Class information for:
Level 1: ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//AKR1B10

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2952 2104 36.7 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
14 4 ORTHOPEDICS//DENTISTRY, ORAL SURGERY & MEDICINE//SPORT SCIENCES 808941
444 3       CARPAL TUNNEL SYNDROME//MEDIAN NERVE//ALDOSE REDUCTASE 26401
2198 2             ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//DIABETIC NEUROPATHY 4878
2952 1                   ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//AKR1B10 2104

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALDOSE REDUCTASE authKW 3430570 20% 57% 418
2 ALDOSE REDUCTASE INHIBITOR authKW 1556414 9% 57% 187
3 AKR1B10 authKW 662159 2% 89% 51
4 POLYOL PATHWAY authKW 625367 4% 46% 94
5 ALDO KETO REDUCTASE authKW 494877 5% 33% 103
6 OCULAR THER EUT address 302236 1% 77% 27
7 ALDEHYDE REDUCTASE authKW 188019 2% 36% 36
8 ALDO KETO REDUCTASE 1B10 authKW 145112 0% 100% 10
9 EPALRESTAT authKW 112573 1% 52% 15
10 SORBITOL DEHYDROGENASE authKW 107224 1% 24% 31

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 5184 15% 0% 320
2 Ophthalmology 3453 11% 0% 240
3 Endocrinology & Metabolism 3116 16% 0% 331
4 Biochemistry & Molecular Biology 2486 31% 0% 653
5 Pharmacology & Pharmacy 2140 20% 0% 431
6 Biophysics 615 7% 0% 152
7 Toxicology 235 4% 0% 83
8 Integrative & Complementary Medicine 117 1% 0% 22
9 Medicine, Research & Experimental 54 3% 0% 66
10 Chemistry, Organic 46 4% 0% 82

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OCULAR THER EUT 302236 1% 77% 27
2 IGBMCUPR BIOL STRUCT 72556 0% 100% 5
3 SIMMONSCOOPER CANC 42204 0% 36% 8
4 JEWISH CARDIOVASC 36273 0% 50% 5
5 HARRY B AILEEN GORDON DIABET 33165 0% 57% 4
6 ABORAT POSTDOCTORAL MOBILE STN 29022 0% 100% 2
7 DIPARTIMENTO FISIOL BIOQUIM 29022 0% 100% 2
8 FISIOL BIOCHIM 29022 0% 100% 2
9 MOL DIABET METAB SECT 25906 0% 36% 5
10 MED MICROBIOL IMMUNOL CELL BIOL 25422 1% 9% 20

