Class information for:
Level 1: METHIONINE ADENOSYLTRANSFERASE//S ADENOSYLMETHIONINE//GLYCINE N METHYLTRANSFERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7647 1343 36.5 66%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
502 3       HOMOCYSTEINE//FOLATE//FOLIC ACID 22046
254 2             HOMOCYSTEINE//FOLATE//FOLIC ACID 19695
7647 1                   METHIONINE ADENOSYLTRANSFERASE//S ADENOSYLMETHIONINE//GLYCINE N METHYLTRANSFERASE 1343

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METHIONINE ADENOSYLTRANSFERASE authKW 1168042 5% 76% 68
2 S ADENOSYLMETHIONINE authKW 1055524 14% 25% 187
3 GLYCINE N METHYLTRANSFERASE authKW 603852 2% 80% 33
4 S ADENOSYL L METHIONINE authKW 576234 6% 30% 85
5 S ADENOSYLMETHIONINE SYNTHETASE authKW 360731 2% 55% 29
6 HYPERMETHIONINEMIA authKW 262117 1% 82% 14
7 GNMT authKW 211607 1% 85% 11
8 SAME authKW 174860 1% 38% 20
9 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY authKW 113675 0% 100% 5
10 METHIONINE METABOLISM authKW 98624 1% 27% 16

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1570 31% 0% 415
2 Gastroenterology & Hepatology 1444 11% 0% 142
3 Pharmacology & Pharmacy 680 15% 0% 206
4 Nutrition & Dietetics 512 6% 0% 77
5 Substance Abuse 501 3% 0% 41
6 Biophysics 327 7% 0% 90
7 Medicine, Research & Experimental 317 7% 0% 92
8 Toxicology 214 5% 0% 61
9 Biotechnology & Applied Microbiology 107 5% 0% 71
10 Cell Biology 87 6% 0% 84

