Class information for:
Level 1: S ADENOSYLHOMOCYSTEINE HYDROLASE//S ADENOSYL L HOMOCYSTEINE HYDROLASE//3 DEAZAADENOSINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11426 982 31.5 51%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
502 3       HOMOCYSTEINE//FOLATE//FOLIC ACID 22046
254 2             HOMOCYSTEINE//FOLATE//FOLIC ACID 19695
11426 1                   S ADENOSYLHOMOCYSTEINE HYDROLASE//S ADENOSYL L HOMOCYSTEINE HYDROLASE//3 DEAZAADENOSINE 982

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 S ADENOSYLHOMOCYSTEINE HYDROLASE authKW 833707 5% 53% 51
2 S ADENOSYL L HOMOCYSTEINE HYDROLASE authKW 365499 2% 51% 23
3 3 DEAZAADENOSINE authKW 163568 1% 48% 11
4 PHOSPHOLIPID METHYLATION authKW 157403 1% 56% 9
5 AHCY authKW 129555 1% 83% 5
6 ADENOSINE ANALOGUES authKW 79589 1% 32% 8
7 ADOHCY HYDROLASE authKW 71068 0% 57% 4
8 2 FLUORONORARISTEROMYCIN authKW 62187 0% 100% 2
9 COFACTOR SITE TARGETING authKW 62187 0% 100% 2
10 CONFOCAL LSM authKW 62187 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3087 47% 0% 463
2 Biophysics 1669 16% 0% 154
3 Pharmacology & Pharmacy 500 15% 0% 151
4 Chemistry, Medicinal 255 5% 0% 54
5 Medicine, Research & Experimental 197 6% 0% 63
6 Cell Biology 113 8% 0% 74
7 Neurosciences 62 7% 0% 72
8 Biology 50 3% 0% 27
9 Immunology 37 5% 0% 48
10 Chemistry, Organic 36 4% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED PHYSIOL EXPTL CARDIOL SECT 62187 0% 100% 2
2 DIAZYME S 41457 0% 67% 2
3 328 HERITAGE MED BLDG 31094 0% 100% 1
4 730 WILLIAM AVE 31094 0% 100% 1
5 ARTMENT BIOPHYS BIOPHYS CHEM 31094 0% 100% 1
6 ARTMENT PHARMACOL MOL SCI 31094 0% 100% 1
7 CHILDRENS MED INVEST LIM 36 31094 0% 100% 1
8 CIRADENSAM 31094 0% 100% 1
9 CNRSUMR 6061IFR 140GFAS MED 31094 0% 100% 1
10 DIAZYME 31094 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHIMICA ET BIOPHYSICA ACTA 2981 5% 0% 53
2 BIOCHEMICAL PHARMACOLOGY 2254 4% 0% 37
3 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1283 1% 0% 14
4 EUROPEAN PAEDIATRIC HAEMATOLOGY AND ONCOLOGY 1001 0% 3% 1
5 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 850 2% 0% 22
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 790 4% 0% 43
7 JOURNAL OF ENZYME INHIBITION 780 0% 1% 3
8 MEMBRANE BIOCHEMISTRY 773 0% 1% 2
9 JOURNAL OF NEUROCHEMISTRY 753 2% 0% 23
10 JOURNAL OF MEDICINAL CHEMISTRY 729 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 S ADENOSYLHOMOCYSTEINE HYDROLASE 833707 5% 53% 51 Search S+ADENOSYLHOMOCYSTEINE+HYDROLASE Search S+ADENOSYLHOMOCYSTEINE+HYDROLASE
2 S ADENOSYL L HOMOCYSTEINE HYDROLASE 365499 2% 51% 23 Search S+ADENOSYL+L+HOMOCYSTEINE+HYDROLASE Search S+ADENOSYL+L+HOMOCYSTEINE+HYDROLASE
3 3 DEAZAADENOSINE 163568 1% 48% 11 Search 3+DEAZAADENOSINE Search 3+DEAZAADENOSINE
4 PHOSPHOLIPID METHYLATION 157403 1% 56% 9 Search PHOSPHOLIPID+METHYLATION Search PHOSPHOLIPID+METHYLATION
5 AHCY 129555 1% 83% 5 Search AHCY Search AHCY
6 ADENOSINE ANALOGUES 79589 1% 32% 8 Search ADENOSINE+ANALOGUES Search ADENOSINE+ANALOGUES
7 ADOHCY HYDROLASE 71068 0% 57% 4 Search ADOHCY+HYDROLASE Search ADOHCY+HYDROLASE
8 2 FLUORONORARISTEROMYCIN 62187 0% 100% 2 Search 2+FLUORONORARISTEROMYCIN Search 2+FLUORONORARISTEROMYCIN
9 COFACTOR SITE TARGETING 62187 0% 100% 2 Search COFACTOR+SITE+TARGETING Search COFACTOR+SITE+TARGETING
10 CONFOCAL LSM 62187 0% 100% 2 Search CONFOCAL+LSM Search CONFOCAL+LSM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CHIANG, PK , (1998) BIOLOGICAL EFFECTS OF INHIBITORS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE.PHARMACOLOGY & THERAPEUTICS. VOL. 77. ISSUE 2. P. 115 -134 82 57% 129
2 VANCE, DE , RIDGWAY, ND , (1988) THE METHYLATION OF PHOSPHATIDYLETHANOLAMINE.PROGRESS IN LIPID RESEARCH. VOL. 27. ISSUE 1. P. 61-79 58 64% 143
3 WNUK, SF , (2001) TARGETING "HYDROLYTIC" ACTIVITY OF THE S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 1. ISSUE 3. P. 307-316 38 68% 13
4 KUSAKABE, Y , ISHIHARA, M , UMEDA, T , KURODA, D , NAKANISHI, M , KITADE, Y , GOUDA, H , NAKAMURA, KT , TANAKA, N , (2015) STRUCTURAL INSIGHTS INTO THE REACTION MECHANISM OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE.SCIENTIFIC REPORTS. VOL. 5. ISSUE . P. - 29 60% 1
5 WNUK, SF , LEWANDOWSKA, E , SACASA, PR , CRAIN, LN , ZHANG, JS , BORCHARDT, RT , DE CLERCQ, E , (2004) STEREOSELECTIVE SYNTHESIS OF SUGAR-MODIFIED ENYNE ANALOGUES OF ADENOSINE AND URIDINE. INTERACTION WITH S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE AND ANTIVIRAL AND CYTOTOXIC EFFECTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 47. ISSUE 21. P. 5251 -5257 26 79% 11
6 CAI, SM , LI, QS , FANG, JW , BORCHARDT, RT , KUCZERA, K , MIDDAUGH, CR , SCHOWEN, RL , (2009) THE RATIONALE FOR TARGETING THE NAD/NADH COFACTOR BINDING SITE OF PARASITIC S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FOR THE DESIGN OF ANTI-PARASITIC DRUGS.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. VOL. 28. ISSUE 5-7. P. 485-503 23 74% 5
7 HORROCKS, LA , YEO, YK , HARDER, HW , MOZZI, R , GORACCI, G , (1986) CHOLINE PLASMALOGENS, GLYCEROPHOSPHOLIPID METHYLATION, AND RECEPTOR-MEDIATED ACTIVATION OF ADENYLATE-CYCLASE.ADVANCES IN CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH. VOL. 20. ISSUE . P. 263-292 62 65% 12
8 AULTRICHE, DB , YUAN, CS , BORCHARDT, RT , (1994) A SINGLE MUTATION AT LYSINE-426 OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE INACTIVATES THE ENZYME.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 269. ISSUE 50. P. 31472-31478 32 80% 27
9 KLOOR, D , HERMES, M , KIRSCHLER, J , MULLER, M , HAGEN, N , KALBACHER, H , STEVANOVIC, S , OSSWALD, H , (2009) DETERMINANTS FOR THE CAMP-BINDING SITE AT THE S-ADENOSYLHOMOCYSTEINE-HYDROLASE.NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. VOL. 380. ISSUE 3. P. 215 -222 20 80% 1
10 YUAN, CS , AULTRICHE, DB , BORCHARDT, RT , (1996) CHEMICAL MODIFICATION AND SITE-DIRECTED MUTAGENESIS OF CYSTEINE RESIDUES IN HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 271. ISSUE 45. P. 28009-28016 26 87% 30