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPERIMENTAL EYE RESEARCH 9288 3% 1% 65
2 CHEMICO-BIOLOGICAL INTERACTIONS 7411 3% 1% 54
3 DIABETES 4863 3% 1% 64
4 JOURNAL OF DIABETES AND ITS COMPLICATIONS 4222 1% 1% 23
5 DIABETES RESEARCH AND CLINICAL PRACTICE 2755 2% 1% 32
6 JOURNAL OF MEDICINAL CHEMISTRY 2588 3% 0% 63
7 OPHTHALMIC RESEARCH 2451 1% 1% 19
8 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2268 3% 0% 56
9 METABOLISM-CLINICAL AND EXPERIMENTAL 2185 2% 0% 37
10 CURRENT EYE RESEARCH 2072 1% 1% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ALDOSE REDUCTASE 3430570 20% 57% 418 Search ALDOSE+REDUCTASE Search ALDOSE+REDUCTASE
2 ALDOSE REDUCTASE INHIBITOR 1556414 9% 57% 187 Search ALDOSE+REDUCTASE+INHIBITOR Search ALDOSE+REDUCTASE+INHIBITOR
3 AKR1B10 662159 2% 89% 51 Search AKR1B10 Search AKR1B10
4 POLYOL PATHWAY 625367 4% 46% 94 Search POLYOL+PATHWAY Search POLYOL+PATHWAY
5 ALDO KETO REDUCTASE 494877 5% 33% 103 Search ALDO+KETO+REDUCTASE Search ALDO+KETO+REDUCTASE
6 ALDEHYDE REDUCTASE 188019 2% 36% 36 Search ALDEHYDE+REDUCTASE Search ALDEHYDE+REDUCTASE
7 ALDO KETO REDUCTASE 1B10 145112 0% 100% 10 Search ALDO+KETO+REDUCTASE+1B10 Search ALDO+KETO+REDUCTASE+1B10
8 EPALRESTAT 112573 1% 52% 15 Search EPALRESTAT Search EPALRESTAT
9 SORBITOL DEHYDROGENASE 107224 1% 24% 31 Search SORBITOL+DEHYDROGENASE Search SORBITOL+DEHYDROGENASE
10 DIABETIC COMPLICATIONS 106739 4% 10% 77 Search DIABETIC+COMPLICATIONS Search DIABETIC+COMPLICATIONS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GREWAL, AS , BHARDWAJ, S , PANDITA, D , LATHER, V , SEKHON, BS , (2016) UPDATES ON ALDOSE REDUCTASE INHIBITORS FOR MANAGEMENT OF DIABETIC COMPLICATIONS AND NON-DIABETIC DISEASES.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 2. P. 120 -162 201 67% 2
2 MACCARI, R , OTTANA, R , (2015) TARGETING ALDOSE REDUCTASE FOR THE TREATMENT OF DIABETES COMPLICATIONS AND INFLAMMATORY DISEASES: NEW INSIGHTS AND FUTURE DIRECTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 5. P. 2047 -2067 132 86% 13
3 DEL CORSO, A , CAPPIELLO, M , MURA, U , (2008) FROM A DULL ENZYME TO SOMETHING ELSE: FACTS AND PERSPECTIVES REGARDING ALDOSE REDUCTASE.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 15. P. 1452-1461 133 73% 28
4 HUANG, L , HE, RZ , LUO, WH , ZHU, YS , LI, J , TAN, T , ZHANG, X , HU, Z , LUO, DX , (2016) ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 INHIBITORS: POTENTIAL DRUGS FOR CANCER TREATMENT.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 11. ISSUE 2. P. 184 -196 80 76% 2
5 PETRASH, JM , (2004) ALL IN THE FAMILY: ALDOSE REDUCTASE AND CLOSELY RELATED ALDO-KETO REDUCTASES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 61. ISSUE 7-8. P. 737-749 90 88% 100
6 RAMASAMY, R , GOLDBERG, IJ , (2010) ALDOSE REDUCTASE AND CARDIOVASCULAR DISEASES, CREATING HUMAN-LIKE DIABETIC COMPLICATIONS IN AN EXPERIMENTAL MODEL.CIRCULATION RESEARCH. VOL. 106. ISSUE 9. P. 1449-1458 83 70% 44
7 KADOR, PF , WYMAN, M , OATES, PJ , (2016) ALDOSE REDUCTASE, OCULAR DIABETIC COMPLICATIONS AND THE DEVELOPMENT OF TOPICAL KINOSTAT (R).PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 54. ISSUE . P. 1 -29 94 51% 2
8 CRABBE, MJC , GOODE, D , (1998) ALDOSE REDUCTASE: A WINDOW TO THE TREATMENT OF DIABETIC COMPLICATIONS?.PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 17. ISSUE 3. P. 313 -383 136 59% 56
9 SUZEN, S , BUYUKBINGOL, E , (2003) RECENT STUDIES OF ALDOSE REDUCTASE ENZYME INHIBITION FOR DIABETIC COMPLICATIONS.CURRENT MEDICINAL CHEMISTRY. VOL. 10. ISSUE 15. P. 1329-1352 84 72% 87
10 ALEXIOU, P , PEGKLIDOU, K , CHATZOPOULOU, M , NICOLAOU, I , DEMOPOULOS, VJ , (2009) ALDOSE REDUCTASE ENZYME AND ITS IMPLICATION TO MAJOR HEALTH PROBLEMS OF THE 21(ST) CENTURY.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 6. P. 734-752 85 56% 82

Classes with closest relation at Level 1


Rank Class id link
1 10359 CARBONYL REDUCTASE//ALDO KETO REDUCTASE//DIHYDRODIOL DEHYDROGENASE
2 2099 DIABETIC NEUROPATHY//NERVE BLOOD FLOW//VASA NERVORUM
3 12936 HYPERTONICITY//NFAT5//ORGANIC OSMOLYTES
4 23186 CORNEAL AUTOFLUORESCENCE//DIABETIC CORNEA//DIABETIC KERATOPATHY
5 18494 RUBOXISTAURIN//LY333531//PKC BETA II INHIBITORS
6 35532 BENDAZAC//BOVINE EARS//ANTI DENATURANT AGENTS
7 28674 SUGAR CATARACT//P 31 MRS IN VITRO//PERDEUTERATED LIPIDS
8 34694 TRANSFUSION GELATIN//BALLISTOCONIDIA//CELL IRON DISTRIBUTION
9 1851 CATARACT//AGE RELATED CATARACT//AUSTRALIAN CATARACT FDN
10 4577 DIABETIC RETINOPATHY//K GE EYE//OPHTHALMOL

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