Class information for:
Level 1: CARBONYL REDUCTASE//ALDO KETO REDUCTASE//DIHYDRODIOL DEHYDROGENASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10359 1070 34.9 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
159 3       MENOPAUSE//ISOFLAVONES//TAMOXIFEN 61134
1407 2             2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE 8029
10359 1                   CARBONYL REDUCTASE//ALDO KETO REDUCTASE//DIHYDRODIOL DEHYDROGENASE 1070

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARBONYL REDUCTASE authKW 885945 7% 39% 79
2 ALDO KETO REDUCTASE authKW 776494 9% 30% 92
3 DIHYDRODIOL DEHYDROGENASE authKW 673199 3% 69% 34
4 20 ALPHA HYDROXYSTEROID DEHYDROGENASE authKW 406205 2% 65% 22
5 AKR1C3 authKW 306917 2% 51% 21
6 EXCELLENCE ENVIRONM TOXICOL address 298560 4% 24% 44
7 ORACIN authKW 283677 1% 76% 13
8 3 ALPHA HYDROXYSTEROID DEHYDROGENASE authKW 251166 2% 35% 25
9 CARBONYL REDUCTASE 1 authKW 215798 1% 69% 11
10 ALDO KETO REDUCTASE FAMILY authKW 182628 1% 80% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3448 48% 0% 510
2 Pharmacology & Pharmacy 2578 30% 0% 320
3 Biophysics 969 12% 0% 126
4 Toxicology 864 9% 0% 98
5 Endocrinology & Metabolism 861 12% 0% 128
6 Chemistry, Medicinal 314 6% 0% 62
7 Reproductive Biology 132 3% 0% 27
8 Oncology 122 8% 0% 82
9 Cell Biology 103 7% 0% 76
10 Biochemical Research Methods 22 3% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXCELLENCE ENVIRONM TOXICOL 298560 4% 24% 44
2 TOXICOL PHARMACOL NAT SCIENTISTS 72615 1% 18% 14
3 TOXICOL PHARMACOL NAT SCI 64849 0% 45% 5
4 BIOMOL PHARMACEUT CHEM 64199 1% 38% 6
5 EXPT PATHOL MED BIOTECHNOL 50726 0% 44% 4
6 BIOCHEM MOL TOXICOL MED 38047 0% 67% 2
7 CHEM MOL TOXICOL MED 38047 0% 67% 2
8 PHARMACOL MOL TOXICOL MED 38047 0% 67% 2
9 VICTORIAN PHARM 37097 3% 5% 27
10 BIOCHEM 61 MITAHORA HIGASHI 5 CHOME 28536 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMICO-BIOLOGICAL INTERACTIONS 15226 5% 1% 55
2 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 6362 4% 1% 45
3 BIOLOGICAL & PHARMACEUTICAL BULLETIN 4021 3% 0% 35
4 JOURNAL OF BIOCHEMISTRY 3593 3% 0% 37
5 BIOCHEMICAL PHARMACOLOGY 1736 3% 0% 34
6 BIOCHEMICAL JOURNAL 1508 4% 0% 40
7 DRUG METABOLISM AND DISPOSITION 1488 2% 0% 20
8 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 1377 1% 0% 16
9 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1273 3% 0% 28
10 XENOBIOTICA 873 1% 0% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CARBONYL REDUCTASE 885945 7% 39% 79 Search CARBONYL+REDUCTASE Search CARBONYL+REDUCTASE
2 ALDO KETO REDUCTASE 776494 9% 30% 92 Search ALDO+KETO+REDUCTASE Search ALDO+KETO+REDUCTASE
3 DIHYDRODIOL DEHYDROGENASE 673199 3% 69% 34 Search DIHYDRODIOL+DEHYDROGENASE Search DIHYDRODIOL+DEHYDROGENASE
4 20 ALPHA HYDROXYSTEROID DEHYDROGENASE 406205 2% 65% 22 Search 20+ALPHA+HYDROXYSTEROID+DEHYDROGENASE Search 20+ALPHA+HYDROXYSTEROID+DEHYDROGENASE
5 AKR1C3 306917 2% 51% 21 Search AKR1C3 Search AKR1C3
6 ORACIN 283677 1% 76% 13 Search ORACIN Search ORACIN
7 3 ALPHA HYDROXYSTEROID DEHYDROGENASE 251166 2% 35% 25 Search 3+ALPHA+HYDROXYSTEROID+DEHYDROGENASE Search 3+ALPHA+HYDROXYSTEROID+DEHYDROGENASE
8 CARBONYL REDUCTASE 1 215798 1% 69% 11 Search CARBONYL+REDUCTASE+1 Search CARBONYL+REDUCTASE+1
