Class information for:
Level 2: PHENYLKETONURIA//PHENYLALANINE HYDROXYLASE//PKU

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2411 4184 34.0 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
124 3       PARKINSONS DISEASE//MOVEMENT DISORDERS//DEEP BRAIN STIMULATION 67777
2411 2             PHENYLKETONURIA//PHENYLALANINE HYDROXYLASE//PKU 4184
2133 1                   PHENYLKETONURIA//PKU//HYPERPHENYLALANINEMIA 2346
9156 1                   PHENYLALANINE HYDROXYLASE//AROMATIC AMINO ACID HYDROXYLASE//TRYPTOPHAN HYDROXYLASE 1182
16385 1                   PHENYLETHANOLAMINE N METHYLTRANSFERASE//TYROSINE HYDROXYLASE//PNMT 656

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHENYLKETONURIA authKW 4286734 18% 77% 765
2 PHENYLALANINE HYDROXYLASE authKW 1072463 5% 78% 189
3 PKU authKW 879574 3% 84% 144
4 HYPERPHENYLALANINEMIA authKW 721590 3% 73% 136
5 MATERNAL PHENYLKETONURIA authKW 277948 1% 95% 40
6 SAPROPTERIN authKW 273833 1% 89% 42
7 TYROSINE HYDROXYLASE authKW 258693 8% 10% 345
8 PHENYLALANINE authKW 215776 4% 17% 176
9 JOURNAL OF INHERITED METABOLIC DISEASE journal 161909 8% 7% 317
10 TETRAHYDROBIOPTERIN authKW 151183 3% 16% 131

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Genetics & Heredity 11927 23% 0% 961
2 Endocrinology & Metabolism 6741 16% 0% 684
3 Medicine, Research & Experimental 6672 16% 0% 658
4 Neurosciences 5005 22% 0% 915
5 Pediatrics 4437 12% 0% 503
6 Biochemistry & Molecular Biology 4157 29% 0% 1210
7 Nutrition & Dietetics 590 4% 0% 157
8 Biophysics 297 4% 0% 175
9 Medical Laboratory Technology 154 1% 0% 53
10 Education, Special 133 1% 0% 28

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIDAD ENFERMENDADES METAB 72962 0% 100% 10
2 DEBELLE 55171 0% 69% 11
3 PKU FOLLOW UP UNIT 51074 0% 100% 7
4 PSYCHIAT MOL DEV NEUROBIOL 51074 0% 100% 7
5 UNIT DIAG TREATMENT CONGENITAL METAB DIS 42208 0% 64% 9
6 SECT METAB DIS 37437 1% 22% 23
7 PKU CLIN 36481 0% 100% 5
8 BEATRIX CHILDRENS HOSP 32494 2% 7% 63
9 PKU 30597 0% 26% 16
10 PKU PROGRAM 30399 0% 83% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF INHERITED METABOLIC DISEASE 161909 8% 7% 317
2 MOLECULAR GENETICS AND METABOLISM 103955 5% 7% 211
3 JOURNAL OF NEUROCHEMISTRY 17017 5% 1% 222
4 EUROPEAN JOURNAL OF PEDIATRICS 10073 2% 1% 102
5 MOLECULAR BRAIN RESEARCH 7376 2% 2% 68
6 SCREENING 4019 0% 14% 4
7 HUMAN MUTATION 3981 1% 1% 47
8 PTERIDINES 3027 0% 3% 13
9 ACTA PAEDIATRICA 2938 1% 1% 58
10 HUMAN GENETICS 2778 1% 1% 56

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHENYLKETONURIA 4286734 18% 77% 765 Search PHENYLKETONURIA Search PHENYLKETONURIA
2 PHENYLALANINE HYDROXYLASE 1072463 5% 78% 189 Search PHENYLALANINE+HYDROXYLASE Search PHENYLALANINE+HYDROXYLASE
3 PKU 879574 3% 84% 144 Search PKU Search PKU
4 HYPERPHENYLALANINEMIA 721590 3% 73% 136 Search HYPERPHENYLALANINEMIA Search HYPERPHENYLALANINEMIA
5 MATERNAL PHENYLKETONURIA 277948 1% 95% 40 Search MATERNAL+PHENYLKETONURIA Search MATERNAL+PHENYLKETONURIA
6 SAPROPTERIN 273833 1% 89% 42 Search SAPROPTERIN Search SAPROPTERIN
7 TYROSINE HYDROXYLASE 258693 8% 10% 345 Search TYROSINE+HYDROXYLASE Search TYROSINE+HYDROXYLASE
8 PHENYLALANINE 215776 4% 17% 176 Search PHENYLALANINE Search PHENYLALANINE
9 TETRAHYDROBIOPTERIN 151183 3% 16% 131 Search TETRAHYDROBIOPTERIN Search TETRAHYDROBIOPTERIN
10 PHENYLKETONURIA PKU 139693 1% 64% 30 Search PHENYLKETONURIA+PKU Search PHENYLKETONURIA+PKU

