Class information for:
Level 1: PLASMEPSIN//CRUZIPAIN//FALCIPAIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10701 1041 41.5 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
326 3       LEISHMANIA//TRYPANOSOMA CRUZI//PARASITIOLOGY 38360
108 2             TRYPANOSOMA CRUZI//CHAGAS DISEASE//PARASITIOLOGY 25255
10701 1                   PLASMEPSIN//CRUZIPAIN//FALCIPAIN 1041

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PLASMEPSIN authKW 1194051 5% 77% 53
2 CRUZIPAIN authKW 803009 5% 54% 51
3 FALCIPAIN authKW 750865 3% 80% 32
4 CRUZAIN authKW 733269 3% 83% 30
5 FALCIPAIN 2 authKW 509206 2% 69% 25
6 FALCIPAIN 2 INHIBITORS authKW 441691 2% 94% 16
7 RHODESAIN authKW 395194 2% 84% 16
8 PLASMEPSIN II authKW 326459 2% 70% 16
9 CHAGASIN authKW 215981 1% 82% 9
10 CYSTEINE PROTEASE authKW 176783 8% 7% 83

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Parasitiology 11771 20% 0% 213
2 Chemistry, Medicinal 7352 25% 0% 262
3 Biochemistry & Molecular Biology 2894 45% 0% 465
4 Tropical Medicine 555 4% 0% 38
5 Biophysics 385 8% 0% 83
6 Chemistry, Organic 385 10% 0% 106
7 Microbiology 318 9% 0% 90
8 Pharmacology & Pharmacy 219 11% 0% 114
9 Infectious Diseases 174 5% 0% 48
10 Cell Biology 43 5% 0% 57

