Class information for:
Level 2: WILSONS DISEASE//METALLOTHIONEIN//ATP7B

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1113 9713 37.4 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
4 4 ENVIRONMENTAL SCIENCES//GEOSCIENCES, MULTIDISCIPLINARY//METEOROLOGY & ATMOSPHERIC SCIENCES 1766162
184 3       METALLOTHIONEIN//WILSONS DISEASE//CADMIUM 56156
1113 2             WILSONS DISEASE//METALLOTHIONEIN//ATP7B 9713
1307 1                   METALLOTHIONEIN//METALLOTHIONEIN III//GROWTH INHIBITORY FACTOR 2727
2857 1                   MENKES DISEASE//ATP7A//COPPER TRANSPORT 2129
4943 1                   WILSONS DISEASE//ATP7B//HEPATOLENTICULAR DEGENERATION 1699
9254 1                   METALLOTHIONEIN//METAL THIOLATE CLUSTER//PLANT METALLOTHIONEIN 1173
14925 1                   DISULFIRAM//NEPICASTAT//DIETHYLDITHIOCARBAMATE 741
18017 1                   LEC RAT//LONG EVANS CINNAMON RAT//INDIAN CHILDHOOD CIRRHOSIS 570
21819 1                   BEDLINGTON TERRIER//MURR1//COMMD1 404
25841 1                   TETRATHIOMOLYBDATE//CLIOQUINOL//UNITA RIC CATANIA 270

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 WILSONS DISEASE authKW 2219047 9% 79% 897
2 METALLOTHIONEIN authKW 1831072 15% 41% 1435
3 ATP7B authKW 635077 2% 91% 223
4 MENKES DISEASE authKW 492434 2% 87% 181
5 LEC RAT authKW 306967 1% 86% 114
6 ATP7A authKW 284658 1% 85% 106
7 DISULFIRAM authKW 194006 2% 39% 159
8 HEPATOLENTICULAR DEGENERATION authKW 170803 1% 86% 63
9 COPPER TRANSPORT authKW 169224 1% 61% 89
10 GROWTH INHIBITORY FACTOR authKW 137786 1% 88% 50

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 11507 31% 0% 3018
2 Toxicology 6042 8% 0% 791
3 Gastroenterology & Hepatology 1603 5% 0% 454
4 Biophysics 1265 5% 0% 508
5 Pharmacology & Pharmacy 1264 9% 0% 899
6 Cell Biology 1062 7% 0% 720
7 Pathology 997 4% 0% 346
8 Genetics & Heredity 840 5% 0% 517
9 Clinical Neurology 810 6% 0% 541
10 Endocrinology & Metabolism 611 4% 0% 422

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIDAD FISIOL ANIM 76867 0% 64% 38
2 UNIT HUMAN COPPER METAB 33180 0% 81% 13
3 UNIT PEDIAT GENET 25274 0% 62% 13
4 SECT TRANSLAT NEUROSCI 23132 0% 82% 9
5 UNITA RIC CATANIA 21111 0% 61% 11
6 REFERENCE MALAD WILSON 19570 0% 69% 9
7 SECT C 18095 0% 41% 14
8 SECT NEUROPROTECT 17577 0% 40% 14
9 CELLULAR BIOL PHYSIOL IMMUNOL 15353 0% 21% 23
10 PHARMACEUT HLTH SCI 13408 0% 17% 25

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METALLOMICS 23132 1% 9% 87
2 JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE 14125 0% 13% 36
3 BIOMETALS 10621 1% 4% 77
4 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 9125 1% 4% 77
5 JOURNAL OF INORGANIC BIOCHEMISTRY 7323 1% 2% 116
6 TOXICOLOGY AND APPLIED PHARMACOLOGY 5026 1% 1% 128
7 BIOLOGICAL TRACE ELEMENT RESEARCH 4902 1% 2% 97
8 JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 4785 0% 4% 42
9 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 4311 0% 4% 34
10 TOXICOLOGY 2673 1% 1% 79

