Class information for:
Level 1: DRUG DESIGN SYNTH//GUANINE DEAMINASE//ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
29228 190 18.7 46%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
3150 2             ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1 2232
29228 1                   DRUG DESIGN SYNTH//GUANINE DEAMINASE//ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY 190

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG DESIGN SYNTH address 725188 10% 24% 19
2 GUANINE DEAMINASE authKW 482133 3% 50% 6
3 ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY authKW 214282 1% 67% 2
4 1 4 DIAZEPINE 2 5 DIONE authKW 160713 1% 100% 1
5 2 2 DICARBOXYLIC ACID ESTER authKW 160713 1% 100% 1
6 2 2 DISUBSTITUTION authKW 160713 1% 100% 1
7 2 CARBOXYHYPOXANTHINE authKW 160713 1% 100% 1
8 5 8 FUSED authKW 160713 1% 100% 1
9 ALKYLATION OF IMIDAZOLES authKW 160713 1% 100% 1
10 ANTIVIRAL ANTICANCER ACTIVITIES authKW 160713 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 995 33% 0% 63
2 Medical Laboratory Technology 175 5% 0% 10
3 Crystallography 140 8% 0% 15
4 Biochemistry & Molecular Biology 134 25% 0% 48
5 Chemistry, Medicinal 113 8% 0% 15
6 Chemistry, Multidisciplinary 44 13% 0% 24
7 Biochemical Research Methods 32 5% 0% 10
8 Chemistry, Analytical 24 6% 0% 12
9 Pharmacology & Pharmacy 22 9% 0% 17
10 Biophysics 6 3% 0% 6

