Class information for:
Level 1: TRYPANOTHIONE REDUCTASE//TRYPANOTHIONE//TRYPAREDOXIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14422 770 39.1 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
326 3       LEISHMANIA//TRYPANOSOMA CRUZI//PARASITIOLOGY 38360
108 2             TRYPANOSOMA CRUZI//CHAGAS DISEASE//PARASITIOLOGY 25255
14422 1                   TRYPANOTHIONE REDUCTASE//TRYPANOTHIONE//TRYPAREDOXIN 770

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRYPANOTHIONE REDUCTASE authKW 2969376 12% 80% 94
2 TRYPANOTHIONE authKW 1713636 9% 64% 68
3 TRYPAREDOXIN authKW 774499 3% 78% 25
4 TRYPAREDOXIN PEROXIDASE authKW 546952 3% 69% 20
5 TRYPANOTHIONE SYNTHETASE authKW 360497 1% 91% 10
6 GLUTATHIONYLSPERMIDINE authKW 253788 1% 80% 8
7 HYDROPEROXIDE METABOLISM authKW 200745 1% 56% 9
8 GLUTATHIONE REDUCTASE authKW 172588 9% 6% 70
9 ZENTRUM BIOCHEM address 172408 5% 11% 38
10 TRYPANOTHIONE REDUCTASE INHIBITORS authKW 126894 1% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5039 66% 0% 505
2 Parasitiology 2225 11% 0% 81
3 Chemistry, Medicinal 1928 15% 0% 118
4 Biophysics 669 12% 0% 89
5 Tropical Medicine 293 3% 0% 24
6 Chemistry, Organic 120 7% 0% 56
7 Biochemical Research Methods 71 4% 0% 32
8 Pharmacology & Pharmacy 69 8% 0% 63
9 Microbiology 28 4% 0% 31
10 Cell Biology 14 4% 0% 34