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CAMP, KM , PARISI, MA , ACOSTA, PB , BERRY, GT , BILDER, DA , BLAU, N , BODAMER, OA , BROSCO, JP , BROWN, CS , BURLINA, AB , ET AL (2014) PHENYLKETONURIA SCIENTIFIC REVIEW CONFERENCE: STATE OF THE SCIENCE AND FUTURE RESEARCH NEEDS.MOLECULAR GENETICS AND METABOLISM. VOL. 112. ISSUE 2. P. 87 -122 239 87% 24
2 TEKIN, I , ROSKOSKI, R , CARKACI-SALLI, N , VRANA, KE , (2014) COMPLEX MOLECULAR REGULATION OF TYROSINE HYDROXYLASE.JOURNAL OF NEURAL TRANSMISSION. VOL. 121. ISSUE 12. P. 1451 -1481 203 74% 8
3 ENNS, GM , KOCH, R , BRUMM, V , BLAKELY, E , SUTER, R , JURECKI, E , (2010) SUBOPTIMAL OUTCOMES IN PATIENTS WITH PKU TREATED EARLY WITH DIET ALONE: REVISITING THE EVIDENCE.MOLECULAR GENETICS AND METABOLISM. VOL. 101. ISSUE 2-3. P. 99-109 147 94% 45
4 KUMER, SC , VRANA, KE , (1996) INTRICATE REGULATION OF TYROSINE HYDROXYLASE ACTIVITY AND GENE EXPRESSION.JOURNAL OF NEUROCHEMISTRY. VOL. 67. ISSUE 2. P. 443 -462 157 86% 514
5 MITCHELL, JJ , TRAKADIS, YJ , SCRIVER, CR , (2011) PHENYLALANINE HYDROXYLASE DEFICIENCY.GENETICS IN MEDICINE. VOL. 13. ISSUE 8. P. 697 -707 104 95% 41
6 KAPPOCK, TJ , CARADONNA, JP , (1996) PTERIN-DEPENDENT AMINO ACID HYDROXYLASES.CHEMICAL REVIEWS. VOL. 96. ISSUE 7. P. 2659 -2756 247 50% 229
7 FITZPATRICK, PF , (1999) TETRAHYDROPTERIN-DEPENDENT AMINO ACID HYDROXYLASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 355 -381 112 90% 282
8 SINGH, RH , CUNNINGHAM, AC , MOFIDI, S , DOUGLAS, TD , FRAZIER, DM , HOOK, DG , JEFFERS, L , MCCUNE, H , MOSELEY, KD , OGATA, B , ET AL (2016) UPDATED, WEB-BASED NUTRITION MANAGEMENT GUIDELINE FOR PKU: AN EVIDENCE AND CONSENSUS BASED APPROACH.MOLECULAR GENETICS AND METABOLISM. VOL. 118. ISSUE 2. P. 72 -83 94 95% 0
9 DICKSON, PW , VON NAGY-FELSOBUKI, EI , GRAHAM, ME , BOBROVSKAYA, L , DUNKLEY, PR , (2004) TYROSINE HYDROXYLASE PHOSPHORYLATION: REGULATION AND CONSEQUENCES.JOURNAL OF NEUROCHEMISTRY. VOL. 91. ISSUE 5. P. 1025-1043 95 88% 249
10 BLAU, N , VAN SPRONSEN, FJ , LEVY, HL , (2010) PHENYLKETONURIA.LANCET. VOL. 376. ISSUE 9750. P. 1417 -1427 74 90% 158

Classes with closest relation at Level 2


Rank Class id link
1 1818 DYSTONIA//TETRAHYDROBIOPTERIN//WRITERS CRAMP
2 2144 JOURNAL OF INHERITED METABOLIC DISEASE//NEWBORN SCREENING//METHYLMALONIC ACIDEMIA
3 3564 14 3 3 PROTEIN//14 3 3//14 3 3 SIGMA
4 3543 ALKAPTONURIA//OCHRONOSIS//HOMOGENTISIC ACID
5 2077 HOMOVANILLIC ACID//TRACE AMINES//BETA PHENYLETHYLAMINE
6 3679 ADRENERGIC DRUG//FARMACO-EDIZIONE SCIENTIFICA//1 2 4TRIAZOLO1 5 AQUINOLINES
7 3120 GALACTOSEMIA//GALACTOSE 1 PHOSPHATE URIDYLTRANSFERASE//GALACTOSAEMIA
8 2070 SUPERIOR CERVICAL GANGLION//JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM//PTERYGOPALATINE GANGLION
9 1384 GDNF//GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR//NEURAL TRANSPLANTATION
10 1709 C FOS//EGR 1//IMMEDIATE EARLY GENE

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