9 ALDO KETO REDUCTASE FAMILY 182628 1% 80% 8 Search ALDO+KETO+REDUCTASE+FAMILY Search ALDO+KETO+REDUCTASE+FAMILY
10 ACETOHEXAMIDE REDUCTASE ACTIVITY 171217 1% 100% 6 Search ACETOHEXAMIDE+REDUCTASE+ACTIVITY Search ACETOHEXAMIDE+REDUCTASE+ACTIVITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MATSUNAGA, T , SHINTANI, S , HARA, A , (2006) MULTIPLICITY OF MAMMALIAN REDUCTASES FOR XENOBIOTIC CARBONYL COMPOUNDS.DRUG METABOLISM AND PHARMACOKINETICS. VOL. 21. ISSUE 1. P. 1 -18 87 64% 76
2 HOFFMANN, F , MASER, E , (2007) CARBONYL REDUCTASES AND PLURIPOTENT HYDROXYSTEROID DEHYDROGENASES OF THE SHORTCHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY.DRUG METABOLISM REVIEWS. VOL. 39. ISSUE 1. P. 87 -144 101 40% 98
3 FORREST, GL , GONZALEZ, B , (2000) CARBONYL REDUCTASE.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 129. ISSUE 1-2. P. 21-40 64 57% 158
4 PENNING, TM , CHEN, M , JIN, Y , (2015) PROMISCUITY AND DIVERSITY IN 3-KETOSTEROID REDUCTASES.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 151. ISSUE . P. 93 -101 35 76% 3
5 BROZIC, P , TURK, S , RIZNER, TL , GOBEC, S , (2011) INHIBITORS OF ALDO-KETO REDUCTASES AKR1C1-AKR1C4.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 17. P. 2554-2565 41 69% 17
6 MASER, E , (1995) XENOBIOTIC CARBONYL REDUCTION AND PHYSIOLOGICAL STEROID OXIDOREDUCTION - THE PLURIPOTENCY OF SEVERAL HYDROXYSTEROID DEHYDROGENASES.BIOCHEMICAL PHARMACOLOGY. VOL. 49. ISSUE 4. P. 421-440 83 50% 104
7 MALATKOVA, P , MASER, E , WSOL, V , (2010) HUMAN CARBONYL REDUCTASES.CURRENT DRUG METABOLISM. VOL. 11. ISSUE 8. P. 639 -658 60 43% 22
8 MIURA, T , NISHINAKA, T , TERADA, T , (2009) IMPORTANCE OF THE SUBSTRATE-BINDING LOOP REGION OF HUMAN MONOMERIC CARBONYL REDUCTASES IN CATALYSIS AND COENZYME BINDING.LIFE SCIENCES. VOL. 85. ISSUE 7-8. P. 303 -308 32 84% 3
9 ZHANG, B , ZHU, DW , HU, XJ , ZHOU, M , SHANG, P , LIN, SX , (2014) HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 (3 ALPHA-HSD3): THE V54L MUTATION RESTRICTING THE STEROID ALTERNATIVE BINDING AND ENHANCING THE 20 ALPHA-HSD ACTIVITY.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 141. ISSUE . P. 135 -143 29 73% 5
10 SKARYDOVA, L , HOFMAN, J , CHLEBEK, J , HAVRANKOVA, J , KOSANOVA, K , SKARKA, A , HOSTALKOVA, A , PLUCHA, T , CAHLIKOVA, L , WSOL, V , (2014) ISOQUINOLINE ALKALOIDS AS A NOVEL TYPE OF AKR1C3 INHIBITORS.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 143. ISSUE . P. 250 -258 32 67% 3

Classes with closest relation at Level 1


Rank Class id link
1 13102 17 BETA HYDROXYSTEROID DEHYDROGENASE//17 BETA HSD2//17 BETA HSD1
2 2952 ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//AKR1B10
3 25991 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE//15 PGDH//15 HYDROXYPROSTAGLANDIN DEHYDROGENASE 15 PGDH
4 34043 LOXOPROFEN//CS 670//PELUBIPROFEN
5 24408 3 BETA HYDROXYSTEROID DEHYDROGENASE//HSD3B2 GENE//SHORT CHAIN OXIDOREDUCTASE
6 26290 ANTIOXIDASE//MORPHINONE//AVE TONY GARNIER
7 32091 1 4 PERHYDROTHIAZINES//THIODIGLYCOL//2 METHOXYPHENYLMETYRAPONE
8 23258 7 ALPHA DEHYDROXYLATION//7 ALPHA HYDROXYSTEROID DEHYDROGENASE//CLOSTRIDIUM SCINDENS
9 36100 SALICYLIDENEAMINO 2 THIOPHENOL//ALPHA AMINOPHENYL CEPHALOPSORINS//APO 27 MONOCLONAL ANTIBODY
10 30744 DIACETYL//FLAVORINGS//BUTTER FLAVORINGS

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