Class information for:
Level 1: BENZNIDAZOLE//NIFURTIMOX//TRYPANOSOMA CRUZI

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9995 1100 40.6 70%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
326 3       LEISHMANIA//TRYPANOSOMA CRUZI//PARASITIOLOGY 38360
108 2             TRYPANOSOMA CRUZI//CHAGAS DISEASE//PARASITIOLOGY 25255
9995 1                   BENZNIDAZOLE//NIFURTIMOX//TRYPANOSOMA CRUZI 1100

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BENZNIDAZOLE authKW 854953 7% 42% 73
2 NIFURTIMOX authKW 506636 3% 49% 37
3 TRYPANOSOMA CRUZI authKW 420311 20% 7% 225
4 CHAGAS DISEASE authKW 332183 17% 6% 187
5 CATEDRA QUIM INORGAN address 259146 4% 22% 43
6 QUEEN MARY PRECLIN DRUG DISCOVERY GRP address 252342 1% 91% 10
7 STEROL BIOSYNTHESIS INHIBITORS authKW 235925 2% 50% 17
8 5 NITROFURYL CONTAINING THIOSEMICARBAZONES authKW 194305 1% 100% 7
9 QUIM ORGAN M LORA TAMAYO address 170015 1% 88% 7
10 SENNA VILLOSA authKW 166547 1% 100% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Parasitiology 13698 21% 0% 236
2 Tropical Medicine 6192 11% 0% 125
3 Chemistry, Medicinal 5578 21% 0% 236
4 Pharmacology & Pharmacy 1757 25% 0% 274
5 Microbiology 866 13% 0% 142
6 Biochemistry & Molecular Biology 284 17% 0% 192
7 Toxicology 251 5% 0% 58
8 Chemistry, Organic 184 7% 0% 82
9 Infectious Diseases 136 4% 0% 45
10 Integrative & Complementary Medicine 112 1% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CATEDRA QUIM INORGAN 259146 4% 22% 43
2 QUEEN MARY PRECLIN DRUG DISCOVERY GRP 252342 1% 91% 10
3 QUIM ORGAN M LORA TAMAYO 170015 1% 88% 7
4 FARMACOL CLIN MOL 138789 0% 100% 5
5 INTERACC MOL 134014 1% 37% 13
6 CEITOX 124383 1% 41% 11
7 GRP QUIM MED 120267 1% 33% 13
8 DISENO TRANSPORTADO DROGAS 111031 0% 100% 4
9 PARASITOL VET SCI 111031 0% 100% 4
10 PARASITOL CELULAR MOL 97803 2% 21% 17

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 7251 7% 0% 79
2 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 6531 4% 1% 47
3 INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE 6234 1% 4% 6
4 MEMORIAS DO INSTITUTO OSWALDO CRUZ 5561 3% 1% 32
5 PLOS NEGLECTED TROPICAL DISEASES 4308 2% 1% 27
6 MEDICINA-BUENOS AIRES 3364 2% 1% 19
7 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 3263 2% 0% 26
8 EXPERIMENTAL PARASITOLOGY 3184 2% 0% 24
9 ACTA TROPICA 2583 2% 0% 20
10 JOURNAL OF MEDICINAL CHEMISTRY 2117 4% 0% 41