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SOUTHERN CALIF ALCOHOL PANCREAT DIS C 90940 0% 100% 4
2 HEPATOL TER IA GEN 74400 0% 55% 6
3 CIC BIOGUNE 70462 1% 16% 20
4 KECK MEDLIVER DIS 68205 0% 100% 3
5 MOL HEPATOL GRP 68205 0% 100% 3
6 HEPATOL GENE THER Y 67211 2% 11% 28
7 VA ALCOHOL 61881 1% 39% 7
8 USC UCLA ALCOHOL LIVER PANCREAT DIS 58455 0% 43% 6
9 GASTROINTESTINAL LIVER DIS 54978 2% 8% 32
10 GASTROENTEROL LIVER DIS LIVER DIS 51152 0% 75% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG INVESTIGATION 9432 1% 4% 11
2 HEPATOLOGY 5524 4% 0% 54
3 ALCOHOL 2502 1% 1% 17
4 CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 2059 2% 0% 21
5 JOURNAL OF NUTRITION 1718 2% 0% 32
6 JOURNAL OF HEPATOLOGY 1167 1% 0% 20
7 AMINO ACIDS 897 1% 0% 12
8 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 896 1% 0% 18
9 BIOCHEMICAL ARCHIVES 866 0% 1% 5
10 JOURNAL OF INHERITED METABOLIC DISEASE 826 1% 0% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 METHIONINE ADENOSYLTRANSFERASE 1168042 5% 76% 68 Search METHIONINE+ADENOSYLTRANSFERASE Search METHIONINE+ADENOSYLTRANSFERASE
2 S ADENOSYLMETHIONINE 1055524 14% 25% 187 Search S+ADENOSYLMETHIONINE Search S+ADENOSYLMETHIONINE
3 GLYCINE N METHYLTRANSFERASE 603852 2% 80% 33 Search GLYCINE+N+METHYLTRANSFERASE Search GLYCINE+N+METHYLTRANSFERASE
4 S ADENOSYL L METHIONINE 576234 6% 30% 85 Search S+ADENOSYL+L+METHIONINE Search S+ADENOSYL+L+METHIONINE
5 S ADENOSYLMETHIONINE SYNTHETASE 360731 2% 55% 29 Search S+ADENOSYLMETHIONINE+SYNTHETASE Search S+ADENOSYLMETHIONINE+SYNTHETASE
6 HYPERMETHIONINEMIA 262117 1% 82% 14 Search HYPERMETHIONINEMIA Search HYPERMETHIONINEMIA
7 GNMT 211607 1% 85% 11 Search GNMT Search GNMT
8 SAME 174860 1% 38% 20 Search SAME Search SAME
9 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY 113675 0% 100% 5 Search METHIONINE+ADENOSYLTRANSFERASE+DEFICIENCY Search METHIONINE+ADENOSYLTRANSFERASE+DEFICIENCY
10 METHIONINE METABOLISM 98624 1% 27% 16 Search METHIONINE+METABOLISM Search METHIONINE+METABOLISM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LU, SC , MATO, JM , (2012) S-ADENOSYLMETHIONINE IN LIVER HEALTH, INJURY, AND CANCER.PHYSIOLOGICAL REVIEWS. VOL. 92. ISSUE 4. P. 1515 -1542 120 50% 84
2 MARKHAM, GD , PAJARES, MA , (2009) STRUCTURE-FUNCTION RELATIONSHIPS IN METHIONINE ADENOSYLTRANSFERASES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 66. ISSUE 4. P. 636 -648 69 86% 46
3 MATO, JM , ALVAREZ, L , ORTIZ, P , PAJARES, MA , (1997) S-ADENOSYLMETHIONINE SYNTHESIS: MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS.PHARMACOLOGY & THERAPEUTICS. VOL. 73. ISSUE 3. P. 265 -280 78 64% 241
4 BARIC, I , STAUFNER, C , AUGOUSTIDES-SAVVOPOULOU, P , CHIEN, YH , DOBBELAERE, D , GRUNERT, SC , OPLADEN, T , RAMADZA, DP , RAKIC, B , WEDELL, A , ET AL (2017) CONSENSUS RECOMMENDATIONS FOR THE DIAGNOSIS, TREATMENT AND FOLLOW-UP OF INHERITED METHYLATION DISORDERS.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 40. ISSUE 1. P. 5 -20 35 67% 1
5 ANSTEE, QM , DAY, CP , (2012) S-ADENOSYLMETHIONINE (SAME) THERAPY IN LIVER DISEASE: A REVIEW OF CURRENT EVIDENCE AND CLINICAL UTILITY.JOURNAL OF HEPATOLOGY. VOL. 57. ISSUE 5. P. 1097 -1109 58 58% 44
6 PUROHIT, V , ABDELMALEK, MF , BARVE, S , BENEVENGA, NJ , HALSTED, CH , KAPLOWITZ, N , KHARBANDA, KK , LIU, QY , LU, SC , MCCLAIN, CJ , ET AL (2007) ROLE OF S-ADENOSYLMETHIONINE, FOLATE, AND BETAINE IN THE TREATMENT OF ALCOHOLIC LIVER DISEASE: SUMMARY OF A SYMPOSIUM.AMERICAN JOURNAL OF CLINICAL NUTRITION. VOL. 86. ISSUE 1. P. 14-24 54 67% 70
7 CEDERBAUM, AI , (2010) HEPATOPROTECTIVE EFFECTS OF S-ADENOSYL-L-METHIONINE AGAINST ALCOHOL- AND CYTOCHROME P450 2E1-INDUCED LIVER INJURY.WORLD JOURNAL OF GASTROENTEROLOGY. VOL. 16. ISSUE 11. P. 1366 -1376 57 59% 34
8 FRAU, M , FEO, F , PASCALE, RM , (2013) PLEIOTROPIC EFFECTS OF METHIONINE ADENOSYLTRANSFERASES DEREGULATION AS DETERMINANTS OF LIVER CANCER PROGRESSION AND PROGNOSIS.JOURNAL OF HEPATOLOGY. VOL. 59. ISSUE 4. P. 830-841 59 53% 17
9 CHU, J , QIAN, JC , ZHUANG, YP , ZHANG, SL , LI, YR , (2013) PROGRESS IN THE RESEARCH OF S-ADENOSYL-L-METHIONINE PRODUCTION.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. VOL. 97. ISSUE 1. P. 41-49 41 76% 16
10 CHIEN, YH , ABDENUR, JE , BARONIO, F , BANNICK, AA , CORRALES, F , COUCE, M , DONNER, MG , FICICIOGLU, C , FREEHAUF, C , FRITHIOF, D , ET AL (2015) MUDD'S DISEASE (MAT I/III DEFICIENCY): A SURVEY OF DATA FOR MAT1A HOMOZYGOTES AND COMPOUND HETEROZYGOTES.ORPHANET JOURNAL OF RARE DISEASES. VOL. 10. ISSUE . P. - 42 76% 1

Classes with closest relation at Level 1


Rank Class id link
1 26698 S ADENOSYLHOMOCYSTEINE//W CHINA PRECLIN FORENS MED SCI//BASIC CARDIOCEREBRAL VASC DIS
2 11426 S ADENOSYLHOMOCYSTEINE HYDROLASE//S ADENOSYL L HOMOCYSTEINE HYDROLASE//3 DEAZAADENOSINE
3 8011 BETAINE//CHOLINE//CHOLINE DEFICIENCY
4 37481 SARCOSINE//SARCOSINE IN URINE//SERUM SARCOSINE
5 22214 MTAP//METHYLTHIOADENOSINE PHOSPHORYLASE//METHIONINE SALVAGE PATHWAY
6 21832 HOMOCYSTINURIA//CYSTATHIONINE BETA SYNTHASE//CYSTATHIONINE BETA SYNTHASE DEFICIENCY
7 36693 ATYPICAL ACINAR CELL NODULES//BIOMARKER DISCOVERY VALIDAT//LONG CHAIN FATTY ACID COLORECTAL CANCER
8 17681 FOLATE//L METHYLFOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE GENE MTHFR
9 2233 ALCOHOLIC LIVER DISEASE//HEPATOBIOL TOXICOL//CYP2E1
10 19331 METHIONINE BIOSYNTHESIS//COBALAMIN INDEPENDENT//METHIONINE REPRESSOR

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