Class information for:
Level 2: ADJUVANT//ISCOM//VACCINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1525 7477 41.0 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
494 3       AVIAN DISEASES//AVIAN PATHOLOGY//NEWCASTLE DISEASE VIRUS 22905
1525 2             ADJUVANT//ISCOM//VACCINE 7477
3572 1                   CHOLERA TOXIN//HEAT LABILE ENTEROTOXIN//MUCOSAL ADJUVANT 1955
5170 1                   VACCINE DELIVERY//ADJUVANT//ANTIGEN DELIVERY 1662
13376 1                   B CELL EPITOPE PREDICTION//PREDETERMINED SPECIFICITY//SYNTHETIC ANTIGENIC SITE 841
14411 1                   ISCOM//QUIL A//QUILLAJA SAPONARIA MOLINA 771
17047 1                   ALUMINUM HYDROXIDE ADJUVANT//ALUMINUM CONTAINING ADJUVANTS//MACROPHAGIC MYOFASCIITIS 620
17280 1                   LIPOAMINO ACIDS//LIPOPEPTIDE//LIPIDIC AMINO ACID 607
19461 1                   LIPOSOMAL ANTIGENS//DRUG DELIVERY SYST DEV//FUSOGENIC LIPIDS 504
22255 1                   GRP PEPTIDE CHEM//PEPTIDE PROT CHEM//PHYSICOCHEM UNIT 388
33088 1                   VIROSOMES//FUSOGENIC LIPOSOME//FRAGMENT A OF DIPHTHERIA TOXIN 129

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADJUVANT authKW 530064 11% 17% 788
2 ISCOM authKW 270261 1% 66% 100
3 VACCINE journal 173333 12% 5% 876
4 CHOLERA TOXIN authKW 136902 2% 19% 180
5 VACCINE DELIVERY authKW 124242 1% 34% 89
6 VACCINE ADJUVANT authKW 123619 1% 35% 86
7 ANTIGEN DELIVERY authKW 121716 1% 45% 66
8 MUCOSAL ADJUVANT authKW 119411 1% 49% 60
9 HEAT LABILE ENTEROTOXIN authKW 104594 1% 57% 45
10 IMMUNOBIOL VACCINE address 93663 1% 43% 54

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Immunology 57450 42% 0% 3156
2 Medicine, Research & Experimental 11728 16% 0% 1167
3 Pharmacology & Pharmacy 4236 16% 0% 1200
4 Infectious Diseases 2307 6% 0% 446
5 Biochemistry & Molecular Biology 1886 17% 0% 1294
6 Materials Science, Biomaterials 1616 3% 0% 200
7 Biochemical Research Methods 1202 5% 0% 386
8 Virology 707 3% 0% 214
9 Chemistry, Medicinal 660 4% 0% 266
10 Microbiology 571 5% 0% 384

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IMMUNOBIOL VACCINE 93663 1% 43% 54
2 GRP PEPTIDE CHEM 63719 1% 24% 64
3 PEPTIDE PROT CHEM 42291 0% 31% 33
4 PHYSICOCHEM UNIT 30055 0% 82% 9
5 AK TUMORIMMUNOL VAKZINE 25000 0% 88% 7
6 ADJUVANT UNIT 24492 0% 100% 6
7 PLA BIOPHARMACEUT PROD FORMULAT ENGN 19441 0% 53% 9
8 DRUG DELIVERY TECHNOL 19175 0% 13% 36
9 PROD 1 18178 0% 64% 7
10 SAFETY BLOOD BIOL PROD 17615 0% 21% 21

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VACCINE 173333 12% 5% 876
2 JOURNAL OF CONTROLLED RELEASE 12784 2% 2% 154
3 EXPERT REVIEW OF VACCINES 10192 1% 5% 56
4 INFECTION AND IMMUNITY 8493 3% 1% 240
5 MOLECULAR IMMUNOLOGY 7887 2% 2% 118
6 JOURNAL OF IMMUNOLOGICAL METHODS 5794 2% 1% 119
7 IMMUNOLOGY 5559 1% 1% 111
8 INTERNATIONAL JOURNAL OF PHARMACEUTICS 4961 2% 1% 142
9 IMMUNOLOGICAL COMMUNICATIONS 4786 0% 7% 16
10 ADVANCED DRUG DELIVERY REVIEWS 4358 1% 2% 54

