Class information for:
Level 1: CATHEPSIN K//PYCNODYSOSTOSIS//CATHEPSIN K INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11865 948 37.6 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
427 3       JOURNAL OF THE INSTITUTE OF BREWING//KERATINASE//CYSTATIN 27946
1744 2             CATHEPSIN//CATHEPSIN K//CATHEPSIN B 6503
11865 1                   CATHEPSIN K//PYCNODYSOSTOSIS//CATHEPSIN K INHIBITOR 948

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CATHEPSIN K authKW 3862875 23% 56% 216
2 PYCNODYSOSTOSIS authKW 1400162 5% 91% 48
3 CATHEPSIN K INHIBITOR authKW 942088 4% 75% 39
4 ODANACATIB authKW 792180 4% 72% 34
5 CATHEPSIN authKW 429601 11% 12% 107
6 ONO 5334 authKW 354297 1% 100% 11
7 CATHEPSIN S INHIBITOR authKW 289879 1% 100% 9
8 PYKNODYSOSTOSIS authKW 229038 1% 89% 8
9 DISCOVERY COMPUTAT ANALYT STRUCT SCI address 225462 1% 100% 7
10 WORLD WIDE PHYS PROPERTIES address 206133 1% 80% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 3065 17% 0% 164
2 Endocrinology & Metabolism 1682 17% 0% 162
3 Chemistry, Organic 346 10% 0% 96
4 Biochemistry & Molecular Biology 317 19% 0% 181
5 Rheumatology 237 3% 0% 30
6 Dentistry, Oral Surgery & Medicine 150 4% 0% 35
7 Peripheral Vascular Diseases 150 4% 0% 42
8 Pharmacology & Pharmacy 133 9% 0% 90
9 Medicine, Research & Experimental 81 5% 0% 44
10 Cell Biology 64 6% 0% 60

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DISCOVERY COMPUTAT ANALYT STRUCT SCI 225462 1% 100% 7
2 WORLD WIDE PHYS PROPERTIES 206133 1% 80% 8
3 GENE EXP S PROT PURIFICAT 193253 1% 100% 6
4 SECT OXIDAT ST S INFLAMMAT 96626 0% 100% 3
5 CLIN DEV PLANNING 89464 1% 56% 5
6 PHYS STRUCT CHEM 70254 1% 18% 12
7 BONE CARTILAGE BIOL 66360 1% 16% 13
8 CLIN CELL BIOLLILLEBAELT HOSP 64418 0% 100% 2
9 LILLEBAELT VEJLE HOSP 64418 0% 100% 2
10 SHANGHAI ENDOCRINE METAB 64418 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BONE 12079 5% 1% 50
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7323 8% 0% 76
3 JOURNAL OF BONE AND MINERAL RESEARCH 6958 4% 1% 38
4 CALCIFIED TISSUE INTERNATIONAL 2382 2% 0% 19
5 JOURNAL OF MEDICINAL CHEMISTRY 1895 4% 0% 36
6 JOURNAL OF BONE AND MINERAL METABOLISM 1426 1% 1% 8
7 EXPERT OPINION ON THERAPEUTIC PATENTS 1157 1% 0% 9
8 BIOLOGICAL CHEMISTRY 800 1% 0% 9
9 CURRENT TOPICS IN MEDICINAL CHEMISTRY 684 1% 0% 7
10 CURRENT OSTEOPOROSIS REPORTS 522 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CATHEPSIN K 3862875 23% 56% 216 Search CATHEPSIN+K Search CATHEPSIN+K
2 PYCNODYSOSTOSIS 1400162 5% 91% 48 Search PYCNODYSOSTOSIS Search PYCNODYSOSTOSIS
3 CATHEPSIN K INHIBITOR 942088 4% 75% 39 Search CATHEPSIN+K+INHIBITOR Search CATHEPSIN+K+INHIBITOR
4 ODANACATIB 792180 4% 72% 34 Search ODANACATIB Search ODANACATIB
5 CATHEPSIN 429601 11% 12% 107 Search CATHEPSIN Search CATHEPSIN
6 ONO 5334 354297 1% 100% 11 Search ONO+5334 Search ONO+5334
7 CATHEPSIN S INHIBITOR 289879 1% 100% 9 Search CATHEPSIN+S+INHIBITOR Search CATHEPSIN+S+INHIBITOR
8 PYKNODYSOSTOSIS 229038 1% 89% 8 Search PYKNODYSOSTOSIS Search PYKNODYSOSTOSIS
9 DRYNARIAE RHIZOMA 134202 1% 83% 5 Search DRYNARIAE+RHIZOMA Search DRYNARIAE+RHIZOMA
10 CTSK 128831 1% 67% 6 Search CTSK Search CTSK