Classes with closest relation at Level 1


Rank Class id link
1 26698 S ADENOSYLHOMOCYSTEINE//W CHINA PRECLIN FORENS MED SCI//BASIC CARDIOCEREBRAL VASC DIS
2 5617 CARBOCYCLIC NUCLEOSIDES//CARBANUCLEOSIDES//MOLETTE DRUG DISCOVERY
3 22214 MTAP//METHYLTHIOADENOSINE PHOSPHORYLASE//METHIONINE SALVAGE PATHWAY
4 7647 METHIONINE ADENOSYLTRANSFERASE//S ADENOSYLMETHIONINE//GLYCINE N METHYLTRANSFERASE
5 7688 CHOLINE KINASE//CYTIDYLYLTRANSFERASE//CTP PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE
6 11045 ISOASPARTATE//DEAMIDATION//PROTEIN L ISOASPARTYL METHYLTRANSFERASE
7 13094 POLYMETHYLENE ANALOGUES//TRICYCLIC ANALOGUES//ACYCLONUCLEOSIDES
8 8011 BETAINE//CHOLINE//CHOLINE DEFICIENCY
9 5370 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
10 14339 SPERMIDINE SYNTHASE//S ADENOSYLMETHIONINE DECARBOXYLASE//AMINOPROPYLTRANSFERASE

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