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG DESIGN SYNTH 725188 10% 24% 19
2 MED ENZYME CHEM 160713 1% 100% 1
3 MSU BIOL MODELING 80355 1% 50% 1
4 SUB INORGAN ENVIRONM CHEM 58438 1% 18% 2
5 DRUG DESIGN SYNTHESIS 53570 1% 33% 1
6 MOL BIOSCI PROGRAM 32137 2% 7% 3
7 MARLENE STEWART GREENBAUM CANC 22164 1% 7% 2
8 MED PHARMACOL MIZUHO KU 20087 1% 13% 1
9 MED PATHOL 1 12853 1% 4% 2
10 TRANSLAT CORE 6179 1% 4% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES & NUCLEOTIDES 8688 3% 1% 6
2 ACTA PHARMACEUTICA JUGOSLAVICA 3505 2% 1% 3
3 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 3438 5% 0% 10
4 ENZYME 3402 2% 1% 4
5 KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII 2048 5% 0% 9
6 JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH 1443 2% 0% 3
7 RUSSIAN JOURNAL OF ORGANIC CHEMISTRY 1044 3% 0% 6
8 FARMACO 821 2% 0% 3
9 JOURNAL OF HETEROCYCLIC CHEMISTRY 716 4% 0% 7
10 PHARMACOLOGICAL RESEARCH COMMUNICATIONS 701 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GUANINE DEAMINASE 482133 3% 50% 6 Search GUANINE+DEAMINASE Search GUANINE+DEAMINASE
2 ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY 214282 1% 67% 2 Search ORGANIC+SYNTHESIS+AND+MEDICINAL+CHEMISTRY Search ORGANIC+SYNTHESIS+AND+MEDICINAL+CHEMISTRY
3 1 4 DIAZEPINE 2 5 DIONE 160713 1% 100% 1 Search 1+4+DIAZEPINE+2+5+DIONE Search 1+4+DIAZEPINE+2+5+DIONE
4 2 2 DICARBOXYLIC ACID ESTER 160713 1% 100% 1 Search 2+2+DICARBOXYLIC+ACID+ESTER Search 2+2+DICARBOXYLIC+ACID+ESTER
5 2 2 DISUBSTITUTION 160713 1% 100% 1 Search 2+2+DISUBSTITUTION Search 2+2+DISUBSTITUTION
6 2 CARBOXYHYPOXANTHINE 160713 1% 100% 1 Search 2+CARBOXYHYPOXANTHINE Search 2+CARBOXYHYPOXANTHINE
7 5 8 FUSED 160713 1% 100% 1 Search 5+8+FUSED Search 5+8+FUSED
8 ALKYLATION OF IMIDAZOLES 160713 1% 100% 1 Search ALKYLATION+OF+IMIDAZOLES Search ALKYLATION+OF+IMIDAZOLES
9 ANTIVIRAL ANTICANCER ACTIVITIES 160713 1% 100% 1 Search ANTIVIRAL+ANTICANCER+ACTIVITIES Search ANTIVIRAL+ANTICANCER+ACTIVITIES
10 AZEPINOMYCIN 160713 1% 100% 1 Search AZEPINOMYCIN Search AZEPINOMYCIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TANTRAVEDI, S , CHAKRABORTY, S , SHAH, NH , FISHBEIN, JC , HOSMANE, RS , (2013) ANALOGS OF ISO-AZEPINOMYCIN AS POTENTIAL TRANSITION-STATE ANALOG INHIBITORS OF GUANASE: SYNTHESIS, BIOCHEMICAL SCREENING, AND STRUCTURE-ACTIVITY CORRELATIONS OF VARIOUS SELECTIVELY SUBSTITUTED IMIDAZO[4,5-E][1,4]DIAZEPINES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 21. ISSUE 17. P. 4893 -4903 21 84% 2
2 BURNETT, FN , HOSMANE, RS , (1997) IMIDAZO[4,5-E][1,2,4]TRIAZOCINE: A NOVEL 5:8-FUSED RING SYSTEM RIDDLED WITH REARRANGEMENTS.HETEROCYCLES. VOL. 45. ISSUE 5. P. 857-861 23 96% 1
3 CHAKRABORTY, S , SHAH, NH , FISHBEIN, JC , HOSMANE, RS , (2011) A NOVEL TRANSITION STATE ANALOG INHIBITOR OF GUANASE BASED ON AZEPINOMYCIN RING STRUCTURE: SYNTHESIS AND BIOCHEMICAL ASSESSMENT OF ENZYME INHIBITION.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 21. ISSUE 2. P. 756-759 18 67% 6
4 UJJINAMATADA, RK , BHAN, A , HOSMANE, RS , (2006) DESIGN OF INHIBITORS AGAINST GUANASE: SYNTHESIS AND BIOCHEMICAL EVALUATION OF ANALOGUES OF AZEPINOMYCIN.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 16. ISSUE 21. P. 5551-5554 16 80% 6
5 WANG, LJ , BHAN, A , HOSMANE, RS , GUILES, RD , (1994) A SHORT SYNTHESIS OF A NOVEL RING-EXPANDED PURINE AND ITS NUCLEOSIDE ANALOG CONTAINING THE IMIDAZO[4,5-E][1,3]DIAZEPINE RING SKELETON WITH MULTIPLE AMINO SUBSTITUENTS ATTACHED TO THE 7-MEMBERED RING.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. VOL. 13. ISSUE 10. P. 2307-2320 17 89% 3
6 CHEN, HM , SOOD, R , HOSMANE, RS , (1999) AN EFFICIENT, SHORT SYNTHESIS AND POTENT ANTI-HEPATITIS B VIRAL ACTIVITY OF A NOVEL RING-EXPANDED PURINE NUCLEOSIDE ANALOGUE CONTAINING A 5 : 7-FUSED, PLANAR, AROMATIC, IMIDAZO [4,5-E][1,3]DIAZEPINE RING SYSTEM.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. VOL. 18. ISSUE 3. P. 331-335 15 83% 7
7 BHAN, A , HOSMANE, RS , ZHANG, HM , HOSMANE, NS , (1995) A UNIQUE DIAMINOMALONATE DERIVATIVE USEFUL FOR BUILDING NOVEL HETEROCYCLES.SYNTHETIC COMMUNICATIONS. VOL. 25. ISSUE 18. P. 2723-2737 15 94% 1
8 BURNETT, FN , HOSMANE, RS , (1995) SYNTHETIC APPROACHES TO 5/8-FUSED HETEROCYCLIC-SYSTEMS - A NOVEL REARRANGEMENT DURING THE SYNTHESIS OF IMIDAZO[4,5-E][L,2,4]TRIAZOCINE RING-SYSTEM.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. VOL. 14. ISSUE 3-5. P. 325-328 15 83% 0
9 CHAKRABORTY, S , SHAH, NH , FISHBEIN, JC , HOSMANE, RS , (2012) INVESTIGATIONS INTO SPECIFICITY OF AZEPINOMYCIN FOR INHIBITION OF GUANASE: DISCRIMINATION BETWEEN THE NATURAL HETEROCYCLIC INHIBITOR AND ITS SYNTHETIC NUCLEOSIDE ANALOGUES.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 22. ISSUE 23. P. 7214 -7218 12 60% 2
10 BURNETT, FN , HOSMANE, RS , (2002) SYNTHESIS OF A NOVEL RING-EXPANDED PURINE ANALOGUE CONTAINING A 5 : 8-FUSED IMIDAZO[4,5-E][1,2,4]TRIAZOCINE RING SYSTEM AMIDST OPPORTUNISTIC REARRANGEMENTS AND RING TRANSFORMATIONS.TETRAHEDRON. VOL. 58. ISSUE 47. P. 9567 -9578 13 62% 1

Classes with closest relation at Level 1


Rank Class id link
1 36009 ARXULA ADENINIVORANS//AUXOTROPHIC SELECTION MARKER//APHO1
2 26087 CYTIDINE DEAMINASE//ANTIBIOTIC FUNGICIDE//BLASTICIDIN S
3 31866 EHU MED FISIOL POB 699//RABBIT PARIETAL CELLS//ATP ATP ANALOGS
4 35981 ACID INDUCED INDOLE CYCLIZATION//22810 TAMAGAWA SETAGAYA KU//1 1 7 7 TETRAMETHOXY 4 HEPTANONE DERIVATIVE
5 5370 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
6 25415 PYRAZOLO1 5 A1 3 5TRIAZINE//5 AZAPURINE//PURINE ISOSTERE
7 24386 BENZODIAZEPINOOXAZOLE//DAYA DRUG DISCOVERIES INC//PHARMACEUT SCI 31 TANABE DORI MIZUHO KU
8 27638 1 4 PYRAZOLYL TRANSFER//IMIDAZO4 5 CPYRAZOLES//PYRAZOLO3 4 CISOTHIAZOLE
9 29931 DIPHENYLBORON CHELATES//BENZOYLCYANAMIDE//DIFLUOROBORON CHELATES
10 17445 AGELASINE//PL BIOL SAKYO KU//ASMARINE

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