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ADJUVANT 530064 11% 17% 788 Search ADJUVANT Search ADJUVANT
2 ISCOM 270261 1% 66% 100 Search ISCOM Search ISCOM
3 CHOLERA TOXIN 136902 2% 19% 180 Search CHOLERA+TOXIN Search CHOLERA+TOXIN
4 VACCINE DELIVERY 124242 1% 34% 89 Search VACCINE+DELIVERY Search VACCINE+DELIVERY
5 VACCINE ADJUVANT 123619 1% 35% 86 Search VACCINE+ADJUVANT Search VACCINE+ADJUVANT
6 ANTIGEN DELIVERY 121716 1% 45% 66 Search ANTIGEN+DELIVERY Search ANTIGEN+DELIVERY
7 MUCOSAL ADJUVANT 119411 1% 49% 60 Search MUCOSAL+ADJUVANT Search MUCOSAL+ADJUVANT
8 VACCINE 111691 9% 4% 692 Search VACCINE Search VACCINE
9 HEAT LABILE ENTEROTOXIN 104594 1% 57% 45 Search HEAT+LABILE+ENTEROTOXIN Search HEAT+LABILE+ENTEROTOXIN
10 ALUMINUM HYDROXIDE ADJUVANT 83047 0% 88% 23 Search ALUMINUM+HYDROXIDE+ADJUVANT Search ALUMINUM+HYDROXIDE+ADJUVANT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DE HAAN, L , HIRST, TR , (2000) CHOLERA TOXIN AND RELATED ENTEROTOXINS: A CELL BIOLOGICAL AND IMMUNOLOGICAL PERSPECTIVE.JOURNAL OF NATURAL TOXINS. VOL. 9. ISSUE 3. P. 281 -297 111 94% 13
2 SHARMA, S , MUKKUR, TKS , BENSON, HAE , CHEN, Y , (2009) PHARMACEUTICAL ASPECTS OF INTRANASAL DELIVERY OF VACCINES USING PARTICULATE SYSTEMS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 98. ISSUE 3. P. 812-843 119 56% 69
3 IRVINE, DJ , HANSON, MC , RAKHRA, K , TOKATLIAN, T , (2015) SYNTHETIC NANOPARTICLES FOR VACCINES AND IMMUNOTHERAPY.CHEMICAL REVIEWS. VOL. 115. ISSUE 19. P. 11109 -11146 111 33% 52
4 WANG, SJ , LIU, HQ , ZHANG, XY , QIAN, F , (2015) INTRANASAL AND ORAL VACCINATION WITH PROTEIN-BASED ANTIGENS: ADVANTAGES, CHALLENGES AND FORMULATION STRATEGIES.PROTEIN & CELL. VOL. 6. ISSUE 7. P. 480 -503 119 49% 3
5 ZHAO, L , SETH, A , WIBOWO, N , ZHAO, CX , MITTER, N , YU, CZ , MIDDELBERG, APJ , (2014) NANOPARTICLE VACCINES.VACCINE. VOL. 32. ISSUE 3. P. 327 -337 78 42% 123
6 CONNELL, TD , (2007) CHOLERA TOXIN, LT-I, LT-IIA AND LT-IIB: THE CRITICAL ROLE OF GANGLIOSIDE BINDING IN IMMUNOMODULATION BY TYPE I AND TYPE II HEAT-LABILE ENTEROTOXINS.EXPERT REVIEW OF VACCINES. VOL. 6. ISSUE 5. P. 821 -834 90 70% 30
7 SILVA, AL , SOEMA, PC , SLUTTER, B , OSSENDORP, F , JISKOOT, W , (2016) PLGA PARTICULATE DELIVERY SYSTEMS FOR SUBUNIT VACCINES: LINKING PARTICLE PROPERTIES TO IMMUNOGENICITY.HUMAN VACCINES & IMMUNOTHERAPEUTICS. VOL. 12. ISSUE 4. P. 1056 -1069 73 68% 0
8 ALLAHYARI, M , MOHIT, E , (2016) PEPTIDE/PROTEIN VACCINE DELIVERY SYSTEM BASED ON PLGA PARTICLES.HUMAN VACCINES & IMMUNOTHERAPEUTICS. VOL. 12. ISSUE 3. P. 806 -828 75 60% 1
9 FERREIRA, SA , GAMA, FM , VILANOVA, M , (2013) POLYMERIC NANOGELS AS VACCINE DELIVERY SYSTEMS.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. VOL. 9. ISSUE 2. P. 159-173 80 56% 24
10 HAJISHENGALLIS, G , ARCE, S , GOCKEL, CM , CONNELL, TD , RUSSELL, MW , (2005) IMMUNOMODULATION WITH ENTEROTOXINS FOR THE GENERATION OF SECRETORY IMMUNITY OR TOLERANCE: APPLICATIONS FOR ORAL INFECTIONS.JOURNAL OF DENTAL RESEARCH. VOL. 84. ISSUE 12. P. 1104 -1116 92 64% 45

Classes with closest relation at Level 2


Rank Class id link
1 2628 M CELLS//PEYERS PATCHES//FOLLICLE ASSOCIATED EPITHELIUM
2 3191 SECRETORY COMPONENT//POLYMERIC IMMUNOGLOBULIN RECEPTOR//CD89
3 741 ANTIGEN PRESENTATION//IMMUNOLOGY//ANTIGEN PROCESSING
4 543 TOLL LIKE RECEPTORS//INNATE IMMUNITY//CPG ODN
5 147 SOLID LIPID NANOPARTICLES//POLYMERIC MICELLES//LIPOSOMES
6 1694 MUCOADHESION//THIOMERS//ABSORPTION ENHANCER
7 3862 IGY//EGG YOLK ANTIBODIES//IMMUNOGLOBULIN Y
8 476 GENE DELIVERY//CELL PENETRATING PEPTIDE//CATIONIC LIPID
9 1367 DENDRITIC CELLS//DC SIGN//LANGERHANS CELLS
10 3470 CONVECTION ENHANCED DELIVERY//POLYANHYDRIDE//POLYESTER ANHYDRIDE

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