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BENZNIDAZOLE 854953 7% 42% 73 Search BENZNIDAZOLE Search BENZNIDAZOLE
2 NIFURTIMOX 506636 3% 49% 37 Search NIFURTIMOX Search NIFURTIMOX
3 TRYPANOSOMA CRUZI 420311 20% 7% 225 Search TRYPANOSOMA+CRUZI Search TRYPANOSOMA+CRUZI
4 CHAGAS DISEASE 332183 17% 6% 187 Search CHAGAS+DISEASE Search CHAGAS+DISEASE
5 STEROL BIOSYNTHESIS INHIBITORS 235925 2% 50% 17 Search STEROL+BIOSYNTHESIS+INHIBITORS Search STEROL+BIOSYNTHESIS+INHIBITORS
6 5 NITROFURYL CONTAINING THIOSEMICARBAZONES 194305 1% 100% 7 Search 5+NITROFURYL+CONTAINING+THIOSEMICARBAZONES Search 5+NITROFURYL+CONTAINING+THIOSEMICARBAZONES
7 SENNA VILLOSA 166547 1% 100% 6 Search SENNA+VILLOSA Search SENNA+VILLOSA
8 TRYPANOCIDAL ACTIVITY 128901 2% 19% 24 Search TRYPANOCIDAL+ACTIVITY Search TRYPANOCIDAL+ACTIVITY
9 2 PROPEN 1 AMINES 111031 0% 100% 4 Search 2+PROPEN+1+AMINES Search 2+PROPEN+1+AMINES
10 TYPE I NITROREDUCTASE 111031 0% 100% 4 Search TYPE+I+NITROREDUCTASE Search TYPE+I+NITROREDUCTASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SALOMAO, K , MENNA-BARRETO, RFS , DE CASTRO, SL , (2016) STAIRWAY TO HEAVEN OR HELL? PERSPECTIVES AND LIMITATIONS OF CHAGAS DISEASE CHEMOTHERAPY.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 20. P. 2266 -2289 123 44% 1
2 BERMUDEZ, J , DAVIES, C , SIMONAZZI, A , REAL, JP , PALMA, S , (2016) CURRENT DRUG THERAPY AND PHARMACEUTICAL CHALLENGES FOR CHAGAS DISEASE.ACTA TROPICA. VOL. 156. ISSUE . P. 1 -16 57 40% 8
3 CASTRO, JA , DE MECCA, MM , GOMEZ, MID , CASTRO, GD , (2015) CHAGAS DISEASE: THE CONTRIBUTION OF THE CENTER FOR TOXICOLOGICAL RESEARCH.ACTA BIOQUIMICA CLINICA LATINOAMERICANA. VOL. 49. ISSUE 1. P. 73 -82 34 97% 1
4 CASTRO, JA , DE MECCA, MM , BARTEL, LC , (2006) TOXIC SIDE EFFECTS OF DRUGS USED TO TREAT CHAGAS' DISEASE (AMERICAN TRYPANOSOMIASIS).HUMAN & EXPERIMENTAL TOXICOLOGY. VOL. 25. ISSUE 8. P. 471-479 34 83% 219
5 DE MACEDO-SILVA, ST , DE SOUZA, W , RODRIGUES, JCF , (2015) STEROL BIOSYNTHESIS PATHWAY AS AN ALTERNATIVE FOR THE ANTI-PROTOZOAN PARASITE CHEMOTHERAPY.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 18. P. 2186 -2198 49 58% 3
6 BUCKNER, FS , URBINA, JA , (2012) RECENT DEVELOPMENTS IN STEROL 14-DEMETHYLASE INHIBITORS FOR CHAGAS DISEASE.INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. VOL. 2. ISSUE . P. 236-242 31 79% 40
7 CHOI, JY , PODUST, LM , ROUSH, WR , (2014) DRUG STRATEGIES TARGETING CYP51 IN NEGLECTED TROPICAL DISEASES.CHEMICAL REVIEWS. VOL. 114. ISSUE 22. P. 11242 -11271 73 32% 11
8 GASPAR, L , MORAES, CB , FREITAS, LH , FERRARI, S , COSTANTINO, L , COSTI, MP , CORON, RP , SMITH, TK , SIQUEIRA-NETO, JL , MCKERROW, JH , ET AL (2015) CURRENT AND FUTURE CHEMOTHERAPY FOR CHAGAS DISEASE.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 37. P. 4293 -4312 57 37% 4
9 VIEIRA, DF , CHOI, JY , CALVET, CM , SIQUEIRA-NETO, JL , JOHNSTON, JB , KELLAR, D , GUT, J , CAMERON, MD , MCKERROW, JH , ROUSH, WR , ET AL (2014) BINDING MODE AND POTENCY OF N-INDOLYLOXOPYRIDINYL-4-AMINOPROPANYL-BASED INHIBITORS TARGETING TRYPANOSOMA CRUZI CYP51.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 23. P. 10162 -10175 31 74% 1
10 BAHIA, MT , DINIZ, LD , MOSQUEIRA, VCF , (2014) THERAPEUTICAL APPROACHES UNDER INVESTIGATION FOR TREATMENT OF CHAGAS DISEASE.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 23. ISSUE 9. P. 1225 -1237 38 52% 11

Classes with closest relation at Level 1


Rank Class id link
1 14422 TRYPANOTHIONE REDUCTASE//TRYPANOTHIONE//TRYPAREDOXIN
2 1492 TRYPANOSOMA CRUZI//CHAGAS DISEASE//TRYPANOSOMA RANGELI
3 30453 IRIDIUM PENTAMIDINE COMPLEX//3 SUBSTITUTED 6 DIALKOXYPHOSPHORYLTHIAZOLO3 2 D1 2 3 4TETRAZOL 7 IUM CHLORIDE//5 METHYLENE 1 3 OXAZOLINES
4 13361 GLYCOSOME//UNIDAD BIOQUIM PARASITOS//TROP DIS UNIT
5 3390 LEISHMANIA//MILTEFOSINE//ANTIMONY RESISTANCE
6 33515 DINITROANILINE//PHOSPHOROTHIOAMIDATE//2R 3S N BENZOYL 3 PHENYLISOSERINE
7 10701 PLASMEPSIN//CRUZIPAIN//FALCIPAIN
8 31686 MUEHLENBECKIA HASTULATA//ANTITRYPANOSOMAL ACTIVITY//KHAYA SENEGALENSIS
9 30746 METACASPASE//DYSKINETOPLASTIDY//WITS MALARIA MOL MED HAEMATOL
10 6509 HUMAN AFRICAN TRYPANOSOMIASIS//TRYPANOSOMA BRUCEI GAMBIENSE//SLEEPING SICKNESS

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