15
7 BRD2 authKW 381759 2% 64% 16
8 BET PROTEINS authKW 332141 2% 64% 14
9 BRD4 NUT authKW 301985 1% 90% 9
10 BRDT authKW 255640 1% 57% 12

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 2267 28% 0% 228
2 Chemistry, Medicinal 1965 15% 0% 123
3 Oncology 1346 22% 0% 183
4 Biochemistry & Molecular Biology 1080 32% 0% 266
5 Pathology 161 5% 0% 38
6 Genetics & Heredity 109 6% 0% 51
7 Developmental Biology 97 3% 0% 21
8 Biophysics 95 5% 0% 41
9 Hematology 43 3% 0% 25
10 Pharmacology & Pharmacy 19 6% 0% 46

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPINOVA DPU 224448 2% 35% 17
2 STRUCT GENOM CONSORTIUM 180388 8% 8% 64
3 TARGET DISCOVERY 171648 4% 14% 34
4 CELLZOME GMBH 170426 1% 57% 8
5 EPINOVA DISCOVERY PERFORMANCE UNIT 162086 1% 43% 10
6 EPINOVA 119302 0% 80% 4
7 EPINOVA EPIGENET DISCOVERY PERFORMANCE UNIT 111847 0% 100% 3
8 BUCHMANN LIFE SCI 103557 1% 56% 5
9 MOL GROWTH REGULAT 92989 3% 11% 23
10 CANC EPIGENET DPU 85213 0% 57% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 4827 6% 0% 53
2 MEDCHEMCOMM 4648 2% 1% 13
3 ONCOTARGET 3472 4% 0% 34
4 CELL REPORTS 2548 2% 0% 15
5 ACS CHEMICAL BIOLOGY 2478 1% 1% 12
6 NATURE CHEMICAL BIOLOGY 2188 1% 1% 9
7 ACS MEDICINAL CHEMISTRY LETTERS 1723 1% 1% 8
8 LANCET HAEMATOLOGY 1416 0% 2% 2
9 MOLECULAR CELL 1317 2% 0% 14
10 CHEMMEDCHEM 1303 1% 0% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BROMODOMAIN 2533593 14% 59% 116 Search BROMODOMAIN Search BROMODOMAIN
2 BRD4 1475780 7% 65% 61 Search BRD4 Search BRD4
3 NUT MIDLINE CARCINOMA 1201857 4% 92% 35 Search NUT+MIDLINE+CARCINOMA Search NUT+MIDLINE+CARCINOMA
4 JQ1 1037958 4% 80% 35 Search JQ1 Search JQ1
5 BET INHIBITORS 489746 2% 77% 17 Search BET+INHIBITORS Search BET+INHIBITORS
6 ATAD2 441494 2% 79% 15 Search ATAD2 Search ATAD2
7 BRD2 381759 2% 64% 16 Search BRD2 Search BRD2
8 BET PROTEINS 332141 2% 64% 14 Search BET+PROTEINS Search BET+PROTEINS
9 BRD4 NUT 301985 1% 90% 9 Search BRD4+NUT Search BRD4+NUT
10 BRDT 255640 1% 57% 12 Search BRDT Search BRDT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 JUNG, M , GELATO, KA , FERNANDEZ-MONTALVAN, A , SIEGEL, S , HAENDLER, B , (2015) TARGETING BET BROMODOMAINS FOR CANCER TREATMENT.EPIGENOMICS. VOL. 7. ISSUE 3. P. 487 -501 100 89% 21
2 FILIPPAKOPOULOS, P , KNAPP, S , (2014) TARGETING BROMODOMAINS: EPIGENETIC READERS OF LYSINE ACETYLATION.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 5. P. 339 -358 85 56% 210
3 GALDEANO, C , CIULLI, A , (2016) SELECTIVITY ON-TARGET OF BROMODOMAIN CHEMICAL PROBES BY STRUCTURE-GUIDED MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY.FUTURE MEDICINAL CHEMISTRY. VOL. 8. ISSUE 13. P. 1655 -1680 95 79% 5
4 ROMERO, FA , TAYLOR, AM , CRAWFORD, TD , TSUI, V , COTE, A , MAGNUSON, S , (2016) DISRUPTING ACETYL-LYSINE RECOGNITION: PROGRESS IN THE DEVELOPMENT OF BROMODOMAIN INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 4. P. 1271 -1298 75 65% 18
5 FRENCH, CA , (2016) SMALL-MOLECULE TARGETING OF BET PROTEINS IN CANCER.ADVANCES IN CANCER RESEARCH, VOL 131. VOL. 131. ISSUE . P. 21 -58 102 82% 1
6 FERRI, E , PETOSA, C , MCKENNA, CE , (2016) BROMODOMAINS: STRUCTURE, FUNCTION AND PHARMACOLOGY OF INHIBITION.BIOCHEMICAL PHARMACOLOGY. VOL. 106. ISSUE . P. 1 -18 89 62% 9
7 WANG, CY , FILIPPAKOPOULOS, P , (2015) BEATING THE ODDS: BETS IN DISEASE.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 40. ISSUE 8. P. 468 -479 83 73% 18
8 BRAND, M , MEASURES, AM , WILSON, BG , CORTOPASSI, WA , ALEXANDER, R , HOSS, M , HEWINGS, DS , ROONEY, TPC , PATON, RS , CONWAY, SJ , (2015) SMALL MOLECULE INHIBITORS OF BROMODOMAIN-ACETYL-LYSINE INTERACTIONS.ACS CHEMICAL BIOLOGY. VOL. 10. ISSUE 1. P. 22 -39 76 67% 36
9 THEODOULOU, NH , TOMKINSON, NCO , PRINJHA, RK , HUMPHREYS, PG , (2016) PROGRESS IN THE DEVELOPMENT OF NON-BET BROMODOMAIN CHEMICAL PROBES.CHEMMEDCHEM. VOL. 11. ISSUE 5. P. 477 -487 58 89% 6
10 YU, L , WANG, Z , ZHANG, Z , REN, XM , LU, XY , DING, K , (2015) SMALL-MOLECULE BET INHIBITORS IN CLINICAL AND PRECLINICAL DEVELOPMENT AND THEIR THERAPEUTIC POTENTIAL.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 8. P. 776 -794 79 80% 5

Classes with closest relation at Level 1


Rank Class id link
1 12023 SET8//HISTONE//PR SET7
2 8607 HISTONE ACETYLTRANSFERASE//GCN5//MOZ
3 5889 P TEFB//CDK9//RNA POLYMERASE II
4 22567 BRD7//NGX6//BRD7 GENE
5 4702 CHIP SEQ//ENHANCER//PEAK CALLING
6 22210 PROTEIN KNOCKDOWN//PROTACS//CHEMICAL INDUCERS OF DIMERIZATION
7 8082 HISTONE DEMETHYLASE//LSD1//HISTONE DEMETHYLATION
8 11825 FRAGMENT SCREENING//FRAGMENT BASED DRUG DISCOVERY//NMR SCREENING
9 6164 RHABDOID TUMOR//ATYPICAL TERATOID RHABDOID TUMOR//MALIGNANT RHABDOID TUMOR
10 3273 NUCLEOSOME POSITIONING//ISWI//NUCLEOSOME

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