Work package 3 - Downstream processing for biologics and gene therapy
The technology previously developed in AdBioPro for downstream processing of biologics, particularly for antibodies, will be adapted and further developed for gene therapy. The work package is focused of adeno-associated virus, AAV, and lenti virus, LV and the work has two tasks;
- Purification of AAV: The aim is to develop and optimize an integrated downstream process for AAV purification. Novel technology based on polymer brush is also studied.
- Novel ligand for LV capture: The aim is to develop a novel ligand for interaction with the surface of lenti virus.
Academic Team
Prof. Bernt Nilsson (PI), Division of Chemical Engineering, LU
Prof. Sophia Hober (PI), Division of Protein Technology, KTH
Dr. Gustav Ferrand-Drake del Castillo, Nyctea
Julius Lorek (PhD student), Division of Chemical Engineering, LU
Oscar Friberg (PhD student), Division of Protein Technology, KTH
Industrial Partners
Cytiva
Nyctea
Valneva