Class information for:
Level 1: PRODRUG//DIFFUSION CELL EXPERIMENTS//DERMAL PRODRUG

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13198 854 25.6 54%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
41 3       INTERNATIONAL JOURNAL OF PHARMACEUTICS//DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY//PHARMACOLOGY & PHARMACY 99449
3405 2             LOTEPREDNOL ETABONATE//PRODRUG//ANTEDRUG 1608
13198 1                   PRODRUG//DIFFUSION CELL EXPERIMENTS//DERMAL PRODRUG 854

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PRODRUG authKW 338128 18% 6% 151
2 DIFFUSION CELL EXPERIMENTS authKW 255382 1% 71% 10
3 DERMAL PRODRUG authKW 250280 1% 100% 7
4 TRANSFORMED POTTS GUY EQUATION authKW 214525 1% 100% 6
5 MUTUAL PRODRUG authKW 205932 1% 48% 12
6 ROBERTS SLOAN EQUATION authKW 190684 1% 67% 8
7 ULCEROGENICITY authKW 155480 2% 23% 19
8 LIPID SOLUBILITY authKW 147087 1% 34% 12
9 ACETYLSALICYLIC ACID MALTOL ESTER authKW 143017 0% 100% 4
10 NANAOCAM authKW 143017 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 6920 52% 0% 447
2 Chemistry, Medicinal 6752 27% 0% 227
3 Chemistry, Multidisciplinary 1539 29% 0% 247
4 Chemistry, Organic 508 12% 0% 106
5 Crystallography 254 5% 0% 45
6 Polymer Science 152 6% 0% 53
7 Materials Science, Biomaterials 50 2% 0% 13
8 Materials Science, Textiles 10 0% 0% 4
9 Materials Science, Paper & Wood 7 0% 0% 4
10 Toxicology 3 1% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CENQAM 80446 0% 75% 3
2 CECF 58444 1% 15% 11
3 ANAL SUPERFICI 35754 0% 100% 1
4 ANALYT CHEM MED CHEM 35754 0% 100% 1
5 BASE POSTDOCTORAL SCI 35754 0% 100% 1
6 C T POIMEROS 35754 0% 100% 1
7 CARBOHYDRATES NAT POLYMERS 35754 0% 100% 1
8 EA 3036IFR 31 35754 0% 100% 1
9 FOOD SCI BIOTECHNOL ENVIROMN ENGN 35754 0% 100% 1
10 GEN MED SCI NIGMS BRIDGES DOCTORATE 35754 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF PHARMACEUTICS 35306 15% 1% 125
2 JOURNAL OF PHARMACEUTICAL SCIENCES 14286 8% 1% 67
3 ACTA PHARMACEUTICA NORDICA 12156 1% 4% 8
4 PHARMACEUTICAL RESEARCH 3722 3% 0% 29
5 OMNI 3249 0% 9% 1
6 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2912 2% 0% 17
7 DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 2624 2% 0% 20
8 ACTA PHARMACEUTICA SUECICA 2432 1% 1% 5
9 ACTA PHARMACEUTICA 2208 1% 1% 5
10 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1505 2% 0% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PRODRUG 338128 18% 6% 151 Search PRODRUG Search PRODRUG
2 DIFFUSION CELL EXPERIMENTS 255382 1% 71% 10 Search DIFFUSION+CELL+EXPERIMENTS Search DIFFUSION+CELL+EXPERIMENTS
3 DERMAL PRODRUG 250280 1% 100% 7 Search DERMAL+PRODRUG Search DERMAL+PRODRUG
4 TRANSFORMED POTTS GUY EQUATION 214525 1% 100% 6 Search TRANSFORMED+POTTS+GUY+EQUATION Search TRANSFORMED+POTTS+GUY+EQUATION
5 MUTUAL PRODRUG 205932 1% 48% 12 Search MUTUAL+PRODRUG Search MUTUAL+PRODRUG
6 ROBERTS SLOAN EQUATION 190684 1% 67% 8 Search ROBERTS+SLOAN+EQUATION Search ROBERTS+SLOAN+EQUATION
7 ULCEROGENICITY 155480 2% 23% 19 Search ULCEROGENICITY Search ULCEROGENICITY
8 LIPID SOLUBILITY 147087 1% 34% 12 Search LIPID+SOLUBILITY Search LIPID+SOLUBILITY
9 ACETYLSALICYLIC ACID MALTOL ESTER 143017 0% 100% 4 Search ACETYLSALICYLIC+ACID+MALTOL+ESTER Search ACETYLSALICYLIC+ACID+MALTOL+ESTER
10 NANAOCAM 143017 0% 100% 4 Search NANAOCAM Search NANAOCAM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MAJUMDAR, S , MUELLER-SPAETH, M , SLOAN, KB , (2012) PRODRUGS OF THEOPHYLLINE INCORPORATING ETHYLENEOXY GROUPS IN THE PROMOIETY: SYNTHESIS, CHARACTERIZATION, AND TRANSDERMAL DELIVERY.AAPS PHARMSCITECH. VOL. 13. ISSUE 3. P. 853-862 22 81% 3
2 SLOAN, KB , WASDO, S , (2003) DESIGNING FOR TOPICAL DELIVERY: PRODRUGS CAN MAKE THE DIFFERENCE.MEDICINAL RESEARCH REVIEWS. VOL. 23. ISSUE 6. P. 763-793 34 60% 52
3 HALEN, PK , MURUMKAR, PR , GIRIDHAR, R , YADAV, MR , (2009) PRODRUG DESIGNING OF NSAIDS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 1. P. 124-139 41 42% 26
4 THOMAS, JD , MAJUMDAR, S , SLOAN, KB , (2009) SOFT ALKYL ETHER PRODRUGS OF A MODEL PHENOLIC DRUG: THE EFFECT OF INCORPORATION OF ETHYLENEOXY GROUPS ON TRANSDERMAL DELIVERY.MOLECULES. VOL. 14. ISSUE 10. P. 4231-4245 18 90% 8
5 THOMAS, JD , SLOAN, KB , (2009) EVALUATION OF ALKYLOXYCARBONYLOXYMETHYL (AOCOM) ETHERS AS NOVEL PRODRUGS OF PHENOLS FOR TOPICAL DELIVERY: AOCOM PRODRUGS OF ACETAMINOPHEN.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 371. ISSUE 1-2. P. 25-32 21 78% 5
6 THOMAS, JD , SLOAN, KB , (2008) IN VITRO EVALUATION OF ALKYLCARBONYLOXYMETHYL (ACOM) ETHERS AS NOVEL PRODRUGS OF PHENOLS FOR TOPICAL DELIVERY: ACOM PRODRUGS OF ACETAMINOPHEN.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 346. ISSUE 1-2. P. 80-88 20 63% 10
7 NIELSEN, AB , BUUR, A , LARSEN, C , (2005) BIOREVERSIBLE QUATERNARY N-ACYLOXYMETHYL DERIVATIVES OF THE POORLY SOLUBLE TERTIARY AMINE LU 28-179 - SYNTHESIS, PHARMACEUTICAL CHEMICAL CHARACTERIZATION AND BIOAVAILABILITY STUDIES IN DOGS.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 26. ISSUE 5. P. 421 -428 14 88% 2
8 MAJUMDAR, S , SLOAN, KB , (2007) SYNTHESIS AND TOPICAL DELIVERY OF N-ALKYL-N-ALKYLOXYCARBONYLAMINOMETHYL PRODRUGS OF A MODEL PHENOLIC DRUG: ACETAMINOPHEN.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 337. ISSUE 1-2. P. 48-55 17 65% 8
9 MENDES, E , FURTADO, T , NERES, J , ILEY, J , JARVINEN, T , RAUTIO, J , MOREIRA, R , (2002) SYNTHESIS, STABILITY AND IN VITRO DERMAL EVALUATION OF AMINOCARBONYLOXYMETHYL ESTERS AS PRODRUGS OF CARBOXYLIC ACID AGENTS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 10. ISSUE 3. P. 809-816 15 79% 13
10 BABAZADEH, M , (2008) DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ETHER TYPE POLYMERIC PRODRUGS OF IBUPROFEN, KETOPROFEN AND NAPROXEN.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 356. ISSUE 1-2. P. 167 -173 13 72% 25