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MALARIA BIOL 163213 2% 35% 16
2 SANDLER BASIC PARASIT DIS 148647 2% 24% 21
3 DIPARTMENTO SCI BIOCHIM A ROSSI FANELLI 87993 0% 100% 3
4 ESTUDIO PROTEINAS 78214 0% 67% 4
5 TECNOL FARMACOS FARMANGUINHOS 73681 1% 18% 14
6 BIOQUIM PROTEASES 73323 0% 50% 5
7 BIOL MOL DOENCAS ENDEM 72874 2% 16% 16
8 DRUG DISCOVERY BIOCHEM 58662 0% 100% 2
9 GRP QUIM MED IQSC USP 58662 0% 100% 2
10 INSERMEMI U 00 10 58662 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 34677 8% 1% 82
2 CHEMMEDCHEM 7340 2% 1% 24
3 EXPERIMENTAL PARASITOLOGY 5276 3% 1% 30
4 JOURNAL OF MEDICINAL CHEMISTRY 2959 5% 0% 47
5 BIOORGANIC & MEDICINAL CHEMISTRY 2877 3% 0% 36
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2402 4% 0% 46
7 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1356 2% 0% 21
8 PARASITOLOGY RESEARCH 1258 2% 0% 19
9 BIOLOGICAL CHEMISTRY 900 1% 0% 10
10 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 861 3% 0% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PLASMEPSIN 1194051 5% 77% 53 Search PLASMEPSIN Search PLASMEPSIN
2 CRUZIPAIN 803009 5% 54% 51 Search CRUZIPAIN Search CRUZIPAIN
3 FALCIPAIN 750865 3% 80% 32 Search FALCIPAIN Search FALCIPAIN
4 CRUZAIN 733269 3% 83% 30 Search CRUZAIN Search CRUZAIN
5 FALCIPAIN 2 509206 2% 69% 25 Search FALCIPAIN+2 Search FALCIPAIN+2
6 FALCIPAIN 2 INHIBITORS 441691 2% 94% 16 Search FALCIPAIN+2+INHIBITORS Search FALCIPAIN+2+INHIBITORS
7 RHODESAIN 395194 2% 84% 16 Search RHODESAIN Search RHODESAIN
8 PLASMEPSIN II 326459 2% 70% 16 Search PLASMEPSIN+II Search PLASMEPSIN+II
9 CHAGASIN 215981 1% 82% 9 Search CHAGASIN Search CHAGASIN
10 CYSTEINE PROTEASE 176783 8% 7% 83 Search CYSTEINE+PROTEASE Search CYSTEINE+PROTEASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WEGSCHEID-GERLACH, C , GERBER, HD , DIEDERICH, WE , (2010) PROTEASES OF PLASMODIUM FALCIPARUM AS POTENTIAL DRUG TARGETS AND INHIBITORS THEREOF.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 3. P. 346-367 119 71% 15
2 LIMA, APCA , REIS, FCG , COSTA, TFR , (2013) CYSTEINE PEPTIDASE INHIBITORS IN TRYPANOSOMATID PARASITES.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 25. P. 3152 -3173 110 64% 1
3 PEREZ, B , TEIXEIRA, C , GOMES, JRB , GOMES, P , (2013) DEVELOPMENT OF PLASMODIUM FALCIPARUM PROTEASE INHIBITORS IN THE PAST DECADE (2002-2012).CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 25. P. 3049 -3068 92 64% 11
4 ROSENTHAL, PJ , (2011) FALCIPAINS AND OTHER CYSTEINE PROTEASES OF MALARIA PARASITES.CYSTEINE PROTEASES OF PATHOGENIC ORGANISMS. VOL. 712. ISSUE . P. 30 -48 81 67% 59
5 MARCO, M , COTERON, JM , (2012) FALCIPAIN INHIBITION AS A PROMISING ANTIMALARIAL TARGET.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 12. ISSUE 5. P. 408 -444 77 71% 25
6 DAN, N , BHAKAT, S , (2015) NEW PARADIGM OF AN OLD TARGET: AN UPDATE ON STRUCTURAL BIOLOGY AND CURRENT PROGRESS IN DRUG DESIGN TOWARDS PLASMEPSIN II.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 95. ISSUE . P. 324 -348 60 81% 4
7 CAFFREY, CR , LIMA, AP , STEVERDING, D , (2011) CYSTEINE PEPTIDASES OF KINETOPLASTID PARASITES.CYSTEINE PROTEASES OF PATHOGENIC ORGANISMS. VOL. 712. ISSUE . P. 84 -99 81 67% 13
8 ERSMARK, K , SAMUELSSON, B , HALLBERG, A , (2006) PLASMEPSINS AS POTENTIAL TARGETS FOR NEW ANTIMALARIAL THERAPY.MEDICINAL RESEARCH REVIEWS. VOL. 26. ISSUE 5. P. 626-666 80 58% 100
9 CAZZULO, JJ , STOKA, V , TURK, V , (2001) THE MAJOR CYSTEINE PROTEINASE OF TRYPANOSOMA CRUZI: A VALID TARGET FOR CHEMOTHERAPY OF CHAGAS DISEASE.CURRENT PHARMACEUTICAL DESIGN. VOL. 7. ISSUE 12. P. 1143 -1156 72 77% 93
10 DUSCHAK, VG , COUTO, AS , (2009) CRUZIPAIN, THE MAJOR CYSTEINE PROTEASE OF TRYPANOSOMA CRUZI: A SULFATED GLYCOPROTEIN ANTIGEN AS RELEVANT CANDIDATE FOR VACCINE DEVELOPMENT AND DRUG TARGET. A REVIEW.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 24. P. 3174-3202 90 48% 34

Classes with closest relation at Level 1


Rank Class id link
1 6333 HEMOZOIN//BETA HEMATIN//4 AMINOQUINOLINE
2 9995 BENZNIDAZOLE//NIFURTIMOX//TRYPANOSOMA CRUZI
3 30746 METACASPASE//DYSKINETOPLASTIDY//WITS MALARIA MOL MED HAEMATOL
4 4372 LIPOPHOSPHOGLYCAN//GP63//LEISHMANIA
5 752 CATHEPSIN B//CYSTATIN//CATHEPSIN L
6 8266 TRANS SIALIDASE//TRYPANOSOMA CRUZI//METACYCLIC TRYPOMASTIGOTES
7 13541 NEW PERMEABILITY PATHWAYS//CHOLINE ANALOGUES//PFHT
8 8830 HOOKWORM//HAEMONCHUS CONTORTUS//ANCYLOSTOMA CANINUM
9 15980 PHYTOMONAS//TRYPANOSOMATIDAE//TRYPANOSOMATIDS
10 12529 APICOPLAST//MED MALARIA VENTURE//DIS DEV WORLD

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