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ZENTRUM BIOCHEM 172408 5% 11% 38
2 GRP BIOREACT TECH 79310 0% 100% 2
3 BIOL CHEM MOL MICROBIOL 60287 2% 8% 18
4 WELLCOME TRUST BIO 57974 3% 6% 26
5 CATEDRA QUIM CUANT 52872 0% 67% 2
6 ANTIVIRAL ONDERZOEK 39655 0% 100% 1
7 BIOCHEM ZNETRUM HEIDELBERG 39655 0% 100% 1
8 BIOINFORMAT BIOMODELADO MOL 39655 0% 100% 1
9 BIOL CHEM MOL BIOCHEM 39655 0% 100% 1
10 BIOL GRENZFLACHEN IGB 2 39655 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 11129 5% 1% 40
2 JOURNAL OF ENZYME INHIBITION 3998 1% 2% 6
3 CHEMMEDCHEM 2905 2% 1% 13
4 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1541 3% 0% 26
5 BIOLOGICAL CHEMISTRY 1482 1% 0% 11
6 EUROPEAN JOURNAL OF BIOCHEMISTRY 1320 3% 0% 26
7 BIOCHEMISTRY 1195 5% 0% 41
8 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 987 1% 0% 7
9 BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 914 1% 0% 7
10 JOURNAL OF MEDICINAL CHEMISTRY 782 3% 0% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TRYPANOTHIONE REDUCTASE 2969376 12% 80% 94 Search TRYPANOTHIONE+REDUCTASE Search TRYPANOTHIONE+REDUCTASE
2 TRYPANOTHIONE 1713636 9% 64% 68 Search TRYPANOTHIONE Search TRYPANOTHIONE
3 TRYPAREDOXIN 774499 3% 78% 25 Search TRYPAREDOXIN Search TRYPAREDOXIN
4 TRYPAREDOXIN PEROXIDASE 546952 3% 69% 20 Search TRYPAREDOXIN+PEROXIDASE Search TRYPAREDOXIN+PEROXIDASE
5 TRYPANOTHIONE SYNTHETASE 360497 1% 91% 10 Search TRYPANOTHIONE+SYNTHETASE Search TRYPANOTHIONE+SYNTHETASE
6 GLUTATHIONYLSPERMIDINE 253788 1% 80% 8 Search GLUTATHIONYLSPERMIDINE Search GLUTATHIONYLSPERMIDINE
7 HYDROPEROXIDE METABOLISM 200745 1% 56% 9 Search HYDROPEROXIDE+METABOLISM Search HYDROPEROXIDE+METABOLISM
8 GLUTATHIONE REDUCTASE 172588 9% 6% 70 Search GLUTATHIONE+REDUCTASE Search GLUTATHIONE+REDUCTASE
9 TRYPANOTHIONE REDUCTASE INHIBITORS 126894 1% 80% 4 Search TRYPANOTHIONE+REDUCTASE+INHIBITORS Search TRYPANOTHIONE+REDUCTASE+INHIBITORS
10 GLUTATHIONYLSPERMIDINE SYNTHETASE 118965 0% 100% 3 Search GLUTATHIONYLSPERMIDINE+SYNTHETASE Search GLUTATHIONYLSPERMIDINE+SYNTHETASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 O'SULLIVAN, MC , DURHAM, TB , VALDES, HE , DAUER, KL , KARNEY, NJ , FORRESTEL, AC , BACCHI, CJ , BAKER, JF , (2015) DIBENZOSUBERYL SUBSTITUTED POLYAMINES AND ANALOGS OF CLOMIPRAMINE AS EFFECTIVE INHIBITORS OF TRYPANOTHIONE REDUCTASE; MOLECULAR DOCKING, AND ASSESSMENT OF TRYPANOCIDAL ACTIVITIES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 23. ISSUE 5. P. 996 -1010 72 61% 5
2 AUGUSTYNS, K , AMSSOMS, K , YAMANI, A , RAJAN, PK , HAEMERS, A , (2001) TRYPANOTHIONE AS A TARGET IN THE DESIGN OF ANTITRYPANOSOMAL AND ANTILEISHMANIAL AGENTS.CURRENT PHARMACEUTICAL DESIGN. VOL. 7. ISSUE 12. P. 1117 -1141 88 72% 60
3 BERNARDES, LSC , ZANI, CL , CARVALHO, I , (2013) TRYPANOSOMATIDAE DISEASES: FROM THE CURRENT THERAPY TO THE EFFICACIOUS ROLE OF TRYPANOTHIONE REDUCTASE IN DRUG DISCOVERY.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 21. P. 2673 -2696 68 62% 24
4 FLOHE, L , (2012) THE TRYPANOTHIONE SYSTEM AND THE OPPORTUNITIES IT OFFERS TO CREATE DRUGS FOR THE NEGLECTED KINETOPLAST DISEASES.BIOTECHNOLOGY ADVANCES. VOL. 30. ISSUE 1. P. 294 -301 63 73% 13
5 MAYA, JD , SALAS, CO , AGUILERA-VENEGAS, B , DIAZ, MV , LOPEZ-MUNOZ, R , (2014) KEY PROTEINS IN THE POLYAMINE-TRYPANOTHIONE PATHWAY AS DRUG TARGETS AGAINST TRYPANOSOMA CRUZI.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 15. P. 1757-1771 84 52% 7
6 KRAUTH-SIEGEL, RL , COMINI, MA , (2008) REDOX CONTROL IN TRYPANOSOMATIDS, PARASITIC PROTOZOA WITH TRYPANOTHIONE-BASED THIOL METABOLISM.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1780. ISSUE 11. P. 1236 -1248 71 48% 151
7 KRAUTH-SIEGEL, RL , BAUER, H , SCHIRMER, H , (2005) DITHIOL PROTEINS AS GUARDIANS OF THE INTRACELLULAR REDOX MILIEU IN PARASITES: OLD AND NEW DRUG TARGETS IN TRYPANOSOMES AND MALARIA-CAUSING PLASMODIA.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 44. ISSUE 5. P. 690-715 87 45% 180
8 KRAUTH-SIEGEL, RL , LEROUX, AE , (2012) LOW-MOLECULAR-MASS ANTIOXIDANTS IN PARASITES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 17. ISSUE 4. P. 583 -607 96 35% 33
9 KRAUTH-SIEGEL, RL , MEIERING, SK , SCHMIDT, H , (2003) THE PARASITE-SPECIFIC TRYPANOTHIONE METABOLISM OF TRYPANOSOMA AND LEISHMANIA.BIOLOGICAL CHEMISTRY. VOL. 384. ISSUE 4. P. 539-549 64 64% 71
10 OLIN-SANDOVAL, V , MORENO-SANCHEZ, R , SAAVEDRA, E , (2010) TARGETING TRYPANOTHIONE METABOLISM IN TRYPANOSOMATID HUMAN PARASITES.CURRENT DRUG TARGETS. VOL. 11. ISSUE 12. P. 1614-1630 62 55% 17

Classes with closest relation at Level 1


Rank Class id link
1 9995 BENZNIDAZOLE//NIFURTIMOX//TRYPANOSOMA CRUZI
2 27737 NADH OXIDASE//H2O FORMING NADH OXIDASE//NADH PEROXIDASE
3 21458 ERGOTHIONEINE//MYCOTHIOL//BACILLITHIOL
4 14339 SPERMIDINE SYNTHASE//S ADENOSYLMETHIONINE DECARBOXYLASE//AMINOPROPYLTRANSFERASE
5 25058 DRUG METAB MOL TOXICOL S//KUVIN TROP DIS//P VINCKEI PETTERI
6 19000 6 PHOSPHOGLUCONATE DEHYDROGENASE//GLUCOSE 6 PHOSPHATE DEHYDROGENASE//BIOTECHNOL PLICAT
7 13361 GLYCOSOME//UNIDAD BIOQUIM PARASITOS//TROP DIS UNIT
8 3390 LEISHMANIA//MILTEFOSINE//ANTIMONY RESISTANCE
9 6036 PEROXIREDOXIN//THIOREDOXIN PEROXIDASE//SULFIREDOXIN
10 30746 METACASPASE//DYSKINETOPLASTIDY//WITS MALARIA MOL MED HAEMATOL

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