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BROMME, D , PANWAR, P , TURAN, S , (2016) CATHEPSIN K OSTEOPOROSIS TRIALS, PYCNODYSOSTOSIS AND MOUSE DEFICIENCY MODELS: COMMONALITIES AND DIFFERENCES.EXPERT OPINION ON DRUG DISCOVERY. VOL. 11. ISSUE 5. P. 457 -472 114 79% 0
2 COSTA, AG , CUSANO, NE , SILVA, BC , CREMERS, S , BILEZIKIAN, JP , (2011) CATHEPSIN K: ITS SKELETAL ACTIONS AND ROLE AS A THERAPEUTIC TARGET IN OSTEOPOROSIS.NATURE REVIEWS RHEUMATOLOGY. VOL. 7. ISSUE 8. P. 447 -456 67 84% 84
3 BROMME, D , LECAILLE, F , (2009) CATHEPSIN K INHIBITORS FOR OSTEOPOROSIS AND POTENTIAL OFF-TARGET EFFECTS.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 18. ISSUE 5. P. 585-600 89 72% 71
4 WEN, X , YI, LZ , LIU, F , WEI, JH , XUE, Y , (2016) THE ROLE OF CATHEPSIN K IN ORAL AND MAXILLOFACIAL DISORDERS.ORAL DISEASES. VOL. 22. ISSUE 2. P. 109 -115 64 80% 1
5 XUE, Y , CAI, T , SHI, ST , WANG, WG , ZHANG, YL , MAO, TQ , DUAN, XH , (2011) CLINICAL AND ANIMAL RESEARCH FINDINGS IN PYCNODYSOSTOSIS AND GENE MUTATIONS OF CATHEPSIN K FROM 1996 TO 2011.ORPHANET JOURNAL OF RARE DISEASES. VOL. 6. ISSUE . P. - 69 81% 23
6 NOVINEC, M , LENARCIC, B , (2013) CATHEPSIN K: A UNIQUE COLLAGENOLYTIC CYSTEINE PEPTIDASE.BIOLOGICAL CHEMISTRY. VOL. 394. ISSUE 9. P. 1163-1179 77 63% 25
7 DUONG, LT , LEUNG, AT , LANGDAHL, B , (2016) CATHEPSIN K INHIBITION: A NEW MECHANISM FOR THE TREATMENT OF OSTEOPOROSIS.CALCIFIED TISSUE INTERNATIONAL. VOL. 98. ISSUE 4. P. 381 -397 47 70% 6
8 KOMETANI, M , NONOMURA, K , TOMOO, T , NIWA, S , (2010) HURDLES IN THE DRUG DISCOVERY OF CATHEPSIN K INHIBITORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 7. P. 733-744 81 64% 9
9 MUKHERJEE, K , CHATTOPADHYAY, N , (2016) PHARMACOLOGICAL INHIBITION OF CATHEPSIN K: A PROMISING NOVEL APPROACH FOR POSTMENOPAUSAL OSTEOPOROSIS THERAPY.BIOCHEMICAL PHARMACOLOGY. VOL. 117. ISSUE . P. 10 -19 57 70% 1
10 LECAILLE, F , BROMME, D , LALMANACH, G , (2008) BIOCHEMICAL PROPERTIES AND REGULATION OF CATHEPSIN K ACTIVITY.BIOCHIMIE. VOL. 90. ISSUE 2. P. 208 -226 108 41% 68

Classes with closest relation at Level 1


Rank Class id link
1 752 CATHEPSIN B//CYSTATIN//CATHEPSIN L
2 27423 AP 1 C FOS//ASCORBATE INDUCED OSTEOBLASTIC DIFFERENTIATION//BIOL CHIM PROT BIOL INGN CARTILAGE
3 10505 OSTEOPETROSIS//CRANIOMETAPHYSEAL DYSPLASIA//CAMURATI ENGELMANN DISEASE
4 2847 OSTEOCLAST//BONE RESORPTION//OP OP MOUSE
5 1120 OSTEOCLAST//RANKL//OSTEOCLASTOGENESIS
6 24803 PAPILLON LEFEVRE SYNDROME//CATHEPSIN C//HAIM MUNK SYNDROME
7 31440 DRYNARIA FORTUNEI//DRYNARIA QUERCIFOLIA//BIOABSORBED BONE GRAFT
8 10701 PLASMEPSIN//CRUZIPAIN//FALCIPAIN
9 9336 SCLEROSTIN//SOST//LRP5
10 15484 PURPLE ACID PHOSPHATASE//TARTRATE RESISTANT ACID PHOSPHATASE//SPECIAL HEMATOL

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