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 WILSONS DISEASE 2219047 9% 79% 897 Search WILSONS+DISEASE Search WILSONS+DISEASE
2 METALLOTHIONEIN 1831072 15% 41% 1435 Search METALLOTHIONEIN Search METALLOTHIONEIN
3 ATP7B 635077 2% 91% 223 Search ATP7B Search ATP7B
4 MENKES DISEASE 492434 2% 87% 181 Search MENKES+DISEASE Search MENKES+DISEASE
5 LEC RAT 306967 1% 86% 114 Search LEC+RAT Search LEC+RAT
6 ATP7A 284658 1% 85% 106 Search ATP7A Search ATP7A
7 DISULFIRAM 194006 2% 39% 159 Search DISULFIRAM Search DISULFIRAM
8 HEPATOLENTICULAR DEGENERATION 170803 1% 86% 63 Search HEPATOLENTICULAR+DEGENERATION Search HEPATOLENTICULAR+DEGENERATION
9 COPPER TRANSPORT 169224 1% 61% 89 Search COPPER+TRANSPORT Search COPPER+TRANSPORT
10 GROWTH INHIBITORY FACTOR 137786 1% 88% 50 Search GROWTH+INHIBITORY+FACTOR Search GROWTH+INHIBITORY+FACTOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LUTSENKO, S , BARNES, NL , BARTEE, MY , DMITRIEV, OY , (2007) FUNCTION AND REGULATION OF HUMAN COPPER-TRANSPORTING ATPASES.PHYSIOLOGICAL REVIEWS. VOL. 87. ISSUE 3. P. 1011-1046 231 80% 275
2 DE BIE, P , MULLER, P , WIJMENGA, C , KLOMP, LWJ , (2007) MOLECULAR PATHOGENESIS OF WILSON AND MENKES DISEASE: CORRELATION OF MUTATIONS WITH MOLECULAR DEFECTS AND DISEASE PHENOTYPES.JOURNAL OF MEDICAL GENETICS. VOL. 44. ISSUE 11. P. 673 -688 210 93% 132
3 ROBERTS, EA , SCHILSKY, ML , (2008) DIAGNOSIS AND TREATMENT OF WILSON DISEASE: AN UPDATE.HEPATOLOGY. VOL. 47. ISSUE 6. P. 2089-2111 162 91% 288
4 MILES, AT , HAWKSWORTH, GM , BEATTIE, JH , RODILLA, V , (2000) INDUCTION, REGULATION, DEGRADATION, AND BIOLOGICAL SIGNIFICANCE OF MAMMALIAN METALLOTHIONEINS.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 35. ISSUE 1. P. 35 -70 234 87% 278
5 COYLE, P , PHILCOX, JC , CAREY, LC , ROFE, AM , (2002) METALLOTHIONEIN: THE MULTIPURPOSE PROTEIN.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 59. ISSUE 4. P. 627 -647 170 74% 680
6 FERENCI, P , CZLONKOWSKA, A , STREMMEL, W , HOUWEN, R , ROSENBERG, W , SCHILSKY, M , JANSEN, P , MORADPOUR, D , GITLIN, J , (2012) EASL CLINICAL PRACTICE GUIDELINES: WILSON'S DISEASE.JOURNAL OF HEPATOLOGY. VOL. 56. ISSUE 3. P. 671-685 107 93% 113
7 CAPDEVILA, M , BOFILL, R , PALACIOS, O , ATRIAN, S , (2012) STATE-OF-THE-ART OF METALLOTHIONEINS AT THE BEGINNING OF THE 21ST CENTURY.COORDINATION CHEMISTRY REVIEWS. VOL. 256. ISSUE 1-2. P. 46 -62 149 77% 57
8 BOAL, AK , ROSENZWEIG, AC , (2009) STRUCTURAL BIOLOGY OF COPPER TRAFFICKING.CHEMICAL REVIEWS. VOL. 109. ISSUE 10. P. 4760 -4779 138 80% 152
9 TELIANIDIS, J , HUNG, YH , MATERIA, S , LA FONTAINE, S , (2013) ROLE OF THE P-TYPE ATPASES, ATP7A AND ATP7B IN BRAIN COPPER HOMEOSTASIS.FRONTIERS IN AGING NEUROSCIENCE. VOL. 5. ISSUE . P. - 152 78% 23
10 DENOYER, D , MASALDAN, S , LA FONTAINE, S , CATER, MA , (2015) TARGETING COPPER IN CANCER THERAPY: 'COPPER THAT CANCER'.METALLOMICS. VOL. 7. ISSUE 11. P. 1459 -1476 145 67% 18

Classes with closest relation at Level 2


Rank Class id link
1 667 ZINC//ZINC DEFICIENCY//COPPER DEFICIENCY
2 443 LEAD//CADMIUM//BLOOD LEAD
3 1715 LACCASE//CERULOPLASMIN//BLUE COPPER PROTEIN
4 1409 SIDEROPHORE//COLICIN//PYOVERDIN
5 672 ENDOSULFAN//BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY//TOXICOLOGY
6 1065 CISPLATIN//NEPHROTOXICITY//PLATINUMII COMPLEXES
7 4040 ECOL QUAL MANAGEMENT//ASSOC SAO BENTO DE ENSINO//COPPER GLUTATHIONE COMPLEXES
8 2650 EXTRACELLULAR SUPEROXIDE DISMUTASE//SUPEROXIDE DISMUTASE//SOD MIMIC
9 2222 TRIBUTYLTIN//IMPOSEX//ORGANOTIN
10 2226 EARTHWORMS//ONISCIDEA//DEROCERAS RETICULATUM

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