Classes with closest relation at Level 1


Rank Class id link
1 27814 FOSPHENYTOIN//PURPLE GLOVE SYNDROME//PHENYTOIN
2 26291 IN VIVO ANTITUMOUR ACTIVITY//MOUSE LYMPHOID NEOPLASMA P 388//MOUSE MAMMARY CARCINOMA FM 3A
3 25636 ESTERASE SENSITIVE PRODRUGS//KIRBYS ENZYME MODEL//PROXIMITY ORIENTATION
4 21370 NO NSAIDS//NCX 4016//NO ASPIRIN
5 21088 LOTEPREDNOL ETABONATE//CHEMICAL DELIVERY SYSTEM//NBP ASSAY
6 21790 N SUCCINYL CHITOSAN//DEXTRAN PRODRUGS//BIOPHARMACEUT DRUG METAB
7 30886 BENZILIC ESTER REARRANGEMENT//BASE CATALYSED HYDROLYSIS//1 ACYL 2 3 DIHYDROINDOLE 2 3 DIONES
8 320 PENETRATION ENHANCER//PERCUTANEOUS ABSORPTION//TRANSDERMAL
9 29518 ACEMETACIN//1 1 DIOXO 1 2 THIAZINE 6 CARBALDEHYDES//ACEMETACIN ACE
10 26122 N BENZYLOXYCARBONYLGLYCINE//1 3 DIACYLAMINOPROPAN 2 OLS//1 3 DIACYLAMINO 2 O ACYL PROPANES

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